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Your search keyword '"N. Fazio"' showing total 11 results
Start Over Author "N. Fazio" Publisher elsevier bv
11 results on '"N. Fazio"'

8. 65 - Role of Doublecortin-Like Kinase 1 (DCLK1) Positive Tuft Cells in Colitis-Associated Colorectal Cancer

Author

Liyue Zhang, Timothy C. Wang, Elena N. Fazio, Hayley Good, Philip M. Sherman, Samuel Asfaha, and Alice E. Shin

Subjects
Hepatology, Colorectal cancer, business.industry, Gastroenterology, Cancer, Tumor initiation, medicine.disease, medicine.disease_cause, medicine, Cancer research, Stem cell, medicine.symptom, Colitis, business, Carcinogenesis, Anaplasia, Tamoxifen, medicine.drug
Published
2018
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10. Real-word analysis on the use of somatostatin analogs (SSAs) in patients with neuroendocrine neoplasms (NENs): results of a survey conducted by the Italian Society of Medical Oncology (AIOM)

Author

F. Spada and N. Fazio

Subjects
0301 basic medicine, Gynecology, medicine.medical_specialty, business.industry, General surgery, Hematology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Somatostatin, Oncology, 030220 oncology & carcinogenesis, medicine, In patient, business
Published
2016
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11. Diphenidol-related diamines as novel muscarinic M4 receptor antagonists

Author

Massimiliano Granaiola, Andrea Bedini, Lucilla Varoli, Alberto Leoni, Alessandra Locatelli, Aldo Andreani, Mirella Rambaldi, Rita Morigi, Silvia Burnelli, Santi Mario Spampinato, Nicola Fazio, L. Varoli, A. Andreani, S. Burnelli, M. Granaiola, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi, A. Bedini, N. Fazio, and S. Spampinato

Subjects
Allosteric modulator, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, M4-SELECTIVE MUSCARINIC ANTAGONISTS, CHO Cells, Muscarinic Antagonists, Diamines, Binding, Competitive, Biochemistry, ALLOSTERIC MODULATION, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, MUSCARINIC RECEPTOR BINDING ASSAYS, Allosteric Regulation, Piperidines, Cricetinae, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Animals, Humans, Diphenidol, Methiodide, Receptor, Molecular Biology, FUNCTIONAL STUDIES, Acetylcholine receptor, Receptor, Muscarinic M4, Staining and Labeling, Cell Membrane, Organic Chemistry, N-Methylscopolamine, Kinetics, DIPHENIDOL DIAMINE DERIVATIVES, chemistry, Competitive antagonist, Molecular Medicine
Abstract

A series of hydrochloride derivatives 2a – 9a and quaternary ammonium derivatives 3b – 9b of diphenidol have been synthesized and characterized in receptor binding and cellular functional assays versus human muscarinic M 1 –M 5 receptors expressed in CHO cells. Compound 8b , a methiodide derivative with a bipiperidinyl moiety and a second diphenidol framework, showed a potent and selective M 4 activity as competitive antagonist. Moreover 8b , acting as an allosteric modulator, was able to retard the dissociation rate of [ 3 H]- N -methylscopolamine from CHO-M 4 cell membranes exposed to atropine. Taken together, these data suggest that 8b might open new avenues to the discovery of novel multivalent antagonists for the muscarinic receptors.

Published
2008
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