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3. Left Atrial Appendage Closure in Patients With a Mechanical Mitral Valve Prosthesis: A Multicentre Italian Pilot Study

Author

Preda, Alberto, primary, Margonato, Davide, additional, Gaspardone, Carlo, additional, Rizza, Vincenzo, additional, Vella, Ciro, additional, Rampa, Lorenzo, additional, Marzi, Alessandra, additional, Guarracini, Fabrizio, additional, della Bella, Paolo, additional, Agricola, Eustachio, additional, Gaspardone, Achille, additional, Montorfano, Matteo, additional, and Mazzone, Patrizio, additional

Published
2024
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7. AMBRA1 is a predictive biomarker of melanoma response to targeted therapy

Author

Di Leo, L., primary, Pagliuca, C., additional, Kishk, A., additional, Rizza, S., additional, Tsiavou, C., additional, Pecorari, C., additional, Dahl, C., additional, Pacheco, M., additional, Tholstrup, R., additional, Brewer, J., additional, Berico, P., additional, Hernando, E., additional, Cecconi, F., additional, Ballotti, R., additional, Bertolotto, C., additional, Filomeni, G., additional, Gjerstorff, M., additional, Sauter, T., additional, Lovat, P., additional, Guldberg, P., additional, and De Zio, D., additional

Published
2024
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10. Vasovagal syncope: An overview of pathophysiological mechanisms

Author

Susanna Longo, Jacopo M. Legramante, Stefano Rizza, and Massimo Federici

Subjects
Transient loss of consciousness, Cerebral hypoperfusion, Vasovagal sincope, Internal Medicine, Settore MED/09, Gut microbiota, Baroreflex, Syncope, Vagus nerve
Published
2023

12. TCT-665 A Real-World Comparative Analysis of Surgical and Transcatheter Approaches to Tricuspid Regurgitation

Author

Gaspardone, Carlo, primary, Gramegna, Federica, additional, Morosato, Michele, additional, Vetrugno, Laura, additional, Paci, Gabriele, additional, Mula, Caterina, additional, Fuga, Alessandro, additional, Morciano, Davide Antonio, additional, Rizza, Vincenzo, additional, Ancona, Francesco, additional, Denti, Paolo, additional, Buzzatti, Nicola, additional, Agricola, Eustachio, additional, Maisano, Francesco, additional, and Godino, Cosmo, additional

Published
2023
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14. Accuracy and Reliability of Left Atrial Appendage Morphology Assessment by Three-Dimensional Transesophageal Echocardiographic Glass Rendering Modality: A Comparative Study With Computed Tomography

Author

Fiore, Giorgio, primary, Gaspardone, Carlo, additional, Ingallina, Giacomo, additional, Rizza, Vincenzo, additional, Melillo, Francesco, additional, Stella, Stefano, additional, Ancona, Francesco, additional, Biondi, Federico, additional, Margonato, Davide, additional, Palmisano, Anna, additional, Esposito, Antonio, additional, and Agricola, Eustachio, additional

Published
2023
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25. Preliminary results from an Italian National Registry on the outcomes of the Najuta fenestrated aortic arch endograft

Author

Isernia, Giacomo, primary, Simonte, Gioele, additional, Orrico, Matteo, additional, Silingardi, Roberto, additional, Gaggiano, Andrea, additional, Covic, Tea, additional, Ferri, Michelangelo, additional, Lenti, Massimo, additional, Mangialardi, Nicola, additional, Isernia, Giacomo, additional, Parlani, Gianbattista, additional, Fino, Gianluigi, additional, Baccani, Luigi, additional, Leonardi, Paolo, additional, Gennai, Stefano, additional, Ferrero, Emanuele, additional, Quaglino, Simone, additional, Rizza, Antonio, additional, Maritati, Gabriele, additional, Portoghese, Michele, additional, Verzini, Fabio, additional, Pulli, Raffaele, additional, Fargion, Aaron, additional, Bonvini, Stefano, additional, Intrieri, Francesco, additional, Speziale, Francesco, additional, Mansour, Wassim, additional, Moniaci, Diego, additional, Berchiolli, Raffaella, additional, Troisi, Nicola, additional, Colli, Andrea, additional, Camparini, Stefano, additional, Pratesi, Giovanni, additional, Massi, Francesco, additional, Michelagnoli, Stefano, additional, Chisci, Emanuele, additional, Bonardelli, Stefano, additional, Maione, Massimo, additional, and Angiletta, Domenico, additional

