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92 results on '"Qiu, W."'

1. 1063 Small molecule antagonists of interleukin 17 offer an orthogonal approach to inhibit key inflammatory processes

Author

Goedken, E.R., primary, Argiriadi, M.A., additional, Dietrich, J.D., additional, Petros, A.M., additional, Panchal, S.C., additional, Qiu, W., additional, Wu, H., additional, Zhu, H., additional, Srikumaran, M., additional, Gopalakrishnan, S.M., additional, Cox, P.B., additional, Stoll, V.C., additional, and Sun, C., additional

Published
2023
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7. 511TiP A phase III, multicenter, open-label, randomized study to assess the efficacy and safety of cetuximab plus capecitabine versus cetuximab as maintenance treatment following first-line induction treatment with FOLFOX and cetuximab in Chinese patients with RAS and BRAF WT mCRC

Author

Zhang, D., primary, Bai, C., additional, Zhang, J., additional, Zhang, Y., additional, Liu, T., additional, Pan, H., additional, Zhong, H., additional, Lin, X., additional, Qiu, W-S., additional, Liu, Y., additional, Yuan, X., additional, Zhang, T., additional, Yin, X., additional, Deng, Y., additional, Hu, X., additional, and Xu, R., additional

Published
2021
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8. LBA52 Sintilimab plus chemotherapy versus chemotherapy as first-line therapy in patients with advanced or metastatic esophageal squamous cell cancer: First results of the phase III ORIENT-15 study

Author

Shen, L., primary, Lu, Z-H., additional, Wang, J-Y., additional, Shu, Y-Q., additional, Kong, L., additional, Yang, L., additional, Wang, B-H., additional, Wang, Z-W., additional, Ji, Y-H., additional, Cao, G-C., additional, Liu, H., additional, Cui, T-J., additional, Li, N., additional, Qiu, W-S., additional, Ma, Z., additional, Chen, Y-L., additional, Li, H-Y., additional, Sun, X., additional, Wang, Y., additional, and Zhou, H., additional

Published
2021
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10. 136P Modified ypTNM staging classification for gastric cancer after neoadjuvant therapy: A multi-institutional study

Author

Qiu, W-W., primary, Zhong, Q., additional, Wang, Z-K., additional, Chen, Q-Y., additional, Zheng, C-H., additional, Li, P., additional, Xie, J-W., additional, Wang, J-B., additional, Lin, J-X., additional, Lu, J., additional, Cao, L-L., additional, Lin, M., additional, Tu, R-H., additional, Huang, Z-N., additional, Lin, J-L., additional, Zheng, H-L., additional, and Huang, C., additional

Published
2020
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11. 159P Open surgery can improve the 3-year postoperative survival in some patients with advanced gastric cancer compared with laparoscopic surgery: A multicenter, propensity score matching, in-depth analysis

Author

Huang, Z-N., primary, Qiu, W-W., additional, Lin, T-X., additional, Chen, Q-Y., additional, Zheng, C-H., additional, Li, P., additional, Xie, J-W., additional, Wang, J-B., additional, Lin, J-X., additional, Lu, J., additional, Cao, L-L., additional, Lin, M., additional, Tu, R-H., additional, Lin, J-L., additional, Zheng, H-L., additional, and Huang, C., additional

Published
2020
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12. 140P Preoperative and postoperative C-reactive protein levels predict recurrence and chemotherapy benefit in gastric cancer

Author

Shen, L-L., primary, Tang, Y-H., additional, Qiu, W-W., additional, Lu, J., additional, Zheng, C-H., additional, Li, P., additional, Xie, J-W., additional, Wang, J-B., additional, Lin, J-X., additional, Chen, Q-Y., additional, Cao, L-L., additional, Lin, M., additional, Tu, R-H., additional, Huang, Z-N., additional, Lin, J-L., additional, Zheng, H-L., additional, and Huang, C., additional

Published
2020
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13. 142P Prognostic analysis of patients with intra-abdominal infectious complications after laparoscopy and open radical gastrectomy for gastric cancer: A propensity score-matching analysis

