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23 results on '"Ortega, X."'

1. CONGENITAL MYOPATHIES 2

Author

Jofre, J., primary, Suarez, B., additional, Martinez-Jalilie, M., additional, Diemer, M., additional, Hervias, C., additional, Calcagno, G., additional, Ortega, X., additional, Palomino, M., additional, Villanueva, X., additional, Haro, S., additional, Lillo, S., additional, Vial, T., additional, Fattori, F., additional, Bertini, E., additional, and Castiglioni, C., additional

Published
2020
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2. CONGENITAL MUSCULAR DYSTROPHIES

Author

Suarez, B., primary, Jofre, J., additional, Martinez-Jalilie, M., additional, Diemer, M., additional, Ortega, X., additional, Vial, T., additional, Lillo, S., additional, Haro, M., additional, Calcagno, G., additional, Palomino, M., additional, Hervias, C., additional, and Castiglioni, C., additional

Published
2020
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3. INFLAMMATORY MYOPATHIES

Author

Suárez, B., primary, Lozano, A., additional, Díaz, A., additional, Ortega, X., additional, Diaz, J., additional, Calcagno, G., additional, Hervias, C., additional, Bevilacqua, J., additional, and Castiglioni, C., additional

Published
2018
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4. 211th ENMC International Workshop

Author

Quinlivan, Ros, primary, Andreu, Antoni L., additional, Marti, Ramon, additional, Andreu, A., additional, Godfrey, R., additional, Haller, R., additional, Laforêt, P., additional, Lucía, A., additional, Martí, R., additional, Martín, M., additional, Martinuzzi, A., additional, Oldfors, A., additional, Ortega, X., additional, Pagliarani, S., additional, Piirila, P., additional, Piercy, R., additional, Pinós, T., additional, Quinlivan, R., additional, Scalco, R., additional, Schoser, B., additional, Toscano, A., additional, Vissing, J., additional, and Wakelin, A., additional

Published
2017
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5. The EUROMAC registry for rare glycogen storage diseases: preliminary report

Author

Scalco, R., primary, Quinlivan, R., additional, Lucia, A., additional, Santalla, A., additional, Martinuzzi, A., additional, Toscano, A., additional, Musumeci, O., additional, Milan, B. San, additional, Durmus, H., additional, Voermans, N., additional, Laforêt, P., additional, Kuhnle, E., additional, Martin, M., additional, Siciliano, G., additional, Sacconi, S., additional, Ortega, X., additional, Pinos, T., additional, Marti, R., additional, and Vissing, J., additional

Published
2017
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7. The use of different types of thermoluminescent dosimeters to measure extremity doses in nuclear medicine

Author

Carnicer, A., primary, Ginjaume, M., additional, Duch, M.A., additional, Vanhavere, F., additional, Sans Merce, M., additional, Baechler, S., additional, Barth, I., additional, Donadille, L., additional, Ferrari, P., additional, Fulop, M., additional, Gualdrini, G., additional, Krim, S., additional, Mariotti, M., additional, Ortega, X., additional, Rimpler, A., additional, Ruiz, N., additional, and Olko, P., additional

Published
2011
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8. Hand exposure in diagnostic nuclear medicine with 18F- and 99mTc-labelled radiopharmaceuticals - Results of the ORAMED project

Author

Carnicer, A., primary, Sans-Merce, M., additional, Baechler, S., additional, Barth, I., additional, Donadille, L., additional, Ferrari, P., additional, Fulop, M., additional, Ginjaume, M., additional, Gualdrini, G., additional, Krim, S., additional, Mariotti, M., additional, Ortega, X., additional, Rimpler, A., additional, Ruiz, N., additional, and Vanhavere, F., additional

Published
2011
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9. Extremity exposure in nuclear medicine therapy with 90Y-labelled substances – Results of the ORAMED project

Author

Rimpler, A., primary, Barth, I., additional, Ferrari, P., additional, Baechler, S., additional, Carnicer, A., additional, Donadille, L., additional, Fulop, M., additional, Ginjaume, M., additional, Mariotti, M., additional, Sans-Merce, M., additional, Gualdrini, G., additional, Krim, S., additional, Ortega, X., additional, Ruiz, N., additional, and Vanhavere, F., additional

