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72 results on '"Pan, Han"'

35. Early life stress induces anxiety-like behavior during adulthood through dysregulation of neuronal plasticity in the basolateral amygdala

Author

Qin, Xia, primary, Liu, Xiao-Xuan, additional, Wang, Yu, additional, Wang, Dan, additional, Song, Ying, additional, Zou, Jia-Xin, additional, Pan, Han-Qing, additional, Zhai, Xiao-Zhou, additional, Zhang, Yong-Mei, additional, Zhang, Yang-Bo, additional, Hu, Ping, additional, and Zhang, Wen-Hua, additional

Published
2021
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36. Computational analysis of a flapping uvula on aerodynamics and pharyngeal wall collapsibility in sleep apnea

Author

John Pontius, Niphattha Wongwiset, Junshi Wang, Haibo Dong, Pan Han, and Jinxiang Xi

Subjects
Adult, Male, Models, Anatomic, 0206 medical engineering, Biomedical Engineering, Biophysics, Direct numerical simulation, 02 engineering and technology, 03 medical and health sciences, Sleep Apnea Syndromes, 0302 clinical medicine, medicine, Humans, Orthopedics and Sports Medicine, Physics, Snoring, Rehabilitation, Work (physics), Pharynx, Sleep apnea, Mechanics, Aerodynamics, Vorticity, medicine.disease, 020601 biomedical engineering, Biomechanical Phenomena, respiratory tract diseases, Airway Obstruction, medicine.anatomical_structure, Uvula, Flapping, Airway, 030217 neurology & neurosurgery
Abstract

Studying the airflows and the resultant aerodynamic pressure/force in the pharyngeal airway is critical for understanding the pathophysiology of snoring and sleep apnea. In this work, an experiment-driven computational study was conducted to examine the aerodynamics in human pharyngeal airway. An anatomically accurate pharynx model associated with different uvula kinematics was reconstructed from human magnetic resonance image (MRI) and high-speed photography. An immersed-boundary-method (IBM)-based direct numerical simulation (DNS) flow solver was adopted to simulate the corresponding unsteady flows in all their complexity. Analyses were performed on vortex dynamics and pressure fluctuations in the pharyngeal airway and force oscillations on the pharyngeal wall under the influence of varying airway obstructions, uvula flapping mode, and uvula flapping frequencies. It was found the vortex formation, aerodynamic pressure, and pharyngeal wall force were significantly affected by the width of the pharyngeal airway. By contrast, the influences from the uvula flapping mode were insignificant when other parameters were similar. Fast Fourier transformation (FFT) and continuous wavelet transform (CWT) analysis of the pressure time history revealed the existence of higher order harmonics of base frequency with significant pressure amplitudes and energy intensities. It was also found the airway pressure and pharyngeal wall force oscillate more dramatically at higher uvula flapping frequencies, which tends to promote the collapse of pharyngeal wall and initiates sleep apnea.

Published
2019

38. Propulsive performance and vortex wakes of multiple tandem foils pitching in-line

Author

Geng Liu, Yu Pan, Pan Han, and Haibo Dong

Subjects
Physics, symbols.namesake, Mechanical Engineering, symbols, Strouhal number, Reynolds number, Thrust, Mechanics, Wake, Propulsion, Vorticity, Propulsive efficiency, Vortex
Abstract

Numerical studies are presented on the propulsive performance and vortex dynamics of multiple hydrofoils pitching in an in-line configuration. The study is motivated by the quest to understand the hydrodynamics of multiple fin–fin interactions in fish swimming. Using the flow conditions (Strouhal and Reynolds numbers) obtained from a solitary pitching foil of zero net thrust, the effect of phase differences between neighboring foils on the hydrodynamic performance is examined both in position-fixed two- and three-foil systems at Reynolds number R e = 500 . It is found that the three-foil system achieves a thrust enhancement up to 118% and an efficiency enhancement up to 115% compared to the two-foil system. Correspondingly, the leading-edge vortex (LEV) and the trailing-edge vortex (TEV) of the hindmost foil combine to form a ‘2P’ wake structure behind the three-foil system with the optimal phase differences instead of a ‘2S’ wake, a coherent wake pattern observed behind the optimal two-foil system. The finding suggests that a position-fixed three-foil system can generate a ‘2P’ wake to achieve the maximum thrust production and propulsive efficiency simultaneously by deliberately choosing the undulatory phase for each foil. When increasing Reynolds number to 1000, though the maximum thrust and propulsive efficiency are not achieved simultaneously, the most efficient case still produces more thrust than most of the other cases. Besides, the study on the effects of three-dimensionality shows that when the foils have a larger aspect ratio, the three-foil system has a better hydrodynamic performance, and it follows a similar trend as the two-dimensional (2D) foil system. This work aids in the future design of high-performance underwater vehicles with multiple controlled propulsion elements.

