29 results on '"Taiane de Azevedo Cardoso"'
Search Results
2. The HARM models: Predicting longitudinal physical aggression in patients with schizophrenia at an individual level
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Devon Watts, Mini Mamak, Heather Moulden, Casey Upfold, Taiane de Azevedo Cardoso, Flavio Kapczinski, and Gary Chaimowitz
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Psychiatry and Mental health ,Biological Psychiatry - Published
- 2023
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3. Triggers for acute mood episodes in bipolar disorder: A systematic review
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Catarina Rodrigues Cordeiro, Beatriz Romão Côrte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, and Taiane de Azevedo Cardoso
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Psychiatry and Mental health ,Biological Psychiatry - Published
- 2023
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4. Biological rhythms disruption mediates the association between mother's diagnosis of bipolar disorder and offspring's emotional/behavioral problems
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Karen Jansen, Mateus Grellert, Adile Nexha, Jean Pierre Oses, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Flavio Kapczinski, Benicio N. Frey, and Taiane de Azevedo Cardoso
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Psychiatry and Mental health ,Clinical Psychology - Published
- 2023
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5. Childhood trauma, inflammatory biomarkers and the presence of a current depressive episode: Is there a relationship in subjects from a population study?
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Leonardo Carvalho Oliveira, Natália Wirowski, Pedro Borges de Souza, Andressa Schneider Lobato, Karen Jansen, Taiane de Azevedo Cardoso, Thaíse Campos Mondin, Jean Pierre Oses, Flávio Kapczinski, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, and Fernanda Pedrotti Moreira
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Psychiatry and Mental health ,Biological Psychiatry - Abstract
This study aims to compare the serum cytokine levels between controls, individuals with a current depressive episode (CDE) with childhood trauma and individuals with CDE without childhood trauma. This is a cross-sectional with paired sample nested in a population-based study. For the purposes of the current study, subjects who had psychotic symptoms, generalized anxiety disorder, and who refused to perform blood collection were excluded. Subsequently, only individuals who had a current depressive episode were selected (n = 76). Another 76 subjects were randomly paired by sex and age, constituting a population control group. The measurements of serum cytokine levels were performed using the multiplex analysis method. In the group with a CDE, when compared to the population control group, the following cytokines were high: IL-1β, IL-2, IL-4, IL-6, IL-17A, IFN-γ and TNF-α (p 0.05). On the other hand, there was a decrease in the levels of cytokines IL-10 (p = 0.027) and IL12p70 (p = 0.001). Bonferroni test demonstrates that there is no statistically significant difference in serum cytokine levels between subjects with a CDE, with and without trauma (p 0.05). In a multivariable logistic regression, adjusting for socioeconomic status, tobacco, alcohol and illicit drugs abuse/dependence, and use of psychiatric medication, we found that cytokines serum levels remained associated with CDE even when adjusted for these potential confounders. Our findings demonstrate that monitoring cytokine levels and immune function may be beneficial in preventing the development of a CDE. However, future research is necessary to investigate the impact of trauma on the relationship between inflammation and CDE.
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- 2023
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6. Lifestyle in bipolar disorder: a cross-sectional study
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Mario Simjanoski, Taiane de Azevedo Cardoso, Benicio N. Frey, Luciano Minuzzi, Raquel B. De Boni, Vicent Balanzá-Martínez, and Flavio Kapczinski
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Psychiatry and Mental health - Published
- 2023
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7. The relationship between parental bonding and mood, anxiety and related disorders in adulthood: A systematic review and meta-analysis
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Katrina N. Kidd, Divya Prasad, Jasmyn E.A. Cunningham, Taiane de Azevedo Cardoso, and Benicio N. Frey
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Adult ,Parents ,Depressive Disorder, Major ,Psychiatry and Mental health ,Clinical Psychology ,Mood Disorders ,Humans ,Anxiety ,Child ,Anxiety Disorders ,Retrospective Studies - Abstract
A strong bond between parents and their children is essential in promoting healthy psychological development. Poor quality parent-child relationships can render children vulnerable to various adverse outcomes. Although extensive research has highlighted the association between abnormal parent-child bonding and mood and anxiety-related psychopathology in offspring, no systematic review or meta-analysis has assessed this relationship in adults.A literature search was conducted in five databases (MEDLINE, Embase, PsycINFO, CINAHL, Web of Science) on January 4th, 2021. Studies that assessed the relationship between parental bonding and the presence of a mood or anxiety disorder in adults were eligible for inclusion.Fifty-seven studies were included in the systematic review (n = 44 in the meta-analysis). Quantitative results indicated that individuals with major depression, panic disorder, or persistent depressive disorder reported lower parental care and higher overprotection compared to individuals without psychiatric diagnoses. Qualitative results indicated that individuals with diagnoses of mood or anxiety disorders tended to report higher parental abuse than controls.The measures of parental bonding used by the included studies are retrospective and subject to biases. All studies had a case-control design and thus, causal-relationships cannot be drawn from the results.Our findings suggest that poor-quality parental bonding early in life may place offspring at greater risk for mood and anxiety disorders during adulthood. Future research should extend these results by confirming the relationship between parental bonding and other psychiatric disorders, as well as identifying which factors mediate the relationship between abnormal parental bonding and psychiatric disorders.
