Search

Your search keyword '"Mugyenyi, Peter"' showing total 23 results
Start Over Author "Mugyenyi, Peter" Publisher elsevier bv
23 results on '"Mugyenyi, Peter"'

1. Translocated microbiome composition determines immunological outcome in treated HIV infection

Author

Nganou-Makamdop, Krystelle, primary, Talla, Aarthi, additional, Sharma, Ashish Arunkumar, additional, Darko, Sam, additional, Ransier, Amy, additional, Laboune, Farida, additional, Chipman, Jeffrey G., additional, Beilman, Gregory J., additional, Hoskuldsson, Torfi, additional, Fourati, Slim, additional, Schmidt, Thomas E., additional, Arumugam, Sahaana, additional, Lima, Noemia S., additional, Moon, Damee, additional, Callisto, Samuel, additional, Schoephoerster, Jordan, additional, Tomalka, Jeffery, additional, Mugyenyi, Peter, additional, Ssali, Francis, additional, Muloma, Proscovia, additional, Ssengendo, Patrick, additional, Leda, Ana R., additional, Cheu, Ryan K., additional, Flynn, Jacob K., additional, Morou, Antigoni, additional, Brunet-Ratnasingham, Elsa, additional, Rodriguez, Benigno, additional, Lederman, Michael M., additional, Kaufmann, Daniel E., additional, Klatt, Nichole R., additional, Kityo, Cissy, additional, Brenchley, Jason M., additional, Schacker, Timothy W., additional, Sekaly, Rafick P., additional, and Douek, Daniel C., additional

Published
2021
Full Text
View/download PDF

2. Lopinavir plus nucleoside reverse-transcriptase inhibitors, lopinavir plus raltegravir, or lopinavir monotherapy for second-line treatment of HIV (EARNEST): 144-week follow-up results from a randomised controlled trial

Author

Hakim, James G, Thompson, Jennifer, Kityo, Cissy, Hoppe, Anne, Kambugu, Andrew, van Oosterhout, Joep J, Lugemwa, Abbas, Siika, Abraham, Mwebaze, Raymond, Mweemba, Aggrey, Abongomera, George, Thomason, Margaret J, Easterbrook, Philippa, Mugyenyi, Peter, Walker, A Sarah, Paton, Nicholas I, and Europe Africa Research Network for Evaluation of Second-line The

Abstract

BACKGROUND: Millions of HIV-infected people worldwide receive antiretroviral therapy (ART) in programmes using WHO-recommended standardised regimens. Recent WHO guidelines recommend a boosted protease inhibitor plus raltegravir as an alternative second-line combination. We assessed whether this treatment option offers any advantage over the standard protease inhibitor plus two nucleoside reverse-transcriptase inhibitors (NRTIs) second-line combination after 144 weeks of follow-up in typical programme settings. METHODS: We analysed the 144-week outcomes at the completion of the EARNEST trial, a randomised controlled trial done in HIV-infected adults or adolescents in 14 sites in five sub-Saharan African countries (Uganda, Zimbabwe, Malawi, Kenya, Zambia). Participants were those who were no longer responding to non-NRTI-based first-line ART, as assessed with WHO criteria, confirmed by viral-load testing. Participants were randomly assigned to receive a ritonavir-boosted protease inhibitor (lopinavir 400 mg with ritonavir 100 mg, twice per day) plus two or three clinician-selected NRTIs (protease inhibitor plus NRTI group), protease inhibitor plus raltegravir (400 mg twice per day; protease inhibitor plus raltegravir group), or protease inhibitor monotherapy (plus raltegravir induction for first 12 weeks, re-intensified to combination therapy after week 96; protease inhibitor monotherapy group). Randomisation was by computer-generated randomisation sequence, with variable block size. The primary outcome was viral load of less than 400 copies per mL at week 144, for which we assessed non-inferiority with a one-sided α of 0·025, and superiority with a two-sided α of 0·025. The EARNEST trial is registered with ISRCTN, number 37737787. FINDINGS: Between April 12, 2010, and April 29, 2011, 1837 patients were screened for eligibility, of whom 1277 patients were randomly assigned to an intervention group. In the primary (complete-case) analysis at 144 weeks, 317 (86%) of 367 in the protease inhibitor plus NRTI group had viral loads of less than 400 copies per mL compared with 312 (81%) of 383 in the protease inhibitor plus raltegravir group (p=0·07; lower 95% confidence limit for difference 10·2% vs specified non-inferiority margin 10%). In the protease inhibitor monotherapy group, 292 (78%) of 375 had viral loads of less than 400 copies per mL; p=0·003 versus the protease inhibitor plus NRTI group at 144 weeks. There was no difference between groups in serious adverse events, grade 3 or 4 adverse events (total or ART-related), or events that resulted in treatment modification. INTERPRETATION: Protease inhibitor plus raltegravir offered no advantage over protease inhibitor plus NRTI in virological efficacy or safety. In the primary analysis, protease inhibitor plus raltegravir did not meet non-inferiority criteria. A regimen of protease inhibitor with NRTIs remains the best standardised second-line regimen for use in programmes in resource-limited settings. FUNDING: European and Developing Countries Clinical Trials Partnership (EDCTP), UK Medical Research Council, Instituto de Salud Carlos III, Irish Aid, Swedish International Development Cooperation Agency, Instituto Superiore di Sanita, Merck, ViiV Healthcare, WHO.

