1. Withdrawal from chronic nicotine fails to produce a conditioned taste aversion to saccharin in rats
- Author
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Heidi F. Villanueva, Shahwali Arezo, John A. Rosecrans, and John R. James
- Subjects
Male ,Nicotine ,Time Factors ,medicine.medical_treatment ,Clinical Biochemistry ,Pharmacology ,Toxicology ,Choice Behavior ,Biochemistry ,Behavioral Neuroscience ,chemistry.chemical_compound ,Saccharin ,Conditioning, Psychological ,Avoidance Learning ,medicine ,Animals ,Saline ,Biological Psychiatry ,Rats, Inbred Strains ,Rats ,Substance Withdrawal Syndrome ,Discontinuation ,Regimen ,chemistry ,Taste ,Morphine ,Taste aversion ,Withdrawal syndrome ,Psychology ,psychological phenomena and processes ,medicine.drug - Abstract
Sprague-Dawley rats were maintained on a daily regimen of nicotine, morphine or saline administration for 28 days. Following the discontinuation of the daily drug regimen, rats were given a choice of tap water or a saccharin-water solution. The rats previously receiving morphine drank significantly less saccharin-water solution than did the rats receiving nicotine or saline injections. The failure of the nicotine rats to display a conditioned aversion to the novel saccharin flavor suggests that nicotine did not produce a physiological withdrawal syndrome analogous to morphine withdrawal in this paradigm.
- Published
- 1990