1. Effects of constitutively active IKKβ on cardiac development
- Author
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Sachiko Sugioka, Shinya Ikeda, Masayuki Harada, Masako Kishihata, Isehaq Al-Huseini, Takeshi Kimura, and Noboru Ashida
- Subjects
Mice ,Myocardium ,Bone Morphogenetic Proteins ,NF-kappa B ,Biophysics ,Animals ,Heart ,Cell Biology ,T-Box Domain Proteins ,Molecular Biology ,Biochemistry ,I-kappa B Kinase ,Transcription Factors - Abstract
NF-κB is a major transcription factor regulating cell survival, organ development and inflammation, but its role in cardiac development has been inadequately explored. To examine this function, we generated mice in which IKKβ, an essential kinase for NF-κB activation, was constitutively activated in embryonic cardiomyocytes. For this purpose, we used smooth muscle-22α (SM22α)-Cre mice, which are frequently used for gene recombination in embryonic cardiomyocytes. Embryonic hearts of SM22αCre-CA (constitutively active) IKKβ
- Published
- 2022
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