1. Improved nerve conspicuity with water-weighting and denoising in two-point Dixon magnetic resonance neurography
- Author
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Ek Tsoon Tan, Darryl B. Sneag, Yoshimi Endo, Bin Lin, Julia Sternberg, Hollis G. Potter, Sophie C. Queler, and Alissa J. Burge
- Subjects
Male ,Muscle Denervation ,Magnetic Resonance Spectroscopy ,business.industry ,Image quality ,Noise reduction ,Magnetic resonance neurography ,Infant, Newborn ,Biomedical Engineering ,Biophysics ,Water ,Ringing artifacts ,Signal-To-Noise Ratio ,Magnetic Resonance Imaging ,Article ,Confidence interval ,Weighting ,Quantitative assessment ,Humans ,Medicine ,Female ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Nuclear medicine ,business - Abstract
BACKGROUND: T(2)-weighted, two-point Dixon fast-spin-echo (FSE) is an effective technique for magnetic resonance neurography (MRN) that can provide quantitative assessment of muscle denervation. Low signal-to-noise ratio and inadequate fat suppression, however, can impede accurate interpretation. PURPOSE: To quantify effects of principal component analysis (PCA) denoising on tissue signal intensities and fat fraction (FF) and to determine qualitative image quality improvements from both denoising and water-weighting (WW) algorithms to improve nerve conspicuity and fat suppression. STUDY TYPE: Prospective. SUBJECTS: Twenty-one subjects undergoing MR neurography evaluation (11/10 male/female, mean age=46.3+/−13.7 years) with 60 image volumes. Twelve subjects (23 image volumes) were determined to have muscle denervation based on diffusely elevated T(2) signal intensity. FIELD STRENGTH/SEQUENCE: 3T, 2D, two-point Dixon FSE. ASSESSMENT: Qualitative assessment included overall image quality, nerve conspicuity, fat suppression, pulsation and ringing artifacts by 3 radiologists separately on a three-point scale (1=poor, 2=average, 3=excellent). Quantitative measurements for FF and signal intensity relative to normal muscle were made for nerve, abnormal muscle and subcutaneous fat. STATISTICAL TESTS: Linear and ordinal regression models were used for quantitative and qualitative comparisons, respectively; 95% confidence intervals (CIs) and p-values for pairwise comparisons were adjusted using the Holm-Bonferroni method. Inter-rater agreement was assessed using Gwet’s agreement coefficient (AC(2)). RESULTS: Simulations showed PCA-denoising reduced FF error from 2.0% to 1.0%, and from 7.6% to 3.1% at noise levels of 10% and 30%, respectively. In human subjects, PCA-denoising did not change signal levels and FF quantitatively. WW decreased fat signal significantly (−83.6%, p
- Published
- 2021