1. Heat stress response of somatic cells in the testis
- Author
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Rashid A. Aldahhan and Peter G. Stanton
- Subjects
Male ,0301 basic medicine ,endocrine system ,Somatic cell ,030209 endocrinology & metabolism ,Biology ,Biochemistry ,Abnormal sperm morphology ,Andrology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,medicine ,Animals ,Humans ,Spermatogenesis ,Molecular Biology ,Sperm motility ,Sertoli Cells ,Leydig cell ,urogenital system ,Leydig Cells ,Thermoregulation ,Sertoli cell ,Spermatozoa ,Heat stress ,030104 developmental biology ,medicine.anatomical_structure ,Sperm Motility ,Heat-Shock Response - Abstract
The testis is a temperature-sensitive organ that needs to be maintained 2–7 °C below core body temperature to ensure the production of normal sperm. Failure to maintain testicular temperature in mammals impairs spermatogenesis and leads to low sperm counts, poor sperm motility and abnormal sperm morphology in the ejaculate. This review discusses the recent knowledge on the response of testicular somatic cells to heat stress and, specifically, regarding the relevant contributions of heat, germ cell depletion and inflammatory reactions on the functions of Sertoli and Leydig cells. It also outlines mechanisms of testicular thermoregulation, as well as the thermogenic factors that impact testicular function.
- Published
- 2021
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