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104 results on '"Moses R."'

1. Integrated HIV, diabetes, and hypertension care in sub-Saharan Africa

Author: Havlir, Diane, primary, Kamya, Moses R, additional, and Petersen, Maya, additional
Published: 2024
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2. The emergence of artemisinin partial resistance in Africa: how do we respond?

Author: Rosenthal, Philip J, primary, Asua, Victor, additional, Bailey, Jeffrey A, additional, Conrad, Melissa D, additional, Ishengoma, Deus S, additional, Kamya, Moses R, additional, Rasmussen, Charlotte, additional, Tadesse, Fitsum G, additional, Uwimana, Aline, additional, and Fidock, David A, additional
Published: 2024
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3. Financial incentives for reduced alcohol use and increased isoniazid adherence during tuberculosis preventive therapy among people with HIV in Uganda: an open-label, factorial randomised controlled trial

Author: Chamie, Gabriel, primary, Hahn, Judith A, additional, Kekibiina, Allen, additional, Emenyonu, Nneka I, additional, Beesiga, Brian, additional, Marson, Kara, additional, Fatch, Robin, additional, Lodi, Sara, additional, Adong, Julian, additional, Thirumurthy, Harsha, additional, McDonell, Michael G, additional, Gandhi, Monica, additional, Bryant, Kendall, additional, Havlir, Diane V, additional, Kamya, Moses R, additional, and Muyindike, Winnie R, additional
Published: 2023
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4. Geographical, social, and political contexts of tuberculosis control and intervention, as reported by mid-level health managers in Uganda: ‘The activity around town’

Author: Johnson-Peretz, Jason, primary, Chamie, Gabriel, additional, Kakande, Elijah, additional, Christian, Canice, additional, Kamya, Moses R., additional, Akatukwasa, Cecilia, additional, Atwine, Fred, additional, Havlir, Diane V., additional, and Camlin, Carol S., additional
Published: 2023
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5. Small babies, big risks: global estimates of prevalence and mortality for vulnerable newborns to accelerate change and improve counting

Author: Joy E Lawn, Eric O Ohuma, Ellen Bradley, Lorena Suárez Idueta, Elizabeth Hazel, Yemisrach B Okwaraji, Daniel J Erchick, Judith Yargawa, Joanne Katz, Anne C C Lee, Mike Diaz, Mihretab Salasibew, Jennifer Requejo, Chika Hayashi, Ann-Beth Moller, Elaine Borghi, Robert E Black, Hannah Blencowe, Per Ashorn, Ulla Ashorn, Nigel Klein, G Justus Hofmeyr, Marleen Temmerman, Sufia Askari, Samuel Chakwera, Laith Hussain-Alkhateeb, Alexandra Lewin, Wahyu Retno Mahanani, Emily White Johansson, Tina Lavin, Diana Estevez Fernandez, Giovanna Gatica Domínguez, Ayesha de Costa, Jenny A Cresswell, Julia Krasevec, Allisyn C Moran, Veronica Pingray, Gabriela Cormick, Luz Gibbons, José Belizan, Carlos Guevel, Kara Warrilow, Adrienne Gordon, Vicki Flenady, Jessica Sexton, Harriet Lawford, Enny S. Paixao, Ila Rocha Falcão, Mauricio Lima Barreto, Sarka Lisonkova, Qi Wen, Francisco Mardones, Raúl Caulier-Cisterna, José Acuña, Petr Velebil, Jitka Jirova, Erzsébet Horváth-Puhó, Henrik Toft Sørensen, Luule Sakkeus, Liili Abuladze, Mika Gissler, Maziar Moradi-Lakeh, Mohammad Heidarzadeh, Narjes Khalili, Khalid A. Yunis, Ayah Al Bizri, Pascale Nakad, Shamala Devi Karalasingam, J Ravichandran R Jeganathan, Nurakman binti Baharum, Lorena Suárez-Idueta, Arturo Barranco Flores, Jesus F Gonzalez Roldan, Sonia Lopez Alvarez, Aimée E. van Dijk, Lisa Broeders, Luis Huicho, Hugo G Quezada Pinedo, Kim N Cajachagua-Torres, Rodrigo M Carrillo-Larco, Carla Estefania Tarazona Meza, Wilmer Cristobal Guzman-Vilca, Tawa O. Olukade, Hamdy A. Ali, Fawziya Alyafei, Mai AlQubaisi, Mohamad R Alturk, Ho Yeon Kim, Geum Joon Cho, Neda Razaz, Jonas Söderling, Lucy K Smith, Jennifer J Kurinczuk, Ruth J Matthews, Bradley N Manktelow, Elizabeth S Draper, Alan C Fenton, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Celina Davis, Samantha Clarke, Lee S.F. Wu, Sachiyo Yoshida, Rajiv Bahl, Carlos Grandi, Alain B Labrique, Mabhubur Rashid, Salahuddin Ahmed, Arunangshu D. Roy, Rezwanul Haque, Saijuddin Shaikh, Abdullah H. Baqui, Samir K. Saha, Rasheda Khanam, Sayedur Rahman, Roger Shapiro, Rebecca Zash, Mariângela F. Silveira, Romina Buffarini, Patrick Kolsteren, Carl Lachat, Lieven Huybregts, Dominique Roberfroid, Lingxia Zeng, Zhonghai Zhu, Jianrong He, Xiu Qui, Seifu H. Gebreyesus, Kokeb Tesfamariam, Delayehu Bekele, Grace Chan, Estifanos Baye, Firehiwot Workneh, Kwaku P. Asante, Ellen Boanmah-Kaali, Seth Adu-Afarwuah, Kathryn G. Dewey, Stephaney Gyaase, Blair J. Wylie, Betty R. Kirkwood, Alexander Manu, Ravilla D Thulasiraj, James Tielsch, Ranadip Chowdhury, Sunita Taneja, Giridhara R Babu, Prafulla Shriyan, Kenneth Maleta, Charles Mangani, Sandra Acevedo-Gallegos, Maria J. Rodriguez-Sibaja, Subarna K. Khatry, Steven C. LeClerq, Luke C. Mullany, Fyezah Jehan, Muhammad Ilyas, Stephen J. Rogerson, Holger W. Unger, Rakesh Ghosh, Sabine Musange, Vundli Ramokolo, Wanga Zembe-Mkabile, Marzia Lazzerini, Rishard Mohamed, Dongqing Wang, Wafaie W. Fawzi, Daniel T.R. Minja, Christentze Schmiegelow, Honorati Masanja, Emily Smith, John P.A. Lusingu, Omari A. Msemo, Fathma M. Kabole, Salim N. Slim, Paniya Keentupthai, Aroonsri Mongkolchati, Richard Kajubi, Abel Kakuru, Peter Waiswa, Dilys Walker, Davidson H. Hamer, Katherine E.A. Semrau, Enesia B. Chaponda, R. Matthew Chico, Bowen Banda, Kebby Musokotwane, Albert Manasyan, Jake M. Pry, Bernard Chasekwa, Jean Humphrey, Abu Ahmed Shamim, Parul Christian, Hasmot Ali, Rolf D.W. Klemm, Alan B. Massie, Maithili Mitra, Sucheta Mehra, Kerry J. Schulze, Abu Amed Shamim, Alfred Sommer, Barkat Ullah, Keith P. West, Nazma Begum, Nabidul Haque Chowdhury, Shafiqul Islam, Dipak Kumar Mitra, Abdul Quaiyum, Modiegi Diseko, Joseph Makhema, Yue Cheng, Yixin Guo, Shanshan Yuan, Meselech Roro, Bilal Shikur, Frederick Goddard, Sebastien Haneuse, Bezawit Hunegnaw, Yemane Berhane, Alemayehu Worku, Seyram Kaali, Charles D. Arnold, Darby Jack, Seeba Amenga-Etego, Lisa Hurt, Caitlin Shannon, Seyi Soremekun, Nita Bhandari, Jose Martines, Sarmila Mazumder, Yamuna Ana, Deepa R, Lotta Hallamaa, Juha Pyykkö, Mario I. Lumbreras-Marquez, Claudia E. Mendoza-Carrera, Atiya Hussain, Muhammad Karim, Farzana Kausar, Usma Mehmood, Naila Nadeem, Muhammad Imran Nisar, Muhammad Sajid, Ivo Mueller, Maria Ome-Kaius, Elizabeth Butrick, Felix Sayinzoga, Ilaria Mariani, Willy Urassa, Thor Theander, Phillippe Deloron, Birgitte Bruun Nielsen, Alfa Muhihi, Ramadhani Abdallah Noor, Ib Bygbjerg, Sofie Lykke Moeller, Fahad Aftab, Said M. Ali, Pratibha Dhingra, Usha Dhingra, Arup Dutta, Sunil Sazawal, Atifa Suleiman, Mohammed Mohammed, Saikat Deb, Moses R. Kamya, Miriam Nakalembe, Jude Mulowooz, Nicole Santos, Godfrey Biemba, Julie M. Herlihy, Reuben K. Mbewe, Fern Mweena, Kojo Yeboah-Antwi, Jane Bruce, Daniel Chandramohan, and Andrew Prendergast
Subjects: General Medicine
Published: 2023

6. A multilevel health system intervention for virological suppression in adolescents and young adults living with HIV in rural Kenya and Uganda (SEARCH-Youth): a cluster randomised trial

Author: Ruel, Theodore, primary, Mwangwa, Florence, additional, Balzer, Laura B, additional, Ayieko, James, additional, Nyabuti, Marilyn, additional, Mugoma, Wafula Erick, additional, Kabami, Jane, additional, Kamugisha, Brian, additional, Black, Douglas, additional, Nzarubara, Bridget, additional, Opel, Fred, additional, Schrom, John, additional, Agengo, George, additional, Nakigudde, Janet, additional, Atuhaire, Hellen N, additional, Schwab, Josh, additional, Peng, James, additional, Camlin, Carol, additional, Shade, Starley B, additional, Bukusi, Elizabeth, additional, Kapogiannis, Bill G, additional, Charlebois, Edwin, additional, Kamya, Moses R, additional, and Havlir, Diane, additional
Published: 2023
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7. Acceptability of an adapted mindfulness and acceptance-based intervention to support adolescents with HIV: A qualitative study with Ugandan health care providers

Author: Musanje, Khamisi, primary, Kamya, Moses R., additional, Kasujja, Rosco, additional, Hooper, Nic, additional, Katahoire, Anne R., additional, White, Ross G., additional, Kimera, Emmanuel, additional, Getahun, Monica, additional, Sinclair, Deborah L., additional, Ojiambo, Deborah, additional, and Camlin, Carol S., additional
Published: 2023
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8. A mid-level health manager intervention to promote uptake of isoniazid preventive therapy among people with HIV in Uganda: a cluster randomised trial