Author

Que, S-J., primary, Qiu, W-W., additional, Zhong, Q., additional, Chen, Q-Y., additional, Zheng, C-H., additional, Li, P., additional, Xie, J-W., additional, Wang, J-B., additional, Lin, J-X., additional, Lu, J., additional, Cao, L-L., additional, Lin, M., additional, Tu, R-H., additional, Huang, Z-N., additional, Lin, J-L., additional, Zheng, H-L., additional, and Huang, C., additional

Published
2020
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14. 148P MCV-the ideal answer to predict the prognosis of remnant gastric cancer: An analysis from a multi-institutional database

Author

Weng, K., primary, Xu, K-X., additional, Qiu, W-W., additional, Zheng, C-H., additional, Li, P., additional, Xie, J-W., additional, Wang, J-B., additional, Lin, J-X., additional, Lu, J., additional, Chen, Q-Y., additional, Cao, L-L., additional, Lin, M., additional, Tu, R-H., additional, Huang, Z-N., additional, Lin, J-L., additional, Zheng, H-L., additional, and Huang, C., additional

Published
2020
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15. Chinese expert group consensus on diagnosis and clinical management of osteoradionecrosis of the mandible

Author

He, Y., primary, Ma, C., additional, Hou, J., additional, Li, X., additional, Peng, X., additional, Wang, H., additional, Wang, S., additional, Liu, L., additional, Liu, B., additional, Tian, L., additional, Liu, Z., additional, Liu, X., additional, Xu, X., additional, Zhang, D., additional, Jiang, C., additional, Wang, J., additional, Yao, Y., additional, Zhu, G., additional, Bai, Y., additional, Sun, C., additional, Li, J., additional, He, S., additional, Wang, C., additional, Zhang, Z., additional, and Qiu, W., additional

Published
2020
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18. 677 Discovery and characterization of a small molecule IL-36γ antagonist as a novel approach to treat plaque psoriasis

Author

Todorovic, V., primary, Su, Z., additional, Putman, C., additional, Kakavas, S.J., additional, Salte, K., additional, McDonald, H.A., additional, Wetter, J., additional, Paulsboe, S.E., additional, Sun, Q., additional, Medina, L., additional, Sielaff, B., additional, Gerstein, C., additional, Olson, L., additional, Stockmann, H., additional, Richardson, P., additional, Qiu, W., additional, Argiriadi, M.A., additional, Henry, R.F., additional, Herold, M.J., additional, McGaraughty, S., additional, Honore, P., additional, Shotwell, J., additional, Gopalakrishnan, S.M., additional, Sun, C.C., additional, and Scott, V.E., additional

Published
2019
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20. Prognostic value of MRI-derived residual retropharyngeal lymph node after intensity-modulated radiotherapy in nasopharyngeal carcinoma and a nomogram for the prediction of it

Author

Li, W.-Z., primary, Liang, H., additional, Lv, X., additional, Ke, L.-R., additional, Ye, Y.-F., additional, Yu, Y.-H., additional, Qiu, W.-Z., additional, Liu, G.-Y., additional, Huang, X.-J., additional, Liu, K.-Y., additional, Lv, S.-H., additional, Guo, X., additional, Xiang, Y.-Q., additional, and Xia, W.-X., additional

Published
2018
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24. Natural history of benign multiple sclerosis: Clinical and HLA correlates in a Western Australian cohort

Author

Fabis-Pedrini, M.J., James, I., Seewann, A., Yau, W.Y., van de Bovenkamp, A.A., Sanders, F.R.K., Qiu, W., Burton, J., Mastaglia, F.L., Carroll, W.M., Kermode, A.G., Fabis-Pedrini, M.J., James, I., Seewann, A., Yau, W.Y., van de Bovenkamp, A.A., Sanders, F.R.K., Qiu, W., Burton, J., Mastaglia, F.L., Carroll, W.M., and Kermode, A.G.

