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Introduction Studies have shown the importance of psychosocial risks for physical and mental health particularly in the medical sector and among hospital workers. Objective The main goal of our study is to measure the magnitude of the six dimensions of the psychosocial work environment in a French hospital. The second goal is to highlight from the six dimensions, which are the most important ones for the hospital workers in order to propose specific actions of improvement of the well-being at work and prevention of social risks. Method Our sample is composed of 1139 hospital workers. (1) A 24-item scale was created, based on the six dimensions identified by the DARES study. This scale allows measuring the degree of psychosocial risk and of well-being at work. (2) Social representations are measured by a free association task based on the target expression: well-being at work in the hospital . (3) Participants also answered an open-ended question, on how to improve well-being at work in the hospital; answers were analyzed by a hierarchical classification. Results Four of the six dimensions extracted from the factorial analysis are equal to those identified by the DARES’ report: Work demand, Emotional demands, Relationships at work and Job insecurity. Quantitative analyses show that, for hospital workers, the level of risk is the highest on the first two. The social representation of well-being at work in the hospital , and the discourse analysis indicate that the dimension which is the most important for the hospital workers is Relationships at work. Conclusion In this study, the use of both quantitative and qualitative assessments allows having some elements to analyze the quality of working conditions in the hospital. Moreover, reducing the level of psychosocial risk has a positive effect on workers’ satisfaction, well-being and health.