1. Novel water-soluble 99mTc(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging
- Author
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Gilles Gasser, Cinzia Spagnul, Teresa Gianferrara, Enzo Alessio, Alberta Bergamo, Roger Alberto, Vanessa Pierroz, Stefano Ferrari, Cinzia, Spagnul, Roger, Alberto, Gilles, Gasser, Stefano, Ferrari, Vanessa, Pierroz, Bergamo, Alberta, Gianferrara, Teresa, and Alessio, Enzo
- Subjects
Porphyrin conjugates ,Technetium 99m ,Rhenium ,Radio-diagnostics ,Molecular imaging ,Porphyrins ,Stereochemistry ,Porphyrin conjugate ,chemistry.chemical_element ,Biochemistry ,Medicinal chemistry ,Inorganic Chemistry ,chemistry.chemical_compound ,Moiety ,Chelation ,Chromatography, High Pressure Liquid ,Aqueous solution ,Molecular Structure ,Technetium ,Water ,Organotechnetium Compounds ,Radio-diagnostic ,Porphyrin ,Solubility ,chemistry ,Diethylenetriamine ,Linker ,Conjugate - Abstract
The synthesis and characterization of two novel water soluble porphyrins with three meso pyridyl rings and one peripheral chelator - either a diethylenetriamine unit (4) or a bipyridyl fragment (8) - for binding to the {(99m)Tc(CO)3}(+) moiety is reported. In 8, despite the presence of a flexible and hydrophilic PEG-like linker that connects the bpy unit to the macrocycle, good water solubility was only obtained by methylation of the pyridyl N atoms that provided three extra positive charges. Furthermore, the water-soluble conjugates of 4 and 8 with either one fac-{Re(CO)3}(+) (9 and 10, respectively) or one fac-{(99m)Tc(CO)3}(+) fragment (9a and 10a, respectively) are described.
- Published
- 2013
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