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7,694 results on '"Seth, A."'

7. Angiographic quantification of aortic regurgitation following myval octacor implantation; independent core lab adjudication

Author

Ahmed Elkoumy, John Jose, Sengottuvelu Gunasekaran, Asish Kumar, B.C. Srinivas, C.N. Manjunath, K.S. Ravindranath, Maulik Parekh, Praveen Chandra, Rajneesh Kapoor, Mahmoud Abdelshafy, Ashok Seth, Praveer Agrawal, Atul Mathur, Ravindra Singh Rao, Hesham Elzomor, K.S. Sadanada, Vijay Kumar, Shahram Arsang-Jang, Sanjay Mehrotra, Bagirath Raghuraman, Uday Khanolkar, Rajendra Kumar Premchand, Manik Chopra, Prem Krishna, Haresh Mehta, Rahul Gupta, Viveka Kumar, Nagendra Boopathy Senguttuvan, Andreas Baumbach, Patrick W. Serruys, and Osama Soliman

Subjects
Cardiology and Cardiovascular Medicine
Published
2023

8. Detection of endometrial cancer using tampon-based collection and methylated DNA markers

Author

Jamie N. Bakkum-Gamez, Mark E. Sherman, Seth W. Slettedahl, Douglas W. Mahoney, Maureen A. Lemens, Shannon K. Laughlin-Tommaso, Matthew R. Hopkins, Ann VanOosten, Viji Shridhar, Julie K. Staub, Xiaoming Cao, Patrick H. Foote, Megan A. Clarke, Kelli N. Burger, Calise K. Berger, Maria C. O'Connell, Karen A. Doering, Karl C. Podratz, Christopher C. DeStephano, J. Kenneth Schoolmeester, Sarah E. Kerr, Nicolas Wentzensen, William R. Taylor, and John B. Kisiel

Subjects
Oncology, Obstetrics and Gynecology
Published
2023

11. Poly(ethylene) oxide/erbium oxide as T2 and T1-T2 dual-mode MRI diagnostic nanofibres

Author

Munirah Jamil, Iskandar Shahrim Mustafa, Naser Mahmoud Ahmed, Shahrul Bariyah Sahul Hamid, Thair Hussien Khazaalah, Efenji Godwin, Nabasu Seth Ezra, and Hayder Naeem Salah

Subjects
Process Chemistry and Technology, Materials Chemistry, Ceramics and Composites, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials
Published
2023

12. Clinical Policy: Critical Issues in the Evaluation and Management of Emergency Department Patients With Suspected Appendicitis

Author

Deborah B. Diercks, Eric J. Adkins, Nicholas Harrison, Peter E. Sokolove, Heemun Kwok, Stephen J. Wolf, John D. Anderson, Richard Byyny, Christopher R. Carpenter, Benjamin Friedman, Seth R. Gemme, Charles J. Gerardo, Steven A. Godwin, Sigrid A. Hahn, Benjamin W. Hatten, Jason S. Haukoos, Amy Kaji, Bruce M. Lo, Sharon E. Mace, Maggie Moran, Susan B. Promes, Kaushal H. Shah, Richard D. Shih, Scott M. Silvers, Andrea Slivinski, Michael D. Smith, Molly E.W. Thiessen, Christian A. Tomaszewski, Stacy Trent, Jonathan H. Valente, Stephen P. Wall, Lauren M. Westafer, Yanling Yu, Stephen V. Cantrill, John T. Finnell, Travis Schulz, and Kaeli Vandertulip

Subjects
Emergency Medicine
Published
2023

14. Association of Androgen Deprivation Therapy with Metabolic Disease in Prostate Cancer Patients: An Updated Meta-Analysis

Author

Justin Swaby, Ankita Aggarwal, Akshee Batra, Anubhav Jain, Lakshya Seth, Nickolas Stabellini, Marcio Sommer Bittencourt, Darryl Leong, Zachary Klaassen, Pedro Barata, Nicolas Sayegh, Neeraj Agarwal, Martha Terris, and Avirup Guha