Published
2011
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10. Recommendations to reduce hand exposure for standard nuclear medicine procedures

Author

Sans-Merce, M., primary, Ruiz, N., additional, Barth, I., additional, Carnicer, A., additional, Donadille, L., additional, Ferrari, P., additional, Fulop, M., additional, Ginjaume, M., additional, Gualdrini, G., additional, Krim, S., additional, Mariotti, F., additional, Ortega, X., additional, Rimpler, A., additional, Vanhavere, F., additional, and Baechler, S., additional

Published
2011
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17. Radon activity concentration—a Euromet and BIPM supplementary comparison

Author

Röttger, A., primary, Honig, A., additional, Schmidt, V., additional, Buchröder, H., additional, Rox, A., additional, Butterweck, G., additional, Schuler, Ch., additional, Maringer, F.J., additional, Jachs, P., additional, Edelmaier, R., additional, Michielsen, N., additional, Howarth, C.B., additional, H. Miles, J.C., additional, Vargas, A., additional, Ortega, X., additional, Burian, I., additional, Turtiainen, T., additional, and Hagberg, N., additional

Published
2006
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23. A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans

Author

Ximena Ortega, David DeShazer, Bart J. Currie, Leonard J. Foster, Rebecca J. Ingram, Heather Green, Cristina De Castro, Ganjana Lertmemongkolchai, Yasmine Fathy Mohamed, Antonio Molinaro, Carole Creuzenet, Michael M. Tunney, Nichollas E. Scott, Andrew Jones, Miguel A. Valvano, Mohamed, Y. F., Scott, N. E., Molinaro, A., Creuzenet, C., Ortega, X., Lertmemongkolchai, G., Tunney, M. M., Green, H., Jones, A. M., Deshazer, D., Currie, B. J., Foster, L. J., Ingram, R., De Castro, C., and Valvano, M. A.

Subjects
0301 basic medicine, phenotypic arrays, Glycosylation, glycosylation, Burkholderia cenocepacia, Burkholderia, nuclear magnetic resonance (NMR), immunogenicity, Biochemistry, Microbiology, 03 medical and health sciences, chemistry.chemical_compound, Burkholderia mallei, Gene cluster, melioidosi, medicine, bacteria, Molecular Biology, cystic fibrosi, glander, galleria mellonella, chemistry.chemical_classification, 030102 biochemistry & molecular biology, biology, Glanders, Burkholderia multivorans, Cell Biology, bacterial infections and mycoses, biology.organism_classification, medicine.disease, carbohydrates (lipids), 030104 developmental biology, chemistry, Glycoprotein
Abstract

The Burkholderia genus encompasses many Gram-negative bacteria living in the rhizosphere. Some Burkholderia species can cause life-threatening human infections, highlighting the need for clinical interventions targeting specific lipopolysaccharide proteins. Burkholderia cenocepacia O-linked protein glycosylation has been reported, but the chemical structure of the O-glycan and the machinery required for its biosynthesis are unknown and could reveal potential therapeutic targets. Here, using bioinformatics approaches, gene-knockout mutants, purified recombinant proteins, LC-MS–based analyses of O-glycans, and NMR-based structural analyses, we identified a B. cenocepacia O-glycosylation (ogc) gene cluster necessary for synthesis, assembly, and membrane translocation of a lipid-linked O-glycan, as well as its structure, which consists of a β-Gal-(1,3)–α-GalNAc-(1,3)–β-GalNAc trisaccharide. We demonstrate that the ogc cluster is conserved in the Burkholderia genus, and we confirm the production of glycoproteins with similar glycans in the Burkholderia species: B. thailandensis, B. gladioli, and B. pseudomallei. Furthermore, we show that absence of protein O-glycosylation severely affects bacterial fitness and accelerates bacterial clearance in a Galleria mellonella larva infection model. Finally, our experiments revealed that patients infected with B. cenocepacia, Burkholderia multivorans, B. pseudomallei, or Burkholderia mallei develop O-glycan–specific antibodies. Together, these results highlight the importance of general protein O-glycosylation in the biology of the Burkholderia genus and its potential as a target for inhibition or immunotherapy approaches to control Burkholderia infections.

Published
2019

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