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33 results on '"Rosa, Stefano"'

1. Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule

Author

Ben Nasr, Moufida, primary, Usuelli, Vera, additional, Dellepiane, Sergio, additional, Seelam, Andy Joe, additional, Fiorentino, Teresa Vanessa, additional, D’Addio, Francesca, additional, Fiorina, Emma, additional, Xu, Cong, additional, Xie, Yanan, additional, Balasubramanian, Hari Baskar, additional, Castillo-Leon, Eduardo, additional, Loreggian, Lara, additional, Maestroni, Anna, additional, Assi, Emma, additional, Loretelli, Cristian, additional, Abdelsalam, Ahmed, additional, El Essawy, Basset, additional, Uccella, Silvia, additional, Pastore, Ida, additional, Lunati, Maria Elena, additional, Sabiu, Gianmarco, additional, Petrazzuolo, Adriana, additional, Ducci, Giacomo, additional, Sacco, Elena, additional, Centofanti, Lucia, additional, Venturini, Massimo, additional, Mazzucchelli, Serena, additional, Mattinzoli, Deborah, additional, Ikehata, Masami, additional, Castellano, Giuseppe, additional, Visner, Gary, additional, Kaifeng, Liu, additional, Lee, Kang Mi, additional, Wang, Zhimin, additional, Corradi, Domenico, additional, La Rosa, Stefano, additional, Danese, Silvio, additional, Yang, Jun, additional, Markmann, James F., additional, Zuccotti, Gian Vincenzo, additional, Abdi, Reza, additional, Folli, Franco, additional, and Fiorina, Paolo, additional

Published
2024
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3. Hemicolectomy versus appendectomy for patients with appendiceal neuroendocrine tumours 1–2 cm in size: a retrospective, Europe-wide, pooled cohort study

Author

Nesti, Cédric, primary, Bräutigam, Konstantin, additional, Benavent, Marta, additional, Bernal, Laura, additional, Boharoon, Hessa, additional, Botling, Johan, additional, Bouroumeau, Antonin, additional, Brcic, Iva, additional, Brunner, Maximilian, additional, Cadiot, Guillaume, additional, Camara, Maria, additional, Christ, Emanuel, additional, Clerici, Thomas, additional, Clift, Ashley K, additional, Clouston, Hamish, additional, Cobianchi, Lorenzo, additional, Ćwikła, Jarosław B, additional, Daskalakis, Kosmas, additional, Frilling, Andrea, additional, Garcia-Carbonero, Rocio, additional, Grozinsky-Glasberg, Simona, additional, Hernando, Jorge, additional, Hervieu, Valérie, additional, Hofland, Johannes, additional, Holmager, Pernille, additional, Inzani, Frediano, additional, Jann, Henning, additional, Jimenez-Fonseca, Paula, additional, Kaçmaz, Enes, additional, Kaemmerer, Daniel, additional, Kaltsas, Gregory, additional, Klimacek, Branislav, additional, Knigge, Ulrich, additional, Kolasińska-Ćwikła, Agnieszka, additional, Kolb, Walter, additional, Kos-Kudła, Beata, additional, Kunze, Catarina Alisa, additional, Landolfi, Stefania, additional, La Rosa, Stefano, additional, López, Carlos López, additional, Lorenz, Kerstin, additional, Matter, Maurice, additional, Mazal, Peter, additional, Mestre-Alagarda, Claudia, additional, del Burgo, Patricia Morales, additional, van Dijkum, Els J M Nieveen, additional, Oleinikov, Kira, additional, Orci, Lorenzo A, additional, Panzuto, Francesco, additional, Pavel, Marianne, additional, Perrier, Marine, additional, Reims, Henrik Mikael, additional, Rindi, Guido, additional, Rinke, Anja, additional, Rinzivillo, Maria, additional, Sagaert, Xavier, additional, Satiroglu, Ilker, additional, Selberherr, Andreas, additional, Siebenhüner, Alexander R, additional, Tesselaar, Margot E T, additional, Thalhammer, Michael J, additional, Thiis-Evensen, Espen, additional, Toumpanakis, Christos, additional, Vandamme, Timon, additional, van den Berg, José G, additional, Vanoli, Alessandro, additional, van Velthuysen, Marie-Louise F, additional, Verslype, Chris, additional, Vorburger, Stephan A, additional, Lugli, Alessandro, additional, Ramage, John, additional, Zwahlen, Marcel, additional, Perren, Aurel, additional, and Kaderli, Reto M, additional

