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Your search keyword '"Mocchegiani, E."' showing total 27 results
Start Over Author "Mocchegiani, E." Publisher elsevier bv
27 results on '"Mocchegiani, E."'

5. Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects

Author

Mariani, E., primary, Mangialasche, F., additional, Feliziani, F.T., additional, Cecchetti, R., additional, Malavolta, M., additional, Bastiani, P., additional, Baglioni, M., additional, Dedoussis, G., additional, Fulop, T., additional, Herbein, G., additional, Jajte, J., additional, Monti, D., additional, Rink, L., additional, Mocchegiani, E., additional, and Mecocci, P., additional

Published
2008
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26. Combination of biomarkers to predict mortality in elderly patients with myocardial infarction

Author

Liana Spazzafumo, Fabiola Olivieri, Roberto Antonicelli, Simona Giovagnetti, Claudio Franceschi, Roberta Galeazzi, Francesca Marchegiani, Maurizio Cardelli, C. Sirolla, Eugenio Mocchegiani, Olivieri F, Spazzafumo L, Antonicelli R, Marchegiani F, Cardelli M, Sirolla C, Galeazzi R, Giovagnetti S, Mocchegiani E, and Franceschi C.

Subjects
Male, Senescence, Aging, medicine.medical_specialty, Homocysteine, Myocardial Infarction, Gastroenterology, chemistry.chemical_compound, Internal medicine, medicine, Risk of mortality, Humans, Vitamin B12, Myocardial infarction, Risk factor, Aged, Aged, 80 and over, business.industry, Plasma levels, medicine.disease, Surgery, Survival Rate, chemistry, Concomitant, Female, business, Biomarkers, Follow-Up Studies, Forecasting, Developmental Biology
Abstract

The elderly subjects affected by Acute Myocardial Infarction (AMI) have the highest risk of mortality. Our study was designed to improve the capability of mortality risk stratification in elderly AMI patients through the concurrent evaluations of different biomarkers, including genetic markers.One-year follow-up study was performed in 250 elderly AMI patients. The combination of high total Homocysteine (tHcy), low folate and vitamin B12 plasma levels (18.0+/-9.0 micromol/l; 4.4+/-1.2 ng/ml; 404.2+/-287.5 pg/ml, respectively) and elevated CRP plasma levels (or =6 mg/dl) identify the highest-risk pathway of heart mortality (RR=4.20, IC 95% 1.62-10.89, P0.002) with respect to the combination of low total tHcy, high folate and vitamin B12 plasma levels (12.4+/-5.2 micromol/l; 8.9+/-2.5 ng/ml; 546.9+/-379.8 pg/ml, respectively) and low CRP plasma levels (6 mg/dl).In elderly AMI patients the concomitant elevation of CRP and tHcy, associated with folate and vitamin B12 low levels, could be considered a significant predictive heart mortality risk factor.

Published
2008
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27. Major Histocompatibility Complex Polymorphisms and Ageing

Author

Calogero Caruso, Giuseppina Candore, Domenico Lio, Giuseppina Colonna-Romano, STRAUB RH, MOCCHEGIANI E., CANDORE G, CARUSO C, COLONNA ROMANO G, and LIO D

Subjects
Genetics, Immune system, Genotype, Antigen presentation, biology.protein, Human leukocyte antigen, Biology, Allele, Major histocompatibility complex, Histocompatibility, Genetic association
Abstract

ASTRACT Longevity seems to be directly correlated with optimal functioning of the immune system, suggesting that some genetic determinants of longevity might reside in those polymorphisms for the immune system genes that regulate immune responses. Accordingly, mouse lifespan is influenced by MHC (major histocompatibility complex) genotype. The HLA (the human MHC) region encompasses over 4 Mb of DNA on the chromosome band 6p21.3 and its extensive characterisation has recently culminated in the determination of the nucleotide sequence of the entire region, confirming the presence of ~ 220 genes. The MHC is traditionally divided into the class I, class II and class III regions. Most HLA genes involved in the immune response fall into classes I and II, which encode highly polymorphic heterodimeric glycoproteins involved in graft rejection and antigen presentation to T cells. However, many genes of the class III region are also involved in the immune and inflammatory responses.. MHC polymorphisms have been the focus of a vast number of ageing association studies. One of the limitations in the most reported studies is the number of aged individuals available of both genders, and the lack of complete background histories of health or ethnicity for study participants. However, also taking into account well planned and designed studies, discordant results have been obtained. The discordant results of MHC/ageing association studies might be due to distinct linkage in different cohorts or to other interacting, genetic or environmental factors or to the heterogeneity of ageing. Nevertheless, bearing all the reported studies in mind, there is no convincing evidence of a strong, direct association between longevity and any MHC alleles.

Published
2004

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