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Objective Pilocytic astrocytoma (PA) is rare in adults comprising 5.1% of the primary central nervous system tumors. The aim is to describe the first Brazilian series of adult patients with PA and compare its features with the available literature. Methods We retrospectively review all patients 18 years or older with PA from our institution's database from 1991 to 2018. We analyzed information regarding clinical presentation, location, imaging features, extent of resection, adjuvant treatments, and follow-up. Results Twenty-three patients with PA were analyzed: 60.9% male; median age 26 years. The most frequent symptoms were headache (34.8%) and seizure (26.1%). Temporal and parietal lobes were the most common locations, 21.7% each. All patients underwent a surgical procedure, gross total resection in 40.9%, subtotal resection in 22.7%, and biopsy in 27.3%. Adjuvant treatment with radiotherapy was performed in 2 patients. Only 4 patients had disease progression, 2 after gross total resection and 2 after subtotal resection. They were all alive and without evidence of new progression at the last follow-up (October 2018). Median overall survival was not reached after a median follow-up time of 88.9 months. Conclusions This is the first Brazilian series regarding adults with PA, and our patients had a favorable outcome as reported in recent literature reviews. The tumor's prevalence reduces within older patients and supratentorial lesions are more frequent, especially on the temporal lobe. There was no significant relationship between location and progression, although according to the literature the extent of resection remains the most important prognostic factor.

Introdução/Objetivo: A sífilis é uma doença curável causada pela bactéria Treponema pallidum de transmissão sexual, sanguínea ou vertical. Se não tratada na gravidez, é uma causa de morbidade, mortalidade e sífilis congênita. É um bom indicador de acesso à saúde ao demonstrar falhas de diagnóstico e tratamento durante o pré-natal. Na Portaria nº33 (14/07/2005), a sífilis em gestantes tornou-se um agravo de notificação compulsória no Sistema de Informação de Agravos de Notificação (SINAN). Nos últimos anos, o Brasil apresenta um crescimento na taxa de sífilis congênita, sendo que em 2019 a detecção foi de 20,8/1.000 nascidos vivos. Esse aumento ocorreu na região Norte e Sul, com diferenças em relação ao momento do diagnóstico da sífilis materna. Frente a isso, buscamos comparar as regiões Sul e Norte do Brasil em relação aos casos de sífilis materna e congênita, além das medidas de realização de pré-natal e o momento de diagnóstico da sífilis na gestante. Métodos: Trata-se de uma pesquisa quantitativa, retrospectiva, com coleta de dados no SINAN (Datasus). Extraíram-se informações referentes à incidência da sífilis gestacional e congênita de 2012 a 2019 em ambas regiões, além das taxas de diagnóstico da sífilis congênita segundo a realização do pré-natal e período do diagnóstico da sífilis materna e óbitos por sífilis congênita (

Identify and analyze cases of child and adolescent abuse and neglect in Curitiba, Brazil. This is an exploratory descriptive study that takes a quantitative approach. Secondary data from the reporting registry of the Network for the Protection of Children and Adolescents at Risk for Violence in Curitiba, Brazil, dating from 2004 to 2009, were analyzed. Variables included the victims' sociodemographic profile, place of notification, type, nature and severity of abuse, information about the author of the aggression or abuse, and physical lesions. The frequency distribution and associations between the variables were analyzed using the Chi-square test at a 5% significance level. The analysis of 19,316 records showed that domestic violence, abuse and neglect directed against children and adolescents were the most frequently recorded situation, with 17,082 cases (88.4%) distributed in the following manner: neglect, with 9742 reports (57.0%); physical violence, with 1341 reports (7.9%); sexual violence, with 796 reports (4.7%); psychological violence, with 574 reports (3.4%); and abandonment, with 190 reports (1.1%). Of the total, 43.9% were considered severe cases. The most affected age group was between 5 and 14 years of age, with balance between genders. In the majority of cases, the mother was registered as the author of the abuse or neglect. Physical sequelae (20.2%) mostly affected the head and upper and lower limbs, with consequent lesions manifesting as bruises, cuts, and fractures. An increase in the visibility of domestic violence and children and adolescents abuse and neglect has been observed in the city during the last few years, suggesting the effectiveness of the reporting strategies proposed by the protection network. It is important to increase social security and public welfare policies to prevent child and adolescent abuse and neglect, focusing on family support.