Subjects
Oncology, Urology
Abstract

Androgen deprivation therapy (ADT), a backbone treatment for advanced prostate cancer (PC), is known to have a variety of metabolic side effects. We conducted an updated meta-analysis to quantify the metabolic risks of ADT.We searched PubMed, Web of Science, and Scopus in May of 2022 for studies investigating the risk of metabolic syndrome (MetS), diabetes, and hypertension from ADT in PC patients using keywords. Only full-length studies with a control group of PC patients not on ADT were included. All results compatible with each outcome domain in each included study were sought. For included studies, relative risk (RR) was pooled using a random effects model and a trim-fill approach was used to adjust for publication bias.1,846 records were screened, of which 19 were found suitable for data extraction. Five studies, including 891 patients, were evaluated for MetS as an outcome, with the random effects model showing a pooled RR of 1.60 ([95% Confidence Interval (CI), 1.06-2.42]; P=0.03) for patients on ADT while twelve studies, including 336,330 patients, examined diabetes as an outcome, and the random effects model showed a RR of 1.43 ([95% CI, 1.28-1.59]; P0.01). After adjustment for publication bias, ADT was associated with a 25% increased risk for diabetes but was not associated with MetS. 4 studies, including 7,051 patients, examined hypertension as an outcome, and the random effects model showed a RR of 1.30 ([95% CI, 1.08-1.55]; P=0.18) in ADT patients.In patients with PC, ADT was not associated with MetS and the association with diabetes was not as strong as previously reported. Our novel meta-analysis of hypertension showed that ADT increased the risk of hypertension by 30%. These results should be understood in the context of collaborating care between a patient's oncologist and primary care provider to optimize care.

Published
2023

18. Laser time-transfer facility and preliminary results from the CHOMPTT CubeSat mission

Author

Tyler Ritz, Danielle Coogan, John W. Conklin, Joseph T Coffaro, Paul Serra, Seth Nydam, John Hanson, Anh N. Nguyen, Cedric Priscal, Jan Stupl, and Adam Zufall

Subjects
Atmospheric Science, Geophysics, Space and Planetary Science, Aerospace Engineering, General Earth and Planetary Sciences, Astronomy and Astrophysics
Published
2023

19. Age-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimer's disease

Author

Michael A. Kelberman, Jacki M. Rorabaugh, Claire R. Anderson, Alexia Marriott, Seth D. DePuy, Kurt Rasmussen, Katharine E. McCann, Jay M. Weiss, and David Weinshenker

Subjects
Aging, General Neuroscience, Neurology (clinical), Geriatrics and Gerontology, Developmental Biology
Abstract

Accumulation of hyperphosphorylated tau in the locus coeruleus (LC) is a ubiquitous feature of prodromal Alzheimer’s disease (AD), and LC neurons degenerate as AD progresses. Tau-mediated LC dysfunction may contribute to early neuropsychiatric symptoms, while loss of LC integrity is associated with conversion to cognitive impairment. Hyperphosphorylated tau alters firing rates in other brain regions, but its effects on LC neurons have not been described. The purpose of this study was to characterize changes in firing properties of LC neurons when they are the only cells containing hyperphosphorylated tau, as well as later in disease when β-amyloid (Aβ) and tau pathology is abundant in the forebrain. Single unit LC activity was recorded from anesthetized wild-type (WT) and TgF344-AD rats, which carry the APP/PS1 transgene. Similar to human AD, these rats develop hyperphosphorylated tau in the LC (at 6 months) prior to Aβ or tau pathology in forebrain regions (at 12-15 months). At baseline, LC neurons from TgF344-AD rats were hypoactive at both ages compared to WT littermates, but showed elevated spontaneous bursting properties, particularly in younger animals. Differences in footshock-evoked LC firing depended on age, with 6-month TgF344-AD rats demonstrating aspects of hyperactivity, and aged transgenic rats showing hypoactivity relative to WT. Tau-induced alterations in LC firing rates may contribute to the pathophysiology of AD, with early hyperactivity associated with prodromal symptoms, followed by hypoactivity contributing to cognitive impairment. These results support further investigation into disease stage-dependent noradrenergic interventions for AD.HighlightsRecorded locus coeruleus (LC) neurons in a rat model of Alzheimer’s disease (AD)TgF344-AD rats develop early endogenous LC tau pathology akin to human AD6- and 15-month TgF344-AD rats had reduced tonic LC firingLC neurons from 6-month TgF344-AD rats were hyperactive in response to footshockLC neuron dysfunction may contribute to AD symptoms

