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36 results on '"Rossini G."'

3. 439 Cystic fibrosis transmembrane conductance regulator impairment strongly decreases SARS-CoV-2 replication in human bronchial epithelial cells

Author

Sorio, C., primary, Lotti, V., additional, Merigo, F., additional, Lagni, A., additional, Di Clemente, A., additional, Ligozzi, M., additional, Bernardi, P., additional, Rossini, G., additional, Concia, E., additional, Plebani, R., additional, Romano, M., additional, Sbarbati, A., additional, and Gibellini, D., additional

Published
2022
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8. Characterization of antibody response in neuroinvasive infection caused by Toscana virus

Author

Pierro, A., primary, Ficarelli, S., additional, Ayhan, N., additional, Morini, S., additional, Raumer, L., additional, Bartoletti, M., additional, Mastroianni, A., additional, Prati, F., additional, Schivazappa, S., additional, Cenni, P., additional, Vocale, C., additional, Rossini, G., additional, Gaibani, P., additional, Sambri, V., additional, Landini, M.P., additional, Lewis, R.E., additional, Charrel, R.N., additional, and Varani, S., additional

Published
2017
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20. Imported cases of dengue virus infection: Emilia-Romagna, Italy, 2010

Author

Pierro, A., primary, Varani, S., additional, Rossini, G., additional, Gaibani, P., additional, Cavrini, F., additional, Finarelli, A.C., additional, Macini, P., additional, Cagarelli, R., additional, Mattivi, A., additional, Angelini, P., additional, Landini, M.P., additional, and Sambri, V., additional

Published
2011
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33. Respiratory bacterial co-infections in intensive care unit-hospitalized COVID-19 patients: Conventional culture vs BioFire FilmArray pneumonia Plus panel

Author

Tiziana Lazzarotto, Andrea Liberatore, Anna Zignoli, Caterina Vocale, Gabriele Turello, Simone Ambretti, Silvia Lafratta, Paolo Gaibani, Claudio Foschi, Giada Rossini, Foschi C., Zignoli A., Gaibani P., Vocale C., Rossini G., Lafratta S., Liberatore A., Turello G., Lazzarotto T., and Ambretti S.

Subjects
Adult, Microbiology (medical), medicine.medical_specialty, Microbiological culture, FilmArray, medicine.drug_class, Antibiotics, Coinfections, medicine.disease_cause, Sensitivity and Specificity, Microbiology, Article, 03 medical and health sciences, Respiratory infection, Internal medicine, Intensive care, medicine, Humans, Respiratory Tract Infections, Molecular Biology, Retrospective Studies, 030304 developmental biology, 0303 health sciences, Bacteria, biology, Respiratory tract infections, Coinfection, SARS-CoV-2, 030306 microbiology, business.industry, Respiratory infections, COVID-19, biology.organism_classification, medicine.disease, Bacterial Typing Techniques, Intensive Care Units, Stenotrophomonas maltophilia, Pneumonia, medicine.anatomical_structure, Staphylococcus aureus, business, Multiplex Polymerase Chain Reaction, Respiratory tract
Abstract

The prevalence and microbiology of concomitant respiratory bacterial infections in patients with SARS-CoV-2 infection are not yet fully understood. In this retrospective study, we assessed respiratory bacterial co-infections in lower respiratory tract samples taken from intensive care unit-hospitalized COVID-19 patients, by comparing the conventional culture approach to an innovative molecular diagnostic technology. A total of 230 lower respiratory tract samples (i.e., bronchial aspirates or bronchoalveolar lavages) were taken from 178 critically ill COVID-19 patients. Each sample was processed by a semi-quantitative culture and by a multiplex PCR panel (FilmArray Pneumonia Plus panel), allowing rapid detection of a wide range of clinically relevant pathogens and a limited number of antimicrobial resistance markers. More than 30% of samples showed a positive bacterial culture, with Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus the most detected pathogens. FilmArray showed an overall sensitivity and specificity of 89.6% and 98.3%, respectively, with a negative predictive value of 99.7%. The molecular test significantly reduced the turn-around-time (TAT) and increased the rates of microbial detection. Most cases missed by culture were characterized by low bacterial loads (104–105 copies/mL). FilmArray missed a list of pathogens not included in the molecular panel, especially Stenotrophomonas maltophilia (8 cases). FilmArray can be useful to detect bacterial pathogens in lower respiratory tract specimens of COVID-19 patients, with a significant decrease of TAT. The test is particularly useful to rule out bacterial co-infections and avoid the inappropriate prescription of antibiotics.

Published
2021
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34. Imported cases of dengue virus infection: Emilia-Romagna, Italy, 2010

Author

Anna Pierro, Vittorio Sambri, Paolo Gaibani, A. Mattivi, Giada Rossini, Stefania Varani, A C Finarelli, R. Cagarelli, Francesca Cavrini, Paola Angelini, P Macini, Maria Paola Landini, Pierro A., Varani S., Rossini G., Gaibani P., Cavrini F., Finarelli A.C., Macini P., Cagarelli R., Mattivi A., Angelini P., Landini M.P., and Sambri V.

