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Breast cancer diagnosis and treatment can lead to longer term cognitive and emotional vulnerability, making the ability to efficiently adapt to setbacks critical. Whilst cancer-related cognitive impairments (CRCI) are often reported amongst breast cancer survivors, investigation into the capacity to efficiently process errors is limited. The present study investigated the neurocognitive correlates of cognitive-control related performance monitoring, an important function influencing behavioural adjustment to mistakes. 62 participants (30 Breast Cancer Survivors, 32 Non-Cancer) completed a modified flanker task designed to challenge response inhibition as we measured neurocognitive indices of performance monitoring (ERN, the error-related negativity; CRN, the correct-response negativity; Pe, the error positivity). Findings indicated a blunted CRN and larger ∆ERN in the breast cancer survivors compared to the non-cancer group, in the absence of performance effects. This was followed by a larger Pe in the breast cancer survivors' group, indicating an exaggerated performance monitoring response. For women affected by breast cancer, findings suggest an early disrupted neural response to monitoring cognitive performance, followed by the requirement for more effortful processing in the conscious response to errors, indicating deficits in neurocognitive efficiency. These findings have important implications for developing cognitive rehabilitation programmes for breast cancer survivors affected by cognitive dysfunction to assist in the monitoring and adjustment of performance required to meet established goals in the face of adversity.

Accumulating evidence suggests that cognitive training may enhance well-being. Yet, mixed findings imply that individual differences and training characteristics may interact to moderate training efficacy. To investigate this possibility, the current paper describes a protocol for a data-driven individual-level meta-analysis study aimed at developing personalized cognitive training. To facilitate comprehensive analysis, this protocol proposes criteria for data search, selection and pre-processing along with the rationale for each decision. Twenty-two cognitive training datasets comprising 1544 participants were collected. The datasets incorporated diverse training methods, all aimed at improving well-being. These training regimes differed in training characteristics such as targeted domain (e.g., working memory, attentional bias, interpretation bias, inhibitory control) and training duration, while participants differed in diagnostic status, age and sex. The planned analyses incorporate machine learning algorithms designed to identify which individuals will be most responsive to cognitive training in general and to discern which methods may be a better fit for certain individuals.

Worry is the principle characteristic of generalised anxiety disorder, and has been linked to deficient attentional control, a main function of working memory (WM). Adaptive WM training and mindfulness meditation practice (MMP) have both shown potential to increase attentional control. The present study hence investigates the individual and combined effects of MMP and a dual adaptive n-back task on a non-clinical, randomised sample of high worriers. 60 participants were tested before and after seven days of training. Assessment included self-report questionnaires, as well as performance tasks measuring attentional control and working memory capacity. Combined training resulted in continued reduction in worry in the week after training, highlighting the potential of utilising n-back training as an adjunct to established clinical treatment. Engagement with WM training correlated with immediate improvements in attentional control and resilience, with worry decreasing over time. Implications of these findings and suggestions for future research are discussed.

Trait anxiety is associated with impairments in attentional control and processing efficiency (see Berggren & Derakshan, 2013, for a review). Working memory training using the adaptive dual n-back task has shown to improve attentional control in subclinical depression with transfer effects at the behavioral and neural level on a working memory task (Owens, Koster, & Derakshan, 2013). Here, we examined the beneficial effects of working memory training on attentional control in pre-selected high trait anxious individuals who underwent a three week daily training intervention using the adaptive dual n-back task. Pre and post outcome measures of attentional control were assessed using a Flanker task that included a stress induction and an emotional a Antisaccade task (with angry and neutral faces as target). Resting state EEG (theta/beta ratio) was recorded to as a neural marker of trait attentional control. Our results showed that adaptive working memory training improved attentional control with transfer effects on the Flanker task and resting state EEG, but effects of training on the Antisaccade task were less conclusive. Finally, training related gains were associated with lower levels of trait anxiety at post (vs pre) intervention. Our results demonstrate that adaptive working memory training in anxiety can have beneficial effects on attentional control and cognitive performance that may protect against emotional vulnerability in individuals at risk of developing clinical anxiety.

Attentional Control Theory (ACT; [Eysenck et al., 2007] and [Derakshan and Eysenck, 2009]) posits that trait anxiety interferes with the inhibition, shifting and updating processes of working memory. Consequently, high anxious individuals are predicted to perform worse on cognitively demanding tasks requiring efficient cognitive processing. Whilst a growing number of studies have provided support for this view, the possible underlying mechanisms of this deficiency are far less understood. In particular, there is conflicting neuroscientific evidence with some work showing associations between anxiety and increased neural activity over frontal areas, while others reportreduced activity. We review recent evidence that hashelped elucidate the cognitive hallmarks of trait anxiety, and suggest how previous discrepancies can be accommodated within ACT's prediction that reduced cognitive efficiency may be ameliorated by strategies such as compensatory effort. Finally, we discuss if ACT's distinction on efficiency and effectiveness can be applied to threat-related processing,often shown to additively override attentional control in anxiety.

