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Your search keyword '"Oksanen, Minna"' showing total 21 results
Start Over Author "Oksanen, Minna" Publisher elsevier bv
21 results on '"Oksanen, Minna"'

2. A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture

Author

Grubman, Alexandra, primary, Vandekolk, Teresa H., additional, Schröder, Jan, additional, Sun, Guizhi, additional, Hatwell-Humble, Jessica, additional, Chan, Jonathan, additional, Oksanen, Minna, additional, Lehtonen, Sarka, additional, Hunt, Cameron, additional, Koistinaho, Jari E., additional, Nilsson, Susan K., additional, Haynes, John M., additional, Pouton, Colin W., additional, and Polo, Jose M., additional

Published
2020
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3. Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

Author

Oikari, Lotta E., primary, Pandit, Rucha, additional, Stewart, Romal, additional, Cuní-López, Carla, additional, Quek, Hazel, additional, Sutharsan, Ratneswary, additional, Rantanen, Laura M., additional, Oksanen, Minna, additional, Lehtonen, Sarka, additional, de Boer, Carmela Maria, additional, Polo, Jose M., additional, Götz, Jürgen, additional, Koistinaho, Jari, additional, and White, Anthony R., additional

Published
2020
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4. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Author

Konttinen, Henna, primary, Cabral-da-Silva, Mauricio e Castro, additional, Ohtonen, Sohvi, additional, Wojciechowski, Sara, additional, Shakirzyanova, Anastasia, additional, Caligola, Simone, additional, Giugno, Rosalba, additional, Ishchenko, Yevheniia, additional, Hernández, Damián, additional, Fazaludeen, Mohammad Feroze, additional, Eamen, Shaila, additional, Budia, Mireia Gómez, additional, Fagerlund, Ilkka, additional, Scoyni, Flavia, additional, Korhonen, Paula, additional, Huber, Nadine, additional, Haapasalo, Annakaisa, additional, Hewitt, Alex W., additional, Vickers, James, additional, Smith, Grady C., additional, Oksanen, Minna, additional, Graff, Caroline, additional, Kanninen, Katja M., additional, Lehtonen, Sarka, additional, Propson, Nicholas, additional, Schwartz, Michael P., additional, Pébay, Alice, additional, Koistinaho, Jari, additional, Ooi, Lezanne, additional, and Malm, Tarja, additional

Published
2019
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5. T-cell Subsets in Peripheral Blood and Tumors of Patients Treated With Oncolytic Adenoviruses

Author

Taipale Kristian, Ristimaki Ari, Karioja-Kallio Aila, Juhila Juuso, Liikanen Ilkka, Kanerva Anna, Vähä-Koskela Markus, Hemminki Akseli, Lundin Johan, Linder Nina, Koski Anniina, Joensuu Timo, Turkki Riku, and Oksanen Minna

Subjects
Oncolytic adenovirus, Lymphocyte, medicine.medical_treatment, T cell, 03 medical and health sciences, 0302 clinical medicine, Immune system, Drug Discovery, Genetics, medicine, Molecular Biology, 030304 developmental biology, Pharmacology, 0303 health sciences, business.industry, Melanoma, Immunotherapy, medicine.disease, 3. Good health, Oncolytic virus, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, Molecular Medicine, business, CD8
Abstract

The quality of the antitumor immune response is decisive when developing new immunotherapies for cancer. Oncolytic adenoviruses cause a potent immunogenic stimulus and arming them with costimulatory molecules reshapes the immune response further. We evaluated peripheral blood T-cell subsets of 50 patients with refractory solid tumors undergoing treatment with oncolytic adenovirus. These data were compared to changes in antiviral and antitumor T cells, treatment efficacy, overall survival, and T-cell subsets in pre- and post-treatment tumor biopsies. Treatment caused a significant ( P + cells, and decrease of CD4 + cells. Concomitant treatment with cyclophosphamide and temozolomide resulted in less CD4 + decrease ( P = 0.041) than cyclophosphamide only. Interestingly, we saw a correlation between T-cell changes in peripheral blood and the tumor site. This correlation was positive for CD8 + and inverse for CD4 + cells. These findings give insight to the interconnections between peripheral blood and tumor-infiltrating lymphocyte (TIL) populations regarding oncolytic virotherapy. In particular, our data suggest that induction of T-cell response is not sufficient for clinical response in the context of immunosuppressive tumors, and that peripheral blood T cells have a complicated and potentially misleading relationship with TILs.

