61 results on '"Shears, Stephen B."'
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2. Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine
3. Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold
4. Corrigendum to ‘Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells’ [Cellular Signalling 46 (2018) 120–128]
5. The Drosophila cytokine, GBP: A model that illuminates the yin-yang of inflammation and longevity in humans?
6. Use of Protein Kinase–Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors
7. Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells
8. Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates
9. Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity
10. Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities
11. The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis
12. The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family
13. Inositol pyrophosphates: Why so many phosphates?
14. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery
15. A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut
16. Structural insight into inositol pyrophosphate turnover
17. Functional Regulation of ClC-3 in the Migration of Vascular Smooth Muscle Cells
18. Diphosphoinositol polyphosphates: What are the mechanisms?
19. Structural Analysis and Detection of Biological Inositol Pyrophosphates Reveal That the Family of VIP/Diphosphoinositol Pentakisphosphate Kinases Are 1/3-Kinases
20. Molecular basis for the integration of inositol phosphate signaling pathways via human ITPK1
21. An Expanded Biological Repertoire for Ins(3,4,5,6)P4 through its Modulation of ClC-3 Function
22. The Nucleolus Exhibits an Osmotically Regulated Gatekeeping Activity That Controls the Spatial Dynamics and Functions of Nucleolin
23. Purification, Sequencing, and Molecular Identification of a Mammalian PP-InsP5 Kinase That Is Activated When Cells Are Exposed to Hyperosmotic Stress
24. Integration of Inositol Phosphate Signaling Pathways via Human ITPK1
25. Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's “phosphate crisis”
26. Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P5 pool
27. Signal transduction during environmental stress: InsP8 operates within highly restricted contexts
28. Cystic Fibrosis Airway Epithelial Ca2+ Signaling
29. Rounding up the usual suspects: protein kinases as therapeutic targets
30. Signaling by Higher Inositol Polyphosphates
31. Cell signaling by a physiologically reversible inositol phosphate kinase/phosphatase
32. Cytosolic Multiple Inositol Polyphosphate Phosphatase in the Regulation of Cytoplasmic Free Ca2+ Concentration
33. The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase
34. An Adjacent Pair of Human NUDT Genes on Chromosome X Are Preferentially Expressed in Testis and Encode Two New Isoforms of Diphosphoinositol Polyphosphate Phosphohydrolase
35. Inositol 3,4,5,6-Tetrakisphosphate Inhibits Insulin Granule Acidification and Fusogenic Potential
36. In Saccharomyces cerevisiae, the Inositol Polyphosphate Kinase Activity of Kcs1p Is Required for Resistance to Salt Stress, Cell Wall Integrity, and Vacuolar Morphogenesis
37. Regulation of Ins(3,4,5,6)P4 Signaling by a Reversible Kinase/Phosphatase
38. Regiospecific phosphohydrolases from Dictyostelium as tools for the chemoenzymatic synthesis of the enantiomers d-myo-inositol 1,2,4-trisphosphate and d-myo-inositol 2,3,6-trisphosphate: non-physiological, potential analogues of biologically active d-myo-inositol 1,3,4-trisphosphate
39. Regulation of a Human Chloride Channel
40. Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2
41. Assessing the omnipotence of inositol hexakisphosphate
42. myo-Inositol 3,4,5,6-Tetrakisphosphate Inhibits an Apical Calcium-activated Chloride Conductance in Polarized Monolayers of a Cystic Fibrosis Cell Line
43. The Inositol Hexakisphosphate Kinase Family
44. Site-directed Mutagenesis of Diphosphoinositol Polyphosphate Phosphohydrolase, a Dual Specificity NUDT Enzyme That Attacks Diadenosine Polyphosphates and Diphosphoinositol Polyphosphates
45. Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling
46. The Diadenosine Hexaphosphate Hydrolases fromSchizosaccharomyces pombe and Saccharomyces cerevisiae Are Homologues of the Human Diphosphoinositol Polyphosphate Phosphohydrolase
47. Inositol 1,3,4-Trisphosphate Acts in Vivo as a Specific Regulator of Cellular Signaling by Inositol 3,4,5,6-Tetrakisphosphate
48. Cloning and functional expression of the cytoplasmic form of rat aminopeptidase P
49. The versatility of inositol phosphates as cellular signals
50. Synthesis of d-1,2-dideoxy-1,2-difluoro-myo-inositol 3,4,5,6-tetrakisphosphate and its enantiomer as analogues of myo-inositol 3,4,5,6-tetrakisphosphate
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