There have been several theoretical attempts to explain the effects of anxiety on cognitive performance. According to attentional control theory, anxiety impairs the efficiency of two executive functions (the inhibition and shifting functions). Another major theoretical assumption is that anxiety impairs performance effectiveness (the quality of performance) to a lesser extent than processing efficiency (the relationship between performance effectiveness and effort or use of processing resources). However, there may be conditions (e.g., prior presentation of threat-related stimuli) in which that assumption is not applicable. The extensive recent research (including several cognitive neuroscience studies) of direct relevance to the theory is discussed, and suggestions are made for maximizing the value of future cognitive neuroscience research. Finally, attentional control theory is developed to explicate the relationship between anxiety and motivation. Implications for theoretical predictions and alternative theoretical accounts are discussed.

According to Attentional Control Theory (Eysenck et al., 2007) anxiety impairs the inhibition function of working memory by increasing the influence of stimulus-driven processes over efficient top-down control. We investigated the neural correlates of impaired inhibitory control in anxiety using an antisaccade task. Low- and high-anxious participants performed anti- and prosaccade tasks and electrophysiological activity was recorded. Consistent with previous research high-anxious individuals had longer antisaccade latencies in response to the to-be-inhibited target, compared with low-anxious individuals. Central to our predictions, high-anxious individuals showed lower ERP activity, at frontocentral and central recording sites, than low anxious individuals, in the period immediately prior to onset of the to-be-inhibited target on correct antisaccade trials. Our findings indicate that anxiety interferes with the efficient recruitment of top-down mechanisms required for the suppression of prepotent responses. Implications are discussed within current models of attentional control in anxiety (Bishop, 2009; Eysenck et al., 2007).

We investigated the neural correlates of cognitive effort/pre-target preparation (Contingent Negative Variation activity; CNV) in anxiety using a mixed antisaccade task that manipulated the interval between offset of instructional cue and onset of target (CTI). According to attentional control theory (Eysenck et al., 2007) we predicted that anxiety should result in increased levels of compensatory effort, as indicated by greater frontal CNV, to maintain comparable levels of performance under competing task demands. Our results showed that anxiety resulted in faster antisaccade latencies during medium compared with short and long CTIs. Accordingly, high-anxious individuals compared with low-anxious individuals showed greater levels of CNV activity at frontal sites during medium CTI suggesting that they exerted greater cognitive effort and invested more attentional resources in preparation for the task goal. Our results are the first to demonstrate the neural correlates of processing efficiency and compensatory effort in anxiety and are discussed within the framework of attentional control theory.

It is generally held that anxiety is characterized by an attentional bias for threatening information. In recent years there has been an important debate whether these biases reside at the level of attentional selection (threat detection) or attentional processing after threat detection (attentional disengagement). In a visual search task containing emotional facial expressions, eye-movements were examined before and after threat detection in high and low trait anxious individuals to further elucidate the temporal unfolding of attentional bias. Results indicated that high-anxious individuals neither showed facilitated orienting to threat nor impaired disengagement of visual attention from threat. Interestingly, the presence of threat in the visual search display was associated with increased decision times in high-anxious individuals. These results challenge some of the current views on attentional bias to threat but indicate that emotional information reduces processing efficiency in anxiety.

We examined inhibitory mechanisms in dysphoria using direct measures of attentional control. Dysphoric and non-dysphoric participants performed standard and delayed versions of the antisaccade and prosaccade tasks with facial expressions as stimuli. Results showed higher error rates in the standard antisaccade task than in the delayed tasks, with the dysphoric group having higher error rates in response to emotional facial expressions, in particular happy expressions. Our findings indicate impaired attentional processing in response to emotional facial expressions, in particular happy expressions, in dysphoria. Implications for understanding the mechanisms underlying attentional control in dysphoria are discussed.

Four groups of participants: repressors (low anxiety–high defensiveness, N=15), low-anxious (low-anxiety–low defensiveness, N=13), high-anxious (high anxiety–low defensiveness, N=14) and defensive high-anxious (high anxiety–high defensiveness, N=10), completed the Monitoring and Blunting Style Scale (MBSS; [Miller, S. M. (1987). Monitoring and blunting: validation of a questionnaire to assess styles of information seeking under threat. Journal of Personality and Social Psychology, 52, 345–353.] and the Coping Orientation to Problems Experienced, (COPE; [Carver, C. S., Scheier, M. F., & Weintraub, J. K. (1989). Assessing coping strategies: a theoretically based approach. Journal of Personality and Social Psychology, 56, 267–283.]) Repressors scored lower than the other groups in their monitoring scores, but the groups did not differ on their blunting scores. This finding may cast some doubt on the validity of the MBSS, since the majority of research has regarded low monitoring and high blunting styles as equivalent. On the COPE, repressors reported higher levels of coping on only some of the scales and both the COPE and the MBSS appear to be suitable measuring instruments for repressors, who do not appear to complete them in a positive fashion.

Predicted and actual examination performance, beliefs in various possible examination outcomes and events, and worrying about examinations were assessed in four groups of students (low-anxious, repressor, high-anxious, and defensive high-anxious). The evidence indicated that the high-anxious and defensive high-anxious groups were unrealistically pessimistic about some examination-related events (they possessed an interpretive bias for such events), whereas the repressor groups were unrealistically optimistic about some examination related events, showing an opposite interpretive bias. The findings were interpreted in the light of a new theory of trait anxiety proposed by Eysenck (Anxiety and cognition: A unified theory. Hove: Psychology Press, 1977).