Published
2015
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7. Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease

Author

Lehtonen, Šárka, primary, Höytyläinen, Ida, additional, Voutilainen, Jenni, additional, Sonninen, Tuuli-Maria, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Hämäläinen, Riikka H., additional, Oksanen, Minna, additional, and Koistinaho, Jari, additional

Published
2018
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9. Human iPSC-derived neurons and astrocytes as models of neurodegeneration, neuroinflammation and vesicular trafficking in Alzheimer's disease

Author

Pinto, Sara, primary, Ferreira, Sofia, additional, Moreira, Filipa, additional, Ribeiro, Ana, additional, Cunha, Carolina, additional, Vaz, Ana R., additional, Oksanen, Minna, additional, Petersen, Andrew J., additional, Puttonen, Katja, additional, Zhang, Su-Chun, additional, Hämäläinen, Riikka H., additional, Koistinaho, Jari, additional, Fernandes, Adelaide, additional, and Brites, Dora, additional

Published
2018
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10. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

Author

Oksanen, Minna, primary, Petersen, Andrew J., additional, Naumenko, Nikolay, additional, Puttonen, Katja, additional, Lehtonen, Šárka, additional, Gubert Olivé, Max, additional, Shakirzyanova, Anastasia, additional, Leskelä, Stina, additional, Sarajärvi, Timo, additional, Viitanen, Matti, additional, Rinne, Juha O., additional, Hiltunen, Mikko, additional, Haapasalo, Annakaisa, additional, Giniatullin, Rashid, additional, Tavi, Pasi, additional, Zhang, Su-Chun, additional, Kanninen, Katja M., additional, Hämäläinen, Riikka H., additional, and Koistinaho, Jari, additional

Published
2017
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13. Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

Author

Taipale, Kristian, primary, Liikanen, Ilkka, additional, Juhila, Juuso, additional, Turkki, Riku, additional, Tähtinen, Siri, additional, Kankainen, Matti, additional, Vassilev, Lotta, additional, Ristimäki, Ari, additional, Koski, Anniina, additional, Kanerva, Anna, additional, Diaconu, Iulia, additional, Cerullo, Vincenzo, additional, Vähä-Koskela, Markus, additional, Oksanen, Minna, additional, Linder, Nina, additional, Joensuu, Timo, additional, Lundin, Johan, additional, and Hemminki, Akseli, additional

Published
2016
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14. Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation

Author

Korhonen, Paula, primary, Kanninen, Katja M., additional, Lehtonen, Šárka, additional, Lemarchant, Sighild, additional, Puttonen, Katja A., additional, Oksanen, Minna, additional, Dhungana, Hiramani, additional, Loppi, Sanna, additional, Pollari, Eveliina, additional, Wojciechowski, Sara, additional, Kidin, Iurii, additional, García-Berrocoso, Teresa, additional, Giralt, Dolors, additional, Montaner, Joan, additional, Koistinaho, Jari, additional, and Malm, Tarja, additional

Published
2015
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18. Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients

Author

Liikanen, Ilkka, primary, Ahtiainen, Laura, additional, Hirvinen, Mari LM, additional, Bramante, Simona, additional, Cerullo, Vincenzo, additional, Nokisalmi, Petri, additional, Hemminki, Otto, additional, Diaconu, Iulia, additional, Pesonen, Sari, additional, Koski, Anniina, additional, Kangasniemi, Lotta, additional, Pesonen, Saila K, additional, Oksanen, Minna, additional, Laasonen, Leena, additional, Partanen, Kaarina, additional, Joensuu, Timo, additional, Zhao, Fang, additional, Kanerva, Anna, additional, and Hemminki, Akseli, additional

Published
2013
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19. Immunological Effects of Low-dose Cyclophosphamide in Cancer Patients Treated With Oncolytic Adenovirus

Author

Cerullo, Vincenzo, primary, Diaconu, Iulia, additional, Kangasniemi, Lotta, additional, Rajecki, Maria, additional, Escutenaire, Sophie, additional, Koski, Anniina, additional, Romano, Valentina, additional, Rouvinen, Noora, additional, Tuuminen, Tamara, additional, Laasonen, Leena, additional, Partanen, Kaarina, additional, Kauppinen, Satu, additional, Joensuu, Timo, additional, Oksanen, Minna, additional, Holm, Sirkka-Liisa, additional, Haavisto, Elina, additional, Karioja-Kallio, Aila, additional, Kanerva, Anna, additional, Pesonen, Sari, additional, Arstila, Petteri T, additional, and Hemminki, Akseli, additional

Published
2011
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20. Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF

Author

Koski, Anniina, primary, Kangasniemi, Lotta, additional, Escutenaire, Sophie, additional, Pesonen, Sari, additional, Cerullo, Vincenzo, additional, Diaconu, Iulia, additional, Nokisalmi, Petri, additional, Raki, Mari, additional, Rajecki, Maria, additional, Guse, Kilian, additional, Ranki, Tuuli, additional, Oksanen, Minna, additional, Holm, Sirkka-Liisa, additional, Haavisto, Elina, additional, Karioja-Kallio, Aila, additional, Laasonen, Leena, additional, Partanen, Kaarina, additional, Ugolini, Matteo, additional, Helminen, Andreas, additional, Karli, Eerika, additional, Hannuksela, Päivi, additional, Pesonen, Saila, additional, Joensuu, Timo, additional, Kanerva, Anna, additional, and Hemminki, Akseli, additional

