65 results on '"Simeonov, Anton"'
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2. A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion
3. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells
4. A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells
5. Small molecule antiviral compound collection (SMACC): A comprehensive, highly curated database to support the discovery of broad-spectrum antiviral drug molecules
6. Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury
7. Scalable generation of sensory neurons from human pluripotent stem cells
8. Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data
9. A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2
10. Corrigendum to “An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication” [Genomics Proteomics Bioinformatics19 (1) (2021) 108–122]
11. eP264: Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome
12. Cross-Platform Bayesian Optimization System for Autonomous Biological Assay Development
13. Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells
14. The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy
15. Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2
16. Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection
17. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome
18. A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers
19. Synergistic and Antagonistic Drug Combinations against SARS-CoV-2
20. An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication
21. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
22. Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2
23. Identification of a G-Protein-Independent Activator of GIRK Channels
24. Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences
25. Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays
26. A Comparative Study of Target Engagement Assays for HDAC1 Inhibitor Profiling
27. High-Throughput Cellular Thermal Shift Assays in Research and Drug Discovery
28. Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy
29. Discovery of Synergistic and Antagonistic Drug Combinations Against SARS-CoV-2 In Vitro
30. The NCATS Pharmaceutical Collection: a 10-year update
31. Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid in vivo Metabolic Rewiring and Vulnerability to Combination Therapy
32. KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
33. High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2
34. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
35. Development of a multitask deep learning QSAR model using data from individual cytochrome P450 isozymes
36. Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform
37. A Platform to Enable the Pharmacological Profiling of Small Molecules in Gel-Based Electrophoretic Mobility Shift Assays
38. Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models
39. Inhibition of DNA glycosylases in development of cancer therapeutics
40. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds
41. In vitro evaluation of imidazo[4,5 -c ]quinolin-2-ones as gametocytocidal antimalarial agents
42. A potent and selective inhibitor targeting human and murine 12/15-LOX
43. Cell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activity
44. KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes
45. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes
46. Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Cell Migration
47. Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1
48. Structure–activity relationship studies and biological characterization of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
49. Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase
50. Peroxiredoxin-1 from the Human Hookworm Ancylostoma ceylanicum Forms a Stable Oxidized Decamer and Is Covalently Inhibited by Conoidin A
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