Published
2023

22. Real-World Evidence of Neutralizing Monoclonal Antibodies for Preventing Hospitalization and Mortality in COVID-19 Outpatients

Author

Matthew K. Wynia, Laurel E. Beaty, Tellen D. Bennett, Nichole E. Carlson, Christopher B. Davis, Bethany M. Kwan, David A. Mayer, Toan C. Ong, Seth Russell, Jeffrey D. Steele, Heather R. Stocker, Adane F. Wogu, Richard D. Zane, Ronald J. Sokol, and Adit A. Ginde

Subjects
Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine
Abstract

Neutralizing monoclonal antibodies (mAbs) were authorized for the treatment of COVID-19 outpatients based on clinical trials completed early in the pandemic, which were underpowered for mortality and subgroup analyses. Real-world data studies are promising for further assessing rapidly deployed therapeutics.Did mAb treatment prevent progression to severe disease and death across pandemic phases and based on risk factors, including prior vaccination status?This observational cohort study included nonhospitalized adult patients with SARS-CoV-2 infection from November 2020 to October 2021 using electronic health records from a statewide health system plus state-level vaccine and mortality data. Using propensity matching, we selected approximately 2.5 patients not receiving mAbs for each patient who received mAb treatment under emergency use authorization. The primary outcome was 28-day hospitalization; secondary outcomes included mortality and hospitalization severity.Of 36,077 patients with SARS-CoV-2 infection, 2,675 receiving mAbs were matched to 6,677 patients not receiving mAbs. Compared with mAb-untreated patients, mAb-treated patients had lower all-cause hospitalization (4.0% vs 7.7%; adjusted OR, 0.48; 95% CI, 0.38-0.60) and all-cause mortality (0.1% vs 0.9%; adjusted OR, 0.11; 95% CI, 0.03-0.29) to day 28; differences persisted to day 90. Among hospitalized patients, mAb-treated patients had shorter hospital length of stay (5.8 vs 8.5 days) and lower risk of mechanical ventilation (4.6% vs 16.6%). Results were similar for preventing hospitalizations during the Delta variant phase (adjusted OR, 0.35; 95% CI, 0.25-0.50) and across subgroups. Number-needed-to-treat (NNT) to prevent hospitalization was lower for subgroups with higher baseline risk of hospitalization; for example, multiple comorbidities (NNT = 17) and not fully vaccinated (NNT = 24) vs no comorbidities (NNT = 88) and fully vaccinated (NNT = 81).Real-world data revealed a strong association between receipt of mAbs and reduced hospitalization and deaths among COVID-19 outpatients across pandemic phases. Real-world data studies should be used to guide practice and policy decisions, including allocation of scarce resources.

Published
2023

23. Psychobiological Treatment Response to a Two-Week Posttraumatic Stress Disorder and Mild Traumatic Brain Injury Integrated Treatment Program: A Case Report

Author

Katie A. Ragsdale, Anastacia Nichols, Laura E. Watkins, Lauren B. McSweeney, Jessica Maples-Keller, Alexandria Bartlett, Mbapelen H. Unongo, Seth D. Norrholm, Sheila A.M. Rauch, and Barbara O. Rothbaum

Subjects
Rehabilitation, Panic Disorder with Agoraphobia, Traumatic brain injury, medicine.medical_treatment, Panic, medicine.disease, Comorbidity, Clinical Psychology, mental disorders, Concussion, medicine, Anxiety, medicine.symptom, Psychology, Depression (differential diagnoses), Clinical psychology
Abstract

Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) demonstrate high prevalence and comorbidity among post-9/11 veterans. Veterans with this comorbidity often present with multiple co-occurring healthcare needs and increased clinical complexity. The current case report describes the clinical presentation of a veteran with mild TBI and PTSD, both before, during, and after treatment within a multidisciplinary 2-week intensive outpatient program involving prolonged exposure, evidence-based PTSD treatment, and Cognitive Symptom Management and Rehabilitation Therapy, evidence-based treatment for postconcussive symptoms. Mr. A was a 25-year-old White, transgender male who presented with a complex mental health history. At intake, presenting complaints included anxiety, panic attacks, nightmares, and depression secondary to military sexual trauma, as well as reported cognitive difficulties secondary to a concussion. He met current criteria for PTSD as well as panic disorder with agoraphobia. Head injury history consisted of a motor vehicle collision with less than 30 seconds loss of consciousness, brief posttraumatic amnesia, and alterations of consciousness. Mr. A demonstrated habituation during individual exposure sessions as assessed via skin conductance during imaginal exposures and decreased subjective ratings during in vivo exposures, as well as a decrease in trauma-potentiated startle response to trauma cues. Posttreatment data indicates significant reduction in neurobehavioral, posttraumatic stress, and depression symptoms and significant improvement in subjective cognitive functioning. The current findings support the feasibility and efficacy of short-term integrated treatment for complex clinical presentations and the need for larger scale research investigating combined PTSD and TBI intervention.

Published
2023

24. Interferon alfa-2b in patients with low-grade lymphomatoid granulomatosis and chemotherapy with DA-EPOCH-R in patients with high-grade lymphomatoid granulomatosis: an open-label, single-centre, phase 2 trial

Author

Christopher Melani, Kennichi Dowdell, Stefania Pittaluga, Kieron Dunleavy, Mark Roschewski, Joo Y Song, Sara Calattini, Jun-ichi Kawada, David A Price, Pratip K Chattopadhyay, Mario Roederer, Andrea N Lucas, Seth M Steinberg, Elaine S Jaffe, Jeffrey I Cohen, and Wyndham H Wilson

Subjects
Hematology
Published
2023

27. Small babies, big risks: global estimates of prevalence and mortality for vulnerable newborns to accelerate change and improve counting