Published
2023
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30. Experience Implementing Internal Audits for an Agnis-Enabled Database

Author

Macioci, Taylor, primary, Rizza, Kristen, additional, King, Bethany, additional, Craig, Kimberly, additional, Bakinowski, Emily, additional, Doherty, Kathleen, additional, Hill, Lauren, additional, Sakhta, Wadea, additional, Porter, Julie, additional, Ho, Dr. Vincent T., additional, and Duncan, Christine N., additional

Published
2023
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33. Lithium recovery through WS2 nanofillers-promoted solar photothermal membrane crystallization of LiCl

Author

Santoro, Sergio, primary, Aquino, Marco, additional, Rizza, Carlo, additional, Occhiuzzi, Jessica, additional, Mastrippolito, Dario, additional, D'Olimpio, Gianluca, additional, Avci, Ahmet H., additional, De Santis, Jessica, additional, Paolucci, Valentina, additional, Ottaviano, Luca, additional, Lozzi, Luca, additional, Ronen, Avner, additional, Bar-Sadan, Maya, additional, Han, Dong Suk, additional, Politano, Antonio, additional, and Curcio, Efrem, additional

Published
2023
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34. GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation

Author

Rizza, Salvatore, primary, Di Leo, Luca, additional, Pecorari, Chiara, additional, Giglio, Paola, additional, Faienza, Fiorella, additional, Montagna, Costanza, additional, Maiani, Emiliano, additional, Puglia, Michele, additional, Bosisio, Francesca M., additional, Petersen, Trine Skov, additional, Lin, Lin, additional, Rissler, Vendela, additional, Viloria, Juan Salamanca, additional, Luo, Yonglun, additional, Papaleo, Elena, additional, De Zio, Daniela, additional, Blagoev, Blagoy, additional, and Filomeni, Giuseppe, additional

Published
2023
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38. Experience Implementing Internal Audits for an Agnis-Enabled Database

Author

Taylor Macioci, Kristen Rizza, Bethany King, Kimberly Craig, Emily Bakinowski, Kathleen Doherty, Lauren Hill, Wadea Sakhta, Julie Porter, Dr. Vincent T. Ho, and Christine N. Duncan

Subjects
Transplantation, Molecular Medicine, Immunology and Allergy, Cell Biology, Hematology
Published
2023

39. Acute Kidney Injury in Severe COVID-19 Has Similarities to Sepsis-Associated Kidney Injury

Author

Peter T. Lin, Denic Aleksandar, Samih H. Nasr, Andrew D. Badley, Andrew D. Rule, Joseph J. Maleszewski, Jon Charlesworth, Sandra M. Herrmann, Marie-Christine Aubry, Anja C. Roden, Ramya Narasimhan, Kiran K. Mangalaparthi, E. Heidi Cheek, Melanie C. Bois, Sanjeev Sethi, Benjamin Adam, Reade A. Quinton, Loren P. Herrera Hernandez, Stacey A. Rizza, Lynn D. Cornell, Kevin D. Pavelko, Anil K. Madugundu, Timucin Taner, Mariam P. Alexander, Akhilesh Pandey, Catherine E. Hagen, Smrita Singh, Ann M. Moyer, Christopher P. Larsen, Rondell P. Graham, Trevor D. McKee, Michael Mengel, and Joseph P. Grande

Subjects
Kidney, Pathology, medicine.medical_specialty, urogenital system, business.industry, Necroptosis, Acute kidney injury, Inflammation, General Medicine, urologic and male genital diseases, medicine.disease, female genital diseases and pregnancy complications, Transcriptome, Sepsis, medicine.anatomical_structure, Immune system, Renal pathology, medicine, medicine.symptom, business
Abstract