Published
2018

3. Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study

Author

Grinsztejn, Beatriz, primary, Hughes, Michael D, additional, Ritz, Justin, additional, Salata, Robert, additional, Mugyenyi, Peter, additional, Hogg, Evelyn, additional, Wieclaw, Linda, additional, Gross, Robert, additional, Godfrey, Catherine, additional, Cardoso, Sandra W, additional, Bukuru, Aggrey, additional, Makanga, Mumbi, additional, Faesen, Sharlaa, additional, Mave, Vidya, additional, Wangari Ndege, Beatrice, additional, Nerette Fontain, Sandy, additional, Samaneka, Wadzanai, additional, Secours, Rode, additional, van Schalkwyk, Marije, additional, Mngqibisa, Rosie, additional, Mohapi, Lerato, additional, Valencia, Javier, additional, Sugandhavesa, Patcharaphan, additional, Montalban, Esmelda, additional, Avihingsanon, Anchalee, additional, Santos, Breno R, additional, Kumarasamy, Nagalingeswaran, additional, Kanyama, Cecilia, additional, Schooley, Robert T, additional, Mellors, John W, additional, Wallis, Carole L, additional, Collier, Ann C, additional, Grinsztejn, B, additional, Mugyenyi, PN, additional, Collier, A, additional, Salata, R, additional, Godfrey, C, additional, Hogg, E, additional, Hughes, M, additional, Ritz, J, additional, Wieclaw, L, additional, Sise, T, additional, Mellors, JW, additional, Wallis, C, additional, Fletcher, CV, additional, Gandhi, M, additional, Gross, R, additional, Schooley, RT, additional, Walensky, R, additional, van Schalkwyk, M, additional, Faesen, S, additional, Mngqibisa, R, additional, Valencia, J, additional, Montalban, E, additional, Kumarasamy, N, additional, Kanyama, C, additional, Cardoso, SW, additional, Santos, BR, additional, Mansfield, B, additional, Mugerwa, H, additional, Ndege, BW, additional, Secours, R, additional, Samaneka, W, additional, Kadam, D, additional, Mave, V, additional, Makanga, M, additional, Fontain, SN, additional, Sugandhavesa, P, additional, Avihingsanon, A, additional, Nakibuuka, L, additional, Nassolo, H, additional, Anthony, P, additional, Kulkarni, V, additional, Nsubuga, M, additional, van Wyk, J, additional, Rooney, J, additional, van Delft, Y, additional, Leavitt, R, additional, Luk, R, additional, Benns, A, additional, Hovind, L, additional, and Shahkolahi, A, additional

Published
2019
Full Text
View/download PDF

4. Two-way mobile phone intervention compared with standard-of-care adherence support after second-line antiretroviral therapy failure: a multinational, randomised controlled trial