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- 2022
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8. Substance use as a risk factor for bipolar disorder: A systematic review
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Mikayla Lalli, Flávio Kapczinski, Khadija Brouillette, and Taiane de Azevedo Cardoso
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medicine.medical_specialty ,Bipolar Disorder ,Substance-Related Disorders ,business.industry ,Psychoactive substance ,PsycINFO ,Cannabis use ,medicine.disease ,Nicotine ,Cocaine-Related Disorders ,Psychiatry and Mental health ,Risk Factors ,medicine ,Humans ,Bipolar disorder ,Substance use ,Risk factor ,Medical prescription ,Psychiatry ,business ,Biological Psychiatry ,medicine.drug - Abstract
Detecting substance use as a predictor of bipolar disorder (BD) is important for clinicians to perform accurate and early diagnosis, as well as better manage the treatment of individuals with BD. The aim of this systematic review was to describe whether substance use is a predictor of BD. A literature search was conducted using the following databases: PubMed, PsycINFO, and Embase. All eligible studies published up to February 9, 2021 were included. This systematic review included 22 studies. We found that 66.7% of the studies assessing overall substance use found that overall substance use was a risk factor for BD. Regarding the specific substances assessed, cannabis use was described as a risk factor for BD in 55.6% of the studies, nonmedical use of prescription medications was a risk factor for BD in 50% of the studies, nicotine was found as a risk factor for BD in 50% of the studies, and alcohol use was described as a risk factor for BD in 42.9% of the studies assessing it. Only one study assessed whether cocaine use was a risk factor for BD and found a significant association. Interestingly, some studies suggested that the greater frequency of cannabis use was associated with greater risk to develop BD or hypomanic/manic symptoms. In conclusion, there is evidence supporting that substance use is a risk factor for BD. Importantly, when assessing the risk factors for BD related to psychoactive substance use, special attention should be given for the frequency of cannabis use.
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- 2021
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9. 5-year incidence of suicide-risk in youth: A gradient tree boosting and SHAP study
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Ricardo Araújo, Flávio Kapczinski, Pedro Ballester, Karen Jansen, Taiane de Azevedo Cardoso, Thaíse Campos Mondin, Fernanda Pedrotti Moreira, Benicio N. Frey, Luciano Dias de Mattos Souza, and Ricardo Azevedo da Silva
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Adult ,Boosting (doping) ,Adolescent ,business.industry ,Incidence ,Incidence (epidemiology) ,Female sex ,Suicide, Attempted ,Suicidal Ideation ,Young Adult ,Psychiatry and Mental health ,Clinical Psychology ,Quality of Life ,Humans ,Medicine ,Female ,Prospective Studies ,Young adult ,Suicide Risk ,Prospective cohort study ,business ,Socioeconomic status ,Aged ,Demography ,Common mental disorder - Abstract
Background Machine learning methods for suicidal behavior so far have failed to be implemented as a prediction tool. In order to use the capabilities of machine learning to model complex phenomenon, we assessed the predictors of suicide risk using state-of-the-art model explanation methods. Methods Prospective cohort study including a community sample of 1,560 young adults aged between 18 and 24. The first wave took place between 2007 and 2009, and the second wave took place between 2012 and 2014. Sociodemographic and clinical characteristics were assessed at baseline. Incidence of suicide risk at five-years of follow-up was the main outcome. The outcome was assessed using the Mini Neuropsychiatric Interview (MINI) at both waves. Results The risk factors for the incidence of suicide risk at follow-up were: female sex, lower socioeconomic status, older age, not studying, presence of common mental disorder symptoms, and poor quality of life. The interaction between overall health and socioeconomic status in relation to suicide risk was also captured and shows a shift from protection to risk by socioeconomic status as overall health increases. Limitations Proximal factors associated with the incidence of suicide risk were not assessed. Conclusions Our findings indicate that factors related to poor quality of life, not studying, and common mental disorder symptoms of young adults are already in place prior to suicide risk. Most factors present critical non-linear patterns that were identified. These findings are clinically relevant because they can help clinicians to early detect suicide risk.
