1. Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry
- Author
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Mirjam Nielen, A.A.M. Stolker, Costas Georgakopoulos, Ariadni Vonaparti, Marianna Stamou, J.G.J. Mol, Ruud J. B. Peters, Yiannis S. Angelis, Emmanouil Lyris, and Arjen Lommen
- Subjects
Veterinary Drugs ,organic pollutants ,RIKILT - Business Unit Veiligheid & Gezondheid ,residue analysis ,Mass spectrometry ,Orbitrap ,High-performance liquid chromatography ,Analytical Chemistry ,law.invention ,metabolite identification ,law ,unknown pesticides ,liquid-chromatography ,Retrospective analysis ,Veterinary drug ,uplc-tof-ms ,growth-promoting agents ,Spectroscopy ,BU Microbiological & Chemical Food Analysis ,Potential impact ,Chromatography ,Chemistry ,RIKILT - R&C Groeibevorderaars ,Organic Chemistry ,Organische Chemie ,horse urine analysis ,RIKILT - R&C Contaminanten ,gas-chromatography ,RIKILT - Business Unit Safety & Health ,BU Microbiologische & Chemische Voedselanalyse ,threshold substances ,Gas chromatography - Abstract
A common trend in food contaminants and sports doping control is towards a limited number of targeted, full-scan, accurate-mass spectrometry (MS) methods based on time-of-flight (TOF) or Fourier-transform orbital trap (Orbitrap) mass analyzers. Retrospective analysis of the full-scan datasets of signals from emerging contaminants, novel metabolites and illegal designer substances is a major step forward. We present data from recent applications of gas chromatography with TOF-MS, ultra-high-performance liquid chromatography (LC) with TOF-MS and LC-Orbitrap MS in the screening of European Commission-regulated veterinary drugs and other contaminants in foods, and World Anti-Doping Agency-prohibited substances. We discuss the potential impact of these new approaches on future developments. more...
- Published
- 2010
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