Author: Elijah Kakande, Canice Christian, Laura B Balzer, Asiphas Owaraganise, Joshua R Nugent, William DiIeso, Derek Rast, Jane Kabami, Jason Johnson Peretz, Carol S Camlin, Starley B Shade, Elvin H Geng, Dalsone Kwarisiima, Moses R Kamya, Diane V Havlir, and Gabriel Chamie
Subjects: Pediatric, Adult, Pediatric AIDS, Epidemiology, Prevention, Clinical Trials and Supportive Activities, Immunology, Antitubercular Agents, COVID-19, HIV Infections, Medical and Health Sciences, Good Health and Well Being, Infectious Diseases, Clinical Research, Virology, Isoniazid, HIV/AIDS, Humans, Uganda, Infection, Pandemics
Abstract: BackgroundDespite longstanding guidelines endorsing isoniazid preventive therapy (IPT) for people with HIV, uptake is low across sub-Saharan Africa. Mid-level health managers oversee IPT programmes nationally; interventions aimed at this group have not been tested. We aimed to establish whether providing structured leadership and management training and facilitating subregional collaboration and routine data feedback to mid-level managers could increase IPT initiation among people with HIV compared with standard practice.MethodsWe conducted a cluster randomised trial in Uganda among district-level health managers. We randomly assigned clusters of between four and seven managers in a 1:1 ratio to intervention or control groups. Our intervention convened managers into mini-collaboratives facilitated by Ugandan experts in tuberculosis and HIV, and provided business leadership and management training, SMS platform access, and data feedback. The control was standard practice. Participants were not masked to trial group, but study statisticians were masked until trial completion. The primary outcome was IPT initiation rates among adults with HIV in facilities overseen by participants over a period of 2 years (2019-21). We conducted prespecified analyses that excluded the third quarter of 2019 (Q3-2019) to understand intervention effects independent of a national 100-day IPT push tied to a financial contingency during Q3-2019. This trial is registered with ClinicalTrials.gov (NCT03315962), and is ongoing.FindingsBetween Nov 15, 2017, and March 14, 2018, managers from 82 of 82 eligible districts (61% of Uganda's 135 districts) were enrolled and randomised: 43 districts to intervention, 39 to control. Intervention delivery took place between Dec 6, 2017, and Feb 2, 2022. Over 2 years, IPT initiation rates were 0·74 versus 0·65 starts per person-year in intervention versus control groups (incidence rate ratio [IRR] 1·14, 95% CI 0·88-1·46; p=0·16). Excluding Q3-2019, IPT initiation was higher in the intervention group versus the control group: 0·32 versus 0·25 starts per person-year (IRR 1·27, 95% CI 1·00-1·61; p=0·026).InterpretationFollowing an intervention targeting managers in more than 60% of Uganda's districts, IPT initiation rates were not significantly higher in intervention than control groups. After accounting for large increases in IPT from a 100-day push in both groups, the intervention led to significantly increased IPT rates, sustained after the push and during the COVID-19 pandemic. Our findings suggest that interventions centred on mid-level health managers can improve IPT implementation on a large, subnational scale, and merit further exploration to address key public health challenges for which strong evidence exists but implementation remains suboptimal.FundingNational Institute of Allergy and Infectious Diseases.
Published: 2022

9. Small babies, big risks: global estimates of prevalence and mortality for vulnerable newborns to accelerate change and improve counting

Author: Lawn, Joy E, primary, Ohuma, Eric O, additional, Bradley, Ellen, additional, Idueta, Lorena Suárez, additional, Hazel, Elizabeth, additional, Okwaraji, Yemisrach B, additional, Erchick, Daniel J, additional, Yargawa, Judith, additional, Katz, Joanne, additional, Lee, Anne C C, additional, Diaz, Mike, additional, Salasibew, Mihretab, additional, Requejo, Jennifer, additional, Hayashi, Chika, additional, Moller, Ann-Beth, additional, Borghi, Elaine, additional, Black, Robert E, additional, Blencowe, Hannah, additional, Ashorn, Per, additional, Lawn, Joy E, additional, Ashorn, Ulla, additional, Klein, Nigel, additional, Hofmeyr, G Justus, additional, Temmerman, Marleen, additional, Askari, Sufia, additional, Chakwera, Samuel, additional, Hussain-Alkhateeb, Laith, additional, Lewin, Alexandra, additional, Retno Mahanani, Wahyu, additional, White Johansson, Emily, additional, Lavin, Tina, additional, Estevez Fernandez, Diana, additional, Gatica Domínguez, Giovanna, additional, de Costa, Ayesha, additional, Cresswell, Jenny A, additional, Krasevec, Julia, additional, Moran, Allisyn C, additional, Pingray, Veronica, additional, Cormick, Gabriela, additional, Gibbons, Luz, additional, Belizan, José, additional, Guevel, Carlos, additional, Warrilow, Kara, additional, Gordon, Adrienne, additional, Flenady, Vicki, additional, Sexton, Jessica, additional, Lawford, Harriet, additional, Paixao, Enny S., additional, Rocha Falcão, Ila, additional, Lima Barreto, Mauricio, additional, Lisonkova, Sarka, additional, Wen, Qi, additional, Mardones, Francisco, additional, Caulier-Cisterna, Raúl, additional, Acuña, José, additional, Velebil, Petr, additional, Jirova, Jitka, additional, Horváth-Puhó, Erzsébet, additional, Sørensen, Henrik Toft, additional, Sakkeus, Luule, additional, Abuladze, Liili, additional, Gissler, Mika, additional, Moradi-Lakeh, Maziar, additional, Heidarzadeh, Mohammad, additional, Khalili, Narjes, additional, A. Yunis, Khalid, additional, Al Bizri, Ayah, additional, Nakad, Pascale, additional, Devi Karalasingam, Shamala, additional, R Jeganathan, J Ravichandran, additional, binti Baharum, Nurakman, additional, Suárez-Idueta, Lorena, additional, Barranco Flores, Arturo, additional, Gonzalez Roldan, Jesus F, additional, Lopez Alvarez, Sonia, additional, van Dijk, Aimée E., additional, Broeders, Lisa, additional, Huicho, Luis, additional, Quezada Pinedo, Hugo G, additional, Cajachagua-Torres, Kim N, additional, Carrillo-Larco, Rodrigo M, additional, Tarazona Meza, Carla Estefania, additional, Guzman-Vilca, Wilmer Cristobal, additional, Olukade, Tawa O., additional, Ali, Hamdy A., additional, Alyafei, Fawziya, additional, AlQubaisi, Mai, additional, Alturk, Mohamad R, additional, Kim, Ho Yeon, additional, Cho, Geum Joon, additional, Razaz, Neda, additional, Söderling, Jonas, additional, Smith, Lucy K, additional, Kurinczuk, Jennifer J, additional, Matthews, Ruth J, additional, Manktelow, Bradley N, additional, Draper, Elizabeth S, additional, Fenton, Alan C, additional, Lowry, Estelle, additional, Rowland, Neil, additional, Wood, Rachael, additional, Monteath, Kirsten, additional, Pereyra, Isabel, additional, Pravia, Gabriella, additional, Davis, Celina, additional, Clarke, Samantha, additional, Wu, Lee S.F., additional, Yoshida, Sachiyo, additional, Bahl, Rajiv, additional, Grandi, Carlos, additional, Labrique, Alain B, additional, Rashid, Mabhubur, additional, Ahmed, Salahuddin, additional, Roy, Arunangshu D., additional, Haque, Rezwanul, additional, Shaikh, Saijuddin, additional, Baqui, Abdullah H., additional, Saha, Samir K., additional, Khanam, Rasheda, additional, Rahman, Sayedur, additional, Shapiro, Roger, additional, Zash, Rebecca, additional, Silveira, Mariângela F., additional, Buffarini, Romina, additional, Kolsteren, Patrick, additional, Lachat, Carl, additional, Huybregts, Lieven, additional, Roberfroid, Dominique, additional, Zeng, Lingxia, additional, Zhu, Zhonghai, additional, He, Jianrong, additional, Qui, Xiu, additional, Gebreyesus, Seifu H., additional, Tesfamariam, Kokeb, additional, Bekele, Delayehu, additional, Chan, Grace, additional, Baye, Estifanos, additional, Workneh, Firehiwot, additional, Asante, Kwaku P., additional, Boanmah-Kaali, Ellen, additional, Adu-Afarwuah, Seth, additional, Dewey, Kathryn G., additional, Gyaase, Stephaney, additional, Wylie, Blair J., additional, Kirkwood, Betty R., additional, Manu, Alexander, additional, Thulasiraj, Ravilla D, additional, Tielsch, James, additional, Chowdhury, Ranadip, additional, Taneja, Sunita, additional, Babu, Giridhara R, additional, Shriyan, Prafulla, additional, Maleta, Kenneth, additional, Mangani, Charles, additional, Acevedo-Gallegos, Sandra, additional, Rodriguez-Sibaja, Maria J., additional, Khatry, Subarna K., additional, LeClerq, Steven C., additional, Mullany, Luke C., additional, Jehan, Fyezah, additional, Ilyas, Muhammad, additional, Rogerson, Stephen J., additional, Unger, Holger W., additional, Ghosh, Rakesh, additional, Musange, Sabine, additional, Ramokolo, Vundli, additional, Zembe-Mkabile, Wanga, additional, Lazzerini, Marzia, additional, Mohamed, Rishard, additional, Wang, Dongqing, additional, Fawzi, Wafaie W., additional, Minja, Daniel T.R., additional, Schmiegelow, Christentze, additional, Masanja, Honorati, additional, Smith, Emily, additional, Lusingu, John P.A., additional, Msemo, Omari A., additional, Kabole, Fathma M., additional, Slim, Salim N., additional, Keentupthai, Paniya, additional, Mongkolchati, Aroonsri, additional, Kajubi, Richard, additional, Kakuru, Abel, additional, Waiswa, Peter, additional, Walker, Dilys, additional, Hamer, Davidson H., additional, Semrau, Katherine E.A., additional, Chaponda, Enesia B., additional, Chico, R. Matthew, additional, Banda, Bowen, additional, Musokotwane, Kebby, additional, Manasyan, Albert, additional, Pry, Jake M., additional, Chasekwa, Bernard, additional, Humphrey, Jean, additional, Shamim, Abu Ahmed, additional, Christian, Parul, additional, Ali, Hasmot, additional, Klemm, Rolf D.W., additional, Massie, Alan B., additional, Mitra, Maithili, additional, Mehra, Sucheta, additional, Schulze, Kerry J., additional, Shamim, Abu Amed, additional, Sommer, Alfred, additional, Ullah, Barkat, additional, West, Keith P., additional, Begum, Nazma, additional, Chowdhury, Nabidul Haque, additional, Islam, Shafiqul, additional, Mitra, Dipak Kumar, additional, Quaiyum, Abdul, additional, Diseko, Modiegi, additional, Makhema, Joseph, additional, Cheng, Yue, additional, Guo, Yixin, additional, Yuan, Shanshan, additional, Roro, Meselech, additional, Shikur, Bilal, additional, Goddard, Frederick, additional, Haneuse, Sebastien, additional, Hunegnaw, Bezawit, additional, Berhane, Yemane, additional, Worku, Alemayehu, additional, Kaali, Seyram, additional, Arnold, Charles D., additional, Jack, Darby, additional, Amenga-Etego, Seeba, additional, Hurt, Lisa, additional, Shannon, Caitlin, additional, Soremekun, Seyi, additional, Bhandari, Nita, additional, Martines, Jose, additional, Mazumder, Sarmila, additional, Ana, Yamuna, additional, R, Deepa, additional, Hallamaa, Lotta, additional, Pyykkö, Juha, additional, Lumbreras-Marquez, Mario I., additional, Mendoza-Carrera, Claudia E., additional, Hussain, Atiya, additional, Karim, Muhammad, additional, Kausar, Farzana, additional, Mehmood, Usma, additional, Nadeem, Naila, additional, Nisar, Muhammad Imran, additional, Sajid, Muhammad, additional, Mueller, Ivo, additional, Ome-Kaius, Maria, additional, Butrick, Elizabeth, additional, Sayinzoga, Felix, additional, Mariani, Ilaria, additional, Urassa, Willy, additional, Theander, Thor, additional, Deloron, Phillippe, additional, Nielsen, Birgitte Bruun, additional, Muhihi, Alfa, additional, Noor, Ramadhani Abdallah, additional, Bygbjerg, Ib, additional, Moeller, Sofie Lykke, additional, Aftab, Fahad, additional, Ali, Said M., additional, Dhingra, Pratibha, additional, Dhingra, Usha, additional, Dutta, Arup, additional, Sazawal, Sunil, additional, Suleiman, Atifa, additional, Mohammed, Mohammed, additional, Deb, Saikat, additional, Kamya, Moses R., additional, Nakalembe, Miriam, additional, Mulowooz, Jude, additional, Santos, Nicole, additional, Biemba, Godfrey, additional, Herlihy, Julie M., additional, Mbewe, Reuben K., additional, Mweena, Fern, additional, Yeboah-Antwi, Kojo, additional, Bruce, Jane, additional, Chandramohan, Daniel, additional, and Prendergast, Andrew, additional
Published: 2023
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10. Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes

Author: Fabra-García, Amanda, primary, Hailemariam, Sophia, additional, de Jong, Roos M., additional, Janssen, Kirsten, additional, Teelen, Karina, additional, van de Vegte-Bolmer, Marga, additional, van Gemert, Geert-Jan, additional, Ivanochko, Danton, additional, Semesi, Anthony, additional, McLeod, Brandon, additional, Vos, Martijn W., additional, de Bruijni, Marloes H.C., additional, Bolscher, Judith M., additional, Szabat, Marta, additional, Vogt, Stefanie, additional, Kraft, Lucas, additional, Duncan, Sherie, additional, Kamya, Moses R., additional, Feeney, Margaret E., additional, Jagannathan, Prasanna, additional, Greenhouse, Bryan, additional, Dechering, Koen J., additional, Sauerwein, Robert W., additional, King, C. Richter, additional, MacGill, Randall S., additional, Bousema, Teun, additional, Julien, Jean-Philippe, additional, and Jore, Matthijs M., additional
Published: 2023
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11. Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): final results of a cluster-randomised trial embedded in a national distribution campaign

Author: Maiteki-Sebuguzi, Catherine, primary, Gonahasa, Samuel, additional, Kamya, Moses R, additional, Katureebe, Agaba, additional, Bagala, Irene, additional, Lynd, Amy, additional, Mutungi, Peter, additional, Kigozi, Simon P, additional, Opigo, Jimmy, additional, Hemingway, Janet, additional, Dorsey, Grant, additional, Donnelly, Martin J, additional, and Staedke, Sarah G, additional
Published: 2023
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12. Nothing about us without us: Community-based participatory research to improve HIV care for mobile patients in Kenya and Uganda

Author: Maeri, Irene, primary, Eyul, Patrick, additional, Getahun, Monica, additional, Hatchett, Khalela, additional, Owino, Lawrence, additional, Akatukwasa, Cecilia, additional, Itiakorit, Harriet, additional, Gutin, Sarah A., additional, Johnson-Peretz, Jason, additional, Ssali, Sarah, additional, Cohen, Craig R., additional, Bukusi, Elizabeth A., additional, Kamya, Moses R., additional, Charlebois, Edwin D., additional, and Camlin, Carol S., additional
Published: 2023
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13. Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230

Author: Ivanochko, Danton, primary, Fabra-García, Amanda, additional, Teelen, Karina, additional, van de Vegte-Bolmer, Marga, additional, van Gemert, Geert-Jan, additional, Newton, Jocelyn, additional, Semesi, Anthony, additional, de Bruijni, Marloes, additional, Bolscher, Judith, additional, Ramjith, Jordache, additional, Szabat, Marta, additional, Vogt, Stefanie, additional, Kraft, Lucas, additional, Duncan, Sherie, additional, Lee, Shwu-Maan, additional, Kamya, Moses R., additional, Feeney, Margaret E., additional, Jagannathan, Prasanna, additional, Greenhouse, Bryan, additional, Sauerwein, Robert W., additional, Richter King, C., additional, MacGill, Randall S., additional, Bousema, Teun, additional, Jore, Matthijs M., additional, and Julien, Jean-Philippe, additional
Published: 2023
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14. Condom, modern contraceptive, and dual method use are associated with HIV status and relationship concurrency in a context of high mobility: A cross-sectional study of women of reproductive age in rural Kenya and Uganda, 2016

Author: Lee, Joi K., primary, Gutin, Sarah A., additional, Getahun, Monica, additional, Okiring, Jaffer, additional, Neilands, Torsten B., additional, Akullian, Adam, additional, Ssali, Sarah, additional, Cohen, Craig R., additional, Maeri, Irene, additional, Eyul, Patrick, additional, Kamya, Moses R., additional, Bukusi, Elizabeth A., additional, Charlebois, Edwin D., additional, and Camlin, Carol S., additional
Published: 2023
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15. Characterizing pyrethroid resistance and mechanisms in Anopheles gambiae (s.s.) and Anopheles arabiensis from 11 districts in Uganda

Author: Mawejje, Henry Ddumba, primary, Weetman, David, additional, Epstein, Adrienne, additional, Lynd, Amy, additional, Opigo, Jimmy, additional, Maiteki-Sebuguzi, Catherine, additional, Lines, Jo, additional, Kamya, Moses R., additional, Rosenthal, Philip J., additional, Donnelly, Martin J., additional, Dorsey, Grant, additional, and Staedke, Sarah G., additional
Published: 2023
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16. A mid-level health manager intervention to promote uptake of isoniazid preventive therapy among people with HIV in Uganda: a cluster randomised trial

Author: Kakande, Elijah, primary, Christian, Canice, additional, Balzer, Laura B, additional, Owaraganise, Asiphas, additional, Nugent, Joshua R, additional, DiIeso, William, additional, Rast, Derek, additional, Kabami, Jane, additional, Johnson Peretz, Jason, additional, Camlin, Carol S, additional, Shade, Starley B, additional, Geng, Elvin H, additional, Kwarisiima, Dalsone, additional, Kamya, Moses R, additional, Havlir, Diane V, additional, and Chamie, Gabriel, additional
Published: 2022
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17. Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaign

Author: Agaba Katureebe, Catherine Maiteki-Sebuguzi, Peter Mutungi, Mary Kyohere, Simon P. Kigozi, Sarah G. Staedke, Amy Lynd, Samuel Gonahasa, Jimmy Opigo, Janet Hemingway, Martin J. Donnelly, Moses R. Kamya, and Grant Dorsey
Subjects: Male, Long lasting, Piperonyl butoxide, Piperonyl Butoxide, Cross-sectional study, Population, Mosquito Vectors, 030204 cardiovascular system & hematology, Article, Insecticide Resistance, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Primary outcome, Pyrethrins, Anopheles, medicine, Pyrethroid resistance, Animals, Humans, Uganda, 030212 general & internal medicine, Insecticide-Treated Bednets, Child, education, Africa South of the Sahara, Baseline values, education.field_of_study, business.industry, Pesticide Synergists, General Medicine, medicine.disease, Malaria, Cross-Sectional Studies, chemistry, Child, Preschool, Female, business, Demography
Abstract: Summary Background Long-lasting insecticidal nets (LLINs) are the primary malaria prevention tool, but their effectiveness is threatened by pyrethroid resistance. We embedded a pragmatic cluster-randomised trial into Uganda's national LLIN campaign to compare conventional LLINs with those containing piperonyl butoxide (PBO), a synergist that can partially restore pyrethroid susceptibility in mosquito vectors. Methods 104 health sub-districts, from 48 districts in Uganda, were randomly assigned to LLINs with PBO (PermaNet 3.0 and Olyset Plus) and conventional LLINs (PermaNet 2.0 and Olyset Net) by proportionate randomisation using an iterative process. At baseline 6, 12, and 18 months after LLIN distribution, cross-sectional surveys were done in 50 randomly selected households per cluster (5200 per survey); a subset of ten households per cluster (1040 per survey) were randomly selected for entomological surveys. The primary outcome was parasite prevalence by microscopy in children aged 2–10 years, assessed in the as-treated population at 6, 12, and 18 months. This trial is registered with ISRCTN, ISRCTN17516395. Findings LLINs were delivered to households from March 25, 2017, to March 18, 2018, 32 clusters were randomly assigned to PermaNet 3.0, 20 to Olyset Plus, 37 to PermaNet 2.0, and 15 to Olyset Net. In the as-treated analysis, three clusters were excluded because no dominant LLIN was received, and four clusters were reassigned, resulting in 49 PBO LLIN clusters (31 received PermaNet 3.0 and 18 received Olyset Plus) and 52 non-PBO LLIN clusters (39 received PermaNet 2.0 and 13 received Olyset Net). At 6 months, parasite prevalence was 11% (386/3614) in the PBO group compared with 15% (556/3844) in the non-PBO group (prevalence ratio [PR] adjusted for baseline values 0·74, 95% CI 0·62–0·87; p=0·0003). Parasite prevalence was similar at month 12 (11% vs 13%; PR 0·73, 95% CI 0·63–0·85; p=0·0001) and month 18 (12% vs 14%; PR 0·84, 95% CI 0·72–0·98; p=0·029). Interpretation In Uganda, where pyrethroid resistance is high, PBO LLINs reduced parasite prevalence more effectively than did conventional LLINs for up to 18 months. This study provides evidence needed to support WHO's final recommendation on use of PBO LLINs. Funding The Against Malaria Foundation, UK Department for International Development, Innovative Vector Control Consortium, and Bill and Melinda Gates Foundation.
Published: 2020

18. Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230

Author: Danton Ivanochko, Amanda Fabra-García, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Jocelyn Newton, Anthony Semesi, Marloes de Bruijni, Judith Bolscher, Jordache Ramjith, Marta Szabat, Stefanie Vogt, Lucas Kraft, Sherie Duncan, Shwu-Maan Lee, Moses R. Kamya, Margaret E. Feeney, Prasanna Jagannathan, Bryan Greenhouse, Robert W. Sauerwein, C. Richter King, Randall S. MacGill, Teun Bousema, Matthijs M. Jore, and Jean-Philippe Julien
Subjects: All institutes and research themes of the Radboud University Medical Center, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Infectious Diseases, Immunology, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Immunology and Allergy, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
Abstract: Contains fulltext : 291404.pdf (Publisher’s version ) (Open Access) Pfs230 is essential for Plasmodium falciparum transmission to mosquitoes and is the protein targeted by the most advanced malaria-transmission-blocking vaccine candidate. Prior understanding of functional epitopes on Pfs230 is based on two monoclonal antibodies (mAbs) with moderate transmission-reducing activity (TRA), elicited from subunit immunization. Here, we screened the B cell repertoire of two naturally exposed individuals possessing serum TRA and identified five potent mAbs from sixteen Pfs230 domain-1-specific mAbs. Structures of three potent and three low-activity antibodies bound to Pfs230 domain 1 revealed four distinct epitopes. Highly potent mAbs from natural infection recognized a common conformational epitope that is highly conserved across P. falciparum field isolates, while antibodies with negligible TRA derived from natural infection or immunization recognized three distinct sites. Our study provides molecular blueprints describing P. falciparum TRA, informed by contrasting potent and non-functional epitopes elicited by natural exposure and vaccination.
Published: 2023

