1. Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients
- Author
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In Joo Kim, Eun Kyung Lee, Sang Soo Kim, Eun Young Lee, Yong Ki Kim, Su Mi Lee, Choon Hee Chung, Sang Heon Song, and Ihm Soo Kwak
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Urology ,Renal function ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Nephropathy ,Diabetic nephropathy ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Kidney ,business.industry ,Type 2 Diabetes Mellitus ,medicine.disease ,female genital diseases and pregnancy complications ,030104 developmental biology ,medicine.anatomical_structure ,Albuminuria ,Biomarker (medicine) ,medicine.symptom ,business - Abstract
Aim The potential role of soluble α-klotho in diabetic kidney disease has not yet been evaluated. The aim of this study was to evaluate the association of plasma and/or urine α-klotho with the progression of type 2 diabetic nephropathy. Methods The baseline values of plasma and urine α-klotho were measured in 147 patients with type 2 diabetes mellitus with an estimated glomerular filtration rate (eGFR) of ≥60mL/min/1.73m 2 . In this prospective observational study, a total of 109 type 2 diabetic patients were followed up for 34months (8–50 months). Results Plasma α-klotho, but not urine α-klotho, was negatively correlated with the decline of eGFR ( r =−0.304, P =0.001; r =0.042, P =0.068, respectively). After adjusting for several clinical parameters, baseline eGFR and urine ACR, plasma α-klotho was significantly associated with the decline of eGFR ( r =−0.219, P =0.008). In the normoalbuminuria group (n=63), the plasma α-klotho remained significantly associated with a decline in eGFR ( r =0.324, P =0.004) in the final model. Conclusions It is suggested that plasma α-klotho may be an early biomarker for predicting renal impairment in type 2 diabetic patients. The disappearance of a compensatory increase of plasma α-klotho might be a predictive marker for the progression of type 2 diabetic nephropathy.
- Published
- 2016