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26 results on '"Olaf Welting"'

1. Fr485 MIR-511 DEFICIENCY IMPROVES DSS COLITIS IN MICE

Author

Patricia van Hamersveld, Caroline Verseijden, Wouter J. de Jonge, Sigrid E.M. Heinsbroek, Claude Libert, Theodorus B. M. Hakvoort, Jolien Vandewalle, Olaf Welting, Sybren L. Meijer, and Shafaque Rahman

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Colitis, business, medicine.disease
Published
2021
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2. Fr481 CARBOXYLESTERASE-1 ASSISTED TARGETING OF HDAC INHIBITOR TO MONONUCLEAR MYELOID CELLS ATTENUATES COLON INFLAMMATION IN T CELL TRANSFER COLITIS MURINE MODEL

Author

Patricia van Hamersveld, Jan Verhoeff, Ishtu Hageman, Rebecca C. Furze, Pal Mander, Sigrid E.M. Heinsbroek, Juan J. Garcia-Vallejo, Wouter J. de Jonge, Ahmed M. I. Elfiky, Manon E. Wildenberg, Nicholas Smithers, Inmaculada Rioja, Matthew J Bell, Huw D. Lewis, Olaf Welting, and M Becker

Subjects
Hepatology, Chemistry, T cell, Carboxylesterase 1, Gastroenterology, Colon inflammation, medicine.disease, medicine.anatomical_structure, Murine model, Myeloid cells, medicine, HDAC inhibitor, Cancer research, Colitis
Published
2021
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3. Mo1104 MONONUCLEAR MYELOID CELL TARGETED HISTONE DEACETYLASE (HDAC) INHIBITOR DEMONSTRATES POTENT ACTIVITY IN MONOCYTES AND IMPAIRS COLON MONOCYTES TO MACROPHAGE DIFFERENTIATION DURING ACUTE DSS COLITIS

Author

Patricia van Hamersveld, Ahmed M. I. Elfiky, Wouter J. de Jonge, Rebecca C. Furze, Olaf Welting, Mohammed Ghiboub, M Becker, Manon E. Wildenberg, Pal Mander, Sigrid E.M. Heinsbroek, Matthew J Bell, Menno P.J. de Winther, Huw D. Lewis, Shafaque Rahman, and iris van den berg

Subjects
medicine.anatomical_structure, Myeloid, Hepatology, Macrophage differentiation, Chemistry, Cell, Gastroenterology, medicine, HDAC inhibitor, Cancer research, Histone deacetylase, Colitis, medicine.disease
Published
2020
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4. Tu1916 CURDLAN FEEDING IN MICE IMPROVES DSS COLITIS AND ENHANCES BIFIDOBACTERIA PRESENCE IN THE INTESTINAL MICROBIOME

Author

Patricia van Hamersveld, Mark Davids, Wouter J. de Jonge, Shafaque Rahman, Rene M. van den Wijngaard, Olaf Welting, Sigrid E.M. Heinsbroek, Sybren L. Meijer, and Theodorus B. M. Hakvoort

Subjects
chemistry.chemical_compound, Hepatology, chemistry, Intestinal Microbiome, Gastroenterology, medicine, Curdlan, Biology, Colitis, medicine.disease, Microbiology
Published
2020
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5. 713 NON-INVASIVE ELECTRICAL SPLENIC NERVE STIMULATION AMELIORATES DSS-INDUCED COLITIS

Author

David J. Brinkman, Wouter J. de Jonge, Patricia van Hamersveld, Misha D. P. Luyer, Rose Willemze, Olaf Welting, Philippe Blancou, Sigrid E.M. Heinsbroek, Thomas Simon, Margriet J. Vervoordeldonk, and Caroline Verseijden

Subjects
Pathology, medicine.medical_specialty, Nerve stimulation, Hepatology, business.industry, Non invasive, Gastroenterology, medicine, Colitis, medicine.disease, business
Published
2020
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6. Orally delivered β-glucans aggravate dextran sulfate sodium (DSS)-induced intestinal inflammation

Author

Sybren L. Meijer, David L. Williams, Olaf Welting, Sigrid E.M. Heinsbroek, Siamon Gordon, Wouter J. de Jonge, Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology, Graduate School, and Pathology

Subjects
beta-Glucans, Colon, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Administration, Oral, Intestinal inflammation, Inflammation, macromolecular substances, Curdlan, Pharmacology, Article, Microbiology, Proinflammatory cytokine, Mice, chemistry.chemical_compound, Endocrinology, Intestinal mucosa, Oral administration, medicine, Animals, Intestinal Mucosa, Colitis, Glucans, Nutrition and Dietetics, Dextran Sulfate, Zymosan, medicine.disease, Mice, Inbred C57BL, carbohydrates (lipids), stomatognathic diseases, Cytokine, chemistry, Cytokines, β-glucans, Chemokines, medicine.symptom
Abstract