Author

Gross, Robert, primary, Ritz, Justin, additional, Hughes, Michael D, additional, Salata, Robert, additional, Mugyenyi, Peter, additional, Hogg, Evelyn, additional, Wieclaw, Linda, additional, Godfrey, Catherine, additional, Wallis, Carole L, additional, Mellors, John W, additional, Mudhune, Victor O, additional, Badal-Faesen, Sharlaa, additional, Grinsztejn, Beatriz, additional, and Collier, Ann C, additional

Published
2019
Full Text
View/download PDF

5. Clinically relevant thresholds for ultrasensitive HIV drug resistance testing: a multi-country nested case-control study

Author

Inzaule, Seth C, primary, Hamers, Raph L, additional, Noguera-Julian, Marc, additional, Casadellà, Maria, additional, Parera, Mariona, additional, Kityo, Cissy, additional, Steegen, Kim, additional, Naniche, Denise, additional, Clotet, Bonaventura, additional, Rinke de Wit, Tobias F, additional, Paredes, Roger, additional, Osibogun, Akin, additional, Wallis, Carole L., additional, Nalubwama, Cathy, additional, Letsoalo, Esrom, additional, Senono, Fred, additional, Adelabu, Hameed, additional, Kakooza, Hanipha, additional, Namata, Harriet, additional, Sanne, Ian, additional, Nankya, Immaculate, additional, Menke, Jack, additional, Lange, Joep M.A., additional, Sigaloff, Kim C.E., additional, Mandaliya, Kishor, additional, Hardman, Margaret, additional, Siwale, Margaret, additional, de Jager, Marleen, additional, Dolan, Marian, additional, Botes, Mariette E., additional, O'Mello, Martin, additional, Wellington, Maureen, additional, Mutebi, Miiro, additional, Nakitto, Miriam, additional, Labib, Moheb, additional, Pakker, Nadine, additional, Ondoa, Pascale, additional, Mugyenyi, Peter, additional, Ive, Prudence, additional, Nakanjako, Ritah, additional, Schuurman, Rob, additional, Lüthy, Ruedi, additional, Balinda, Sheila N., additional, Akanmu, Sulaimon, additional, Boender, T. Sonia, additional, Adeyemo, Titilope A., additional, Rodoye, Tope, additional, Stevens, Wendy S., additional, and Namala, Winnie, additional