19. Nothing about us without us: Community-based participatory research to improve HIV care for mobile patients in Kenya and Uganda

Author: Irene Maeri, Patrick Eyul, Monica Getahun, Khalela Hatchett, Lawrence Owino, Cecilia Akatukwasa, Harriet Itiakorit, Sarah A. Gutin, Jason Johnson-Peretz, Sarah Ssali, Craig R. Cohen, Elizabeth A. Bukusi, Moses R. Kamya, Edwin D. Charlebois, and Carol S. Camlin
Subjects: Community-Based Participatory Research, Health (social science), Economics, Differentiated care, HIV Infections, Medical and Health Sciences, Article, 7.1 Individual care needs, History and Philosophy of Science, Clinical Research, Behavioral and Social Science, Humans, Uganda, Mobility, Prevention, Health Services, Kenya, Community based participatory research, Infectious Diseases, Good Health and Well Being, Studies in Human Society, HIV/AIDS, Mobile populations, Management of diseases and conditions, Generic health relevance, Public Health, HIV care, Infection, Delivery of Health Care
Abstract: BACKGROUND: Population mobility is prevalent and complex in sub-Saharan Africa, and can disrupt HIV care and fuel onward transmission. While differentiated care models show promise for meeting the needs of mobile populations by addressing care cascade gaps, the voices of mobile populations need to be included when designing care delivery models. Moreover, mobile individuals are faced with care challenges such as non-adherence to clinic appointments and HIV medication, poor referral systems, lack of social support, stigma, and non-disclosure that complicate their health outcomes. Mobility includes not only permanent migration but patterns of movement from place to place by mobile populations. We assessed the unmet needs of mobile populations and engaged mobile stakeholders in the design and implementation of service delivery to improve care outcomes for mobile people living with HIV (PLHIV). Involving mobile community stakeholders in community-based participatory research (CBPR) demonstrated that it is a powerful tool for engaging communities in designing services responsive to the needs and priorities of mobile populations. METHODS: CBPR was conducted in 12 rural communities in Kenya and Uganda participating in a mobility study within the Sustainable East Africa Research in Community Health (SEARCH) test-and-treat trial (NCT# 01864603) from 2016–2019. Annual gender-balanced meetings with between 17–33 mobile community stakeholders per meeting were conducted in local languages to gather information on mobility and its influence on HIV-related outcomes. Discussions were audio-recorded, transcribed and translated into English. Findings were shared at subsequent meetings to engage mobile stakeholders in interpretation. At three years of follow up, intervention ideas to address mobile populations’ needs were elicited. After refinement, these intervention options were presented to the same communities for prioritization the following year, using a participatory ranking approach. RESULTS: Key nodes where population mobility patterns intersect with one another were identified as desirable service locations. These nodes included transit hubs, trading centers, and beach sites. Communities prioritized mobile health ‘cards’ (to access services at multiple health facilities) with electronic medical records and peer-delivered home-based services. Mobile health clinics, longer anti-retroviral pill refills, and 24/7 services were less desirable options. Elicited challenges to care included: a lack of transfer letters to other clinics; and inability to adhere to scheduled appointments, medication regimens, and monitoring of treatment outcomes while mobile. This was compounded by the lack of social support and HIV-related stigma if care services were accessed when traveling to new communities. CONCLUSIONS: Iterative discussions with mobile community stakeholders elicited communities’ health priorities and identified challenges to achieving HIV care cascade outcomes among mobile populations. To optimize HIV interventions and create more robust healthcare systems, understanding the mobility patterns and unique needs of mobile populations through responsive community engagement is critical. Simple iterative voting by the affected community on preferred interventions is one model to achieve this engagement.
Published: 2023

20. Characterizing pyrethroid resistance and mechanisms in Anopheles gambiae (s.s.) and Anopheles arabiensis from 11 districts in Uganda

Author: Henry Ddumba Mawejje, David Weetman, Adrienne Epstein, Amy Lynd, Jimmy Opigo, Catherine Maiteki-Sebuguzi, Jo Lines, Moses R. Kamya, Philip J. Rosenthal, Martin J. Donnelly, Grant Dorsey, and Sarah G. Staedke
Subjects: Ocean Engineering
Published: 2023

21. Effect of universal HIV testing and treatment on socioeconomic wellbeing in rural Kenya and Uganda: a cluster-randomised controlled trial

Author: Jakubowski, Aleksandra, primary, Kabami, Jane, additional, Balzer, Laura B, additional, Ayieko, James, additional, Charlebois, Edwin D, additional, Owaraganise, Asiphas, additional, Marquez, Carina, additional, Clark, Tamara D, additional, Black, Douglas, additional, Shade, Starley B, additional, Chamie, Gabriel, additional, Cohen, Craig R, additional, Bukusi, Elizabeth A, additional, Kamya, Moses R, additional, Petersen, Maya, additional, Havlir, Diane V, additional, and Thirumurthy, Harsha, additional
Published: 2022
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22. LLIN evaluation in Uganda project (LLINEUP): The fabric integrity, chemical content and bioefficacy of long-lasting insecticidal nets treated with and without piperonyl butoxide across two years of operational use in Uganda

Author: Mechan, Frank, primary, Katureebe, Agaba, additional, Tuhaise, Violet, additional, Mugote, Martin, additional, Oruni, Ambrose, additional, Onyige, Ismail, additional, Bumali, Kawesa, additional, Thornton, Jonathan, additional, Maxwell, Kilama, additional, Kyohere, Mary, additional, Kamya, Moses R., additional, Mutungi, Peter, additional, Kigozi, Simon P., additional, Yeka, Adoke, additional, Opigo, Jimmy, additional, Maiteki-Sebuguzi, Catherine, additional, Gonahasa, Samuel, additional, Hemingway, Janet, additional, Dorsey, Grant, additional, Reimer, Lisa J., additional, Staedke, Sarah G., additional, Donnelly, Martin J., additional, and Lynd, Amy, additional
Published: 2022
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23. Ivermectin for mass drug administration against malaria

Author: Byakika-Kibwika, Pauline, primary, Kamya, Moses R, additional, and Nankabirwa, Joaniter, additional
Published: 2021
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24. Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study

Author: Andolina, Chiara, primary, Rek, John C, additional, Briggs, Jessica, additional, Okoth, Joseph, additional, Musiime, Alex, additional, Ramjith, Jordache, additional, Teyssier, Noam, additional, Conrad, Melissa, additional, Nankabirwa, Joaniter I, additional, Lanke, Kjerstin, additional, Rodriguez-Barraquer, Isabel, additional, Meerstein-Kessel, Lisette, additional, Arinaitwe, Emmanuel, additional, Olwoch, Peter, additional, Rosenthal, Philip J, additional, Kamya, Moses R, additional, Dorsey, Grant, additional, Greenhouse, Bryan, additional, Drakeley, Chris, additional, Staedke, Sarah G, additional, and Bousema, Teun, additional
Published: 2021
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25. Persistent Malaria Transmission from Asymptomatic Children Despite Highly Effective Malaria Control in Eastern Uganda

Author: Noam Teyssier, Lisette Meerstein-Kessel, Chiara Andolina, Sarah G. Staedke, Melissa D. Conrad, Grant Dorsey, Jessica Briggs, Jordache Ramjith, Moses R. Kamya, Peter Olwoch, Philip J. Rosenthal, Bryan Greenhouse, Kjerstin Lanke, John Rek, Alex K. Musiime, Joaniter I. Nankabirwa, Isabel Rodriguez-Barraquer, Joseph Okoth, Teun Bousema, and Chris Drakeley
Subjects: medicine.medical_specialty, biology, Transmission (medicine), business.industry, Indoor residual spraying, Anopheles, medicine.disease, biology.organism_classification, Asymptomatic, Environmental health, parasitic diseases, Tropical medicine, Cohort, medicine, Gametocyte, medicine.symptom, business, Malaria
Abstract: Background: Persistent asymptomatic Plasmodium falciparum infections are common in malaria- endemic settings, but their contribution to transmission is poorly understood. Methods: A cohort of children and adults from Tororo, Uganda was closely followed for 24 months by continuous passive surveillance and routine assessments. P. falciparum parasite density, gametocyte density and genetic composition were determined molecularly; mosquito membrane feeding assays were performed on samples from participants with symptomatic and asymptomatic infections. Findings: From October 2017 to October 2019, we followed all 531 residents from 80 households. Parasite prevalence was 5·8% by microscopy and 17·3% by PCR at enrolment and declined thereafter. We conducted 538 mosquito feeding experiments on samples from 107 individuals. Mosquito infection rates were strongly associated with gametocyte densities of participants. Considering both transmissibility of infections and their relative frequency, the estimated human infectious reservoir was primarily asymptomatic microscopy-detected infections (83·8%), followed by asymptomatic submicroscopic (15·6%) and symptomatic (0·6%) infections. Over half of the infectious reservoir was children aged 5-15 years (56·8%); individuals 16 years (15·7%) contributed less. Four children were responsible for 62·6% (279/446) of infected mosquitos and were infectious at multiple timepoints. Interpretation: Individuals with asymptomatic infections were important drivers of malaria transmission. School-aged children were responsible for over half of all mosquito infections, with a small minority of asymptomatic children highly infectious. Demographically targeted interventions, aimed at school-aged children, could further reduce transmission in areas under effective vector control. Funding Statement: National institute of Health, Bill & Melinda Gates Foundation, European Research Council. Declaration of Interests: The authors declare no competing interests. Ethics Approval Statement: Ethical approval for the study was received from the Uganda National Council of Science and Technology (HS119ES), Makerere University School of Medicine, the University of California, San Francisco and the London School of Hygiene & Tropical Medicine.
Published: 2020

26. Gaps in the child tuberculosis care cascade in 32 rural communities in Uganda and Kenya

Author: Craig R. Cohen, Diane V. Havlir, Asiphas Owaraganise, Florence Mwangwa, Dalsone Kwarisiima, Albert Plenty, Elizabeth A. Bukusi, Khai Hoan Tram, Theodore Ruel, Tamara D. Clark, Edwin D. Charlebois, Moses R. Kamya, Gabriel Chamie, Maya L. Petersen, Carina Marquez, and James Ayieko
Subjects: Microbiology (medical), Pulmonary and Respiratory Medicine, Treatment completion, Pediatrics, medicine.medical_specialty, Tuberculosis, Tuberculosis Care Cascade, Human immunodeficiency virus (HIV), medicine.disease_cause, Article, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Environmental health, medicine, lcsh:RC109-216, 030212 general & internal medicine, lcsh:RC705-779, Case detection, business.industry, 1. No poverty, HIV, Retrospective cohort study, lcsh:Diseases of the respiratory system, medicine.disease, 3. Good health, Infectious Diseases, Cohort, HIV-exposed uninfected children, Child Tuberculosis, business, Tb treatment
Abstract: Background: Reducing tuberculosis (TB) deaths among children requires a better understanding of the gaps in the care cascade from TB diagnosis to treatment completion. We sought to assess the child TB care cascade in 32 rural communities in Uganda and Kenya using programmatic data. Methods: This is a retrospective cohort study of 160,851 children (agesâ¯
Published: 2017