Published
2023
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4. GLP1R Strives T Cell Negative Costimulation Through a rRNA Gene Repressor Interactome

Author

Ben Nasr, Moufida, primary, Usuelli, Vera, additional, Dellepiane, Sergio, additional, Seelam, Andy Joe, additional, Fiorentino, Teresa Vanessa, additional, D’Addio, Francesca, additional, Fiorina, Emma, additional, Xu, Cong, additional, Xie, Yanan, additional, Balasubramanian, Hari Baskar, additional, Castillo-Leon, Eduardo, additional, Loreggian, Lara, additional, Maestroni, Anna, additional, Assi, Emma, additional, Loretelli, Cristian, additional, Abdelsalem, Ahmed, additional, El Essawy, Basset, additional, Uccella, Silvia, additional, Pastore, Ida, additional, Lunati, Maria Elena, additional, Sabiu, Gianmarco, additional, Petrazzuolo, Adriana, additional, Ducci, Giacomo, additional, Sacco, Elena, additional, Centofanti, Lucia, additional, Venturini, Massimo, additional, Mazzucchelli, Serena, additional, Mattinzoli, Deborah, additional, Ikehata, Masami, additional, Castellano, Giuseppe, additional, Visner, Gary, additional, Kaifeng, Liu, additional, Lee, Kang Mi, additional, Wang, Zhimin, additional, Corradi, Domenico, additional, La Rosa, Stefano, additional, Yang, Jun, additional, Markmann, James F., additional, Zuccotti, Gian Vincenzo, additional, Abdi, Reza, additional, Folli, Franco, additional, and Fiorina, Paolo, additional

Published
2023
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7. PAX8–GLIS3 gene fusion is a pathognomonic genetic alteration of hyalinizing trabecular tumors of the thyroid

Author

Marchiò, Caterina, primary, Da Cruz Paula, Arnaud, additional, Gularte-Merida, Rodrigo, additional, Basili, Thais, additional, Brandes, Alissa, additional, da Silva, Edaise M., additional, Silveira, Catarina, additional, Ferrando, Lorenzo, additional, Metovic, Jasna, additional, Maletta, Francesca, additional, Annaratone, Laura, additional, Pareja, Fresia, additional, Rubin, Brian P., additional, Hoschar, Aaron P., additional, De Rosa, Giovanni, additional, La Rosa, Stefano, additional, Bongiovanni, Massimo, additional, Purgina, Bibianna, additional, Piana, Simonetta, additional, Volante, Marco, additional, Weigelt, Britta, additional, Reis-Filho, Jorge S., additional, and Papotti, Mauro, additional

Published
2019
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8. PD-1 (PDCD1) promoter methylation in Merkel cell carcinoma: prognostic relevance and relationship with clinico-pathological parameters

Author

Ricci, Costantino, primary, Morandi, Luca, additional, Righi, Alberto, additional, Gibertoni, Dino, additional, Maletta, Francesca, additional, Ambrosi, Francesca, additional, Agostinelli, Claudio, additional, Uccella, Silvia, additional, Asioli, Silvia, additional, Sessa, Fausto, additional, Pellilli, Maria, additional, Maragliano, Roberta, additional, La Rosa, Stefano, additional, Papotti, Mauro Giulio, additional, and Asioli, Sofia, additional

Published
2019
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9. Angiosarcoma and anaplastic carcinoma of the thyroid are two distinct entities: a morphologic, immunohistochemical, and genetic study

Author

Kuhn, Elisabetta, primary, Ragazzi, Moira, additional, Ciarrocchi, Alessia, additional, Torricelli, Federica, additional, de Biase, Dario, additional, Zanetti, Eleonora, additional, Bisagni, Alessandra, additional, Corrado, Stefania, additional, Uccella, Silvia, additional, La Rosa, Stefano, additional, Bongiovanni, Massimo, additional, Losito, Simona, additional, and Piana, Simonetta, additional

Published
2019
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12. New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1α

Author

Uccella, Silvia, primary, La Rosa, Stefano, additional, Scaldaferri, Debora, additional, Monti, Laura, additional, Maragliano, Roberta, additional, Sorrenti, Elisa, additional, Gariboldi, Marzia, additional, Taramelli, Roberto, additional, Sessa, Fausto, additional, and Acquati, Francesco, additional