Objective To compare coronavirus disease 2019 (COVID-19) acute kidney injury (AKI) to sepsis-AKI (S-AKI). The morphology and transcriptomic and proteomic characteristics of autopsy kidneys were analyzed. Patients and Methods Individuals 18 years of age and older who died from COVID-19 and had an autopsy performed at Mayo Clinic between April 2020 to October 2020 were included. Morphological evaluation of the kidneys of 17 individuals with COVID-19 was performed. In a subset of seven COVID-19 cases with postmortem interval of less than or equal to 20 hours, ultrastructural and molecular characteristics (targeted transcriptome and proteomics analyses of tubulointerstitium) were evaluated. Molecular characteristics were compared with archived cases of S-AKI and nonsepsis causes of AKI. Results The spectrum of COVID-19 renal pathology included macrophage-dominant microvascular inflammation (glomerulitis and peritubular capillaritis), vascular dysfunction (peritubular capillary congestion and endothelial injury), and tubular injury with ultrastructural evidence of mitochondrial damage. Investigation of the spatial architecture using a novel imaging mass cytometry revealed enrichment of CD3+CD4+ T cells in close proximity to antigen-presenting cells, and macrophage-enriched glomerular and interstitial infiltrates, suggesting an innate and adaptive immune tissue response. Coronavirus disease 2019 AKI and S-AKI, as compared to nonseptic AKI, had an enrichment of transcriptional pathways involved in inflammation (apoptosis, autophagy, major histocompatibility complex class I and II, and type 1 T helper cell differentiation). Proteomic pathway analysis showed that COVID-19 AKI and to a lesser extent S-AKI were enriched in necroptosis and sirtuin-signaling pathways, both involved in regulatory response to inflammation. Upregulation of the ceramide-signaling pathway and downregulation of oxidative phosphorylation in COVID-19 AKI were noted. Conclusion This data highlights the similarities between S-AKI and COVID-19 AKI and suggests that mitochondrial dysfunction may play a pivotal role in COVID-19 AKI. This data may allow the development of novel diagnostic and therapeutic targets.

Published
2021

40. Metabolic characteristics in patients with COVID-19 and no-COVID-19 interstitial pneumonia with mild-to-moderate symptoms and similar radiological severity

Author

Gianluca Vanni, Alfonso Bellia, Francesca Davato, Marcello Chiocchi, Luca Coppeta, Daniele Mereu, Marta Ballanti, Giovanni Di Cola, Romualdo Gervasi, Marina Cardellini, Davide Lauro, Alessandro Nucera, Massimo Federici, Claudio Oreste Buonomo, Stefano Rizza, and Gianluigi Ferrazza

Subjects
Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, Medicine (miscellaneous), Settore MED/09, Severity of Illness Index, Article, chemistry.chemical_compound, Settore MED/13, Risk Factors, Internal medicine, Diabetes mellitus, Severity of illness, Diabetes Mellitus, Humans, Medicine, education, Aged, Retrospective Studies, Aged, 80 and over, Glycated Hemoglobin, education.field_of_study, Nutrition and Dietetics, diabetes, SARS-CoV-2, business.industry, Mortality rate, Case-control study, COVID-19, Retrospective cohort study, Pneumonia, Middle Aged, medicine.disease, chemistry, Case-Control Studies, Female, Glycated hemoglobin, Lung Diseases, Interstitial, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business
Abstract

Background and aims It is known that the highest COVID-19 mortality rates are among patients who develop severe COVID-19 pneumonia. However, despite the high sensitivity of chest CT scans for diagnosing COVID-19 in a screening population, the appearance of a chest CT is thought to have low diagnostic specificity. The aim of this retrospective case–control study is based on evaluation of clinical and radiological characteristics in patients with COVID-19 (n = 41) and no-COVID-19 interstitial pneumonia (n = 48) with mild-to-moderate symptoms. Methods and results To this purpose we compared radiological, clinical, biochemical, inflammatory, and metabolic characteristics, as well as clinical outcomes, between the two groups. Notably, we found similar radiological severity of pneumonia, which we quantified using a disease score based on a high-resolution computed tomography scan (COVID-19 = 18.6 ± 14.5 vs n-COVID-19 = 23.2 ± 15.2, p = 0.289), and comparable biochemical and inflammatory characteristics. However, among patients without diabetes, we observed that COVID-19 patients had significantly higher levels of HbA1c than n-COVID-19 patients (COVID-19 = 41.5 ± 2.6 vs n-COVID-19 = 38.4 ± 5.1, p = 0.012). After adjusting for age, sex, and BMI, we found that HbA1c levels were significantly associated with the risk of COVID-19 pneumonia (odds ratio = 1.234 [95%CI = 1.051–1.449], p = 0.010). Conclusions In this retrospective case–control study, we found similar radiological and clinical characteristics in patients with COVID-19 and n-COVID-19 pneumonia with mild-to-moderate symptoms. However, among patients without diabetes HbA1c levels were higher in COVID-19 patients than in no-COVID-19 individuals. Future studies should assess whether reducing transient hyperglycemia in individuals without overt diabetes may lower the risk of SARS-CoV-2 infection.