27. Point-of-care C-reactive protein-based tuberculosis screening for people living with HIV: a diagnostic accuracy study

Author: Adithya Cattamanchi, Sandra Mwebe, Jane Katende, Laurence Huang, Fred C. Semitala, Christina Yoon, David W. Dowdy, Derek T. Armstrong, Alfred Andama, Moses R. Kamya, J Luke Davis, Lucy Asege, and Elly Atuhumuza
Subjects: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Tuberculosis, Adolescent, Anti-HIV Agents, Point-of-care testing, 030106 microbiology, HIV Infections, Sensitivity and Specificity, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Tuberculosis diagnosis, Acquired immunodeficiency syndrome (AIDS), Internal medicine, Humans, Medicine, 030212 general & internal medicine, Young adult, Prospective cohort study, biology, business.industry, C-reactive protein, medicine.disease, CD4 Lymphocyte Count, 3. Good health, C-Reactive Protein, Infectious Diseases, Point-of-Care Testing, Immunology, biology.protein, Sputum, Female, medicine.symptom, business
Abstract: Symptom-based screening for tuberculosis is recommended for all people living with HIV. This recommendation results in unnecessary Xpert MTB/RIF testing in many individuals living in tuberculosis-endemic areas and thus poor implementation of intensified case finding and tuberculosis preventive therapy. Novel approaches to tuberculosis screening are needed to help achieve global targets for tuberculosis elimination. We assessed the performance of C-reactive protein (CRP) measured with a point-of-care assay as a screening tool for active pulmonary tuberculosis.For this prospective study, we enrolled adults (aged ≥18 years) living with HIV with CD4 cell count less than or equal to 350 cells per μL who were initiating antiretroviral therapy (ART) from two HIV/AIDS clinics in Uganda. CRP concentrations were measured at study entry with a point-of-care assay using whole blood obtained by fingerprick (concentration ≥10 mg/L defined as screen positive for tuberculosis). Sputum samples were collected for Xpert MTB/RIF testing and culture. We calculated the sensitivity and specificity of point-of-care CRP and WHO symptom-based screening in reference to culture results. We repeated the sensitivity analysis with Xpert MTB/RIF as the reference standard.Between July 8, 2013, and Dec 15, 2015, 1237 HIV-infected adults were enrolled and underwent point-of-care CRP testing. 60 (5%) patients with incomplete or contaminated cultures were excluded from the analysis. Of the remaining 1177 patients (median CD4 count 165 cells per μL [IQR 75-271]), 163 (14%) had culture-confirmed tuberculosis. Point-of-care CRP testing had 89% sensitivity (145 of 163, 95% CI 83-93) and 72% specificity (731 of 1014, 95% CI 69-75) for culture-confirmed tuberculosis. Compared with WHO symptom-based screening, point-of-care CRP testing had lower sensitivity (difference -7%, 95% CI -12 to -2; p=0·002) but substantially higher specificity (difference 58%, 95% CI 55 to 61; p0·0001). When Xpert MTB/RIF results were used as the reference standard, sensitivity of point-of-care CRP and WHO symptom-based screening were similar (94% [79 of 84] vs 99% [83 of 84], respectively; difference -5%, 95% CI -12 to 2; p=0·10).The performance characteristics of CRP support its use as a tuberculosis screening test for people living with HIV with CD4 count less than or equal to 350 cells per μL who are initiating ART. HIV/AIDS programmes should consider point-of-care CRP-based tuberculosis screening to improve the efficiency of intensified case finding and increase uptake of tuberculosis preventive therapy.National Institutes of Health; President's Emergency Plan for AIDS Relief; University of California, San Francisco, Nina Ireland Program for Lung Health.
Published: 2017

28. Cost-effectiveness of intermittent preventive treatment with dihydroartemisinin–piperaquine for malaria during pregnancy: an analysis using efficacy results from Uganda and Kenya, and pooled data

Author: Fernandes, Silke, primary, Were, Vincent, additional, Gutman, Julie, additional, Dorsey, Grant, additional, Kakuru, Abel, additional, Desai, Meghna, additional, Kariuki, Simon, additional, Kamya, Moses R, additional, ter Kuile, Feiko O, additional, and Hanson, Kara, additional
Published: 2020
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29. Preventive malaria treatment among school-aged children in sub-Saharan Africa: a systematic review and meta-analyses

Author: Cohee, Lauren M, primary, Opondo, Charles, additional, Clarke, Siân E, additional, Halliday, Katherine E, additional, Cano, Jorge, additional, Shipper, Andrea G, additional, Barger-Kamate, Breanna, additional, Djimde, Abdoulaye, additional, Diarra, Seybou, additional, Dokras, Aditi, additional, Kamya, Moses R, additional, Lutumba, Pascal, additional, Ly, Alioune Badara, additional, Nankabirwa, Joaniter I, additional, Njagi, J Kiambo, additional, Maiga, Hamma, additional, Maiteki-Sebuguzi, Catherine, additional, Matangila, Junior, additional, Okello, George, additional, Rohner, Fabian, additional, Roschnik, Natalie, additional, Rouhani, Saba, additional, Sissoko, Mahamadou S, additional, Staedke, Sarah G, additional, Thera, Mahamadou A, additional, Turner, Elizabeth L, additional, Van Geertruyden, JP, additional, Zimmerman, Michael B, additional, Jukes, Matthew C H, additional, Brooker, Simon J, additional, Allen, Elizabeth, additional, Laufer, Miriam K, additional, and Chico, R Matthew, additional
Published: 2020
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30. Overall, anti-malarial, and non-malarial effect of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine on birthweight: a mediation analysis

Author: Roh, Michelle E, primary, Kuile, Feiko O ter, additional, Rerolle, Francois, additional, Glymour, M Maria, additional, Shiboski, Stephen, additional, Gosling, Roly, additional, Gutman, Julie, additional, Kakuru, Abel, additional, Desai, Meghna, additional, Kajubi, Richard, additional, L'Ianziva, Anne, additional, Kamya, Moses R, additional, Dorsey, Grant, additional, and Chico, R Matthew, additional
Published: 2020
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31. Tracheostomy weaning in community and the importance of the Multi-Disciplinary Team (MDT) to optimise outcomes - a case report

Author: Hayward, L., primary, Moses, R., additional, Hughes, L., additional, Forster, E., additional, and Saul, N., additional
Published: 2020
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32. Anemia and Micronutrient Status during Pregnancy, and Their Associations with Obstetric and Infant Outcomes among HIV-Infected Ugandan Women Receiving Antiretroviral Therapy

Author: Finkelstein, Julia L, primary, Herman, Heather S, additional, Plenty, Albert, additional, Mehta, Saurabh, additional, Natureeba, Paul, additional, Clark, Tamara D, additional, Kamya, Moses R, additional, Ruel, Theodore, additional, Charlebois, Edwin D, additional, Cohan, Deborah, additional, Havlir, Diane, additional, and Young, Sera L, additional
Published: 2020
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33. Uptake, engagement, and adherence to pre-exposure prophylaxis offered after population HIV testing in rural Kenya and Uganda: 72-week interim analysis of observational data from the SEARCH study

Author: Koss, Catherine A, primary, Charlebois, Edwin D, additional, Ayieko, James, additional, Kwarisiima, Dalsone, additional, Kabami, Jane, additional, Balzer, Laura B, additional, Atukunda, Mucunguzi, additional, Mwangwa, Florence, additional, Peng, James, additional, Mwinike, Yusuf, additional, Owaraganise, Asiphas, additional, Chamie, Gabriel, additional, Jain, Vivek, additional, Sang, Norton, additional, Olilo, Winter, additional, Brown, Lillian B, additional, Marquez, Carina, additional, Zhang, Kevin, additional, Ruel, Theodore D, additional, Camlin, Carol S, additional, Rooney, James F, additional, Black, Douglas, additional, Clark, Tamara D, additional, Gandhi, Monica, additional, Cohen, Craig R, additional, Bukusi, Elizabeth A, additional, Petersen, Maya L, additional, Kamya, Moses R, additional, and Havlir, Diane V, additional
Published: 2020
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34. Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaign

Author: Staedke, Sarah G, primary, Gonahasa, Samuel, additional, Dorsey, Grant, additional, Kamya, Moses R, additional, Maiteki-Sebuguzi, Catherine, additional, Lynd, Amy, additional, Katureebe, Agaba, additional, Kyohere, Mary, additional, Mutungi, Peter, additional, Kigozi, Simon P, additional, Opigo, Jimmy, additional, Hemingway, Janet, additional, and Donnelly, Martin J, additional
Published: 2020
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35. The Impact of Control Interventions on Malaria Burden in a Historically High Transmission District of Uganda: A Pooled Analyses of Cohort Studies from 2007 to 2018

Author: Anne Gasasira, Humphrey Wanzira, Abel Kakuru, Emmanuel Arinaitwe, James Kapisi, Prasanna Jagannathan, Mary K. Muhindo, Moses R. Kamya, Joaniter I. Nankabirwa, Paul Natureeba, Victor Bigira, Philip J. Rosenthal, Grant Dorsey, Diane V. Havlir, Jane Achan, Isabel Rodriguez-Barraquer, and John Rek
Subjects: business.industry, Incidence (epidemiology), Psychological intervention, Indoor residual spraying, medicine.disease, Clinical trial, Informed consent, Environmental health, parasitic diseases, medicine, Observational study, business, Malaria, Cohort study
Abstract: Background: There is limited evidence malaria elimination is feasible in high transmission areas of Africa. Between 2007-2018, we measured the impact of malaria control interventions in young children enrolled in three clinical trials and two observational studies in Tororo, Uganda, a historically high transmission area. Methods: Data were pooled from children aged 0.5-2 years. Interventions included individually assigned chemoprevention regimens and repeated rounds of indoor residual spraying of insecticide (IRS). All children received long-lasting insecticidal nets (LLINs) and treatment for symptomatic malaria with artemisinin-based combination therapy. Malaria incidence was measured using passive surveillance and parasite prevalence measured by microscopy and molecular methods at regular intervals. Poisson generalized linear mixed effects models were used to estimate the impact of various control interventions. Findings: 939 children were followed over 1221·7 person years. In the absence of chemoprevention and IRS (reference group), malaria incidence was 4·94 episodes per person year and parasite prevalence 47·3%. Compared to the reference group, implementation of the fifth and sixth rounds of IRS was associated with a 97·6% decrease (95% CI 93·3-99·1%, p=0·001) in the incidence of malaria and a 96·0% decrease (95% CI 91·3-98·2%, p
Published: 2019