Author

Joy E Lawn, Eric O Ohuma, Ellen Bradley, Lorena Suárez Idueta, Elizabeth Hazel, Yemisrach B Okwaraji, Daniel J Erchick, Judith Yargawa, Joanne Katz, Anne C C Lee, Mike Diaz, Mihretab Salasibew, Jennifer Requejo, Chika Hayashi, Ann-Beth Moller, Elaine Borghi, Robert E Black, Hannah Blencowe, Per Ashorn, Ulla Ashorn, Nigel Klein, G Justus Hofmeyr, Marleen Temmerman, Sufia Askari, Samuel Chakwera, Laith Hussain-Alkhateeb, Alexandra Lewin, Wahyu Retno Mahanani, Emily White Johansson, Tina Lavin, Diana Estevez Fernandez, Giovanna Gatica Domínguez, Ayesha de Costa, Jenny A Cresswell, Julia Krasevec, Allisyn C Moran, Veronica Pingray, Gabriela Cormick, Luz Gibbons, José Belizan, Carlos Guevel, Kara Warrilow, Adrienne Gordon, Vicki Flenady, Jessica Sexton, Harriet Lawford, Enny S. Paixao, Ila Rocha Falcão, Mauricio Lima Barreto, Sarka Lisonkova, Qi Wen, Francisco Mardones, Raúl Caulier-Cisterna, José Acuña, Petr Velebil, Jitka Jirova, Erzsébet Horváth-Puhó, Henrik Toft Sørensen, Luule Sakkeus, Liili Abuladze, Mika Gissler, Maziar Moradi-Lakeh, Mohammad Heidarzadeh, Narjes Khalili, Khalid A. Yunis, Ayah Al Bizri, Pascale Nakad, Shamala Devi Karalasingam, J Ravichandran R Jeganathan, Nurakman binti Baharum, Lorena Suárez-Idueta, Arturo Barranco Flores, Jesus F Gonzalez Roldan, Sonia Lopez Alvarez, Aimée E. van Dijk, Lisa Broeders, Luis Huicho, Hugo G Quezada Pinedo, Kim N Cajachagua-Torres, Rodrigo M Carrillo-Larco, Carla Estefania Tarazona Meza, Wilmer Cristobal Guzman-Vilca, Tawa O. Olukade, Hamdy A. Ali, Fawziya Alyafei, Mai AlQubaisi, Mohamad R Alturk, Ho Yeon Kim, Geum Joon Cho, Neda Razaz, Jonas Söderling, Lucy K Smith, Jennifer J Kurinczuk, Ruth J Matthews, Bradley N Manktelow, Elizabeth S Draper, Alan C Fenton, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Celina Davis, Samantha Clarke, Lee S.F. Wu, Sachiyo Yoshida, Rajiv Bahl, Carlos Grandi, Alain B Labrique, Mabhubur Rashid, Salahuddin Ahmed, Arunangshu D. Roy, Rezwanul Haque, Saijuddin Shaikh, Abdullah H. Baqui, Samir K. Saha, Rasheda Khanam, Sayedur Rahman, Roger Shapiro, Rebecca Zash, Mariângela F. Silveira, Romina Buffarini, Patrick Kolsteren, Carl Lachat, Lieven Huybregts, Dominique Roberfroid, Lingxia Zeng, Zhonghai Zhu, Jianrong He, Xiu Qui, Seifu H. Gebreyesus, Kokeb Tesfamariam, Delayehu Bekele, Grace Chan, Estifanos Baye, Firehiwot Workneh, Kwaku P. Asante, Ellen Boanmah-Kaali, Seth Adu-Afarwuah, Kathryn G. Dewey, Stephaney Gyaase, Blair J. Wylie, Betty R. Kirkwood, Alexander Manu, Ravilla D Thulasiraj, James Tielsch, Ranadip Chowdhury, Sunita Taneja, Giridhara R Babu, Prafulla Shriyan, Kenneth Maleta, Charles Mangani, Sandra Acevedo-Gallegos, Maria J. Rodriguez-Sibaja, Subarna K. Khatry, Steven C. LeClerq, Luke C. Mullany, Fyezah Jehan, Muhammad Ilyas, Stephen J. Rogerson, Holger W. Unger, Rakesh Ghosh, Sabine Musange, Vundli Ramokolo, Wanga Zembe-Mkabile, Marzia Lazzerini, Rishard Mohamed, Dongqing Wang, Wafaie W. Fawzi, Daniel T.R. Minja, Christentze Schmiegelow, Honorati Masanja, Emily Smith, John P.A. Lusingu, Omari A. Msemo, Fathma M. Kabole, Salim N. Slim, Paniya Keentupthai, Aroonsri Mongkolchati, Richard Kajubi, Abel Kakuru, Peter Waiswa, Dilys Walker, Davidson H. Hamer, Katherine E.A. Semrau, Enesia B. Chaponda, R. Matthew Chico, Bowen Banda, Kebby Musokotwane, Albert Manasyan, Jake M. Pry, Bernard Chasekwa, Jean Humphrey, Abu Ahmed Shamim, Parul Christian, Hasmot Ali, Rolf D.W. Klemm, Alan B. Massie, Maithili Mitra, Sucheta Mehra, Kerry J. Schulze, Abu Amed Shamim, Alfred Sommer, Barkat Ullah, Keith P. West, Nazma Begum, Nabidul Haque Chowdhury, Shafiqul Islam, Dipak Kumar Mitra, Abdul Quaiyum, Modiegi Diseko, Joseph Makhema, Yue Cheng, Yixin Guo, Shanshan Yuan, Meselech Roro, Bilal Shikur, Frederick Goddard, Sebastien Haneuse, Bezawit Hunegnaw, Yemane Berhane, Alemayehu Worku, Seyram Kaali, Charles D. Arnold, Darby Jack, Seeba Amenga-Etego, Lisa Hurt, Caitlin Shannon, Seyi Soremekun, Nita Bhandari, Jose Martines, Sarmila Mazumder, Yamuna Ana, Deepa R, Lotta Hallamaa, Juha Pyykkö, Mario I. Lumbreras-Marquez, Claudia E. Mendoza-Carrera, Atiya Hussain, Muhammad Karim, Farzana Kausar, Usma Mehmood, Naila Nadeem, Muhammad Imran Nisar, Muhammad Sajid, Ivo Mueller, Maria Ome-Kaius, Elizabeth Butrick, Felix Sayinzoga, Ilaria Mariani, Willy Urassa, Thor Theander, Phillippe Deloron, Birgitte Bruun Nielsen, Alfa Muhihi, Ramadhani Abdallah Noor, Ib Bygbjerg, Sofie Lykke Moeller, Fahad Aftab, Said M. Ali, Pratibha Dhingra, Usha Dhingra, Arup Dutta, Sunil Sazawal, Atifa Suleiman, Mohammed Mohammed, Saikat Deb, Moses R. Kamya, Miriam Nakalembe, Jude Mulowooz, Nicole Santos, Godfrey Biemba, Julie M. Herlihy, Reuben K. Mbewe, Fern Mweena, Kojo Yeboah-Antwi, Jane Bruce, Daniel Chandramohan, and Andrew Prendergast

