1. Blood Flow Quantitation by Positron Emission Tomography During Selective Antegrade Cerebral Perfusion
- Author
-
Stefan Thelin, Fredrik Lennmyr, Arvid Morell, Sandeep S.V. Golla, Gunnar Myrdal, Rickard P F Lindblom, Thomas Tovedal, Jens Nørkær Sørensen, Mark Lubberink, Gunnar Antoni, and Sergio Estrada
- Subjects
Pulmonary and Respiratory Medicine ,Swine ,Aorta, Thoracic ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,medicine ,Animals ,Cerebral perfusion pressure ,medicine.diagnostic_test ,business.industry ,Brain ,Reproducibility of Results ,Blood flow ,Aortic surgery ,Perfusion ,Circulatory Arrest, Deep Hypothermia Induced ,Disease Models, Animal ,Glucose ,Regional Blood Flow ,Positron emission tomography ,Cerebrovascular Circulation ,Positron-Emission Tomography ,Circulatory system ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Vascular Surgical Procedures ,030217 neurology & neurosurgery - Abstract
Perfusion strategies during aortic surgery usually comprise hypothermic circulatory arrest (HCA), often combined with selective antegrade cerebral perfusion (SACP) or retrograde cerebral perfusion. Cerebral blood flow (CBF) is a fundamental parameter for which the optimal level has not been clearly defined. We sought to determine the CBF at a pump flow level of 6 mL/kg/min, previously shown likely to provide adequate SACP at 20°C in pigs.Repeated positron emission tomography (PET) scans were used to quantify the CBF and glucose metabolism throughout HCA and SACP including cooling and rewarming. Eight pigs on cardiopulmonary bypass were assigned to either HCA alone (n = 4) or HCA+SACP (n = 4). The CBF was measured by repeated [Cooling to 20°C decreased the cortical CBF from 0.31 ± 0.06 at baseline to 0.10 ± 0.02 mL/cmCooling autoregulated the CBF to 0.10 mL/cm
- Published
- 2017
- Full Text
- View/download PDF