Abstract

Background Benign multiple sclerosis (BMS) is a controversial term that has been used for MS patients with minimal disability decades after disease onset. Herein, we evaluated disease status after 20 years in a Western Australian cohort defined as BMS based on an Expanded Disability Status Scale (EDSS) score ≤ 3.0 at 10 years from onset. Methods MS patients with an EDSS score ≤ 3.0 at 10 years from onset and minimum of 20 years follow up were included in the study. The 20-year EDSS score was considered the primary outcome. Associations with demographic and clinical characteristics and HLA-DRB1 genotype were investigated. Results Among 120 patients with a benign course at 10 years, 78 (65%) remained benign at the 20-year follow up, but patients with an EDSS ≥ 2.5 were more likely to go on to develop more severe disability in the next decade. When considering factors associated with an increase in EDSS score ≤ 1 from 10 to 20 years, indicating limited progression, apart from the EDSS score at 10 years, poly-symptomatic presentation (p = 0.004) and cerebellar/brainstem mono-symptomatic presentation (p = 0.016) were independently associated with more rapid progression compared with other mono-symptomatic presentations. Carriage of the high risk HLA-DRB1*1501 allele was marginally associated with slower progression. Conclusions In this geographically isolated MS cohort of predominantly Anglo-Celtic origin clinical progression in the benign MS group was similar to that in other published series from Western countries. These results are in keeping with the view that patients labeled as benign MS are part of a heterogeneous continuum of disease progression and do not possess unique clinical characteristics. Possible genetic determinants of a benign course warrant further investigation.

Published
2018

28. Pregnancy in neuromyelitis optica spectrum disorder: A multicenter study from South China

Author

Huang, Y., Wang, Y., Zhou, Y., Huang, Q., Sun, X., Chen, C., Fang, L., Long, Y., Yang, H., Wang, H., Li, C., Lu, Z., Hu, X., Kermode, A.G., Qiu, W., Huang, Y., Wang, Y., Zhou, Y., Huang, Q., Sun, X., Chen, C., Fang, L., Long, Y., Yang, H., Wang, H., Li, C., Lu, Z., Hu, X., Kermode, A.G., and Qiu, W.

Abstract

Objective This study aimed to assess the effect of pregnancy on the course of neuromyelitis optica spectrum disorder (NMOSD), and the effect of this disease on pregnancy outcomes. Methods Consecutive patients with NMOSD were recruited between September 2015 and April 2016 at an outpatient clinic from four referral institutes in South China. Demographic, clinical, and pregnancy data were retrieved by questionnaires to analyze the association between NMOSD and pregnancy, as well as the potential risk factors for relapse. Results Among 249 patients with NMOSD, 55 had pregnancy-related attacks. The annual relapse rate in the first (3.20 ± 6.82) and second (3.25 ± 3.32) 3-month postpartum periods was marginally higher than that before pregnancy (1.44 ± 0.92, p = 0.682) and during pregnancy (1.23 ± 1.32, p = 0.758). The Kurtzke Expanded Disability Status Scale score increased from 1.55 ± 0.38 before pregnancy to 2.88 ± 2.14 at postpartum (p < 0.001). NMOSD significantly increased the premature birth rate in patients after disease onset (8.33%) compared with before disease onset (1.95%, p = 0.025). Multivariate analysis showed that negative anti-aquaporin-4 IgG, concomitance with autoimmune diseases/antibodies, and no treatment in remission were risk factors of recurrence. Conclusion Our study shows a significant association between pregnancy and NMOSD in the Chinese population. Larger scale prospective studies are warranted in the future.

Published
2017

39. The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

Author

Qiu, W., Pham, K., James, Ian, Nolan, D., Castley, A., Christiansen, F., Czarniak, Petra, Luo, Y., Wu, J., Garlepp, Michael, Wilton, S., Carroll, W., Mastaglia, F., Kermode, A., Qiu, W., Pham, K., James, Ian, Nolan, D., Castley, A., Christiansen, F., Czarniak, Petra, Luo, Y., Wu, J., Garlepp, Michael, Wilton, S., Carroll, W., Mastaglia, F., and Kermode, A.

Abstract

Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/CD58, CLEC-16A/CTLA-4, and TYK2/IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups.

Published
2013

40. Spinal cord involvement in multiple sclerosis: A correlative MRI and high-resolution HLA-DRB1 genotyping study

Author

Qiu, W., Raven, S., James, I., Luo, Y., Wu, J., Castley, A., Christiansen, F.T., Carroll, W.M., Mastaglia, F.L., Kermode, A.G., Qiu, W., Raven, S., James, I., Luo, Y., Wu, J., Castley, A., Christiansen, F.T., Carroll, W.M., Mastaglia, F.L., and Kermode, A.G.