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- 2021
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10. Lifestyle interventions for bipolar disorders: A Systematic Review and Meta-Analysis
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Mario Simjanoski, Swara Patel, Raquel De Boni, Vicent Balanzá-Martínez, Benicio N. Frey, Luciano Minuzzi, Flavio Kapczinski, and Taiane de Azevedo Cardoso
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Behavioral Neuroscience ,Neuropsychology and Physiological Psychology ,Cognitive Neuroscience - Published
- 2023
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11. Resilience as a mediator factor in the relationship between childhood trauma and mood disorder: A community sample of young adults
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Flávio Kapczinski, Fernanda Pedrotti Moreira, Karen Jansen, Jerônimo Costa Branco, Thaíse Campos Mondin, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Igor Soares Vieira, and Taiane de Azevedo Cardoso
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Mediation (statistics) ,Bipolar Disorder ,Population ,behavioral disciplines and activities ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,medicine ,Humans ,Child Abuse ,Bipolar disorder ,Child ,education ,Psychological abuse ,Depressive Disorder, Major ,education.field_of_study ,Mood Disorders ,business.industry ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Mood ,Mood disorders ,Major depressive disorder ,business ,030217 neurology & neurosurgery ,Clinical psychology ,Psychological trauma - Abstract
Background Studies on the field of mood disorders has mainly focusing on the risk factors associated to develop the illness or the clinical factors associated with the clinical progression. Less attention was given to factors such as resilience that may be associated with better outcomes in the course of mood disorders. In this study, we assessed the mediation effect of resilience on the relationship between childhood trauma and mood disorders, as well as the severity of depressive symptoms in a population-based sample. Methods This is a cross-sectional study with a community sample of young adults with bipolar disorder (BD), major depressive disorder (MDD), and community controls without any mood disorder. The trauma experiences during childhood were assessed by Childhood Trauma Questionnaire (CTQ). The severity of depressive symptoms was assessed using the Montgomery-Asberg Depression Rating Scale (MADRS) and to assess the resilience was used the Resilience Scale (RS-25). Results All subtypes of trauma were associated with both MDD and BD, however, only physical and emotional abuse differentiated BD from MDD subjects. Bootstrapping-enhanced mediation analyses indicated that resilience partly mediated the association of childhood trauma to both mood disorder and severity of depression. Limitation The employed mediation analyses are cross-sectional in nature, which limits any firm conclusions regarding causality. Conclusions The findings support the clinical assumption that resilient subjects may be partly protected against the detrimental long-term effects of childhood trauma. This study provides important information regarding the relationships among childhood trauma, resilience, and mood disorder.
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- 2020
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12. Mixed episodes and suicide risk: A community sample of young adults
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Irina Sverdlichenko, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Karen Jansen, Flávio Kapczinski, and Taiane de Azevedo Cardoso
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Adult ,Adolescent ,Population ,Suicide, Attempted ,Violence ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Prevalence ,medicine ,Humans ,Young adult ,education ,Depression (differential diagnoses) ,Mini-international neuropsychiatric interview ,Cause of death ,education.field_of_study ,business.industry ,030227 psychiatry ,Assessment of suicide risk ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Hypomania ,medicine.symptom ,business ,Mania ,030217 neurology & neurosurgery ,Demography - Abstract
Suicide is the second leading cause of death among young adults worldwide, and few studies have assessed the factors associated with suicidality in this specific population. Thus, the aim of this study was to assess the association between mixed episodes and suicidality in a community sample of young adults. For this aim, we compared young adults in a mixed episode with individuals in a depressive or (hypo)manic episode, and community controls.This is a cross-sectional population-based study including young adults aged 18-24 years old. Information about participants' age, sex, self-reported skin color and study status were obtained using a sociodemographic questionnaire. Mixed, (hypo)manic and depressive episodes, as well as suicide risk were assessed using the Mini International Neuropsychiatric Interview.The sample included 1560 individuals. Young adults in a mixed episode showed a 13.50 times higher probability to have suicide risk, as compared to community controls (p 0.001), 5.67 higher probability to have suicide risk as compared to individuals in a (hypo)manic episode (p 0.001), and 2.18 times higher probability to have suicide risk as compared to young adults in a depressive episode (p 0.001).The assessment of suicide risk includes both suicide attempts and ideation.Young adults in a mixed episode showed a higher rate of suicide risk than individuals with depression or mania/hypomania. Considering the already increasing prevalence of suicide among young adults, there is an urgent need for the early diagnosis and treatment of mixed episodes in this specific population.
