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3 results on '"Orsini-Piocelle, Frédérique"'

1. Maintenance with daratumumab or observation following treatment with bortezomib, thalidomide, and dexamethasone with or without daratumumab and autologous stem-cell transplant in patients with newly diagnosed multiple myeloma (CASSIOPEIA): an open-label, randomised, phase 3 trial

Author

Moreau, Philippe, primary, Hulin, Cyrille, additional, Perrot, Aurore, additional, Arnulf, Bertrand, additional, Belhadj, Karim, additional, Benboubker, Lotfi, additional, Béné, Marie C, additional, Zweegman, Sonja, additional, Caillon, Hélène, additional, Caillot, Denis, additional, Corre, Jill, additional, Delforge, Michel, additional, Dejoie, Thomas, additional, Doyen, Chantal, additional, Facon, Thierry, additional, Sonntag, Cécile, additional, Fontan, Jean, additional, Mohty, Mohamad, additional, Jie, Kon-Siong, additional, Karlin, Lionel, additional, Kuhnowski, Frédérique, additional, Lambert, Jérôme, additional, Leleu, Xavier, additional, Macro, Margaret, additional, Orsini-Piocelle, Frédérique, additional, Roussel, Murielle, additional, Stoppa, Anne-Marie, additional, van de Donk, Niels W C J, additional, Wuillème, Soraya, additional, Broijl, Annemiek, additional, Touzeau, Cyrille, additional, Tiab, Mourad, additional, Marolleau, Jean-Pierre, additional, Meuleman, Nathalie, additional, Vekemans, Marie-Christiane, additional, Westerman, Matthijs, additional, Klein, Saskia K, additional, Levin, Mark-David, additional, Offner, Fritz, additional, Escoffre-Barbe, Martine, additional, Eveillard, Jean-Richard, additional, Garidi, Réda, additional, Ahmadi, Tahamtan, additional, Krevvata, Maria, additional, Zhang, Ke, additional, de Boer, Carla, additional, Vara, Sanjay, additional, Kampfenkel, Tobias, additional, Vanquickelberghe, Veronique, additional, Vermeulen, Jessica, additional, Avet-Loiseau, Hervé, additional, and Sonneveld, Pieter, additional

Published
2021
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2. Maintenance with daratumumab or observation following treatment with bortezomib, thalidomide, and dexamethasone with or without daratumumab and autologous stem-cell transplant in patients with newly diagnosed multiple myeloma (CASSIOPEIA): an open-label, randomised, phase 3 trial

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Moreau, Philippe, Hulin, Cyrille, Perrot, Aurore, Arnulf, Bertrand, Belhadj, Karim, Benboubker, Lotfi, Béné, Marie C, Zweegman, Sonja, Caillon, Hélène, Caillot, Denis, Corre, Jill, Delforge, Michel, Dejoie, Thomas, Doyen, Chantal, Facon, Thierry, Sonntag, Cécile, Fontan, Jean, Mohty, Mohamad, Jie, Kon-Siong, Karlin, Lionel, Kuhnowski, Frédérique, Lambert, Jérôme, Leleu, Xavier, Macro, Margaret, Orsini-Piocelle, Frédérique, Roussel, Murielle, Stoppa, Anne-Marie, van de Donk, Niels W C J, Wuillème, Soraya, Broijl, Annemiek, Touzeau, Cyrille, Tiab, Mourad, Marolleau, Jean-Pierre, Meuleman, Nathalie, Vekemans, Marie-Christiane, Westerman, Matthijs, Klein, Saskia K, Levin, Mark-David, Offner, Fritz, Escoffre-Barbe, Martine, Eveillard, Jean-Richard, Garidi, Réda, Ahmadi, Tahamtan, Krevvata, Maria, Zhang, Ke, de Boer, Carla, Vara, Sanjay, Kampfenkel, Tobias, Vanquickelberghe, Veronique, Vermeulen, Jessica, Avet-Loiseau, Hervé, Sonneveld, Pieter, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Moreau, Philippe, Hulin, Cyrille, Perrot, Aurore, Arnulf, Bertrand, Belhadj, Karim, Benboubker, Lotfi, Béné, Marie C, Zweegman, Sonja, Caillon, Hélène, Caillot, Denis, Corre, Jill, Delforge, Michel, Dejoie, Thomas, Doyen, Chantal, Facon, Thierry, Sonntag, Cécile, Fontan, Jean, Mohty, Mohamad, Jie, Kon-Siong, Karlin, Lionel, Kuhnowski, Frédérique, Lambert, Jérôme, Leleu, Xavier, Macro, Margaret, Orsini-Piocelle, Frédérique, Roussel, Murielle, Stoppa, Anne-Marie, van de Donk, Niels W C J, Wuillème, Soraya, Broijl, Annemiek, Touzeau, Cyrille, Tiab, Mourad, Marolleau, Jean-Pierre, Meuleman, Nathalie, Vekemans, Marie-Christiane, Westerman, Matthijs, Klein, Saskia K, Levin, Mark-David, Offner, Fritz, Escoffre-Barbe, Martine, Eveillard, Jean-Richard, Garidi, Réda, Ahmadi, Tahamtan, Krevvata, Maria, Zhang, Ke, de Boer, Carla, Vara, Sanjay, Kampfenkel, Tobias, Vanquickelberghe, Veronique, Vermeulen, Jessica, Avet-Loiseau, Hervé, and Sonneveld, Pieter

