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29 results on '"Slob W"'

3. Evaluating the evidence for non-monotonic dose-response relationships: A systematic literature review and (re-)analysis of in vivo toxicity data in the area of food safety

Author

Varret, C., primary, Beronius, A., additional, Bodin, L., additional, Bokkers, B.G.H., additional, Boon, P.E., additional, Burger, M., additional, De Wit-Bos, L., additional, Fischer, A., additional, Hanberg, A., additional, Litens-Karlsson, S., additional, Slob, W., additional, Wolterink, G., additional, Zilliacus, J., additional, Beausoleil, C., additional, and Rousselle, C., additional

Published
2018
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4. Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic

Author

Benford, D., Bolger, P.M., Carthew, P., Coulet, M., DiNovi, M., Leblanc, J.C., Renwick, A.G., Setzer, W., Schlatter, J., Smith, B., Slob, W., Williams, G., Wildemann, T., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS

Subjects
Computer science, Food Contamination, World Health Organization, Toxicology, Risk Assessment, Human health, Humans, Carcinogenic chemicals, Risk management, Models, Statistical, Dose-Response Relationship, Drug, business.industry, Dietary exposure, Uncertainty, General Medicine, Reference Standards, Food safety, Expert group, Margin of exposure, Europe, Risk analysis (engineering), Carcinogens, business, Risk assessment, Mutagens, Food Science
Abstract

This paper presents the work of an expert group established by the International Life Sciences Institute - European branch (ILSI Europe) to follow up the recommendations of an international conference on "Risk Assessment of Compounds that are both Genotoxic and Carcinogenic: New Approaches". Twelve genotoxic and carcinogenic chemicals that can be present in food were selected for calculation of a Margin of Exposure (MOE) between a point of departure on the dose-response for oral carcinogenicity in animal studies and estimates of human dietary exposure. The MOE can be used to support prioritisation of risk management action and, if the MOE is very large, on communication of a low level of human health concern. Depending on the approaches taken in determining the point of departure and the estimation of exposure, it is possible to derive very different values for the MOE. It is therefore essential that the selection of the cancer endpoint and mathematical treatment of the data are clearly described and justified if the results of the MOE approach are to be trusted and of value to risk managers. An outline framework for calculating an MOE is proposed in order to help to ensure transparency in the results.

Published
2010

6. Does EU legislation allow the use of the Benchmark dose (BMD) approach for risk assessment?

Author

Brandon, E.F.A., primary, Bulder, A.S., additional, van Engelen, J.G.M., additional, Mahieu, C.M., additional, Mennes, W.C., additional, Pronk, M.E.J., additional, Rietveld, A.G., additional, van de Ven, B.M., additional, ten Voorde, S.E.C.G., additional, Wolterink, G., additional, Slob, W., additional, Zeilmaker, M.J., additional, and Bessems, J.G.M., additional

Published
2013
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13. Mathematical modelling and quantitative methods

Author

Edler, L., primary, Poirier, K., additional, Dourson, M., additional, Kleiner, J., additional, Mileson, B., additional, Nordmann, H., additional, Renwick, A., additional, Slob, W., additional, Walton, K., additional, and Würtzen, G., additional

Published
2002
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