Subjects
General Medicine
Published
2023

28. Clinical Policy: Critical Issues in the Management of Adult Patients Presenting to the Emergency Department With Mild Traumatic Brain Injury

Author

Jonathan H. Valente, John D. Anderson, William F. Paolo, Kelly Sarmiento, Christian A. Tomaszewski, Jason S. Haukoos, Deborah B. Diercks, Richard Byyny, Christopher R. Carpenter, Benjamin Friedman, Seth R. Gemme, Charles J. Gerardo, Steven A. Godwin, Sigrid A. Hahn, Benjamin W. Hatten, Amy Kaji, Heemun Kwok, Bruce M. Lo, Sharon E. Mace, Maggie Moran, Susan B. Promes, Kaushal H. Shah, Richard D. Shih, Scott M. Silvers, Andrea Slivinski, Michael D. Smith, Molly E.W. Thiessen, Stacy Trent, Stephen P. Wall, Lauren M. Westafer, Yanling Yu, Stephen V. Cantrill, John T. Finnell, Travis Schulz, and Kaeli Vandertulip

Subjects
Emergency Medicine
Published
2023

31. Single-cell transcriptome analysis of xenotransplanted human retinal organoids defines two migratory cell populations of nonretinal origin

Author

Ying V. Liu, Clayton P. Santiago, Akin Sogunro, Gregory J. Konar, Ming-wen Hu, Minda M. McNally, Yu-chen Lu, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Kang V. Li, Zhuo-lin Li, Dzhalal Agakishiev, Sarah E. Hadyniak, Katarzyna A. Hussey, Tyler J. Creamer, Linda D. Orzolek, Derek Teng, M. Valeria Canto-Soler, Jiang Qian, Zheng Jiang, Robert J. Johnston, Seth Blackshaw, and Mandeep S. Singh

Subjects
Genetics, Cell Biology, Biochemistry, Developmental Biology
Published
2023

34. Sixth Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report

Author

Iki Adachi, David M. Peng, Seth A. Hollander, Kathleen E. Simpson, Ryan R. Davies, Jeffrey P. Jacobs, Christina J. VanderPluym, Francis Fynn-Thompson, Dennis A. Wells, Sabrina P. Law, Shahnawaz Amdani, Ryan Cantor, Devin Koehl, James K. Kirklin, David L.S. Morales, and Joseph W. Rossano

Subjects
Pulmonary and Respiratory Medicine, Surgery, Cardiology and Cardiovascular Medicine
Abstract

The Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs), supported by the Society of Thoracic Surgeons, provides detailed information on pediatric patients supported with ventricular assist devices (VADs).From September 19, 2012, to December 31, 2021, there were 1,355 devices in 1,109 patients (19 years) from 42 North American Hospitals.Cardiomyopathy was the most common underlying etiology (58%), followed by congenital heart disease (CHD) (26%) and myocarditis (9%). Regarding device type, implantable continuous (IC) VADs were most common at 40%, followed by paracorporeal pulsatile (PP) (28%), and paracorporeal continuous (PC) (27%). Baseline demographics differed, with the PC cohort being younger, smaller, more complex (ie. CHD), and sicker at implant (P.0001). At six months post-VAD implantation, a favorable outcome (transplant, recovery, or alive on device) was achieved in 84% of patients, which was greatest among those on IC VADs (92%) and least for PC VADs (69%). Adverse events (AEs) were not uncommon, with non-gastrointestinal bleeding (incidence of 14%) and neurological dysfunction (11% [Stroke 4%]), within 2 weeks post implant being the most prevalent. Stroke and bleeding had negative impacts on overall survival (p=0.002 and p0.001, respectively).This Sixth Pedimacs Report demonstrates the continued evolution of the pediatric field. The complexity of cardiac physiologies and anatomical constraint mandates the need for multiple types of devices utilized (PC, PP, IC). Detailed analyses of each device type in this report provide valuable information to further advance the care of this challenging and vulnerable population.

