1. MIP-1γ and SDF-1α Confer to High-Fat Diet Enhanced Lung Adenocarcinoma Progression
- Author
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Min-Hui Chien, Keng-Mao Liao, Yun-Ting Hsieh, Keng-Ieng Wong, Wei-Jia Luo, and Kang-Yi Su
- Subjects
Genetically modified mouse ,Oncology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Cancer ,Institutional Animal Care and Use Committee ,medicine.disease ,Obesity ,Cytokine ,Internal medicine ,medicine ,Adenocarcinoma ,Animal studies ,business ,Lung cancer - Abstract
Background: Obesity is a serious health problem worldwide. The correlation of obesity and chronic diseases and cancer been well-documented. Although obesity can promote cancer progression, the mechanism is largely unknown and thus an ideal animal model is required especially in lung cancer. Methods: We utilized an inducible mutant EGFR driven lung cancer transgenic mouse to address this issue. Mice with lung cancer induction were fed with regular diet (RD) or high-fat diet (HFD) followed by tumor burden evaluation. Lung tissues were harvested for whole-genome transcriptomic, gene enrichment analysis, and cytokine array for potential signatures identification. Findings: Mice with HFD treatments had significant body weight increments compared with RD treatments (p 2-fold, p
- Published
- 2018