Subjects
Adult, Male, Microbiology (medical), Veterinary medicine, Aedes albopictus, Adolescent, viruses, Viral Nonstructural Proteins, Dengue virus, Antibodies, Viral, Real-Time Polymerase Chain Reaction, medicine.disease_cause, Dengue fever, Dengue, Chlorocebus aethiops, medicine, Dengue transmission, Animals, Humans, Child, Vero Cells, imported cases, laboratory diagnosis, vector-borne, Arbovirus, Travel, Denv serotypes, biology, virus diseases, Outbreak, General Medicine, Middle Aged, biochemical phenomena, metabolism, and nutrition, Serum samples, biology.organism_classification, medicine.disease, Virology, Infectious Diseases, Italy, Population Surveillance, surveillance, RNA, Viral, Female, Diagnosi
Abstract

Dengue is a significant mosquito-borne infection in humans, and its worldwide prevalence is rapidly increasing. In 2010, 83 serum samples from febrile travellers returning from dengue-endemic countries to a region in north-eastern Italy, densely infested with Aedes albopictus, were analysed for dengue virus (DENV). DENV RNA was detected in 20.5% of patients. By RT-PCR, DENV serotypes 1 and 3 were the most common. DENV must be identified early in symptomatic travellers returning from high-risk countries, to prevent outbreaks where potential vectors exist.

Published
2011
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35. Monitoring for human cytomegalovirus infection in solid organ transplant recipients through antigenemia and glycoprotein N (gN) variants: evidence of correlation and potential prognostic value of gN genotypes

Author

Sara Pignatelli, Paola Dal Monte, Maria Paola Landini, Daria Camozzi, Maria Rosaria Gatto, Liliana Gabrielli, Tiziana Lazzarotto, Giada Rossini, Rossini G, Pignatelli S, Dal Monte P, Camozzi D, Lazzarotto T, Gabrielli L, Gatto MR, and Landini MP.

Subjects
Adult, Male, Human cytomegalovirus, Genotype, UL73, Immunology, medicine.disease_cause, Immunofluorescence, Microbiology, Herpesviridae, Virus, Pathogenesis, Viral Envelope Proteins, Betaherpesvirinae, SOLID TRANSPLANT, medicine, Humans, Antigens, Viral, Aged, biology, medicine.diagnostic_test, virus diseases, Organ Transplantation, Middle Aged, GENOTYPES, Prognosis, biology.organism_classification, medicine.disease, Virology, HUMAN CYTOMEGALOVIRUS, Infectious Diseases, ANTIGENEMIA, Cytomegalovirus Infections, Female, Viral disease
Abstract

Human cytomegalovirus (HCMV) ORF UL73 encodes the envelope glycoprotein gpUL73-gN, which shows seven genotypes (gN-1, gN-2, gN-3a, gN-3b, gN-4a, gN-4b, gN-4c). The goal of this study was to determine retrospectively the distribution of gN variants in solid organ transplant recipients with HCMV infection and to establish an association with parameters important for monitoring post-transplantation clinical course during a follow-up of up to 2 years. Peripheral blood leukocytes from 40 solid organ transplant recipients were analysed for pp65-antigen by immunofluorescence and gN genotyped by sequencing or RFLP analysis. A correlation between gN genotypes and antigenemia peak was found, showing a highly significant difference between gN-1 and gN-4b variants (P0.005). In particular, gN-1 seems to be associated with patients developing low level antigenemia (50 pp65-positive cells/2 x 10(5) PBLs; PPV = 90%), whereas gN-4b predicts significantly higher values (50 pp65-positive cells/2 x 10(5) PBLs; PPV = 80%). Furthermore, the onset of positive antigenemia is significantly earlier in patients infected with a gN-4b strain, compared with those infected by a gN-1 variant. Reported data further support a role for gN genotypes in HCMV pathogenesis. gN-1 and gN-4b show a significantly different virulence and could serve as early predictors for the progression of HCMV infection in transplant patients.

Published
2005
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36. Genomic variants among human cytomegalovirus (HCMV) clinical isolates: the glycoprotein n (gN) paradigm

Author

Sara Pignatelli, Paola Dal Monte, Maria Paola Landini, Giada Rossini, Dal Monte P, Pignatelli S, Rossini G, and Landini MP.

Subjects
Human cytomegalovirus, viruses, Immunology, Congenital cytomegalovirus infection, Cytomegalovirus, Biology, Immediate-Early Proteins, Open Reading Frames, Viral Proteins, Gene Frequency, Viral Envelope Proteins, Genotype, medicine, GN-UL73, Humans, Immunology and Allergy, Clinical significance, Genetic variability, Gene, Genetics, chemistry.chemical_classification, Membrane Glycoproteins, Polymorphism, Genetic, Virulence, General Medicine, medicine.disease, Virology, POLYMORPHISM, HUMAN CYTOMEGALOVIRUS, chemistry, Cytomegalovirus Infections, Trans-Activators, Tissue tropism, Glycoprotein
Abstract

Human cytomegalovirus (HCMV) clinical isolates display genetic polymorphisms, which are supposed to be implicated in strain-specific tissue tropism and HCMV-induced immunopathogenesis. One highly variable gene is ORF UL73, encoding for the envelope glycoprotein gN, which displays both a structural and an immunologic role as a component of the high-molecular weight complex gC-II. UL73 showed clustered polymorphisms, which originate four distinct genomic variants, denoted gN-1, gN-2, gN-3, and gN-4. This review reports the main features of gN genotypes and their potential implications on HCMV biologic properties. The clinical impact of gN variants is also discussed. This overview on gN clustered polymorphisms should be useful as a prototype model for a better understanding of the biologic and clinical relevance of HCMV clinical isolates genetic variability.

Published
2004
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