β-Glucans have beneficial health effects due to their immune modulatory properties. Oral administration of β-glucans affects tumour growth, microbial infection, sepsis, and wound healing. We hypothesized that pre-treatment with orally delivered soluble and particulate β-glucans could ameliorate the development of aggravate dextran sulfate sodium (DSS) induced intestinal inflammation. To study this, mice were orally pre-treated with β-glucans for 14 days. We tested curdlan (a particulate β-(1,3)-glucan), glucan phosphate (a soluble β-(1,3)-glucan), and zymosan (a particle made from Saccharomyces cerevisiae, which contains around 55% β-glucans). Weight loss, colon weight, and feces score did not differ between β-glucan and vehicle treated groups. However, histology scores indicated that β-glucan–treated mice had increased inflammation at a microscopic level suggesting that β-glucan treatment worsened intestinal inflammation. Furthermore, curdlan and zymosan treatment led to increased colonic levels of inflammatory cytokines and chemokines, compared to vehicle. Glucan phosphate treatment did not significantly affect cytokine and chemokine levels. These data suggest that particulate and soluble β-glucans differentially affect the intestinal immune responses. However, no significant differences in other clinical colitis scores between soluble and particulate β-glucans were found in this study. In summary, β-glucans aggravate the course of dextran sulfate sodium (DSS)-induced intestinal inflammation at the level of the mucosa.

Published
2015
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7. Dietary Marine n–3 PUFAs Do Not Affect Stress-Induced Visceral Hypersensitivity in a Rat Maternal Separation Model1–3

Author

Guy E. Boeckxstaens, Ingrid C. Gaemers, Wouter J. de Jonge, Lieke W J van den Elsen, Sophie A. van Diest, Bert J. M. van de Heijning, Maria Fernanda de Paula Werner, Francisca W. Hilbers, Linette E M Willemsen, Allison J Klok, Rene M. van den Wijngaard, and Olaf Welting

Subjects
chemistry.chemical_classification, Peroxisome proliferator-activated receptor gamma, Lipoprotein lipase, medicine.medical_specialty, Nutrition and Dietetics, business.industry, Degranulation, Medicine (miscellaneous), Mast cell, Eicosapentaenoic acid, medicine.anatomical_structure, Endocrinology, chemistry, Docosahexaenoic acid, Internal medicine, Medicine, business, Rosiglitazone, Polyunsaturated fatty acid, medicine.drug
Abstract

Background: Although never evaluated for efficacy, n-3 (ω-3) long-chain polyunsaturated fatty acids (LCPUFAs) are commercially offered as treatment for irritable bowel syndrome (IBS). Objective: This study was designed to investigate, in a mast cell-dependent model for visceral hypersensitivity, whether this pathophysiologic mechanism can be reversed by dietary LCPUFA treatment via peroxisome proliferator-activated receptor γ (PPARG) activation. Methods: Maternally separated rats were subjected to hypersensitivity-inducing acute stress at adult age. Reversal was attempted by protocols with tuna oil-supplemented diets [4% soy oil (SO) and 3%tuna oil (SO-T3) or 3% SO and 7% tuna oil (SO-T7)] and compared with control SO diets (7% or 10% SO) 4 wk after stress. The PPARG agonist rosiglitazone was evaluated in a 1 wk preventive protocol (30 mg · kg-1 · d-1). Erythrocytes were assessed to confirm LCPUFA uptake and tissue expression of lipoprotein lipase and glycerol kinase as indicators of PPARG activation. Colonic mast cell degranulation was evaluated by toluidine blue staining. In vitro, human mast cell line 1 (HMC-1) cells were pretreated with rosiglitazone, eicosapentaenoic acid, or docosahexaenoic acid, stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore or compound 48/80 and evaluated for tumor necrosis factor α (TNF-α) and β-hexosaminidase release. Results: Stress led to visceral hypersensitivity in all groups. Hypersensitivity was not reversed by SO-T3 or control treatment [prestress vs. 24 h poststress vs. posttreatment area under the curve; 76 ± 4 vs. 128 ± 12 (P

Published
2015
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11. 643 - Reversal of Visceral Hypersensitivity in Rat by a Proprietary Combination of Essential Oils from Peppermint and Caraway Coincides with Mycobiome Modulation

Author

Roy Christiaan Montijn, Egon Koch, Daniele Maria-Ferreira, Evgeni Levin, Theo B.M. Hakvoort, Jurgen Seppen, Sara Botschuijver, Rene M. van den Wijngaard, Olaf Welting, Wouter J. de Jonge, and Frank H. J. Schuren

Subjects
Hepatology, Chemistry, Modulation, Gastroenterology, Pharmacology, Mycobiome
Published
2018
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13. Oral Tyrosine Kinase 2 Inhibitor Ameliorates T Cell Transfer Colitis

Author

Manon E. Wildenberg, Wouter J. de Jonge, Patricia van Hamersveld, Olaf Welting, Geert R. D'Haens, Leonie C. De Vries, and Caroline Verseijden

Subjects
medicine.anatomical_structure, Hepatology, Chemistry, Tyrosine kinase 2, T cell, Gastroenterology, Cancer research, medicine, Colitis, medicine.disease
Published
2017
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15. The sympathetic mesenteric nerve regulates experimental colitis