Published
2010
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21. Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients

Author

Iulia Diaconu, Laura Ahtiainen, Timo Joensuu, Mari Hirvinen, Petri Nokisalmi, Lotta Kangasniemi, Saila K. Pesonen, Minna Oksanen, Ilkka Liikanen, Anniina Koski, Simona Bramante, Sari Pesonen, Leena Laasonen, Fang Zhao, Anna Kanerva, Otto Hemminki, Vincenzo Cerullo, Kaarina Partanen, Akseli Hemminki, Research Programs Unit, Translational Cancer Biology (TCB) Research Programme, Haartman Institute (-2014), Department of Pathology, Transplantation Laboratory, Division of Pharmaceutical Biosciences, ImmunoViroTherapy Lab, University of Helsinki, Department of Obstetrics and Gynecology, Liikanen, Ilkka, Ahtiainen, Laura, Hirvinen, Mari L., Bramante, Simona, Cerullo, Vincenzo, Nokisalmi, Petri, Hemminki, Otto, Diaconu, Iulia, Pesonen, Sari, Koski, Anniina, Kangasniemi, Lotta, Pesonen, Saila K., Oksanen, Minna, Laasonen, Leena, Partanen, Kaarina, Joensuu, Timo, Zhao, Fang, Kanerva, Anna, and Hemminki, Akseli

Subjects
Male, GLIOBLASTOMA-MULTIFORME, medicine.disease_cause, Virus Replication, T-Lymphocytes, Regulatory, Antineoplastic Agent, Mice, 0302 clinical medicine, Adenosine Triphosphate, Neoplasms, Drug Discovery, ADAPTIVE IMMUNITY, HMGB1 Protein, Child, IN-VIVO, Oncolytic Virotherapy, 0303 health sciences, Cell Death, Middle Aged, Acquired immune system, CONDITIONALLY REPLICATING ADENOVIRUS, Combined Modality Therapy, Immunohistochemistry, 3. Good health, CONTROLLED TRIAL, Dacarbazine, MALIGNANT GLIOMA-CELLS, Oncolytic Viruses, 030220 oncology & carcinogenesis, Immunogenic cell death, Cytokines, Molecular Medicine, Female, Original Article, REFRACTORY SOLID TUMORS, Human, Oncolytic adenovirus, Adult, Programmed cell death, Xenograft Model Antitumor Assay, Adolescent, education, Mice, Nude, Oncolytic Viruse, Antineoplastic Agents, Biology, GENE-TRANSFER, OVARIAN-CANCER, Adenoviridae, 03 medical and health sciences, Young Adult, Immune system, Genetic, Cell Line, Tumor, medicine, Autophagy, Temozolomide, Genetics, Animals, Humans, REGULATORY T-CELLS, Cytokine, Cyclophosphamide, Molecular Biology, 030304 developmental biology, Aged, Pharmacology, Dose-Response Relationship, Drug, Animal, Drug Discovery3003 Pharmaceutical Science, Antibodies, Neutralizing, Xenograft Model Antitumor Assays, Oncolytic virus, Microscopy, Electron, DNA, Viral, Cancer research, Neoplasm, 3111 Biomedicine, Calreticulin
Abstract

Oncolytic adenoviruses and certain chemotherapeutics can induce autophagy and immunogenic cancer cell death. We hypothesized that the combination of oncolytic adenovirus with low-dose temozolomide (TMZ) is safe, effective, and capable of inducing antitumor immune responses. Metronomic low-dose cyclophosphamide (CP) was added to selectively reduce regulatory T-cells. Preclinically, combination therapy inhibited tumor growth, increased autophagy, and triggered immunogenic cell death as indicated by elevated calreticulin, adenosine triphosphate (ATP) release, and nuclear protein high-mobility group box-1 (HMGB1) secretion. A total of 41 combination treatments given to 17 chemotherapy-refractory cancer patients were well tolerated. We observed anti- and proinflammatory cytokine release, evidence of virus replication, and induction of neutralizing antibodies. Tumor cells showed increased autophagy post-treatment. Release of HMGB1 into serum--a possible indicator of immune response--increased in 60% of treatments, and seemed to correlate with tumor-specific T-cell responses, observed in 10/15 cases overall (P = 0.0833). Evidence of antitumor efficacy was seen in 67% of evaluable treatments with a trend for increased survival over matched controls treated with virus only. In summary, the combination of oncolytic adenovirus with low-dose TMZ and metronomic CP increased tumor cell autophagy, elicited antitumor immune responses, and showed promising safety and efficacy.

Published
2013
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