Published
2018
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13. Frequent expression of somatostatin receptor 2a in olfactory neuroblastomas: a new and distinctive feature

Author

Czapiewski, Piotr, primary, Kunc, Michał, additional, Gorczyński, Adam, additional, Haybaeck, Johannes, additional, Okoń, Krzysztof, additional, Reszec, Joanna, additional, Lewczuk, Anna, additional, Dzierzanowski, Jaroslaw, additional, Karczewska, Joanna, additional, Biernat, Wojciech, additional, Turri-Zanoni, Mario, additional, Castelnuovo, Paolo, additional, Taverna, Cecilia, additional, Franchi, Alessandro, additional, La Rosa, Stefano, additional, Sessa, Fausto, additional, and Klöppel, Günter, additional

Published
2018
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14. The number of positive nodes accurately predicts recurrence after pancreaticoduodenectomy for nonfunctioning neuroendocrine neoplasms

Author

Andreasi, Valentina, primary, Partelli, Stefano, additional, Javed, Ammar A., additional, He, Jin, additional, Muffatti, Francesca, additional, Weiss, Matthew J., additional, Giannone, Fabio, additional, Sessa, Fausto, additional, La Rosa, Stefano, additional, Doglioni, Claudio, additional, Zamboni, Giuseppe, additional, Wolfgang, Christopher L., additional, and Falconi, Massimo, additional

Published
2018
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15. The number of positive nodes accurately predicts recurrence after pancreaticoduodenectomy for nonfunctioning neuroendocrine neoplasms

Author

Partelli, Stefano, primary, Javed, Ammar A., additional, Andreasi, Valentina, additional, He, Jin, additional, Muffatti, Francesca, additional, Weiss, Matthew J., additional, Sessa, Fausto, additional, La Rosa, Stefano, additional, Doglioni, Claudio, additional, Zamboni, Giuseppe, additional, Wolfgang, Christopher L., additional, and Falconi, Massimo, additional

Published
2018
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16. Combined adenocarcinoma–atypical carcinoid of the lung. Targeted Next-Generation Sequencing (NGS) suggests a monoclonal origin of the two components

Author

La Rosa, Stefano, primary, Simbolo, Michele, additional, Franzi, Francesca, additional, Uccella, Silvia, additional, Imperatori, Andrea, additional, Nardecchia, Elisa, additional, Rotolo, Nicola, additional, Dominioni, Lorenzo, additional, Scarpa, Aldo, additional, and Sessa, Fausto, additional

Published
2018
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17. The clinicopathological spectrum of olfactory neuroblastoma and sinonasal neuroendocrine neoplasms: Refinements in diagnostic criteria and impact of multimodal treatments on survival

Author

Turri-Zanoni, Mario, primary, Maragliano, Roberta, additional, Battaglia, Paolo, additional, Giovannardi, Marta, additional, Antognoni, Paolo, additional, Lombardi, Davide, additional, Morassi, Maria Laura, additional, Pasquini, Ernesto, additional, Tarchini, Paolo, additional, Asioli, Sofia, additional, Foschini, Maria Pia, additional, Sessa, Fausto, additional, Nicolai, Piero, additional, Castelnuovo, Paolo, additional, and La Rosa, Stefano, additional

Published
2017
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18. Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: Correlation with microvessel density and clinicopathologic features

Author

LA ROSA, S, Uccella, Silvia, Finzi, G, Albarello, L, Sessa, Fausto, Capella, CARLO RENATO, and LA ROSA, Stefano

Subjects
Adult, Male, Vascular Endothelial Growth Factor A, Pathology, medicine.medical_specialty, Adolescent, Angiogenesis, medicine.medical_treatment, Enteroendocrine cell, Endothelial Growth Factors, Biology, Digestive System Neoplasms, Pathology and Forensic Medicine, Immunoenzyme Techniques, chemistry.chemical_compound, Endocrine Glands, Endocrine Gland Neoplasms, Biomarkers, Tumor, medicine, Humans, Cellular localization, Aged, Aged, 80 and over, Lymphokines, Vascular Endothelial Growth Factor Receptor-1, Neovascularization, Pathologic, Vascular Endothelial Growth Factors, Microcirculation, Middle Aged, Vascular Endothelial Growth Factor Receptor-2, Vascular endothelial growth factor, Cytokine, chemistry, Tumor progression, Endocrine neoplasm, cardiovascular system, Intercellular Signaling Peptides and Proteins, Immunohistochemistry, Female
Abstract