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- 2020
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13. Persistence of symptoms after cognitive therapies is associated with childhood trauma: A six months follow-up study
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Cristian Patrick Zeni, Caroline Elizabeth Konradt, Karen Jansen, Luciano Dias de Mattos Souza, Igor Soares Vieira, Ricardo Azevedo da Silva, and Taiane de Azevedo Cardoso
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Adult ,Male ,Persistence (psychology) ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Anxiety ,law.invention ,Clinical study ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Humans ,Medicine ,Biological Psychiatry ,Depressive Disorder, Major ,Cognitive Behavioral Therapy ,business.industry ,Follow up studies ,Cognition ,Middle Aged ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Treatment Outcome ,Adult Survivors of Child Adverse Events ,Cognitive therapy ,Psychotherapy, Brief ,Major depressive disorder ,Female ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
This study aims to assess the effect of childhood trauma on the outcomes of brief cognitive therapies for major depressive disorder. This is a follow-up clinical study nested in a randomized clinical trial of cognitive therapies. Sixty-one patients were assessed at baseline, post-intervention and six-month follow-up. The study showed that brief cognitive therapies improved depressive and anxious symptoms at post-intervention and six-month follow-up. Higher childhood trauma scores at baseline were significantly associated with higher severity of depressive and anxious symptoms at six-month follow-up. Longer courses of psychotherapy may be needed to improve the long-lasting effects of traumatic experiences.
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- 2019
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14. Clinical features of differential diagnosis between unipolar and bipolar depression in a drug-free sample of young adults
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André Machado Patella, Taiane de Azevedo Cardoso, Ricardo Azevedo da Silva, Karen Jansen, Luciano Dias de Mattos Souza, and Fábio Monteiro da Cunha Coelho
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Adult ,Male ,Drug ,medicine.medical_specialty ,Bipolar Disorder ,Adolescent ,media_common.quotation_subject ,Disease ,behavioral disciplines and activities ,Diagnosis, Differential ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,Humans ,Medicine ,Bipolar disorder ,Young adult ,Psychiatry ,Depression (differential diagnoses) ,media_common ,Depressive Disorder, Major ,business.industry ,medicine.disease ,030227 psychiatry ,Diagnostic and Statistical Manual of Mental Disorders ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Early Diagnosis ,Adult Survivors of Child Adverse Events ,Mood disorders ,Major depressive disorder ,Female ,Differential diagnosis ,business ,030217 neurology & neurosurgery - Abstract
Subjects with bipolar disorder suffering of a depressive episode are frequently misdiagnosed as unipolar depression, being important studies assessing the differential diagnosis between bipolar and unipolar depression.To assess the sociodemographic and clinical features of drug-free young adults in a depressive episode of bipolar or unipolar disorder in order to identify factors that may differentiate these psychiatric conditions.This is a cross-sectional study with 241 young adults aged between 18 and 29 years who were evaluated using the Structured Clinical Interview for DSM-IV (SCID). The sample comprised patients with BD (n = 89) and major depressive disorder (n = 152), experiencing a depressive episode and not using psychoactive drugs or illicit psychoactive substances.The characteristics associated with bipolar depression were being male (p 0.001), with a family history of BD (p = 0.013), a higher frequency of childhood traumatic experiences (p = 0.001), younger age of onset of mood disorder (p = 0.004), many previous depressive episodes (p = 0.027), greater severity of depressive symptoms (p 0.001) and day/night reversal (p = 0.013). Those with unipolar depression showed a higher frequency of biological rhythm disturbances (p 0.001), and diurnal preference (p = 0.028).The sample has not included subjects with severe suicide risk, a possible important marker in differentiate unipolar from bipolar depression.Some clinical aspects may contribute to an early differential diagnosis of both bipolar and unipolar depression even in the initial stages of the disease.
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- 2019
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15. Metabolic syndrome, depression and anhedonia among young adults
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Igor Soares Vieira, Fernanda Pedrotti Moreira, Thaíse Campos Mondin, Karen Jansen, Luciano Dias de Mattos Souza, Flávio Kapczinski, Carolina David Wiener, Jean Pierre Oses, Pedro Vieira da Silva Magalhães, Ricardo Azevedo da Silva, and Taiane de Azevedo Cardoso
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Adult ,Blood Glucose ,Male ,Anhedonia ,Comorbidity ,behavioral disciplines and activities ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Prevalence ,Humans ,Medicine ,Young adult ,National Cholesterol Education Program ,Triglycerides ,Biological Psychiatry ,Depression (differential diagnoses) ,Mini-international neuropsychiatric interview ,Metabolic Syndrome ,Depression ,business.industry ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Cholesterol ,Cross-Sectional Studies ,behavior and behavior mechanisms ,Female ,medicine.symptom ,Metabolic syndrome ,business ,psychological phenomena and processes ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
The aim of this study was to assess the association between anhedonia and metabolic syndrome (MetS) in a well-characterized community sample of individuals with a current depressive episode. This is a cross-sectional study with young adults aged 24-30 years old. Depressive episode and the presence of anhedonia was assessed using the Mini International Neuropsychiatric Interview - Plus version (MINI Plus). The MetS was assessed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III). The sample included 931 subjects, being 22 had depression without anhedonia, whereas 55 had depression with anhedonia. MetS was more prevalent among subjects with depression and anhedonia (43.6%) when compared to individuals without anhedonia and population control group. Moreover, subjects with depression and anhedonia have a significant increase of levels of glucose, triglycerides, total-cholesterol and LDL-cholesterol, as well as significant decreased in the HDL-cholesterol level. The present study showed that individuals with depression and anhedonia present higher prevalence of MetS. Our study suggests that the use of the concept of anhedonia may contribute to a better understanding of the complex relationship between depression and metabolic syndrome.