36. Costs of Integrating Hypertension Care into HIV Care in Rural East African Clinics

Author: Betty Mwebaza, Haawa Imukeka, Craig R. Cohen, Douglas Black, Elizabeth A. Bukusi, Lillian B. Brown, Enos Kwizera, Asiphas Owaraganise, Diane V. Havlir, Dalsone Kwarisiima, Vivek Jain, James Ayieko, Edwin D. Charlebois, Thomas Osmand, Maya L. Petersen, Florence Mwanga, Alex Luo, Aine Ronald Mwesigye, Starley B. Shade, Moses R. Kamya, and Tamara D. Clark
Subjects: 0301 basic medicine, Rural Population, Human immunodeficiency virus (HIV), HIV Infections, integration, medicine.disease_cause, Cardiovascular, Ambulatory Care Facilities, Medical and Health Sciences, 0302 clinical medicine, 7.1 Individual care needs, Health care, Immunology and Allergy, Medicine, 030212 general & internal medicine, Fixed cost, Chronic care, education.field_of_study, virus diseases, Health Services, Biological Sciences, Infectious Diseases, Hypertension, Community health, HIV/AIDS, Infection, Marginal cost, medicine.medical_specialty, hypertension, noncommunicable diseases, Immunology, Clinical Trials and Supportive Activities, Population, MEDLINE, Stigma (botany), Article, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Clinical Research, Virology, Behavioral and Social Science, Humans, Blood pressure monitoring, Hypertension medications, Noncommunicable Diseases, education, business.industry, Prevention, Psychology and Cognitive Sciences, HIV, medicine.disease, 030104 developmental biology, Good Health and Well Being, Family medicine, Emergency medicine, microcosting, Management of diseases and conditions, business
Abstract: Background: Sub-Saharan Africa faces twin epidemics of HIV and non-communicable diseases including hypertension. While integration of hypertension care into the chronic HIV-focused healthcare infrastructure is a key global priority, cost estimates for integration are largely unavailable. In the SEARCH Study, we performed population-based testing for HIV and hypertension and offered integrated streamlined chronic care. Here, we estimate costs for hypertension care integrated with HIV care for HIV-positive individuals, and the cost for hypertension care for HIV-negative people concomitantly in the same clinics. Methods: SEARCH (NCT:01864603) conducted community health campaigns for diagnosis and linkage to care for both HIV and hypertension. HIV-positive patients received hypertension/HIV care jointly including blood pressure monitoring and medications; HIV-negative patients received hypertension care alone at the same clinics. Within 10 Ugandan study communities during 2015-2016, we estimated incremental annual per-patient costs for hypertension care using standard micro-costing techniques, time-and-motion personnel studies, and administrative/clinical records review. Findings: Overall, 70 HIV-positive and 2355 HIV-negative participants received hypertension care. For HIV-positive participants, average incremental cost of hypertension care was $6.29/person/year, representing a 2.1% marginal increased cost over previously published estimates for HIV care alone. For HIV-negative persons, hypertension care cost $11.39/person/year, a 3.8% marginal increase over HIV care costs. Key costs for HIV-positive patients included hypertension medications ($6.19/patient/year; 98% of total) and laboratory testing ($0.10/ patient/year;2%). Key costs for HIV-negative patients included medications ($5.09/patient/year;45%) and clinic staff salaries ($3.66/patient/year;32%), while minor costs included laboratory testing ($0.10/patient/year;1%), fixed costs ($1.98/patient/year;17%) and other recurring costs ($0.56/patient/year;5%). Interpretation: For only 2-4% estimated additional costs, hypertension care was added to HIV care, and also expanded to all HIV-negative patients in prototypic Ugandan clinics, demonstrating substantial synergy. Our results should encourage accelerated scale-up of hypertension care into existing clinics to address the growing hypertension epidemic, secondarily reduce HIV care-related stigma, and improve community health. Funding: Research reported in this manuscript was supported by Division of AIDS, NIAID, of the National Institutes of Health under award number U01AI099959 and in part by the President’s Emergency Plan for AIDS Relief (PEPFAR), and Gilead Sciences. Declaration of Interest: Related to work in this manuscript, all authors declare no conflicts of interests. Ethical Approval: The SEARCH Study was approved by institutional review boards at Makerere University College of Health Sciences (Kampala, Uganda), the Kenya Medical Research Institute (Nairobi, Kenya), and the University of California, San Francisco, as well as by the Uganda National Council for Science and Technology.
Published: 2019

37. Effects of a multicomponent intervention to streamline initiation of antiretroviral therapy in Africa: a stepped-wedge cluster-randomised trial

Author: Jennifer Namusobya, Richard Katuramu, Jeanna Wallenta, Edwin D. Charlebois, Gideon Amanyire, Fred C. Semitala, James G. Kahn, Elvin Geng, David V. Glidden, Diane V. Havlir, Wei Chang, Carol S. Camlin, Leatitia Kampiire, and Moses R. Kamya
Subjects: Adult, Male, 0301 basic medicine, Pediatrics, medicine.medical_specialty, Anti-HIV Agents, Epidemiology, Immunology, MEDLINE, HIV Infections, Drug Administration Schedule, Time-to-Treatment, law.invention, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), Randomized controlled trial, law, Antiretroviral Therapy, Highly Active, Virology, medicine, Humans, Uganda, 030212 general & internal medicine, Young adult, business.industry, Absolute risk reduction, Middle Aged, Viral Load, medicine.disease, 030112 virology, Antiretroviral therapy, CD4 Lymphocyte Count, Clinical trial, Treatment Outcome, Infectious Diseases, Africa, Physical therapy, Population study, Female, business
Abstract: Summary Background In Africa, up to 30% of HIV-infected patients who are clinically eligible for antiretroviral therapy (ART) do not start timely treatment. We assessed the effects of an intervention targeting prevalent health systems barriers to ART initiation on timing and completeness of treatment initiation. Methods In this stepped-wedge, non-blinded, cluster-randomised controlled trial, 20 clinics in southwestern Uganda were randomly assigned in groups of five clinics every 6 months to the intervention by a computerised random number generator. This procedure continued until all clinics had crossed over from control (standard of care) to the intervention, which consisted of opinion-leader-led training and coaching of front-line health workers, a point-of-care CD4 cell count testing platform, a revised counselling approach without mandatory multiple pre-initiation sessions, and feedback to the facilities on their ART initiation rates and how they compared with other facilities. Treatment-naive, HIV-infected adults (aged ≥18 years) who were clinically eligible for ART during the study period were included in the study population. The primary outcome was ART initiation 14 days after first clinical eligibility for ART. This study is registered with ClinicalTrials.gov, number NCT01810289. Findings Between April 11, 2013, and Feb 2, 2015, 12 024 eligible patients visited one of the 20 participating clinics. Median CD4 count was 310 cells per μL (IQR 179–424). 3753 of 4747 patients (weighted proportion 80%) in the intervention group had started ART by 2 weeks after eligibility compared with 2585 of 7066 patients (38%) in the control group (risk difference 41·9%, 95% CI 40·1–43·8). Vital status was ascertained in a random sample of 208 patients in the intervention group and 199 patients in the control group. Four deaths (2%) occurred in the intervention group and five (3%) occurred in the control group. Interpretation A multicomponent intervention targeting health-care worker behaviour increased the probability of ART initiation 14 days after eligibility. This intervention consists of widely accessible components and has been tested in a real-world setting, and is therefore well positioned for use at scale. Funding National Institute of Allergy and Infectious Diseases (NIAID) and the President's Emergency Fund for AIDS Relief (PEPFAR).
Published: 2016

38. A hybrid mobile approach for population-wide HIV testing in rural east Africa: an observational study

Author: Craig R. Cohen, Teri Liegler, Moses R. Kamya, Kevin Kadede, Elizabeth A. Bukusi, Gabriel Chamie, Harsha Thirumurthy, Emmanuel Ssemmondo, Dalsone Kwarisiima, Geoff Lavoy, Norton Sang, Laura B. Balzer, Edwin D. Charlebois, Tamara D. Clark, Jane Kabami, Diane V. Havlir, Rachel L. Steinfeld, Maya L. Petersen, and Vivek Jain
Subjects: Male, 0301 basic medicine, Gerontology, Epidemiology, HIV Infections, Medical and Health Sciences, 0302 clinical medicine, Mass Screening, Uganda, 030212 general & internal medicine, 10. No inequality, education.field_of_study, 1. No poverty, virus diseases, Middle Aged, 3. Good health, Infectious Diseases, Community health, HIV/AIDS, Marital status, Female, Infection, Adult, Referral, Clinical Trials and Supportive Activities, Immunology, Population, Health Promotion, Article, Young Adult, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Clinical Research, Virology, Behavioral and Social Science, medicine, Humans, education, Africa South of the Sahara, Mass screening, business.industry, Prevention, medicine.disease, Kenya, 030112 virology, Good Health and Well Being, Residence, Rural area, business, Mobile Health Units, Demography
Abstract: Summary Background Despite large investments in HIV testing, only an estimated 45% of HIV-infected people in sub-Saharan Africa know their HIV status. Optimum methods for maximising population-level testing remain unknown. We sought to show the effectiveness of a hybrid mobile HIV testing approach at achieving population-wide testing coverage. Methods We enumerated adult (≥15 years) residents of 32 communities in Uganda (n=20) and Kenya (n=12) using a door-to-door census. Stable residence was defined as living in the community for at least 6 months in the past year. In each community, we did 2 week multiple-disease community health campaigns (CHCs) that included HIV testing, counselling, and referral to care if HIV infected; people who did not participate in the CHCs were approached for home-based testing (HBT) for 1–2 months within the 1–6 months after the CHC. We measured population HIV testing coverage and predictors of testing via HBT rather than CHC and non-testing. Findings From April 2, 2013, to June 8, 2014, 168 772 adult residents were enumerated in the door-to-door census. HIV testing was achieved in 131 307 (89%) of 146 906 adults with stable residence. 13 043 of 136 033 (9·6%, 95% CI 9·4–9·8) adults with and without stable residence had HIV; median CD4 count was 514 cells per μL (IQR 355–703). Among 131 307 adults with stable residence tested, 56 106 (43%) reported no previous testing. Among 13 043 HIV-infected adults, 4932 (38%) were unaware of their status. Among 105 170 CHC attendees with stable residence 104 635 (99%) accepted HIV testing. Of 131 307 adults with stable residence tested, 104 635 (80%; range 60–93% across communities) tested via CHCs. In multivariable analyses of adults with stable residence, predictors of non-testing included being male (risk ratio [RR] 1·52, 95% CI 1·48–1·56), single marital status (1·70, 1·66–1·75), age 30–39 years (1·58, 1·52–1·65 vs 15–19 years), residence in Kenya (1·46, 1·41–1·50), and migration out of the community for at least 1 month in the past year (1·60, 1·53–1·68). Compared with unemployed people, testing for HIV was more common among farmers (RR 0·73, 95% CI 0·67–0·79) and students (0·73, 0·69–0·77); and compared with people with no education, testing was more common in those with primary education (0·84, 0·80–0·89). Interpretation A hybrid, mobile approach of multiple-disease CHCs followed by HBT allowed for flexibility at the community and individual level to help reach testing coverage goals. Men and mobile populations remain challenges for universal testing. Funding National Institutes of Health and President's Emergency Plan for AIDS Relief.
Published: 2016

39. 633: Generation of a malaria-negative African birthweight standard for diagnosis of small for gestational age

Author: Stephanie L. Gaw, Richard Kajubi, John Ategeka, Grant Dorsey, Moses R. Kamya, Abel Kakuru, Mary K. Muhindo, Arthurine Zakama, and Diane V. Havlir
Subjects: medicine.medical_specialty, Obstetrics, business.industry, medicine, Obstetrics and Gynecology, Small for gestational age, medicine.disease, business, Malaria
Published: 2020

40. Intermittent preventive treatment with dihydroartemisinin–piperaquine and risk of malaria following cessation in young Ugandan children: a double-blind, randomised, controlled trial