Angiogenesis, a process related to tumor growth and malignancy, is stimulated by several growth factors. Among these is vascular endothelial growth factor (VEGF), which acts on endothelial cells by binding with 2 specific receptors, VEGFR1 and VEGFR2. Recent studies have demonstrated that VEGF expression is correlated with microvessel density (MVD) and tumor progression. Digestive endocrine tumors are heterogeneous neoplasms exhibiting variable biological aggressiveness and behavior that often are not predictable on morphologic grounds alone. The aims of this study were to evaluate the expression of VEGF, VEGFR1, and VEGFR2 in digestive endocrine tumors and to examine its correlation with MVD and malignancy. A total of 84 specimens from endocrine neoplasms and normal gut and pancreatic tissue were immunohistochemically studied using specific antibodies directed against VEGF, VEGFR1, VEGFR2, endothelial antigens, and gastroenteropancreatic hormones. Ultrastructural immunocytochemistry was performed to identify the cellular localization of VEGF and the VEGFRs. In normal tissues, VEGF immunoreactivity was detected in G cells and PP cells. Ultrastructurally, VEGF was localized within secretory granules. The VEGFRs were not significantly expressed by normal endocrine cells. VEGF-immunoreactive (IR) cells were detected in 40 of 83 tumors, mainly G cell and enterochromaffin cell neoplasms. VEGFR1-IR cells were found in 44 of 82 tumors, and VEGFR2-IR cells were found in 55 of 82 tumors, with no predilection for any specific tumor type. The expression of VEGF and its receptors did not correlate with MVD or malignancy. These results suggest that in normal tissues, endothelial functions may be regulated by VEGF produced by some endocrine cells and that a VEGF/VEGFR binding mechanism may be involved in tumorigenesis, but not in tumor progression and aggressiveness. HUM PATHOL 34:18-27. Copyright 2003, Elsevier Science (USA). All rights reserved.

Published
2003

19. Malignant ectomesenchymoma of the nasal cavity

Author

Cergnul, M., La Rosa, S., Bandera, M., Battaglia, Paolo, Bignami, Maurizio, Castelnuovo, PAOLO GIOCONDO MARIA, Capella, CARLO RENATO, Pinotti, G., and LA ROSA, Stefano

Subjects
Male, Nasal cavity, Pathology, medicine.medical_specialty, Nose Neoplasms, Mucous membrane of nose, Desmin, Diagnosis, Differential, Biopsy, Nasal septum, medicine, Carcinoma, Humans, Mesenchymoma, Rhabdomyosarcoma, rhinorrhea, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Immunohistochemistry, Actins, medicine.anatomical_structure, Oncology, Malignant ectomesenchymoma, Keratins, Nasal Cavity, medicine.symptom, business
Abstract

