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Fibromyalgia (FM) is characterized by chronic widespread pain, sleep disturbance, fatigue, and catastrophizing. This pilot study explored whether gentle, daily yoga-based exercise practice could improve pain and sleep quality, and whether certain patient phenotypes were associated with greater improvement. Fibromyalgia patients (n = 36) attended a six-week yoga program, with weekly, in-person, pain-tailored group yoga classes, and were sent daily yoga videos to practice for 30 minutes at home. Participants completed the Brief Pain Inventory (BPI), Revised Fibromyalgia Impact Questionnaire (FIQR), Promis-29 scales, Pittsburgh Sleep Quality Index (PSQI), and the Pain Catastrophizing Scale (PCS). Additionally, they completed daily electronic diaries and wore a wrist actigraph to measure sleep efficiency during 3 weeks, at baseline, 2nd, and 6th week of yoga. Pain, fatigue, and sleep quality, although improved overall, varied among participants. Multilevel modeling analysis of daily ratings in week 6 revealed no main effect for baseline anxiety and catastrophizing on pain, fatigue and sleep efficiency. However, a significant interaction between these was observed for all three outcomes (fatigue: B=.060±.022, p=0.01, sleep efficiency: B=-.40±.015, p = 0.01, pain: B=.055±.020, p=0

Music has been shown to decrease pain and modulate affect, but the mechanism by which music conveys analgesia in relatively unexplored . Using quantitative sensory testing (QST), we assessed the impact of a novel app-based music intervention on the nociceptive processing of pain. Healthy volunteers (n=60) were assessed for psychosocial traits including anxiety, depression, and catastrophizing using validated questionnaires. QST included investigation of: 1) pain sensitivity as measured by pressure pain threshold and tolerance using a handheld algometer, as well as reported pain to weighted pinprick stimuli, 2) temporal summation of pain (TSP) with a repeated pinprick stimulus, and 3) conditioned pain modulation (CPM) with pressure and cold stimuli. QST was performed in both the absence and presence of an interactive music app (Unwind), with paired t or Wilcoxon rank tests used to determine differences. Pressure pain threshold in both the forearm (p=0.007) and trapezius (p=0.002) increased with music. Initial pinprick pain severity (p