Published
2021

49. Effect of Rehabilitation Treatments on Disability in Persons With Disorders of Consciousness: A Propensity Score Study

Author

Sattin D., Leonardi M., Nelli B., Bramanti P., Marino S., Ferro S., Basaglia N., Guido D., Dolce G., Lucca L. F, Cortese M. D., Ermio C., Dattilo T. L., Capomolla S., Di Iasi G., Estraneo A., De Tanti A., Maradini N., Piperno R., Ferri A., Basaglia N, Bergonzoni A., Chiavaroli F., Di Marco F., Carli S., Biasutti E., Marin D., Formisano R., Rizza F., Pisarri F. M., Vichi R., D'Urso A., Grillo G., Leto A., Guerrasio M., Taliento C., Napolitano F., Castelli E., Lispi M. L., Diverio M., Barbieri C., Bini P. P., Angelino G., Dada O., Orlandi A., Pistarini C., Pisoni C., Manera M., Compostini A., Aiachini B., Pessina A., Musio A., Colombetti E., Taraschi S., Aluas M., Croci M., Negri M., Zucchella M. A., Guizzetti G. B., Salamone E., De Valle G., Caroppi S. M., Ramorino E., Salina D., Spannocchi G., Strazzer S., Villa F., Guarnerio C., Chiambretto P., Dartizio R., Feller S., Franzoni L., Giunco F., Massironi L., Azimonti R., Marcolli S. S., Meinecke C., Buse G., Marchesi V, Molteni F., Gramigna C., Lanfranchi M., Pisani L., Sozzi M., Borri G., Cannata A. P., Grillo A., Roca S., Locati D., Arenare F., Magnoni A., Perin C., Sussele M., Quintana T. Y., Camici M. E., Magistrelli F., Samueli T., San Felici L., Manganelli F., Vignati M., Bellanova L., Cattaneo N., Ferraro F., Olgiati E., Brizioli E., Vallasciani M., Gironelli L., Calderisi E., Novelli A., Scaramuzzo R., Perino C., Forno R., Zamponi E., Corna S., Ferrario S., Lamberti G., Rosso S., Colonna F., Navarro J., Trabacca A., Gennaro L., Bertolini A., Addante L., Amenduni M. T., Fiore P., Amoruso M. T., Colella D., Angelillo M. T., Melis G., Desogus G., Baglieri A., Galardi G., Sant'Angelo A., Posteraro F., Forte F., Logi F., Potenza F., Lino M., Zaccara G., Ragazzoni A., Chiaramonti R., March A., Grober G., Kaczor M., Zelger P, Mazzini N., Monti A., Zampolini M., Scarponi F., Avesani R., Salvi L., Tonin P., Cosentino E., Furlanetto N., Bordin M., Martinuzzi A., Buffoni M., Boldrini P., Semerjian M., Sattin, D, Leonardi, M, Nelli, B, Bramanti, P, Marino, S, Ferro, S, Basaglia, N, Guido, D, Dolce, G, Lucca, L, Cortese, M, Ermio, C, Dattilo, T, Capomolla, S, Di Iasi, G, Estraneo, A, De Tanti, A, Maradini, N, Piperno, R, Ferri, A, Bergonzoni, A, Chiavaroli, F, Di Marco, F, Carli, S, Biasutti, E, Marin, D, Formisano, R, Rizza, F, Pisarri, F, Vichi, R, D'Urso, A, Grillo, G, Leto, A, Guerrasio, M, Taliento, C, Napolitano, F, Castelli, E, Lispi, M, Diverio, M, Barbieri, C, Bini, P, Angelino, G, Dada, O, Orlandi, A, Pistarini, C, Pisoni, C, Manera, M, Compostini, A, Aiachini, B, Pessina, A, Musio, A, Colombetti, E, Taraschi, S, Aluas, M, Croci, M, Negri, M, Zucchella, M, Guizzetti, G, Salamone, E, De Valle, G, Caroppi, S, Ramorino, E, Salina, D, Spannocchi, G, Strazzer, S, Villa, F, Guarnerio, C, Chiambretto, P, Dartizio, R, Feller, S, Franzoni, L, Giunco, F, Massironi, L, Azimonti, R, Marcolli, S, Meinecke, C, Buse, G, Marchesi, V, Molteni, F, Gramigna, C, Lanfranchi, M, Pisani, L, Sozzi, M, Borri, G, Cannata, A, Grillo, A, Roca, S, Locati, D, Arenare, F, Magnoni, A, Perin, C, Sussele, M, Quintana, T, Camici, M, Magistrelli, F, Samueli, T, San Felici, L, Manganelli, F, Vignati, M, Bellanova, L, Cattaneo, N, Ferraro, F, Olgiati, E, Brizioli, E, Vallasciani, M, Gironelli, L, Calderisi, E, Novelli, A, Scaramuzzo, R, Perino, C, Forno, R, Zamponi, E, Corna, S, Ferrario, S, Lamberti, G, Rosso, S, Colonna, F, Navarro, J, Trabacca, A, Gennaro, L, Bertolini, A, Addante, L, Amenduni, M, Fiore, P, Amoruso, M, Colella, D, Angelillo, M, Melis, G, Desogus, G, Baglieri, A, Galardi, G, Sant'Angelo, A, Posteraro, F, Forte, F, Logi, F, Potenza, F, Lino, M, Zaccara, G, Ragazzoni, A, Chiaramonti, R, March, A, Grober, G, Kaczor, M, Zelger, P, Mazzini, N, Monti, A, Zampolini, M, Scarponi, F, Avesani, R, Salvi, L, Tonin, P, Cosentino, E, Furlanetto, N, Bordin, M, Martinuzzi, A, Buffoni, M, Boldrini, P, and Semerjian, M

