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Nonreciprocal elements, such as isolators and circulators, play an important role in classical and quantum information processing. Recently, strong nonreciprocal effects have been experimentally demonstrated in cavity optomechanical systems. In these approaches, the bandwidth of the nonreciprocal photon transmission is limited by the mechanical resonator linewidth, which is arguably much smaller than the linewidths of the cavity modes in most electromechanical or optomechanical devices. In this work, we demonstrate broadband nonreciprocal photon transmission in the \emph{reversed-dissipation} regime, where the mechanical mode with a large decay rate can be adiabatically eliminated while mediating anti-$\mathcal{PT}$-symmetric dissipative coupling with two kinds of phase factors. Adjusting the relative phases allows the observation of \emph{periodic} Riemann-sheet structures with distributed exceptional points (Eps). At the Eps, destructive quantum interference breaks both the $\mathcal{T}$- and $\mathcal{P}$-inversion symmetry, resulting in unidirectional and chiral photon transmissions. In the reversed-dissipation regime, the nonreciprocal bandwidth is no longer limited by the mechanical mode linewidth but is improved to the linewidth of the cavity resonance. Furthermore, we find that the direction of the unidirectional and chiral energy transfer could be reversed by changing the \emph{parity} of the Eps. Extending non-Hermitian couplings to a three-cavity model, the broken anti-$\mathcal{PT}$-symmetry allows us to observe high-order Eps, at which a parity-dependent chiral circulator is demonstrated. The driving-phase controlled periodical Riemann sheets allow observation of the parity-dependent unidirectional and chiral energy transfer and thus provide a useful cell for building up nonreciprocal array and realizing topological, e.g., isolators, circulators, or amplifiers., Comment: 11 pages, 9 figures

Herein, a functional hybrid named metalloporphyrin hemin modified carbon nanotube decorated titanium carbide (Hemin/CNT/Ti

Revealing the organizing principles of developing neural networks is a difficult but significant task in neuroscience. As a creature with a rather compact and well-studied neural network, C. elegans is an ideal subject for neuroscience study. However, the researches on its developing neural network remain challenging. The changes in specific properties of neural network across development may uncover part of its principles. Motif is a typical structure property that can be well applied to various complex networks. Here, we study the motif changes in C. elegans neural network across development. By counting the occurrence number of all three-node subgraph motif structures in its neural network at different stages of C. elegans development, along with those in corresponding random networks, we determine which of these structures are motifs for C. elegans, finding out the regular changes of motifs during its development. Combined with the potential function of these subgraph motifs and synaptic information, we gain insight into the organizing principle of neural network during development, which may increase our understanding of neuroscience and inspire the construction of artificial neural network.

Endovascular repair of the thoracic aorta (TEVAR) outcomes have been studied with an interest in complications related to left subclavian artery (LSA) coverage in patients with atherosclerotic pathologies; however, specific data on the management of the LSA in a trauma population are lacking. The objective of this study is to evaluate outcomes following TEVAR for traumatic aortic injury based on LSA coverage.The Vascular Quality Initiative thoracic endovascular aortic repair module (2010-2017) was analyzed. Patients were included if they had a traumatic aortic injury requiring TEVAR. Patients were placed in 2 groups based on coverage of the LSA. Patients were propensity score matched and the primary outcomes were cerebrovascular symptoms and spinal cord ischemia. Additional clinical and resource utilization outcomes were analyzed.Four hundred and fifty one patients were included in the analysis. There were 268 patients in the LSA not-covered group and 183 patients in the LSA covered group. The mean aortic injury grade was 2.88 ± 0.056 vs. 2.88 ± 0.049 in the covered versus not-covered group (P = 0.957). Glasgow coma scale and injury severity score were not different between the groups. There was no difference between groups for cerebrovascular symptoms or spinal cord ischemia, 1.4% vs. 2.8%, P = 0.684 and 0% vs. 2.1%, P = 0.247, after propensity score matching. Significant differences in access site complications and resource utilization were identified between groups.This is the largest series to evaluate complications based on LSA coverage following TEVAR in trauma patients. Our data demonstrate that coverage of the LSA during TEVAR following blunt trauma is associated with no difference in central nervous system outcomes. As such, LSA revascularization strategies, while possible, are not directly supported by these data and should be individualized based on each patient's specific clinical scenario.

Although neuropeptide corazonin (Crz) has been identified in numerous insect species, the research about its function in regulation of reproduction is still in its infancy. Herein, we characterized the Crz (GmolCrz) and its receptor (GmolCrzR) to investigate their reproductive function in Grapholita molesta. Both molecular docking result and cell-based receptor activity assay showed that GmolCrz could interact with GmolCrzR. Additionally, spatial expression patterns of GmolCrz and GmolCrzR in males were evaluated. Knockdown of GmolCrz or GmolCrzR significantly lengthened copulation duration and decreased fertility in males. In these males, we found that the production of sperm was normal, while the content of accessory gland proteins (Acps) in the accessory gland (AG) was strongly diminished. Furthermore, knockdown of GmolCrz or GmolCrzR in males had no effect on sperm and Acps transfer to females. RNA-seq and gene expression analyses further confirmed that genes involved in serine-type endopeptidase activity were significantly downregulated in the AG upon GmolCrzR knockdown. Finally, sperm activation assays demonstrated that this process was disrupted in the spermatophore of females mated with GmolCrz or GmolCrzR knockdown males, which may cause the decreased fertility in males. Our findings provide new insights into the functions of Crz signaling in a Lepidopteran insect.

Photoacoustic imaging (PAI) has shown great clinical potential in diagnosing various diseases due to its noninvasive, cost-effective, and real-time imaging properties but is limited by the lack of contrast agents with high sensitivity for deep tissue imaging. Here, DNA-templated ultrasmall bismuth sulfide (Bi