In April, 2004, a 62-year-old man with epistaxis, rhinorrhea, and sensation of nasal obstruction attended an appointment at the ear, nose, and throat department that found a solid mass of the right nasal cavity with no clinical evidence of lymph-node or distant metastases as confi rmed by CT and MRI (fi gure 1A). Biopsy of the mass revealed a proliferation of undiff erentiated cells with scant cytoplasm, hyper chromatic nuclei, and high mitotic rate, which formed infi ltrating nests in the stroma of the nasal mucosa (fi gure 2A). Tumour cells showed immuno reactivity for cytokeratin AE1/AE3, synaptophysin, neuron-specifi c enolase (fi gure 2B), CD56, and p53, but not for CD45. The histological features and the immunophenotype were suggestive of a poorly diff erentiated neuroendocrine small-cell carcinoma of the nasal cavity. The patient underwent somatostatin-receptor scintigraphy, which showed tracer uptake in the nasal region only. Blood concentrations of neuron-specifi c enolase, chromogranin A, carcinoembryonic antigen, and Cyfra 21-1 were unremarkable. The patient was treated with carboplatin (area under curve=6) on day 1 and etoposide (100 mg/m) on days 1–3 for seven cycles from May to October, 2004. In October, 2004, CT and MRI showed partial reduction of the mass (fi gure 1B). The patient sub sequently underwent transcranial-endoscopic endo nasal resection of the neoplasm with partial removal of the ethmoid and inferior conchae, the nasal septum, the fl oor and the lateral walls of the right nasal cavity, and the right maxillary sinus. Histologically, the tumour showed two main components. The predominant component was represented by clusters of mature synaptophysin and CD56-positive ganglion cells dispersed in a schwannianlike glial fi brillary acidic protein (GFAP)-positive background (fi gure 2C). Ganglion cells also stained positively for somatostain-receptor 2A (fi gure 2D). The second component was characterised by a proliferation of malignant cells, with abundant eosinophilic cytoplasm strongly positive for actin and desmin (fi gures 2E and 2F). This component was consistent with a rhabdomyosarcoma. The proliferation of undiff erentiated cells seen in the nasal biopsy done during the fi rst clinical investigation was not clearly identifi ed. Only scattered malignant cells that were immunoreactive for cytokeratin AE1/AE3 were seen in the surgically resected tumour tissue. The occurrence of a rhabdomyosarcoma associated with ganglio neuromatous and undiff erentiated components led us to diagnose a malignant ectomesenchymoma. Postsurgical adjuvant treatment with concurrent chemotherapy (weekly cisplatin [45 mg total] and radiotherapy [50 Gy total]) to the right nasal cavity was given from March to April, 2005. The patient was still alive at last follow-up in September, 2006, and had complete remission of the tumour, which was confi rmed both radiologically (fi gure 1C) and histologically. Malignant ectomesenchymoma is a rare multiphenotypic soft-tissue tumour with both mesenchymal and neuroectodermal components. It is believed to arise from pluripotential migratory neural crest cells (ectomesenchym) that can diff erentiate into neuroectodermal and mesenchymal tissues. The mesenchymal component usually consists of rhabdomyoblastic elements, although other malignant mesenchymal components have also been described. Neuroectodermal elements are mainly represented by ganglion cells and neuroma-like structures. About 50 cases have been reported in studies published in English. This neoplasm most frequently aff ects children, although a few cases in Lancet Oncol 2007; 8: 358–60

Published
2007

20. Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy

Author

D’Addio, Francesca, primary, La Rosa, Stefano, additional, Maestroni, Anna, additional, Jung, Peter, additional, Orsenigo, Elena, additional, Ben Nasr, Moufida, additional, Tezza, Sara, additional, Bassi, Roberto, additional, Finzi, Giovanna, additional, Marando, Alessandro, additional, Vergani, Andrea, additional, Frego, Roberto, additional, Albarello, Luca, additional, Andolfo, Annapaola, additional, Manuguerra, Roberta, additional, Viale, Edi, additional, Staudacher, Carlo, additional, Corradi, Domenico, additional, Batlle, Eduard, additional, Breault, David, additional, Secchi, Antonio, additional, Folli, Franco, additional, and Fiorina, Paolo, additional

Published
2015
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21. Chronic Continuous Exenatide Infusion Does Not Cause Pancreatic Inflammation and Ductal Hyperplasia in Non-Human Primates

Author

Fiorentino, Teresa Vanessa, primary, Owston, Michael, additional, Abrahamian, Gregory, additional, La Rosa, Stefano, additional, Marando, Alessandro, additional, Perego, Carla, additional, Di Cairano, Eliana S., additional, Finzi, Giovanna, additional, Capella, Carlo, additional, Sessa, Fausto, additional, Casiraghi, Francesca, additional, Paez, Ana, additional, Adivi, Ashwin, additional, Davalli, Alberto, additional, Fiorina, Paolo, additional, Guardado Mendoza, Rodolfo, additional, Comuzzie, Anthony G., additional, Sharp, Mark, additional, DeFronzo, Ralph A., additional, Halff, Glenn, additional, Dick, Edward J., additional, and Folli, Franco, additional

Published
2015
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23. Histologic changes in type A chronic atrophic gastritis indicating increased risk of neuroendocrine tumor development: the predictive role of dysplastic and severely hyperplastic enterochromaffin-like cell lesions

