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Your search keyword '"Motoki Takaku"' showing total 2 results
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2 results on '"Motoki Takaku"'

1. Correction: The CHD4-related syndrome: a comprehensive investigation of the clinical spectrum, genotype–phenotype correlations, and molecular basis

Author

Karin Weiss, Hayley P. Lazar, Alina Kurolap, Ariel F. Martinez, Tamar Paperna, Lior Cohen, Marie F. Smeland, Sandra Whalen, Solveig Heide, Boris Keren, Pauline Terhal, Melita Irving, Motoki Takaku, John D. Roberts, Robert M. Petrovich, Samantha A. Schrier Vergano, Amy Kenney, Hanne Hove, Elizabeth DeChene, Shane C. Quinonez, Estelle Colin, Alban Ziegler, Melissa Rumple, Mahim Jain, Danielle Monteil, Elizabeth R. Roeder, Kimberly Nugent, Arie van Haeringen, Michael Gambello, Avni Santani, Līvija Medne, Bryan Krock, Cara M. Skraban, Elaine H. Zackai, Holly A. Dubbs, Thomas Smol, Jamal Ghoumid, Michael J. Parker, Michael Wright, Peter Turnpenny, Jill Clayton-Smith, Kay Metcalfe, Hitoshi Kurumizaka, Bruce D. Gelb, Hagit Baris Feldman, Philippe M. Campeau, Maximilian Muenke, Paul A. Wade, and Katherine Lachlan

Subjects
Genetics (clinical)
Published
2020
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2. High-quality ChIP-seq analysis of MBD3 in human breast cancer cells

Author

Motoki Takaku, Paul A. Wade, and Takashi Shimbo

Subjects
0301 basic medicine, lcsh:QH426-470, Computational biology, Biology, Bioinformatics, Biochemistry, Mi-2/NuRD complex, Chromatin remodeling, 3. Good health, Chromatin, ChIP-seq, lcsh:Genetics, 03 medical and health sciences, Breast cancer, 030104 developmental biology, Mi-2/NuRD, Data in Brief, Gene expression, Cancer cell, Gene duplication, Genetics, Molecular Medicine, Nucleosome, Histone deacetylase, Biotechnology
Abstract

Chromatin accessibility is tightly regulated by multiple factors/mechanisms to establish different cell type-specific gene expression programs from a single genome. Dysregulation of this process can lead to diseases including cancer. The Mi-2/nucleosome remodeling and deacetylase (NuRD) complex is thought to orchestrate chromatin structure using its intrinsic nucleosome remodeling and histone deacetylase activities. However, the detailed mechanisms by which the NuRD complex regulates chromatin structure in vivo are not yet known. To explore the regulatory mechanisms of the NuRD complex, we mapped genome-wide localization of MBD3, a structural component of NuRD, in a human breast cancer cell line (MDA-MB-231) using a modified ChIP-seq protocol. Our data showed high quality localization information (i.e., high mapping efficiency and low PCR duplication rate) and excellent consistency between biological replicates. The data are deposited in the Gene Expression Omnibus (GSE76116). Keywords: ChIP-seq, Mi-2/NuRD, Breast cancer

Published
2016
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