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- 2019
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16. Predicting 3-year persistent or recurrent major depressive episode using machine learning techniques
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Amanda Rodrigues Fialho, Bruno Braga Montezano, Pedro Lemos Ballester, Taiane de Azevedo Cardoso, Thaíse Campos Mondin, Fernanda Pedrotti Moreira, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, and Karen Jansen
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- 2022
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17. Personality disorders as predictors for the conversion from major depressive disorder to bipolar disorder: A prospective cohort study
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Gisele Bartz de Ávila, Bruno Braga Montezano, Luciano Dias de Mattos Souza, Taiane de Azevedo Cardoso, Ricardo Azevedo da Silva, Thaíse Campos Mondin, Fernanda Pedrotti Moreira, and Karen Jansen
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- 2022
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18. Influence of maternal bipolar disorder on the biological rhythms of their offspring
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Thierry de Souza Berny, Swara Patel, Taiane de Azevedo Cardoso, Luciano Dias de Mattos Souza, Amanda Neumann Reyes, Amanda Rodrigues Fialho, Kimberli Tiane Sampaio Jansen, Thaíse Mondin, Ricardo Azevedo da Silva, and Karen Jansen
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03 medical and health sciences ,0302 clinical medicine ,030217 neurology & neurosurgery ,030227 psychiatry - Published
- 2022
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19. Metabolic syndrome in subjects with bipolar disorder and major depressive disorder in a current depressive episode: Population-based study
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Carolina David Wiener, Karen Jansen, Pedro Vieira da Silva Magalhães, Fernanda Pedrotti Moreira, Jean Pierre Oses, Thaíse Campos Mondin, Flávio Kapczinski, Taiane de Azevedo Cardoso, Ricardo Azevedo da Silva, and Luciano Dias de Mattos Souza
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medicine.medical_specialty ,medicine.disease ,030227 psychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Prevalence of mental disorders ,Mood disorders ,Internal medicine ,mental disorders ,medicine ,Major depressive disorder ,Bipolar disorder ,Young adult ,Metabolic syndrome ,Psychiatry ,Psychology ,National Cholesterol Education Program ,030217 neurology & neurosurgery ,Biological Psychiatry ,Mini-international neuropsychiatric interview - Abstract
Objective To assess the differences in the prevalence of the metabolic syndrome (MetS) and their components in young adults with bipolar disorder (BD) and major depressive disorder (MDD) in a current depressive episode. Methods This was a cross-sectional study with young adults aged 24–30 years old. Depressive episode (bipolar or unipolar) was assessed using the Mini International Neuropsychiatric Interview – Plus version (MINI Plus). The MetS was assessed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III). Results The sample included 972 subjects with a mean age of 25.81 (±2.17) years. Both BD and MDD patients showed higher prevalence of MetS compared to the population sample (BD = 46.9%, MDD = 35.1%, population = 22.1%, p Conclusion Metabolic components were significantly associated with the presence of depressive symptoms, independently of the diagnosis.
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- 2017
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20. Identifying Nonlinear Patterns of 5-Year Suicide Risk Incidence in Youth: A Gradient Tree Boosting and SHAP Study
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Ricardo Araújo, Benicio N. Frey, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Karen Jansen, Thaíse Campos Mondin, Fernanda Pedrotti Moreira, Pedro Ballester, Taiane de Azevedo Cardoso, Bruno Braga Montezano, and Flávio Kapczinski
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Tree (data structure) ,Boosting (machine learning) ,Incidence (epidemiology) ,Statistics ,Biology ,Suicide Risk ,Biological Psychiatry - Published
- 2021
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21. Early Life Stress is a Risk Factor for Bipolar Disorder: A Prospective Cohort Study of Young Adults
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Kyara Rodrigues de Aguiar, Flávio Kapczinski, Mariana Pouey da Cunha, Karen Jansen, Camila Duarte Porto, Giovanna Oliveira Guimarães, Taiane de Azevedo Cardoso, Pedro Borges de Souza, Thierry Berny, Amanda Rodrigues Fialho, and Júlia Bierhals Bilhalva
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Pediatrics ,medicine.medical_specialty ,business.industry ,Early life stress ,medicine ,Bipolar disorder ,Young adult ,Risk factor ,Prospective cohort study ,medicine.disease ,business ,Biological Psychiatry - Published
- 2021
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22. Sleep Parameters of Offspring of Mothers With Bipolar Disorder as Compared to Offspring of Mothers Without Mood Disorders
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Camila Duarte Porto, Thierry Berny, Amanda Rodrigues Fialho, Pedro Borges de Souza, Karen Jansen, Júlia Bierhals Bilhalva, Taiane de Azevedo Cardoso, Mariana Pouey da Cunha, Kyara Rodrigues de Aguiar, Giovanna Oliveira Guimarães, Benicio N. Frey, and Anastasiya Slyepchenko