Author

Vanoli, Alessandro, primary, La Rosa, Stefano, additional, Luinetti, Ombretta, additional, Klersy, Catherine, additional, Manca, Rachele, additional, Alvisi, Costanza, additional, Rossi, Sandro, additional, Trespi, Erminio, additional, Zangrandi, Adriano, additional, Sessa, Fausto, additional, Capella, Carlo, additional, and Solcia, Enrico, additional

Published
2013
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26. The Glial Glutamate Transporter 1 (GLT1) Is Expressed by Pancreatic β-Cells and Prevents Glutamate-induced β-Cell Death

Author

Di Cairano, Eliana S., primary, Davalli, Alberto M., additional, Perego, Lucia, additional, Sala, Silvia, additional, Sacchi, V. Franca, additional, La Rosa, Stefano, additional, Finzi, Giovanna, additional, Placidi, Claudia, additional, Capella, Carlo, additional, Conti, Paola, additional, Centonze, Victoria E., additional, Casiraghi, Francesca, additional, Bertuzzi, Federico, additional, Folli, Franco, additional, and Perego, Carla, additional

Published
2011
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29. Neuroendocrine carcinomas of the breast

Author

Rovera, Francesca, primary, Masciocchi, Patrizia, additional, Coglitore, Alessandra, additional, La Rosa, Stefano, additional, Dionigi, Gianlorenzo, additional, Marelli, Marina, additional, Boni, Luigi, additional, and Dionigi, Renzo, additional

Published
2008
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30. Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy

Author

Volante, Marco, primary, Brizzi, Maria Pia, additional, Faggiano, Antongiulio, additional, Rosa, Stefano La, additional, Rapa, Ida, additional, Ferrero, Anna, additional, Mansueto, Gelsomina, additional, Righi, Luisella, additional, Garancini, Silvana, additional, Capella, Carlo, additional, De Rosa, Gaetano, additional, Dogliotti, Luigi, additional, Colao, Annamaria, additional, and Papotti, Mauro, additional

Published
2007
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33. Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors

Author

Catherine Klersy, Silvia Uccella, Enrico Solcia, Angelica Sonzogni, Claudio Doglioni, Carlo Capella, Stefano La Rosa, Linda Dainese, Luca Albarello, La Rosa, Stefano, Klersy, Catherine, Uccella, Silvia, Dainese, Linda, Albarello, Luca, Sonzogni, Angelica, Doglioni, Claudio, Capella, Carlo, and Solcia, Enrico

Subjects
medicine.medical_specialty, Pathology, Pancreatic disease, TNM staging system, Malignancy, Pathology and Forensic Medicine, Necrosis, Pancreatic tumor, Biomarkers, Tumor, Mitotic Index, medicine, Humans, Endocrine system, Neoplasm Invasiveness, Neoplasm Staging, Retrospective Studies, business.industry, Cancer, Anatomical pathology, Adenoma, Islet Cell, Prognosis, medicine.disease, Tumor Burden, Pancreatic Neoplasms, Survival Rate, Ki-67 Antigen, medicine.anatomical_structure, Carcinoma, Islet Cell, Insulinoma, Neoplasm Recurrence, Local, business, Pancreas, Carcinoma, Pancreatic Ductal
Abstract

Currently used histopathologic criteria for the diagnosis of pancreatic endocrine tumors are still under discussion as far as to their capacity to identify prognostically different tumor subsets, which are potentially helpful for patient management. A recently developed TNM staging system and a variety of proposed histologic and clinicopathologic parameters still need to be fully validated. One hundred fifty-five pancreatic endocrine tumors encompassing all the main histologic types and stages, operated with intention to cure and then followed tip for a median 126 months, were carefully investigated histologically to identify prognostically informative parameters at univariable, bivariable, and multivariable analysis. Ki67 index, mitotic rate, neuroinvasion with or without vascular, peritumoral or stromal infiltrative patterns, as well as tumor size, and association with endocrine syndromes other than insulinoma proved effective in predicting recurrence and disease-specific death among well-differentiated tumors. Poorly differentiated histologic features, more than 10 mitoses/10 high power fields, and necrosis were helpful in the identification of high-grade cancers with an invariably poor prognosis. The TNM system proved to be highly predictive of patient outcome and easy to combine with histologic and clinicopathologic parameters to classify pancreatic endocrine tumors into groups of increasing malignant potential. (c) 2009 Elsevier Inc. All rights reserved.

Published
2009

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