Author

W J de Jonge, Jurgen Seppen, Harold Darwinkel, Daniel John Chew, Laurens Nijhuis, Joost H.A. Folgering, Arun Sridhar, Olaf Welting, Sigrid E.M. Heinsbroek, and Rose Willemze

Subjects
Cellular and Molecular Neuroscience, Pathology, medicine.medical_specialty, Endocrine and Autonomic Systems, business.industry, Medicine, Experimental colitis, Neurology (clinical), business
Published
2015
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18. 875 The Relation Between Stress, Microscopic Inflammation and Visceral Sensitivity in Patients With Irritable Bowel Syndrome

Author

Chris M. van der Loos, Rene M. van den Wijngaard, Tamira K. Klooker, Mira M. Wouters, Breg Braak, Sophie A. van Diest, Oana I. Stanisor, Guy E. Boeckxstaens, and Olaf Welting

Subjects
medicine.medical_specialty, Visceral sensitivity, Hepatology, business.industry, Gastroenterology, Inflammation, medicine.disease, Internal medicine, medicine, In patient, medicine.symptom, business, Irritable bowel syndrome
Published
2012
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20. M1303 Quantification of Brain Activity Evoked by Colonic Distention in Rats Using H215O Micropet

Author

Mira M. Wouters, Guy E. Boeckxstaens, SanderJohannes Marinus van Wanrooy, Ann Van Santvoort, Rene M. van den Wijngaard, Olaf Welting, Peter Vermaelen, Andrea Nemethova, Dominique Vanderghinste, and Koen Van Laere

Subjects
Pathology, medicine.medical_specialty, Hepatology, business.industry, Brain activity and meditation, Gastroenterology, Medicine, business
Published
2010
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22. 7 The Peripheral Histamine 1-Receptor Antagonist Fexofenadine Effectively Reverses Stress-Induced Visceral Hypersensitivity in a Rat Model of Maternal Separation

Author

Wouter J. de Jonge, Cathy Cailotto, Sophie A. van Diest, Oana I. Stanisor, Rene M. van den Wijngaard, Jan van der Vliet, Guy E. Boeckxstaens, and Olaf Welting

Subjects
Ketotifen, Fexofenadine, Hepatology, medicine.drug_class, business.industry, Gastroenterology, Antagonist, Histamine H1 receptor, Pharmacology, Receptor antagonist, Mast cell, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, medicine, Mast cell stabilizer, business, Histamine, medicine.drug
Abstract

BACKGROUND: We previously showed that the mast cell stabilizer ketotifen reduces IBS symptoms and increases the threshold of discomfort in hypersensitive IBS-patients. However, as ketotifen also has Histamine 1-receptor antagonistic properties and is known to penetrate the blood-brain barrier, its beneficial effect observed in this trial could also result from H1 receptor blockade, either at the peripheral or central level. AIM: To establish whether fexofenadine, a peripherally restricted 2nd generation Histamine 1-receptor antagonist, can mimic the effect of ketotifen and A) reverse stress-induced, mast cell dependent visceral hypersensitivity in a rat model of maternal separation (MS), and B) modulate gastrointestinal transit in MS and non-handled (NH) rats. METHODS: Adult MS and NH rats (n=9 in all groups) were subjected to acute stress (1 hr water avoidance,WA). The visceromotor response (VMR) to colorectal distension (1, 11⁄2, 2ml) was established preand 24 hours post-WA and expressed as area-under-curve (AUC, volume-vs-response, significant difference when P

Published
2010
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23. T2070 IgE Immunoglobulins and Mast Cells in Colonic Mucosa of Patients With Irritable Bowel Syndrome

Author

Sophie A. van Diest, Guy E. Boeckxstaens, Tamira K. Klooker, Rene M. van den Wijngaard, Olaf Welting, Breg Braak, and Chris M. van der Loos

Subjects
Hepatology, biology, business.industry, Gastroenterology, Immunoglobulin E, medicine.disease, Colonic mucosa, Immunology, biology.protein, medicine, Mast (botany), Antibody, business, Irritable bowel syndrome
Published
2010
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24. 908 CRH-Receptor Antagonism Prevents the Development of Stress-Induced Visceral Hypersensitivity But Fails to Affect Established Hypersensitivity

Author

Sophie A. van Diest, Guy E. Boeckxstaens, Rene M. van den Wijngaard, Olaf Welting, Oana I. Stanisor, and Wouter J. de Jonge

Subjects
medicine.medical_specialty, Endocrinology, CRH Receptor, Hepatology, business.industry, Internal medicine, Stress induced, Gastroenterology, medicine, business, Antagonism, Affect (psychology)
Published
2009
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26. S1715 Mast Cell Induced Bacterial Translocation in the Pathogenesis of Post-Operative Ileus Studied in a Mouse Model

Author

Guy E. Boeckxstaens, Wouter J. de Jonge, Rene M. van den Wijngaard, Oana I. Stanisor, Susanne A. Snoek, Cathy Cailotto, and Olaf Welting

Subjects
Pathogenesis, Post operative ileus, Pathology, medicine.medical_specialty, medicine.anatomical_structure, Hepatology, Gastroenterology, medicine, Biology, Bacterial translocation, Mast cell
Published
2008
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