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Mood disorders ,business.industry ,Offspring ,Medicine ,Bipolar disorder ,business ,medicine.disease ,Sleep in non-human animals ,Biological Psychiatry ,Clinical psychology - Published
- 2021
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23. Predictors of conversion from major depressive disorder to bipolar disorder
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Taiane de Azevedo Cardoso, Joseigla Pinto de Oliveira, Karen Jansen, Thaíse Campos Mondin, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira, and Luciano Dias de Mattos Souza
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medicine.medical_specialty ,Bipolar Disorder ,Younger age ,Psychological intervention ,behavioral disciplines and activities ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,Humans ,Medicine ,Prospective Studies ,Significant risk ,Bipolar disorder ,Family history ,Psychiatry ,Prospective cohort study ,Biological Psychiatry ,Mini-international neuropsychiatric interview ,Psychiatric Status Rating Scales ,Depressive Disorder, Major ,business.industry ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Cross-Sectional Studies ,Major depressive disorder ,business ,030217 neurology & neurosurgery - Abstract
The present study has two main aims: (1) To assess whether childhood trauma helps to differentiate Major Depressive Disorder (MDD) from Bipolar Disorder (BD) in a cross-sectional design; and (2) Describe the rate of conversion from MDD to BD, as well as the clinical and demographic predictors of conversion from MDD to BD in a prospective cohort design. We conducted a prospective cohort study in two phases, in the city of Pelotas, RS, Brazil. In the first phase, 565 subjects diagnosed with MDD, and 127 with BD according to the Mini International Neuropsychiatric Interview were included. In the second phase, only individuals with MDD were reevaluated for potential conversion to BD. The rate of conversion from MDD to BD in 3 years was 12.4%. Predictors of conversion from MDD to BD included lower educational level, use of illicit substances, younger age of the first depressive episode, and family history of BD. Childhood trauma was not a significant risk factor for conversion to BD in our prospective study. Our findings can contribute to the prevention and identification of conversion from MDD to BD, as well as to the establishment of more targeted therapeutic interventions, improving the prognosis of these individuals.
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- 2021
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24. Circadian preferences, oxidative stress and inflammatory cytokines in bipolar disorder: A community study
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Carolina David Wiener, Flávio Kapczinski, Karen Jansen, Jean Pierre Oses, Fernanda Pedrotti Moreira, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Taiane de Azevedo Cardoso, Thaíse Campos Mondin, and Pedro Vieira da Silva Magalhães
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Male ,medicine.medical_specialty ,Bipolar Disorder ,Adolescent ,Immunology ,Population ,medicine.disease_cause ,Thiobarbituric Acid Reactive Substances ,Protein Carbonylation ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Residence Characteristics ,Internal medicine ,medicine ,TBARS ,Humans ,Immunology and Allergy ,Bipolar disorder ,Circadian rhythm ,education ,Psychiatric Status Rating Scales ,Depressive Disorder, Major ,Chronobiology ,education.field_of_study ,Chronotype ,medicine.disease ,Circadian Rhythm ,030227 psychiatry ,Oxidative Stress ,Cross-Sectional Studies ,Endocrinology ,Neurology ,Mood disorders ,Cytokines ,Female ,Neurology (clinical) ,Psychology ,030217 neurology & neurosurgery ,Oxidative stress ,Clinical psychology - Abstract
To assess circadian preference among a community sample of people with bipolar disorder, major depression and without any mood disorders. Secondly, we investigated the association of circadian preference with cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and, tumor necrosis factor alpha (TNF-α) and oxidative stress assessed by thiobarbituric acid reactive substances (TBARS), uric acid and Protein Carbonyl Content (PCC).A cross-sectional study nested in a population-based sample. Caseness was confirmed with the Structured Clinical Interview for DSM-IV. A sample of 215 participants, in whom we measured circadian preferences, IL-6, IL-10, TNF-α, TBARS, uric acid, PCC. Biological rhythms were evaluated using the Biological Interview of Assessment in Neuropsychiatry.Bipolar group presented a higher alteration in biological rhythms (40.40±9.78) when compared with the major depression group (36.35±9.18) and control group (27.61±6.89) p0.001. Subjects with bipolar disorder who were active at night and had a day/night cycle reverse showed decreased levels of IL-6 (t, 44=2.096; p=0.042), (t, 44=2.213; p=0.032), respectively. In the bipolar disorder group subjects who presented day/night cycle reverse had lower TBARS levels (t, 41=2.612; p=0.013). TNF-α were decreased in subjects more active at night with bipolar disorder.Lower serum levels of IL-6, TNF-α and TBARS were associated with evening preference in bipolar disorder group. These findings suggest that chronotype may alter the levels of interleukins and oxidative stress levels in bipolar and healthy subjects. A better understanding of the role of circadian preferences in levels of interleukins and oxidative stress are needed.