Author: Muhindo, Mary K, primary, Jagannathan, Prasanna, additional, Kakuru, Abel, additional, Opira, Bishop, additional, Olwoch, Peter, additional, Okiring, Jaffer, additional, Nalugo, Noeline, additional, Clark, Tamara D, additional, Ruel, Theodore, additional, Charlebois, Edwin, additional, Feeney, Margaret E, additional, Havlir, Diane V, additional, Dorsey, Grant, additional, and Kamya, Moses R, additional
Published: 2019
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41. Gendered dimensions of population mobility associated with HIV across three epidemics in rural Eastern Africa

Author: Camlin, Carol S., primary, Akullian, Adam, additional, Neilands, Torsten B., additional, Getahun, Monica, additional, Bershteyn, Anna, additional, Ssali, Sarah, additional, Geng, Elvin, additional, Gandhi, Monica, additional, Cohen, Craig R., additional, Maeri, Irene, additional, Eyul, Patrick, additional, Petersen, Maya L., additional, Havlir, Diane V., additional, Kamya, Moses R., additional, Bukusi, Elizabeth A., additional, and Charlebois, Edwin D., additional
Published: 2019
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42. Monthly sulfadoxine–pyrimethamine versus dihydroartemisinin–piperaquine for intermittent preventive treatment of malaria in pregnancy: a double-blind, randomised, controlled, superiority trial

Author: Kajubi, Richard, primary, Ochieng, Teddy, additional, Kakuru, Abel, additional, Jagannathan, Prasanna, additional, Nakalembe, Miriam, additional, Ruel, Theodore, additional, Opira, Bishop, additional, Ochokoru, Harriet, additional, Ategeka, John, additional, Nayebare, Patience, additional, Clark, Tamara D, additional, Havlir, Diane V, additional, Kamya, Moses R, additional, and Dorsey, Grant, additional
Published: 2019
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43. I’m ready to die now a 12 month review of ventilation withdrawal for MND patients within a regional ventilation service

Author: Moses, R., primary, Vyas, A., additional, and Wood, S., additional
Published: 2019
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44. Reducing the carbon footprint in a regional long term ventilation service with the use of remote monitoring

Author: Moses, R., primary, Vyas, A., additional, and Wood, S., additional
Published: 2019
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45. Impact of Intermittent Preventive Treatment of Malaria in Pregnancy with Dihydroartemisinin-Piperaquine Versus Sulfadoxine-Pyrimethamine on the Incidence of Malaria in Infancy: A Randomised Controlled Trial

Author: Kakuru, Abel, primary, Jagannathan, Prasanna, additional, Kajubi, Richard, additional, Ochieng, Teddy, additional, Ochokoru, Harriet, additional, Nakalembe, Miriam, additional, Clark, Tamara D., additional, Ruel, Theodore, additional, Staedke, Sarah, additional, Chandramohan, Daniel, additional, Havlir, Diane V., additional, Kamya, Moses R., additional, and Dorsey, Grant, additional
Published: 2019
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46. Costs of Integrating Hypertension Care into HIV Care in Rural East African Clinics

Author: Shade, Starley B., primary, Osmand, Thomas, additional, Kwarisiima, Dalsone, additional, Brown, Lillian B., additional, Luo, Alex, additional, Mwebaza, Betty, additional, Mwesigye, R., additional, Kwizera, Enos, additional, Imukeka, Haawa, additional, Mwanga, Florence, additional, Ayieko, James, additional, Owaraganise, Asiphas, additional, Bukusi, Elizabeth A., additional, Cohen, Craig R., additional, Charlebois, Edwin D., additional, Black, Douglas, additional, Clark, Tamara D., additional, Petersen, Maya L., additional, Kamya, Moses R., additional, Havlir, Diane V., additional, and Jain, Vivek, additional
Published: 2019
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47. Protective efficacy of prolonged co-trimoxazole prophylaxis in HIV-exposed children up to age 4 years for the prevention of malaria in Uganda: a randomised controlled open-label trial

Author: Jaco Homsy, Emmanuel Arinaitwe, Jordan W. Tappero, Taylor Sandison, Mary K. Muhindo, Abel Kakuru, Victor Bigira, Humphrey Wanzira, Grant Dorsey, and Moses R. Kamya
Subjects: Male, Pediatrics, medicine.medical_specialty, Population, Breastfeeding, HIV Infections, Rate ratio, law.invention, Acquired immunodeficiency syndrome (AIDS), Randomized controlled trial, law, Trimethoprim, Sulfamethoxazole Drug Combination, medicine, Humans, Uganda, education, 2. Zero hunger, education.field_of_study, Intention-to-treat analysis, business.industry, lcsh:Public aspects of medicine, Incidence (epidemiology), Infant, lcsh:RA1-1270, General Medicine, Antibiotic Prophylaxis, medicine.disease, Anti-Bacterial Agents, CD4 Lymphocyte Count, Malaria, 3. Good health, Breast Feeding, Child, Preschool, Female, business
Abstract: Background: WHO recommends daily co-trimoxazole for children born to HIV-infected mothers from 6 weeks of age until breastfeeding cessation and exclusion of HIV infection. We have previously reported on the effectiveness of continuation of co-trimoxazole prophylaxis up to age 2 years in these children. We assessed the protective efficacy and safety of prolonging co-trimoxazole prophylaxis until age 4 years in HIV-exposed children. Methods: We undertook an open-label randomised controlled trial alongside two observational cohorts in eastern Uganda, an area with high HIV prevalence, malaria transmission intensity, and antifolate resistance. We enrolled HIV-exposed infants between 6 weeks and 9 months of age and prescribed them daily co-trimoxazole until breastfeeding cessation and HIV-status confirmation. At the end of breastfeeding, children who remained HIV-uninfected were randomly assigned (1:1) to discontinue co-trimoxazole or to continue taking it up to age 2 years. At age 2 years, children who continued co-trimoxazole prophylaxis were randomly assigned (1:1) to discontinue or continue prophylaxis from age 2 years to age 4 years. The primary outcome was incidence of malaria (defined as the number of treatments for new episodes of malaria diagnosed with positive thick smear) at age 4 years. For additional comparisons, we observed 48 HIV-infected children who took continuous co-trimoxazole prophylaxis and 100 HIV-unexposed uninfected children who never received prophylaxis. We measured grade 3 and 4 serious adverse events and hospital admissions. All children were followed up to age 5 years and all analyses were by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00527800. Findings: 203 HIV-exposed infants were enrolled between Aug 10, 2007, and March 28, 2008. After breastfeeding ended, 185 children were not infected with HIV and were randomly assigned to stop (n=87) or continue (n=98) co-trimoxazole up to age 2 years. At age 2 years, 91 HIV-exposed children who had remained on co-trimoxazole prophylaxis were randomly assigned to discontinue (n=46) or continue (n=45) co-trimoxazole from age 2 years to age 4 years. We recorded 243 malaria episodes (2·91 per person-years) in the 45 HIV-exposed children assigned to continue co-trimoxazole until age 4 years compared with 503 episodes (5·60 per person-years) in the 46 children assigned to stop co-trimoxazole at age 2 years (incidence rate ratio 0·53, 95% CI 0·39–0·71; p
Published: 2014

48. Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial

Author: Bohula, Erin A, primary, Scirica, Benjamin M, additional, Inzucchi, Silvio E, additional, McGuire, Darren K, additional, Keech, Anthony C, additional, Smith, Steven R, additional, Kanevsky, Estella, additional, Murphy, Sabina A, additional, Leiter, Lawrence A, additional, Dwyer, Jamie P, additional, Corbalan, Ramon, additional, Hamm, Christian, additional, Kaplan, Lee, additional, Nicolau, Jose Carlos, additional, Ophuis, Ton Oude, additional, Ray, Kausik K, additional, Ruda, Mikhail, additional, Spinar, Jindrich, additional, Patel, Tushar, additional, Miao, Wenfeng, additional, Perdomo, Carlos, additional, Francis, Bruce, additional, Dhadda, Shobha, additional, Bonaca, Marc P, additional, Ruff, Christian T, additional, Sabatine, Marc S, additional, Wiviott, Stephen D, additional, Inzucchi, Silvio, additional, Keech, Anthony, additional, Satlin, Andrew, additional, Brown, Conville, additional, Budaj, Andrzej, additional, Dwyer, Jamie, additional, Garcia-Castillo, Armando, additional, Gupta, Milan, additional, Oude Ophuis, Ton, additional, Ray, Kauski, additional, Weissman, Neil, additional, White, Harvey D, additional, Amerena, J, additional, Arstall, M, additional, Colquhoun, D, additional, Jayasinghe, R, additional, Lee, A, additional, Lehman, R, additional, Moses, R, additional, Proietto, J, additional, Purnell, P, additional, Waites, J, additional, Blombery, P, additional, Cross, D, additional, Worthley, M, additional, d'Emden, M, additional, Selvanayagam, J, additional, Oqueli, RE, additional, Whelan, A, additional, Garrahy, P, additional, de Looze, F, additional, Ninio, D, additional, Horowitz, J, additional, William, M, additional, Suranyi, M, additional, Wittert, G, additional, Le May, M, additional, Pandey, AS, additional, Vizel, S, additional, Labonte, R, additional, Beaudry, Y, additional, Fortin, C, additional, Bell, A, additional, Kouz, S, additional, St-Amour, É, additional, Bata, I, additional, St Maurice, F, additional, Chehayeb, R, additional, Constance, C, additional, Wong, G, additional, Hess, A, additional, Liutkus, J, additional, Poirier, P, additional, Teitelbaum, I, additional, Berlingieri, J, additional, Cha, J, additional, Hartleib, M, additional, Heffernan, M, additional, Twum-Barima, D, additional, Pandith, V, additional, Aronson, R, additional, Goldenberg, R, additional, Ajala, B, additional, Jain, A, additional, Ross, S, additional, Bajaj, H, additional, Khandwala, H, additional, Yared, Z, additional, Gupta, N, additional, Bédard, J, additional, Wharton, S, additional, Blouin, F, additional, Savard, D, additional, Shukla, D, additional, Cobos, J, additional, Godoy, G, additional, Perez, L, additional, Pincetti, C, additional, Saavedra Guajardo, V, additional, Varleta, P, additional, Conejeros, C, additional, Lanas, F, additional, Bayram Llamas, E, additional, Cardona Muñoz, E, additional, Garcia, R, additional, Garza Ruiz, J, additional, Llamas Esperon, G, additional, Lopez Rosas, E, additional, Melendez Mier, G, additional, Ramos, G, additional, Hart, H, additional, Scott, D, additional, Ternouth, I, additional, Benatar, J, additional, Elliott, J, additional, Cutfield, R, additional, Manning, P, additional, Williams, M, additional, Ferrier, K, additional, Scott, R, additional, Wilson, S, additional, Leikis, R, additional, Nirmalaraj, BK, additional, Krzyżagórska, E, additional, Miękus, P, additional, Bronisz, M, additional, Mirek-Bryniarska, E, additional, Łanda, K, additional, Stasiewski, A, additional, Żechowicz, T, additional, Zytkiewicz-Jaruga, D, additional, Korecki, J, additional, Ogórek, M, additional, Pawłowicz, L, additional, Piepiorka, M, additional, Skierkowska, J, additional, Stankiewicz, A, additional, Szyprowska, E, additional, Witek, R, additional, Bochenek, A, additional, Kończakowski, P, additional, Wojnowski, Ł, additional, Wujkowski, M, additional, Cymerman, K, additional, Korzeniak, R, additional, Mąder, P, additional, Mikłaszewicz, B, additional, Stachlewski, P, additional, Goch, A, additional, Pomiećko, W, additional, Skórski, M, additional, Romanowski, L, additional, Jusiak, K, additional, Laskowska-Derlaga, E, additional, Bijata-Bronisz, R, additional, Kaźmierczak, J, additional, Goldberg, R, additional, Henderson, D, additional, Korban, E, additional, Rohr, K, additional, Claxton, E, additional, Weiss, R, additional, Angiolillo, D, additional, Boccalandro, F, additional, Chu, K, additional, Thorn, E, additional, Randhawa, P, additional, Singh, N, additional, Bittar, G, additional, Guarnieri, T, additional, Saeed, S, additional, Sharma, S, additional, Shepard, M, additional, French, W, additional, Desai, P, additional, Bernstein, R, additional, Rogers, W, additional, Singal, R, additional, Schneider, R, additional, Shanes, J, additional, Ong, S, additional, Condit, J, additional, Donahoe, S, additional, Brill, D, additional, Einhorn, D, additional, Ebrahimi, R, additional, Labroo, A, additional, Graf, R, additional, Scott, J, additional, Hoekstra, J, additional, Jetty, P, additional, Luckasen, G, additional, O'Donnell, P, additional, Gonte, W, additional, Pomposini, D, additional, Quadrel, M, additional, Koren, M, additional, Schlager, D, additional, Schramm, E, additional, Singal, D, additional, Lupovitch, S, additional, Soni, A, additional, Seigel, P, additional, Roberts, J, additional, Soufer, J, additional, Reza, S, additional, Quinlan, E, additional, Moretto, T, additional, First, B, additional, Khan, M, additional, Chilka, S, additional, Colfer, H, additional, Teklinski, A, additional, Wallace-Wilding, K, additional, Ellison, H, additional, Muse, D, additional, Aronoff, S, additional, Higgins, A, additional, Patel, S, additional, Elinoff, V, additional, Karim, A, additional, Awasty, V, additional, Chuang, R, additional, Roseman, H, additional, Dugano-Daphnis, P, additional, Albert, M, additional, Sheikh, K, additional, Bays, H, additional, Kaster, S, additional, Goldstein, M, additional, Rubino, D, additional, Calatayud, G, additional, Snyder, H, additional, Williams, T, additional, Hershon, K, additional, Hagan, M, additional, Isserman, S, additional, Kahn, B, additional, Anderson, J, additional, Gimness, MP, additional, Raisinghani, A, additional, Christina, M, additional, Raikhel, M, additional, Gillespie, E, additional, Portnay, E, additional, Heiman, M, additional, Qureshi, M, additional, Lee, J, additional, Blonder, R, additional, Cucher, F, additional, Miller, G, additional, Kotlaba, D, additional, Cornett, G, additional, Beavins, J, additional, Augenbraun, C, additional, Reinhardt, S, additional, Bartkowiak, A, additional, Salacata, A, additional, Blevins, T, additional, Benjamin, S, additional, Diener, J, additional, George, W, additional, Barker, B, additional, Richwine, R, additional, Baldari, D, additional, Alfieri, A, additional, Barreto, A, additional, Zhang, L, additional, Shah, R, additional, Hendrix, E, additional, Subramaniyam, V, additional, Hurley, S, additional, Lillestol, M, additional, O'Donoghue, M, additional, Shayani, S, additional, Ryan, E, additional, Call, R, additional, Zemel, L, additional, Chang, A, additional, Kivitz, A, additional, Freyne, B, additional, Bland, V, additional, Shore, K, additional, Mostel, E, additional, Uzoaga, E, additional, Andrawis, N, additional, Gabra, N, additional, Ghitis, A, additional, Sabatino, K, additional, Browder, D, additional, Varma, S, additional, Smith, S, additional, Fink, R, additional, Aycock, GR, additional, Doty, WD, additional, Alfonso, T, additional, Eshaghian, S, additional, Karlsberg, R, additional, Zarich, S, additional, Landau, C, additional, McKenzie, M, additional, Krause, R, additional, Davis, W, additional, Haddad, T, additional, Voyce, S, additional, Alford, C, additional, LeDoux, J, additional, O'Dea, D, additional, Park, J, additional, Aroda, V, additional, Getaneh, A, additional, Graham, B, additional, Bhagwat, R, additional, Korn, D, additional, Ruoff, G, additional, Wiseman, A, additional, Lieber, I, additional, Fialkow, J, additional, Gonzalez-Campoy, JM, additional, Bayron, C, additional, Bertolet, B, additional, Lash, J, additional, Gerrish, C, additional, Robertson, D, additional, Rosenfeld, J, additional, Seidner, M, additional, Agaiby, J, additional, Silverfield, J, additional, Sugimoto, D, additional, Lubin, B, additional, Alhaddad, M, additional, Lui, H, additional, Lakin, G, additional, Chokshi, S, additional, Donovan, D, additional, Felten, W, additional, Minton, S, additional, Kimmelstiel, C, additional, Kuvin, J, additional, Still, C, additional, Byars, W, additional, Talano, J, additional, Desai, V, additional, Bradley, AJ, additional, Baker, S, additional, Chane, M, additional, Mercado, A, additional, Baron, S, additional, Harris, B, additional, Mayer, N, additional, Concha, M, additional, Carr, K, additional, Chaykin, L, additional, Willis, J, additional, Clay, A, additional, Fenstad, E, additional, Furda, J, additional, Peterson, P, additional, Chang, M, additional, Aronne, L, additional, Jones, D, additional, Prashad, R, additional, Benson, M, additional, Stegemoller, R, additional, Longshaw, K, additional, Saleh, J, additional, Jennings, W, additional, Detweiler, R, additional, Viswanath, D, additional, Patel, R, additional, Lederman, S, additional, Weinstein, D, additional, Korabathina, R, additional, Singh, V, additional, Rosen, J, additional, Estevez, R, additional, Levin, P, additional, McNeill, R, additional, Kalen, V, additional, Reed, J, additional, Ashley, R, additional, Herman, L, additional, Tsai, Y, additional, Kayne, D, additional, White, A, additional, Hussain, I, additional, Tami, L, additional, Cohen, K, additional, Robinson, J, additional, Fuchs-Ertman, D, additional, Platt, G, additional, Belardo, L, additional, Reddy, R, additional, Rosendorff, C, additional, Saba, F, additional, Powell, S, additional, Anderson, K, additional, Abidi, M, additional, Rezkalla, S, additional, Paraschos, A, additional, Wilson, J, additional, Moursi, M, additional, Shah, A, additional, Nadar, V, additional, Stonesifer, L, additional, Bialow, M, additional, Cannon, K, additional, Ellison, W, additional, Stedman, M, additional, Brown, J, additional, Harper, W, additional, Lucas, KJ, additional, DiGiovanna, M, additional, Rodbard, H, additional, Biscoveanu, M, additional, Davis, C, additional, Hall, J, additional, Littlefield, R, additional, Gorman, T, additional, Kereiakes, D, additional, Chang, FM, additional, Tatu, H, additional, Cheung, D, additional, Kaine, J, additional, Knutson, T, additional, Logemann, T, additional, Pueblitz, G, additional, Bianco, J, additional, Henson, B, additional, Neustel, M, additional, Gelernt, M, additional, Nelson, W, additional, Moriarty, K, additional, Lefebvre, G, additional, Maw, K, additional, Rink, L, additional, Behn, P, additional, Studdard, H, additional, Argoud, G, additional, O'Connor, T, additional, Krichmar, P, additional, Raad, G, additional, Pereles-Ortiz, J, additional, Sorli, C, additional, Cohen, A, additional, Pettis, K, additional, Cavanaugh, B, additional, Phillips, C, additional, Wahlen, J, additional, Radin, D, additional, Rider, J, additional, Kosinski, E, additional, Leimbach, W, additional, Odhav, A, additional, Hakas, J, additional, Tan, A, additional, Howell, M, additional, Wombolt, D, additional, Fishman, N, additional, Shah, P, additional, Wylie, P, additional, Arauz-Pacheco, C, additional, Cavale, A, additional, George, A, additional, Kroll, R, additional, Krantzler, J, additional, Tahirkheli, N, additional, Jabro, M, additional, Newell, M, additional, Mullen, P, additional, Gencheff, N, additional, Meli, J, additional, Vora, K, additional, Kotek, L, additional, Pyzdrowski, K, additional, Paez, H, additional, Moran, J, additional, Tannenbaum, A, additional, Deck, K, additional, Busch, R, additional, Levinson, L, additional, Azizad, M, additional, Whitaker, J, additional, Fox, B, additional, Huffman, C, additional, Ashraf, M, additional, Diogo, J, additional, Kushner, R, additional, Tallet, J, additional, Channamsetty, V, additional, Suh, D, additional, Atieh, M, additional, Navas, J, additional, Young, V, additional, Shaw, S, additional, Dor, I, additional, Duffy, B, additional, Rubin, P, additional, Lewis, D, additional, Kaye, W, additional, Benton, R, additional, Burbano, J, additional, Hotchkiss, D, additional, Magno, A, additional, Alberton, A, additional, Collins, J, additional, Alvarado, O, additional, Stich, M, additional, Mahal, S, additional, Liu, J, additional, Hong, M, additional, Dy, J, additional, Block, B, additional, Lamantia, J, additional, Pritchard, J, additional, Davis, M, additional, Srivastava, S, additional, Bilazarian, S, additional, Rosario, R, additional, McCartney, M, additional, Blumberg, V, additional, Rajan, R, additional, Martin, E, additional, Wright, S, additional, Brinson, C, additional, Johnston, J, additional, Graves, M, additional, Dominguez, M, additional, McKenzie, W, additional, Abadier, R, additional, Tran, C, additional, Castello, R, additional, Morawski, E, additional, White, J, additional, Morris, F, additional, Perez, A, additional, Trueba, P, additional, Sanchez, M, additional, Andersen, J, additional, Kastelic, R, additional, Khan, J, additional, Rodriguez, H, additional, Izquierdo, W, additional, Matias, A, additional, Essandoh, L, additional, and Ince, C, additional
Published: 2018
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49. Assessment of community-level effects of intermittent preventive treatment for malaria in schoolchildren in Jinja, Uganda (START-IPT trial): a cluster-randomised trial

Author: Staedke, Sarah G, primary, Maiteki-Sebuguzi, Catherine, additional, Rehman, Andrea M, additional, Kigozi, Simon P, additional, Gonahasa, Samuel, additional, Okiring, Jaffer, additional, Lindsay, Steve W, additional, Kamya, Moses R, additional, Chandler, Clare I R, additional, Dorsey, Grant, additional, and Drakeley, Chris, additional
Published: 2018
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50. Rapid improvements to rural Ugandan housing and their association with malaria from intense to reduced transmission: a cohort study

Author: Rek, John C, primary, Alegana, Victor, additional, Arinaitwe, Emmanuel, additional, Cameron, Ewan, additional, Kamya, Moses R, additional, Katureebe, Agaba, additional, Lindsay, Steve W, additional, Kilama, Maxwell, additional, Staedke, Sarah G, additional, Todd, Jim, additional, Dorsey, Grant, additional, and Tusting, Lucy S, additional
Published: 2018
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