Published
2018
Full Text
View/download PDF

6. Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial

Author

Mallewa, Jane, primary, Szubert, Alexander J, additional, Mugyenyi, Peter, additional, Chidziva, Ennie, additional, Thomason, Margaret J, additional, Chepkorir, Priscilla, additional, Abongomera, George, additional, Baleeta, Keith, additional, Etyang, Anthony, additional, Warambwa, Colin, additional, Melly, Betty, additional, Mudzingwa, Shepherd, additional, Kelly, Christine, additional, Agutu, Clara, additional, Wilkes, Helen, additional, Nkomani, Sanele, additional, Musiime, Victor, additional, Lugemwa, Abbas, additional, Pett, Sarah L, additional, Bwakura-Dangarembizi, Mutsa, additional, Prendergast, Andrew J, additional, Gibb, Diana M, additional, Walker, A Sarah, additional, Berkley, James A, additional, Kityo, Cissy, additional, Wavamunno, Priscilla, additional, Nambi, Esther, additional, Ocitti, Paul, additional, Ndigendawani, Milly, additional, Kabahenda, Sheila, additional, Kemigisa, Mable, additional, Acen, Juliet, additional, Olebo, David Francis, additional, Mpamize, Gordon, additional, Amone, Alex, additional, Okweny, David, additional, Mbonye, Andrew, additional, Nambaziira, Florence, additional, Rweyora, Angela, additional, Kangah, Mary, additional, Kabaswahili, Beatrice, additional, Abach, James, additional, Omongin, Joseph, additional, Aciro, Irene, additional, Philliam, Aleti, additional, Arach, Beatrice, additional, Ocung, Emmanuel, additional, Amone, Geoffrey, additional, Miles, Peter, additional, Adong, Claudia, additional, Tumsuiime, Constance, additional, Kidega, Patrick, additional, Otto, Ben, additional, Apio, Florence, additional, Mukuye, Andrew, additional, Abwola, Mary, additional, Ssennono, Fred, additional, Baliruno, David, additional, Tuhirwe, Stephen, additional, Namisi, Ronald, additional, Kigongo, Fredrick, additional, Kikyonkyo, Dickson, additional, Mushahara, Furaha, additional, Tusiime, Julian, additional, Musiime, Alex, additional, Nankya, Agnes, additional, Atwongyeire, Dickens, additional, Sirikye, Sowal, additional, Myalo, Sula, additional, Noowe, Nelson, additional, Kasozi, Mariam, additional, Mwebe, Sandra, additional, Atwine, Lorna, additional, Senkindu, Tapson, additional, Natuhurira, Ian, additional, Katemba, Chrispus, additional, Ninsiima, Emily, additional, Acaku, Moses, additional, Kyomuhangi, Joy, additional, Ankunda, Rogers, additional, Tukwasibwe, Deogratious, additional, Ayesiga, Lillian, additional, Hakim, James, additional, Nathoo, Kusum, additional, Reid, Andrew, additional, Mhute, Tawand, additional, Tinago, Gloria, additional, Bhiri, Joyline, additional, Phiri, Misheck, additional, Steamer, John, additional, Nhema, Ruth, additional, Musoro, Godfrey, additional, Mutsai, Shirley, additional, Nemasango, Beauty, additional, Moyo, Columbus, additional, Chitongo, Stuart, additional, Rashirai, Kennias, additional, Vhembo, Sydney, additional, Mlambo, Brian, additional, Ndemera, Buxton, additional, Willard, Marko, additional, Berejena, Chipo, additional, Musodza, Yeukai, additional, Matiza, Patience, additional, Mudenge, Boniface, additional, Guti, Vongai, additional, Berkley, Jay, additional, Maitland, Kathryn, additional, Njuguna, Patricia, additional, Mwaringa, Shalton, additional, Etyang, Timothy, additional, Awuondo, Ken, additional, Wale, Stephen, additional, Shangala, Jimmy, additional, Kithunga, Jefwa, additional, Mwarumba, Salim, additional, Said Maitha, Salma, additional, Mutai, Robert, additional, Lozi Lewa, Margaret, additional, Mwambingu, Gabriel, additional, Mwanzu, Alfred, additional, Kalama, Connie, additional, Latham, Helen, additional, Shikuku, Joyce, additional, Fondo, Amos, additional, Njogu, Anne, additional, Khadenge, Connie, additional, Mwakisha, Bryan, additional, Siika, Abraham, additional, Wools-Kaloustian, Kara, additional, Nyandiko, Winston, additional, Chepkorir-Cheruiyot, Priscilla, additional, Sudoi, Allan, additional, Wachira, Simon, additional, Meli, Betty, additional, Karoney, Mercy, additional, Nzioka, Agnes, additional, Tanui, Michael, additional, Mokaya, Martha, additional, Ekiru, Wilson, additional, Mboya, Chris, additional, Mwimali, Dorothy, additional, Mengich, Cecilia, additional, Choge, Julie, additional, Injera, Wilfred, additional, Njenga, Kennedy, additional, Cherutich, Salinah, additional, Anyango Orido, Millicent, additional, Omondi Lwande, Gerald, additional, Rutto, Peter, additional, Mudogo, Alice, additional, Kutto, Irene, additional, Shali, Amina, additional, Jaika, Linda, additional, Jerotich, Hellen, additional, Pierre, Mowlem, additional, Mallewa, Jane, additional, Kaunda, Symon, additional, Van Oosterhout, Joep, additional, O'Hare, Bernadette, additional, Heydermann, Robert, additional, Gonzalez, Carmen, additional, Dzabala, Nettie, additional, Denis, Brigitte, additional, Selemani, George, additional, Nyondo- Mipando, Linda, additional, Chirwa, Emmie, additional, Banda, Peter, additional, Mvula, Linley, additional, Msuku, Harrison, additional, Ziwoya, Milton, additional, Manda, Yollam, additional, Nicholas, Simon, additional, Masesa, Clemens, additional, Mwalukomo, Thandi, additional, Makhaza, Lumbani, additional, Sheha, Irene, additional, Bwanali, Joseph, additional, Limbuni, Molly, additional, Walker, Ann Sarah, additional, Griffiths, Anna, additional, Rajapakse, Chathurika, additional, Spyer, Moira J, additional, Klein, Nigel, additional, Rauchenberger, Mary, additional, Van Looy, Nadine, additional, Little, Emma, additional, Fairbrother, Keith, additional, Cowan, Frances, additional, Seeley, Janet, additional, Bernays, Sarah, additional, Kawuma, Rachel, additional, and Mupambireyi, Zivai, additional