Published
2023

38. Transcatheter valve-in-valve or valve-in-ring implantation with a novel balloon-expandable device in patients with bioprosthetic left side heart valves failure: 1-year follow-up from a multicenter experience

Author

Elisabetta Moscarella, Alfonso Ielasi, Abdurashid Mussayev, Matteo Montorfano, Ajit Mullassari, Pedro Martin, Luca Testa, John Jose, Vlasis Ninios, Kostantinos Toutouzas, Francesco Giannini, Attila Kertesz, Daniel Unic, Henrik Nissen, Babu Ezhumalai, Nagendra Boopathy Senguttuvan, Ignacio Amat-Santos, Ashok Seth, Francesco Bedogni, and Maurizio Tespili

Subjects
Cardiology and Cardiovascular Medicine
Published
2023

40. 2023 ACC/AHA/SCAI Advanced Training Statement on Interventional Cardiology (Coronary, Peripheral Vascular, and Structural Heart Interventions)

Author

Theodore A. Bass, J. Dawn Abbott, Ehtisham Mahmud, Sahil A. Parikh, Jamil Aboulhosn, Mahi L. Ashwath, Bryan Baranowski, Lisa Bergersen, Hannah I. Chaudry, Megan Coylewright, Ali E. Denktas, Kamal Gupta, J. Antonio Gutierrez, Jonathan Haft, Beau M. Hawkins, Howard C. Herrmann, Navin K. Kapur, Sena Kilic, John Lesser, C. Huie Lin, Rodrigo Mendirichaga, Vuyisile T. Nkomo, Linda G. Park, Dawn R. Phoubandith, Nishath Quader, Michael W. Rich, Kenneth Rosenfield, Saher S. Sabri, Murray L. Shames, Stanton K. Shernan, Kimberly A. Skelding, Jacqueline Tamis-Holland, Vinod H. Thourani, Jennifer A. Tremmel, Seth Uretsky, Jessica Wageman, Frederick Welt, Brian K. Whisenant, Christopher J. White, and Celina M. Yong

Subjects
Cardiology and Cardiovascular Medicine
Published
2023

41. Cyclical labor market sorting

Author

Leland D. Crane, Henry R. Hyatt, and Seth M. Murray

Subjects
Economics and Econometrics, Applied Mathematics
Published
2023

43. Cost of Home-Based Couples Human Immunodeficiency Virus Counseling and Testing and Human Immunodeficiency Virus Self-Testing During Pregnancy and Postpartum in Southwestern Kenya

Author

Seth J. Borgstede, Assurah Elly, Anna Helova, Zachary Kwena, Lynae A. Darbes, Abigail Hatcher, Harsha Thirumurthy, George Owino, Maria Pisu, Kevin Owuor, Thomas Braun, Janet M. Turan, Elizabeth A. Bukusi, and Van T. Nghiem

Subjects
Health Policy, Economics, Econometrics and Finance (miscellaneous), Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Published
2023

44. Facial masculinization surgery

Author

Neil N. Patel, Arushi Gulati, P. Daniel Knott, and Rahul Seth

Subjects
Otorhinolaryngology, Surgery
Published
2023

45. Chondrolaryngoplasty

Author

VyVy N. Young, Rahul Seth, P. Daniel Knott, and Clark A. Rosen

Subjects
Otorhinolaryngology, Surgery
Published
2023

46. Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence

Author

Megan E. Fox, Andreas B. Wulff, Daniela Franco, Eric Y. Choi, Cali A. Calarco, Michel Engeln, Makeda D. Turner, Ramesh Chandra, Victoria M. Rhodes, Scott M. Thompson, Seth A. Ament, and Mary Kay Lobo