Published
2022

41. Pulmonary scedosporiosis in a patient with acute hematopoietic failure: Diagnosis aided by next-generation sequencing

Author

Zhijun Xu, Man Huang, Pan Han, and Wei Xiao

Subjects
Male, 0301 basic medicine, Microbiology (medical), 030106 microbiology, DNA sequencing, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, Pulmonary consolidation, medicine, Humans, lcsh:RC109-216, Scedosporium, 030212 general & internal medicine, Aged, Bronchiectasis, Lung Diseases, Fungal, medicine.diagnostic_test, business.industry, Septic shock, High-Throughput Nucleotide Sequencing, Scedosporium apiospermum, General Medicine, medicine.disease, Shock, Septic, Hematopoiesis, Haematopoiesis, Infectious Diseases, Bronchoalveolar lavage, Respiratory failure, Immunology, medicine.symptom, Respiratory Insufficiency, business, Bronchoalveolar Lavage Fluid, Invasive Fungal Infections
Abstract

We report the first case of pulmonary scedosporiosis detected by next-generation sequencing (NGS) from bronchoalveolar lavage fluid (BALF) in a 67-year-old male with bronchiectasis and hematopoietic failure. Scedosporium apiospermum is a ubiquitous organism present in the environment with intrinsic resistance to many antifungal agents. The patient developed respiratory failure, pulmonary consolidation, and septic shock shortly thereafter, and responded poorly to antifungal therapy. This case highlights the combined application of NGS and traditional fungal culture in the clinical diagnosis of pulmonary invasive fungal disease. NGS is proposed as an important adjunctive diagnostic approach for uncommon pathogens. Keywords: Scedosporium apiospermum, Pulmonary scedosporiosis, Next-generation sequencing

Published
2019

42. 3-Carboxamide oxindoles as 1,3-C,N-bisnucleophiles for the highly diastereoselective synthesis of CF3-containing spiro-δ-lactam oxindoles featuring acyl at the ortho-position of spiro carbon atom

Author

Linhai Jing, Hongcai Zhao, Wenhua Lu, Pan Han, Zhengbing Zhang, and Wei Wang

Subjects
Ortho position, Trifluoromethyl, Carbon atom, medicine.drug_class, Stereochemistry, Organic Chemistry, Carboxamide, Biochemistry, chemistry.chemical_compound, chemistry, Cascade reaction, Drug Discovery, medicine, Lactam
Abstract

A simple and efficient strategy has been established for the synthesis of δ-lactam fused oxindoles via the Michael/N-hemiketalization cascade reaction of 3-carboxamide oxindoles and α,β-unsaturated trifluoromethyl ketones. A wide range of structurally novel CF3-containing spiro-δ-lactam oxindoles featuring acyl at the ortho-position of spiro carbon atoms were obtained in moderate to good yields with excellent diastereoselectivities under mild conditions. This work represents the first example of a systematic study of 3-carboxamide oxindoles as 1,3-C,N bisnucleophiles.

Published
2021

49. Asymmetric synthesis of epohelmins A, B and 3-epi ent-epohelmin A

Author

Pan Han, Chang-Mei Si, Zhuo-Ya Mao, Yi-Wen Liu, Zhen-Ting Du, and Bang-Guo Wei

Subjects
chemistry.chemical_classification, Natural product, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Imine, Enantioselective synthesis, 010402 general chemistry, 01 natural sciences, Biochemistry, Aldehyde, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Intramolecular force, Drug Discovery, Pyrrolizidine, Malic acid, Divergent synthesis
Abstract

An efficient method for asymmetric synthesis of epohelmins A (3), B (4) and their isomer 24 is detailed in this report. The key feature in this divergent synthesis includes the SmI2-induced cross-coupling of N-tert-butanesulfinyl imine 10 with chiral aldehyde 9 derived from d -malic acid. A cascade cyclization to the pyrrolizidine skeleton is achieved in our synthetic route for epohelmins. In addition, an interesting intramolecular oxa-Michael addition was observed for epohelmin A (3).

Published
2016

50. Studies toward asymmetric synthesis of hoiamides A and B

Author

Juan Xiong, Jin-Feng Hu, Pan Han, Chang-Mei Si, Zhuo-Ya Mao, Ming Li, Wen Zhou, and Bang-Guo Wei

Subjects
010405 organic chemistry, Stereochemistry, Chemistry, Organic Chemistry, Enantioselective synthesis, Cyclic depsipeptide, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Stereocenter, Polyketide, Drug Discovery
Abstract

A convenient method for diastereoselective synthesis of the key intermediate 5 from triheterocyclic fragment and polyketide 6 for hoiamides A (1) and B (2) was developed. The main feature is the successive construction of four stereogenic centers from C33 to C36 for hoiamides A (1) through the well-established Oppolzer’s anti-aldol and Paterson’s anti-aldol methodology. Furthermore, asymmetric allylation was also utilized as a key step to form the stereogenic center at C32 for hoiamides A (1).

Published
2016

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