Published
2018
Full Text
View/download PDF

8. Infecting HIV-1 Subtype Predicts Disease Progression in Women of Sub-Saharan Africa

Author

Venner, Colin M., primary, Nankya, Immaculate, additional, Kyeyune, Fred, additional, Demers, Korey, additional, Kwok, Cynthia, additional, Chen, Pai-Lien, additional, Rwambuya, Sandra, additional, Munjoma, Marshall, additional, Chipato, Tsungai, additional, Byamugisha, Josaphat, additional, Van Der Pol, Barbara, additional, Mugyenyi, Peter, additional, Salata, Robert A., additional, Morrison, Charles S., additional, and Arts, Eric J., additional

Published
2016
Full Text
View/download PDF

9. Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

Author

Hosseinipour, Mina C, primary, Bisson, Gregory P, additional, Miyahara, Sachiko, additional, Sun, Xin, additional, Moses, Agnes, additional, Riviere, Cynthia, additional, Kirui, Fredrick K, additional, Badal-Faesen, Sharlaa, additional, Lagat, David, additional, Nyirenda, Mulinda, additional, Naidoo, Kogieleum, additional, Hakim, James, additional, Mugyenyi, Peter, additional, Henostroza, German, additional, Leger, Paul D, additional, Lama, Javier R, additional, Mohapi, Lerato, additional, Alave, Jorge, additional, Mave, Vidya, additional, Veloso, Valdilea G, additional, Pillay, Sandy, additional, Kumarasamy, Nagalingeswaran, additional, Bao, Jing, additional, Hogg, Evelyn, additional, Jones, Lynne, additional, Zolopa, Andrew, additional, Kumwenda, Johnstone, additional, and Gupta, Amita, additional

Published
2016
Full Text
View/download PDF

11. Induction of opsonophagocytic killing activity with pneumococcal conjugate vaccine in human immunodeficiency virus-infected Ugandan adults

Author

Chen, Meng, Ssali, Francis, Mulungi, Maureen, Awio, Peter, Yoshimine, Hiroyuki, Kuroki, Reiki, Furumoto, Akitsugu, Tanimura, Susumu, Kityo, Cissy, Nagatake, Tsuyoshi, Mugyenyi, Peter, Oishi, Kazunori, Chen, Meng, Ssali, Francis, Mulungi, Maureen, Awio, Peter, Yoshimine, Hiroyuki, Kuroki, Reiki, Furumoto, Akitsugu, Tanimura, Susumu, Kityo, Cissy, Nagatake, Tsuyoshi, Mugyenyi, Peter, and Oishi, Kazunori

Abstract

The levels of IgG determined by ELISA may have limited relevance in human immunodeficiency virus (HIV)-infected adults because of nonfunctional antibodies. 58 HIV-1-infected and 29 HIV-uninfected Ugandan adults were immunized with conjugate vaccine (CV) followed by polysaccharide vaccine (PV) after a two-month interval, and the opsonophagocytic killing (OPK) titers against serotype 4 or 14 pneumococcal strains as well as the levels of serotype-specific IgG in sera were determined. Significant increases were found in the OPK titers and IgG levels for both serotypes after CV vaccination irrespective of HIV status. Increases in IgG levels and OPK titers were largely dependent on the CD4+ cell counts, except for increases in the IgG levels for serotype 4. The proportions with serum OPK titer equal to or greater than 8 were 0-4.3% for serotype 4 and 26.7-42.9% for serotype 14 before vaccination, but the proportions increased up to 43.3-86.2% for serotype 4 and 63.3-96.6% for serotype 14 in all three groups 2 months after CV vaccination. The serum OPK titers remained at levels higher than the pre-vaccination level for at least 8 months after CV vaccination. A single dose of CV could afford some protective immunity in HIV-infected African adults before the introduction of antiretroviral therapy., Vaccine, 26(38), pp.4962-4968; 2008

