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Your search keyword '"Nicholas, Peter"' showing total 24 results
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24 results on '"Nicholas, Peter"'

1. Outcomes of Unrelated Partial T Cell Depleted Stem Cell Transplantation for Patients with Hemoglobinopathies

Author

Gibson, Nora M., primary, Elgarten, Caitlin W., additional, Oved, Joseph H., additional, Wray, Lisa, additional, Freedman, Jason L., additional, Wang, Yongping, additional, Kadauke, Stephan, additional, Hankins, Patricia, additional, Nicholas, Peter, additional, Worster, Elizabeth, additional, Kwiatkowski, Janet L., additional, Grupp, Stephan A., additional, Bunin, Nancy J., additional, and Olson, Timothy S., additional

Published
2024
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3. Symptom-circuit mappings of the schizophrenia connectome

Author

Wang, Yingchan, primary, Wang, Jijun, additional, Su, Wenjun, additional, Hu, Hao, additional, Xia, Mengqing, additional, Zhang, Tianhong, additional, Xu, Lihua, additional, Zhang, Xia, additional, Taylor, Hugh, additional, Osipowicz, Karol, additional, Young, Isabella M., additional, Lin, Yueh-Hsin, additional, Nicholas, Peter, additional, Tanglay, Onur, additional, Sughrue, Michael E., additional, Tang, Yingying, additional, and Doyen, Stephane, additional

Published
2023
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5. Real World Demonstration of Hand Motor Mapping using the Structural Connectivity Atlas

Author

Osipowicz, Karol, primary, Profyris, Christos, additional, Mackenzie, Alana, additional, Nicholas, Peter, additional, Rudder, Peter, additional, Taylor, Hugh M., additional, Young, Isabella M., additional, Joyce, Angus W., additional, Dobbin, Lewis, additional, Tanglay, Onur, additional, Thompson, Lerroy, additional, Mashilwane, Tshimollo, additional, Sughrue, Michael E., additional, and Doyen, Stephane, additional

Published
2023
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6. Connectivity model of the anatomic substrates and network abnormalities in major depressive disorder: A coordinate meta-analysis of resting-state functional connectivity

Author

Young, Isabella M., primary, Dadario, Nicholas B., additional, Tanglay, Onur, additional, Chen, Emily, additional, Cook, Brennan, additional, Taylor, Hugh M., additional, Crawford, Lewis, additional, Yeung, Jacky T., additional, Nicholas, Peter J., additional, Doyen, Stéphane, additional, and Sughrue, Michael E., additional

Published
2023
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10. SMAD proteins: Mediators of diverse outcomes during infection

Author

Lachlan Yuek Shun Lai, Nicholas Peter Gracie, Anjali Gowripalan, Liam Michael Howell, and Timothy Peter Newsome

Subjects
Histology, QH573-671, Pathogen, Transforming Growth Factor β, Smad Proteins, Cell Biology, General Medicine, Fibrosis, Pathology and Forensic Medicine, Cellular Signalling, Transforming Growth Factor beta, Humans, Infection, Cytology, Receptors, Transforming Growth Factor beta, SMAD, Signal Transduction
Abstract

Understanding the relationship between host and pathogen is key to combatting disease. SMAD transcription factors, which transmit TGF-β superfamily signalling, mediate an array of outcomes during embryogenesis, inflammation, cancer, and immunity. Surprisingly, these activities can sometimes be directly opposed; for example, SMAD3 has been reported as tumour suppressor by arresting cell cycle progression but conversely promotes cancer metastasis. A growing body of literature has identified SMADs as prominent targets during viral and bacterial infection for modulating host signalling. During infection, the activity of SMAD-containing transcriptional complexes can be finely tuned by pathogens to enhance infectivity and spread. SMAD signalling can be modulated at many levels, such as upstream at the ligand and receptor, or by direct interactions with SMADs. These alterations can increase pathogen dissemination, induce fibrosis, over-activate, or attenuate the host immune response. Here, we summarise the diverse mechanisms by which pathogens have evolved to sway SMAD signalling in their favour. Understanding the intricacies of host-pathogen interactions through this lens may elucidate aspects of SMAD function in cancer development, homoeostasis, and immune signalling previously overlooked. These insights are an opportunity to identify novel TGF-β or BMP-targeted therapeutics for applications to infectious disease contexts.

Published
2022

13. Optimization of a supercritical fluid chromatograph–atmospheric pressure chemical ionization mass spectrometer interface using an ion trap and two quadrupole mass spectrometers

Author

Nicholas Peter Kitrinos, Kevin L Harbol, and Daniel G Morgan

Subjects
Chemical ionization, Chromatography, Chemistry, Organic Chemistry, Analytical chemistry, Atmospheric-pressure chemical ionization, General Medicine, Mass spectrometry, Biochemistry, Analytical Chemistry, Triple quadrupole mass spectrometer, Selected ion monitoring, Ion trap, Quadrupole mass analyzer, Hybrid mass spectrometer
Abstract

The optimization of an interface for coupling supercritical fluid chromatography (SFC) with atmospheric pressure chemical ionization mass spectrometry (APCI-MS) is described. Data presented demonstrate that the internal diameter and length of the transfer line between the SFC unit and the APCI source are not critical in maintaining peak shape or retention time under the set of conditions tested. The inlet capillary of the APCI source optimizes at 75 μm I.D., thus maintaining peak shape while enabling the use of a full range of pressure gradients (8–37 MPa). A comparison of responses from an in-line UV detector, two quadrupole mass spectrometers and an ion trap is presented to demonstrate limits of detection and linear ranges for the SFC separation of a six-compound test mix.

Published
1998

16. Practical consideration for 3T imaging

Author

Lin, Weili, primary, An, Hongyu, additional, Chen, Yasheng, additional, Nicholas, Peter, additional, Zhai, GuiHua, additional, Gerig, Guido, additional, Gilmore, John, additional, and Bullitt, Elizabeth, additional

Published
2003
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19. A Genomic Screen of Autism: Evidence for a Multilocus Etiology

Author

Risch, Neil, primary, Spiker, Donna, additional, Lotspeich, Linda, additional, Nouri, Nassim, additional, Hinds, David, additional, Hallmayer, Joachim, additional, Kalaydjieva, Luba, additional, McCague, Patty, additional, Dimiceli, Sue, additional, Pitts, Tawna, additional, Nguyen, Loan, additional, Yang, Joan, additional, Harper, Courtney, additional, Thorpe, Danielle, additional, Vermeer, Saritha, additional, Young, Helena, additional, Hebert, Joan, additional, Lin, Alice, additional, Ferguson, Joan, additional, Chiotti, Carla, additional, Wiese-Slater, Susan, additional, Rogers, Tamara, additional, Salmon, Boyd, additional, Nicholas, Peter, additional, Petersen, P. Brent, additional, Pingree, Carmen, additional, McMahon, William, additional, Wong, Dona L., additional, Cavalli-Sforza, L. Luca, additional, Kraemer, Helena C., additional, and Myers, Richard M., additional

Published
1999
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