Abstract

Background CASSIOPEIA part 1 showed superior depth of response and significantly improved progression-free survival with daratumumab, bortezomib, thalidomide, and dexamethasone (D-VTd) versus bortezomib, thalidomide, and dexamethasone (VTd) as induction and consolidation in patients with autologous stem-cell transplant (ASCT)-eligible newly diagnosed multiple myeloma. In part 2, we compared daratumumab maintenance versus observation only. Methods CASSIOPEIA is a two-part, open-label, randomised, phase 3 trial of patients aged 18–65 years with newly diagnosed multiple myeloma and Eastern Cooperative Oncology Group performance status 0–2, done in 111 European academic and community practice centres. In part 1, patients were randomly assigned (1:1) to induction and consolidation with D-VTd or VTd. Patients still on study who had a partial response or better were randomly assigned (1:1) by an interactive web-response system to daratumumab 16 mg/kg intravenously every 8 weeks (a reduced frequency compared with standard daratumumab long-term dosing) or observation only for up to 2 years. Stratification factors were induction treatment and depth of response in part 1. The part 2 primary endpoint was progression-free survival from second randomisation. This preplanned interim analysis of progression-free survival was done after 281 events and shall be considered the primary analysis of progression-free survival. Sponsor personnel and designees who were involved in the analysis were masked to treatment group until the independent data monitoring committee recommended that the preplanned interim analysis be considered the main analysis of progression-free survival in part 2. Otherwise, treatment assignments were unmasked. The interaction between induction and consolidation and maintenance was tested at a two-sided significance level of 0·05 by a stratified Cox regression model that included the interaction term between maintenance treatment and induction and consolidation tre

Published
2021

3. Bortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open-label, phase 3 study

Author

Moreau, Philippe, primary, Attal, Michel, additional, Hulin, Cyrille, additional, Arnulf, Bertrand, additional, Belhadj, Karim, additional, Benboubker, Lotfi, additional, Béné, Marie C, additional, Broijl, Annemiek, additional, Caillon, Hélène, additional, Caillot, Denis, additional, Corre, Jill, additional, Delforge, Michel, additional, Dejoie, Thomas, additional, Doyen, Chantal, additional, Facon, Thierry, additional, Sonntag, Cécile, additional, Fontan, Jean, additional, Garderet, Laurent, additional, Jie, Kon-Siong, additional, Karlin, Lionel, additional, Kuhnowski, Frédérique, additional, Lambert, Jérôme, additional, Leleu, Xavier, additional, Lenain, Pascal, additional, Macro, Margaret, additional, Mathiot, Claire, additional, Orsini-Piocelle, Frédérique, additional, Perrot, Aurore, additional, Stoppa, Anne-Marie, additional, van de Donk, Niels WCJ, additional, Wuilleme, Soraya, additional, Zweegman, Sonja, additional, Kolb, Brigitte, additional, Touzeau, Cyrille, additional, Roussel, Murielle, additional, Tiab, Mourad, additional, Marolleau, Jean-Pierre, additional, Meuleman, Nathalie, additional, Vekemans, Marie-Christiane, additional, Westerman, Matthijs, additional, Klein, Saskia K, additional, Levin, Mark-David, additional, Fermand, Jean Paul, additional, Escoffre-Barbe, Martine, additional, Eveillard, Jean-Richard, additional, Garidi, Reda, additional, Ahmadi, Tahamtan, additional, Zhuang, Sen, additional, Chiu, Christopher, additional, Pei, Lixia, additional, de Boer, Carla, additional, Smith, Elena, additional, Deraedt, William, additional, Kampfenkel, Tobias, additional, Schecter, Jordan, additional, Vermeulen, Jessica, additional, Avet-Loiseau, Hervé, additional, and Sonneveld, Pieter, additional

Published
2019
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