Subjects
Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Propensity score, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Disorders of consciousness, Severity of Illness Index, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, Clinical Protocols, Severity of illness, medicine, Humans, Longitudinal Studies, Aged, Vegetative state, Rehabilitation, business.industry, Minimally conscious state, Recovery of Function, Disability Rating Scale, Middle Aged, medicine.disease, Treatment Outcome, Italy, Propensity score matching, Physical therapy, Consciousness Disorders, Female, Observational study, 0305 other medical science, business, 030217 neurology & neurosurgery
Abstract

To evaluate the effects of rehabilitation (physical and cognitive) treatments on the diagnosis severity and Disability Rating Scale (DRS) scores, adjusted for a number of potential confounders measured at baseline, in a large cohort of patients with disorders of consciousness across time.An observational, longitudinal (2 evaluations), multicenter project was made in 90 Italian centers.Patients (N=364) with a diagnosis of disorders of consciousness.Primary outcome was the severity of diagnosis, expressed on an ordinal scale (OtherMCSVSdeath). In the Other group were included patients who emerged from an MCS and recovered consciousness. The secondary outcome was the DRS score (range of 0-30 with 30 being the worst value). The DRS is a tool used to define the level of residual disability, commonly used to classify the level of functional impairment in patients with acquired brain injury. Both outcomes were measured for each wave.A total of 364 subjects having a complete set of demographic, clinical, and pharmacologic data were included in the propensity score (PS) analysis. Results showed that the rehabilitation treatments (physical and cognitive) reduced the clinical worsening over time in both severity diagnosis and DRS (around 6.5 points) in patients with disorders of consciousness across different propensity score strategies (ie, PS matching, PS adjustment, and PS-weighted procedures). In addition, cognitive protocols seem to be limited to patients with a median value of DRS=23.Our propensity score analysis suggests that rehabilitation treatment protocols seem effective and should be applied to a broader spectrum of patients with disorders of consciousness.

Published
2020

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