Subjects
Biological Psychiatry
Abstract

Opioid discontinuation generates a withdrawal syndrome marked by increased negative affect. Increased symptoms of anxiety and dysphoria during opioid discontinuation are significant barriers to achieving long-term abstinence in opioid-dependent individuals. While adaptations in the nucleus accumbens are implicated in opioid abstinence syndrome, the precise neural mechanisms are poorly understood. Additionally, our current knowledge is limited to changes following natural and semisynthetic opioids, despite recent increases in synthetic opioid use and overdose.We used a combination of cell subtype-specific viral labeling and electrophysiology in male and female mice to investigate structural and functional plasticity in nucleus accumbens medium spiny neuron (MSN) subtypes after fentanyl abstinence. We characterized molecular adaptations after fentanyl abstinence with subtype-specific RNA sequencing and weighted gene co-expression network analysis. We used viral-mediated gene transfer to manipulate the molecular signature of fentanyl abstinence in D1-MSNs.Here, we show that fentanyl abstinence increases anxiety-like behavior, decreases social interaction, and engenders MSN subtype-specific plasticity in both sexes. D1-MSNs, but not D2-MSNs, exhibit dendritic atrophy and an increase in excitatory drive. We identified a cluster of coexpressed dendritic morphology genes downregulated selectively in D1-MSNs that are transcriptionally coregulated by E2F1. E2f1 expression in D1-MSNs protects against loss of dendritic complexity, altered physiology, and negative affect-like behaviors caused by fentanyl abstinence.Our findings indicate that fentanyl abstinence causes unique structural, functional, and molecular changes in nucleus accumbens D1-MSNs that can be targeted to alleviate negative affective symptoms during abstinence.

Published
2023

48. Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease

Author

Andrew N. Bubak, Laetitia Merle, Christy S. Niemeyer, B. Dnate’ Baxter, Arianna Gentile Polese, Vijay Ramakrishnan, Johana Gomez, Lucia Madrigal, Andres Villegas-Lanau, Francisco Lopera, Wendy Macklin, Seth Frietze, Maria A. Nagel, and Diego Restrepo

Subjects
Aging, General Neuroscience, Neurology (clinical), Geriatrics and Gerontology, Developmental Biology
Abstract

ObjectiveAlzheimer’s disease (AD) is characterized by loss of smell and olfactory system pathology that precedes the diagnosis of dementia. Understanding these early processes can potentially identify diagnostic and therapeutic targets to slow AD progression. Here we analyzed differential gene and protein expression in the olfactory bulb (OB) and olfactory tract (OT) of familial AD (FAD) individuals carrying the autosomal dominant presenilin 1 E280A paisa mutation and age-matched controls.MethodsFormalin-fixed, paraffin-embedded sections containing both the OB and OT from 6 FAD individuals and 6 age-matched controls were obtained. Tissue morphology and composition were characterized by immunohistochemistry using antibodies against the myelin marker proteolipid protein (PLP), amyloid-beta (Aβ), and microglia/macrophage markers Iba1 and CD68, respectively. OB and OT were analyzed separately by targeted RNA sequencing of the whole human transcriptome (BioSpyder TempO-Seq); ingenuity pathway analysis and R-computational program were used to identify differentially expressed genes and pathways between groups. The nanoString spatial proteomics assay for 88 proteins, including markers for AD and immune responses, was used to complement gene expression findings.ResultsCompared to control OT, FAD OT had significantly increased immunostaining for Aβ and CD68 in the high and low myelinated regions, as well as increased immunostaining for Iba1 in the high myelinated region only; both control and FAD OT samples had similar total area of high and low myelinated regions. In FAD samples, RNA sequencing showed a transcription profile consistent with: (1) viral infection in the OB; (2) inflammation in the OT that carries information via entorhinal cortex from the OB to hippocampus, a brain region essential for learning and memory; and (3) decreased oligodendrocyte deconvolved transcripts, indicating dysregulation of myelination. Interestingly, spatial proteomic analysis confirmed altered myelination in the OT of FAD individuals, implying dysfunction of communication between the OB and hippocampus.ConclusionsThese findings raise the possibility that viral infection and associated inflammation and dysregulation of myelination of the olfactory system may disrupt downstream hippocampal function, contributing to acceleration of FAD progression.

Published
2023

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