Published
2008

14. Therapeutic immunization in HIV infected Ugandans receiving stable antiretroviral treatment: A Phase I safety study

Author

Kityo, Cissy, primary, Bousheri, Stephanie, additional, Akao, Juliette, additional, Ssali, Francis, additional, Byaruhanga, Rose, additional, Ssewanyana, Isaac, additional, Muloma, Prossy, additional, Myalo, Sula, additional, Magala, Rose, additional, Lu, Yichen, additional, Mugyenyi, Peter, additional, and Cao, Huyen, additional

Published
2011
Full Text
View/download PDF

17. Induction of opsonophagocytic killing activity with pneumococcal conjugate vaccine in human immunodeficiency virus-infected Ugandan adults

Author

Chen, Meng, primary, Ssali, Francis, additional, Mulungi, Maureen, additional, Awio, Peter, additional, Yoshimine, Hiroyuki, additional, Kuroki, Reiki, additional, Furumoto, Akitsugu, additional, Tanimura, Susumu, additional, Kityo, Cissy, additional, Nagatake, Tsuyoshi, additional, Mugyenyi, Peter, additional, and Oishi, Kazunori, additional

Published
2008
Full Text
View/download PDF

18. Detection of recent HIV infections in African individuals infected by HIV-1 non-B subtypes using HIV antibody avidity

Author

Suligoi, Barbara, primary, Buttò, Stefano, additional, Galli, Claudio, additional, Bernasconi, Daniela, additional, Salata, Robert A., additional, Tavoschi, Lara, additional, Chiappi, Michele, additional, Mugyenyi, Peter, additional, Pimpinelli, Fulvia, additional, Kityo, Cissy, additional, Regine, Vincenza, additional, and Rezza, Giovanni, additional

Published
2008
Full Text
View/download PDF

19. Oropharyngeal colonization by Streptococcus pneumoniae among HIV-infected adults in Uganda: assessing prevalence and antimicrobial susceptibility

Author

Blossom, David B., primary, Namayanja-Kaye, Grace, additional, Nankya-Mutyoba, Joan, additional, Mukasa, John B., additional, Bakka, Henry, additional, Rwambuya, Sandra, additional, Windau, Anne, additional, Bajaksouzian, Saralee, additional, Walker, Courtney J., additional, Joloba, Moses L., additional, Kityo, Cissy, additional, Mugyenyi, Peter, additional, Whalen, Christopher C., additional, Jacobs, Michael R., additional, and Salata, Robert A., additional

Published
2006
Full Text
View/download PDF

20. Transmission of HIV-1 infection in sub-Saharan Africa and effect of elimination of unsafe injections

Author

Schmid, George P, primary, Buvé, Anne, additional, Mugyenyi, Peter, additional, Garnett, Geoff P, additional, Hayes, Richard J, additional, Williams, Brian G, additional, Calleja, Jesus Garcia, additional, De Cock, Kevin M, additional, Whitworth, James A, additional, Kapiga, Saidi H, additional, Ghys, Peter D, additional, Hankins, Catherine, additional, Zaba, Basia, additional, Heimer, Robert, additional, and Boerma, J Ties, additional

Published
2004
Full Text
View/download PDF

22. Assessment of a pilot antiretroviral drug therapy programme in Uganda: patients' response, survival, and drug resistance

Author

Weidle, Paul J, primary, Malamba, Samuel, additional, Mwebaze, Raymond, additional, Sozi, Catherine, additional, Rukundo, Gideon, additional, Downing, Robert, additional, Hanson, Debra, additional, Ochola, Dorothy, additional, Mugyenyi, Peter, additional, Mermin, Jonathan, additional, Samb, Badara, additional, and Lackritz, Eve, additional

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results