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- 2016
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25. Biological rhythms, metabolic syndrome and current depressive episode in a community sample
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Thaíse Campos Mondin, Taiane de Azevedo Cardoso, Fernanda Pedrotti Moreira, Karen Jansen, Ricardo Azevedo da Silva, Flávio Kapczinski, Carolina David Wiener, Pedro Vieira da Silva Magalhães, Luciano Dias de Mattos Souza, Benicio N. Frey, and Jean Pierre Oses
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Adult ,Male ,Sleep Wake Disorders ,Periodicity ,medicine.medical_specialty ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,Population ,Neuropsychiatry ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,medicine ,Humans ,Young adult ,education ,Psychiatry ,Biological Psychiatry ,Depression (differential diagnoses) ,Mini-international neuropsychiatric interview ,Metabolic Syndrome ,Depressive Disorder, Major ,education.field_of_study ,Chronobiology ,Endocrine and Autonomic Systems ,Feeding Behavior ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Cross-Sectional Studies ,Female ,Metabolic syndrome ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
The purpose of this study was to assess the disruption in biological rhythms and metabolic syndrome (MetS) in individuals with depressive episode. This was a cross-sectional, population-based study with a representative sample of 905 young adults. Current depressive episode were confirmed by a psychologist using the Mini International Neuropsychiatric Interview (MINI)-Plus. Self-reported biological rhythms were assessed using the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). MetS was defined using modified NCEP/ATPIII criteria. Significant main effects of current depressive episode (p
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- 2016
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26. Effect of alcohol and illicit substance use on verbal memory among individuals with bipolar disorder
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Isabelle E. Bauer, Giovana Zunta-Soares, João Quevedo, Jair C. Soares, David C. Glahn, Taiane de Azevedo Cardoso, Karen Jansen, and Robert Suchting
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Adult ,Male ,medicine.medical_specialty ,Bipolar Disorder ,Alcohol Drinking ,Substance-Related Disorders ,Alcohol use disorder ,Neuropsychological Tests ,Article ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Memory ,Outpatients ,mental disorders ,medicine ,Humans ,Bipolar disorder ,Psychiatry ,Biological Psychiatry ,Wechsler Test of Adult Reading ,California Verbal Learning Test ,Middle Aged ,medicine.disease ,Mental illness ,030227 psychiatry ,Substance abuse ,Psychiatry and Mental health ,Diagnosis, Dual (Psychiatry) ,Disease Progression ,Dual diagnosis ,Female ,Psychology ,Neurocognitive ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Background Cognitive impairment is a well-established feature of bipolar disorder (BD). Comorbid BD and substance use leads to poor psychosocial and clinical outcomes. However, knowledge on the neurocognitive functioning of individuals with dual diagnosis is limited. The aim of this study is to assess the cognitive performance of subjects with BD, BD with comorbid alcohol use disorder (AUD), and BD with comorbid illicit substance use disorders (SUD) as compared to healthy individuals. Methods We included 270 inpatients and outpatients with BD and 211 healthy controls. The diagnostic of BD and substance use disorder was assessed using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders Axis I. Demographic and clinical information were also collected. The cognitive assessment included the Wechsler Test of Adult Reading (WTAR), and a revised version of the California Verbal Learning Test (CVLT) as part of the South Texas Assessment of Neurocognition (STAN). Results The STAN was administered to 134 BD patients (100 female, M±SD: 37.37±12.74 years), 72 BD patients with AUD (40 female, M±SD: 38.42±11.82), 64 BD patients with SUD (39 female, M±SD: 34.50±10.57), and 211 healthy controls with no lifetime history of mental illness and substance use (127 female, M±SD: 34.80±12.57 years). In terms of clinical characteristics, BD+SUD showed a marginally earlier onset of illness compared to BD. Compared to HC, BD performed poorly in the immediate recall and short-delay free tests of the CVLT, while BD patients with AUD and SUD showed significant memory deficits in both the immediate recall and recognition components of the CVLT. There were no differences in memory performance between BD and BD with either AUD or SUD. Conclusions A history of substance use disorders is associated with an earlier onset of BD. BD has marked effects on processes underlying the encoding of new information, while comorbid substance use in BD impairs more specifically the recognition of previously presented information. Future longitudinal studies should evaluate the effects of AUD and SUD on illness progression and therapeutic outcomes.