Abstract

Background: There have been few magnetic resonance imaging (MRI) studies of the spinal cord in large multiple sclerosis (MS) patient cohorts and little is known about correlations between cord lesions and human leukocyte antigen (HLA) alleles. Objective: To investigate the spectrum of MRI changes in the spinal cord in MS and associations with the HLA-DRB1 genotype. Methods: Two hundred and fifty two consecutive MS patients from the Perth Demyelinating Diseases Database had MRI of the spinal cord and brain and high-resolution HLA-DRB1 genotyping. The numbers, locations, shape and segmental extent of cord lesions were analysed and were correlated with carriage of individual HLA-DRB1 alleles and diplotypes. Results: Focal cord lesions were present in 82.9% of cases, with numbers being maximal in the cervical cord and increasing with disease duration. Focal lesions were usually round or oval in shape but in 35% of cases subpial wedge-shaped lesions were present. Diffuse cord involvement was present in 10% of cases and correlated with carriage of HLA-DRB1*1501 and with higher disability. Carriage of the minor allele HLA-DRB1*0701 was significantly associated with numbers of wedge-shaped lesions and lesions in the cervical cord, while HLA-DRB1*1104 and DRB1*0103 were significantly associated respectively with higher and lower numbers of thoracic cord lesions. HLA-DRB1*1501 and the HLA-DRB1*11 sub-alleles DRB1*1101 and DRB1*1104 were significantly associated with the segmental length of cord lesions. Conclusions: Our study is the first to investigate the frequency of subpial wedge-shaped lesions in the cord in vivo and has provided preliminary evidence that HLA-DRB1 alleles may play a role in determining the severity and extent of spinal cord involvement in MS.

Published
2011

41. Wedge-shaped medullary lesions in multiple sclerosis

Author

Qiu, W., Raven, S., Wu, J-S, Carroll, W.M., Mastaglia, F.L., Kermode, A.G., Qiu, W., Raven, S., Wu, J-S, Carroll, W.M., Mastaglia, F.L., and Kermode, A.G.

Abstract

Multiple sclerosis (MS) is a heterogeneous disease with variable clinical features and magnetic resonance imaging (MRI) findings. We report four MS cases with unusual wedge-shaped lesions in the paramedian ventral medulla oblongata demonstrated on MRI. The clinical features and MRI characteristics of the medullary lesions suggest an impairment of venous drainage. We propose that the formation of these wedge-shaped lesions may be related to the pattern of venous drainage in the ventral medulla and raised venous pressure due to chronic cerebrospinal venous insufficiency which has recently been described in MS.

Published
2010

42. Presence of CSF oligoclonal bands (OCB) is associated with the HLA-DRB1 genotype in a West Australian multiple sclerosis cohort

Author

Wu, J-S, Qiu, W., Castley, A., James, I., Joseph, J., Christiansen, F.T., Carroll, W.M., Mastaglia, F.L., Kermode, A.G., Wu, J-S, Qiu, W., Castley, A., James, I., Joseph, J., Christiansen, F.T., Carroll, W.M., Mastaglia, F.L., and Kermode, A.G.

Abstract

High-resolution HLA-DRB1 genotyping was performed in 97 OCB-positive and 68 OCB-negative cases with demyelinating disease to determine the influence of HLA-DRB1 alleles on the presence of OCB in a West Australian multiple sclerosis (MS) cohort. Carriage of the HLA-DRB1*1501 allele was associated with both OCB-positive and OCB-negative MS compared with controls, but more strongly with the OCB-positive group, and increased the likelihood of having OCB 2.1-fold with evidence of a dominant dose-effect. The HLA-DRB1*0301 allele was negatively correlated with OCB, with all homozygotes OCB-negative, suggesting a possible recessive protective effect of HLA-DRB1*0301. There was no significant correlation between OCB and the DRB1*04 alleles which have been associated with OCB-negative MS in previous Swedish and Japanese studies. Evidence of allelic interactions was found with HLA-DRB1*1501/*1301 heterozygotes having a reduced frequency of OCB and HLA-DRB1*0301/*0401 heterozygotes all being OCB-negative. These findings confirm the strong association between HLA-DRB1*1501 and OCB which has been found in other populations but indicate that the influence of other HLA-DRB1 alleles varies in different populations. Our study is the first to show that HLA-DRB1 allele interactions and dose-effects influence the frequency of OCB.

Published
2010

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