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44 results on '"Song, Caixia"'

16. Long-term in vivo study of biodegradable Zn-Cu stent: A 2-year implantation evaluation in porcine coronary artery

Author

Haijun Zhang, Chang-bin Wang, Kang Yao, Xu Kaili, Song Caixia, Xiu-jun Yao, Min Wan, Shi-kun Xu, Egon Toft, Yin Yuxia, Feng Xiangyi, Alex A. Volinsky, Hao Lu, Junbo Ge, Lu Shoutao, Cui Xiaoshan, Zhang Junwei, Ting Li, Maoquan Li, Zhang-Zhi Shi, Shufu Chang, Huafang Li, Liu Guang, Lu-Ning Wang, Jianying Ma, Chao Zhou, Hou Wenbo, and Zhao Yanwei

Subjects
medicine.medical_specialty, Time Factors, Biodegradation performance, Swine, medicine.medical_treatment, 0206 medical engineering, Biomedical Engineering, In vivo evaluation, Coronary artery stent, 02 engineering and technology, Biochemistry, Biomaterials, Zn-based biodegradable stent, In vivo, Internal medicine, Absorbable Implants, Materials Testing, medicine, Animals, Porcine coronary artery, Molecular Biology, business.industry, Stent, Structural integrity, General Medicine, equipment and supplies, 021001 nanoscience & nanotechnology, medicine.disease, Coronary Vessels, 020601 biomedical engineering, Thrombosis, Coronary arteries, Zinc, Medical device performance, medicine.anatomical_structure, Circulatory system, Cardiology, Stents, 0210 nano-technology, business, Copper, Tomography, Optical Coherence, Biotechnology
Abstract

In the present study, a novel biodegradable Zn-0.8Cu coronary artery stent was fabricated and implanted into porcine coronary arteries for up to 24 months. Micro-CT analysis showed that the implanted stent was able to maintain structural integrity after 6 months, while its disintegration occurred after 9 months of implantation. After 24 months of implantation, approximately 28 ± 13 vol% of the stent remained. Optical coherence tomography and histological analysis showed that the endothelialization process could be completed within the first month after implantation, and no inflammation responses or thrombosis formation was observed within 24 months. Cross-section analysis indicated that the subsequent degradation products had been removed in the abluminal direction, guaranteeing that the strut could be replaced by normal tissue without the risk of contaminating the circulatory system, causing neither thrombosis nor inflammation response. The present work demonstrates that the Zn-0.8Cu stent has provided sufficient structural supporting and exhibited an appropriate degradation rate during 24 months of implantation without degradation product accumulation, thrombosis, or inflammation response. The results indicate that the Zn-0.8Cu coronary artery stent is promising for further clinical applications. Statement of Significance Although Zn and its alloys have been considered to be potential candidates of biodegradable metals for vascular stent use, by far, no Zn-based stent with appropriate medical device performance has been reported because of the low mechanical properties of zinc. The present work presents promising results of a Zn-Cu biodegradable vascular stent in porcine coronary arteries. The Zn-Cu stent fabricated in this work demonstrated adequate medical device performance both in vitro and in vivo and degraded at a proper rate without safety problems induced. Furthermore, large animal models have more cardiovascular similarities as humans. Results of this study may provide further information of the Zn-based stents for translational medicine research. This work was supported by the National Key Research & Development Program of China (No. 2016YFC1102500 ), the National Natural Science Foundation of China (No. 31700819 ), the Fundamental Research Funds for the Central Universities (No. 06500098 ), and the Young Elite Scientists Sponsorship Program by CAST (YESS, No. 2018QNRC001 ). As chief scientist, Professor Haijun-Zhang initiated the study and also participated in key details of the experimental processes. Scopus

Published
2019

23. Design and in-situ synthesis of unique catalyst via embedding graphene oxide shell membrane in NiS2 for efficient hydrogen evolution

Author

Lei Chen, Wang Debao, Hongyu Mou, Deliang Zhang, and Song Caixia

Subjects
Chemical substance, Materials science, Graphene, Oxygen evolution, Oxide, General Physics and Astronomy, 02 engineering and technology, Surfaces and Interfaces, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Electrocatalyst, 01 natural sciences, 0104 chemical sciences, Surfaces, Coatings and Films, law.invention, Bifunctional catalyst, Catalysis, chemistry.chemical_compound, Membrane, chemistry, Chemical engineering, law, 0210 nano-technology
Abstract

Exploring novel tactic to synthesize transition-metal-based electrocatalysts with high activity is crucial to renewable gaseous fuel production. Herein, a simple and efficient synthesis strategy has been successfully developed to in-situ synthesize unique catalysts via embed a graphene oxide (GO) shell membrane in the core of NiS2 employing an ionic liquid-like NiCl2-malonic acid (IL Ni-MA). The elaborately designed IL Ni-MA liquid favors the in-situ growth of breathing GO shell membrane on the surface of NiS2 along with the formation of gas channel. The moderate breathing GO shell membrane and tightly coupled interface gain the optimum electrocatalysis hydrogen evolution and oxygen evolution performance in 1.0 M KOH. It just demands 57 and 294 mV to achieve a current density of 10 mA cm−2 toward HER and OER, respectively. Moreover, the optimum NiS2@GO catalysts can be applied for superior bifunctional catalyst for overall splitting of H2O. A cell voltage of 1.52 V and a stable operation for more than 48 h can be gained. The synthetic route may find application in the surface/interfaces engineering of other embedded catalysts toward new energy and environment applications.

Published
2020

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