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- 2016
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27. CCL11 levels in drug-naive bipolar patients: The role of sex and smoking status
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Fernanda Pedrotti Moreira, Bianca Wollenhaupt-Aguiar, Taiane de Azevedo Cardoso, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Karen Jansen, Flávio Pereira Kapczinski, Nicole Greisman, Thaíse Campos Mondin, and Bianca Pfaffenseller
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education.field_of_study ,medicine.medical_specialty ,Multivariate statistics ,Bipolar disorder ,business.industry ,Population ,CCL11 levels ,lcsh:Mental healing ,respiratory system ,medicine.disease ,lcsh:RZ400-408 ,Drug-naïve ,Bayesian multivariate linear regression ,Internal medicine ,Cohort ,Medicine ,Community sample ,Young adult ,business ,education ,Young adults ,medicine.drug ,Mini-international neuropsychiatric interview - Abstract
Background It has been reported that patients with bipolar disorder (BD) present changes in peripheral levels of the inflammatory cytokine CCL11, particularly at latestages. The aim of this study is to evaluate CCL11 levels in a population-based sample of drug-naive young adults. Methods This is a cross-sectional study nested to a large population-based study. 29 drug-naive young adults with BD and 29 controls selected from this cohort were matched for sex, age, and years of education. The diagnosis of psychiatric disorders was performed using the Mini International Neuropsychiatric Interview PLUS. Serum levels of CCL11 were measured using sandwich-ELISA. Independent samples T-test was used to assess differences between groups regarding CCL11 levels. Multivariate linear regression analyses were used to evaluate the effect of independent factors on CCL11 levels. Results There were no demographic differences between individuals with BD and controls. No significant differences were found regarding CCL11 levels between groups. The final multivariate model showed that the variables that remained independently associated with higher CCL11 levels were male sex (B:41.41 [CI95%: 15.66 - 67.15], p = 0.002) and tobacco use (B:22.71 [CI95%: 1.28 - 44.15], p = 0.038). Conclusions The present study suggests that there is a possible influence of sex and tobacco use on CCL11 levels, as male sex and smoking status were associated with higher CCL11 levels in our sample. It also suggests that peripheral levels of CCL11 may not be involved in the pathophysiology of BD at early stages of the disorder.
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- 2020
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28. Long-term effects of cognitive therapy on biological rhythms and depressive symptoms: A randomized clinical trial
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Karen Jansen, Thaíse Campos Mondin, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Taiane de Azevedo Cardoso, and Giovanna Del Grande da Silva
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Male ,Periodicity ,medicine.medical_specialty ,Adolescent ,Hamilton Anxiety Rating Scale ,medicine.medical_treatment ,Neuropsychiatry ,behavioral disciplines and activities ,Time ,law.invention ,Young Adult ,Randomized controlled trial ,law ,Rating scale ,Interview, Psychological ,medicine ,Humans ,HARS ,Psychiatry ,Psychiatric Status Rating Scales ,Depressive Disorder ,Cognitive Behavioral Therapy ,Depression ,Anxiety Disorders ,Cognitive behavioral therapy ,Psychiatry and Mental health ,Clinical Psychology ,Cognitive therapy ,Anxiety ,Female ,Narrative Therapy ,medicine.symptom ,Psychology ,Follow-Up Studies ,Clinical psychology - Abstract
To evaluate the effect of cognitive therapy on biological rhythm and depressive and anxious symptoms in a twelve-month follow-up period. In addition, correlations between the reduction of depression and anxiety symptoms and the regulation of biological rhythm were observed.This was a randomized clinical trial with young adults from 18 to 29 years of age who were diagnosed with depression. Two models of psychotherapy were used: Cognitive Behavioral Therapy (CBT) and Narrative Cognitive Therapy (NCT). Biological rhythm was assessed with the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN). Severity of depressive and anxious symptoms was assessed by the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS), respectively. The sample included 97 patients who were divided within the protocols of psychotherapy.There was a significant reduction in depressive and anxious symptoms (p0.001) and an increase on regulation of biological rhythm (p0.05) at the twelve-month follow-up. Moreover, we showed a positive correlation between the reduction of depressive symptoms and regulation of biological rhythm (r=0.638; p0.001) and between the reduction of anxious symptoms and regulation of biological rhythm (r=0.438; p0.001).Both models showed that cognitive therapy was effective on the reduction of depressive and anxious symptoms and on the regulation of biological rhythm at a twelve-month follow-up evaluation. This study highlights the association between biological rhythm and symptoms of depression and anxiety.We did not assess genetic, hormonal or neurochemical factors and we did not include patients under pharmaceutical treatment or those with severe symptomatology.
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- 2015
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29. Functioning in bipolar disorder with substance abuse/dependence in a community sample of young adults
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Flávio Kapczinski, Luciano Dias de Mattos Souza, Taiane de Azevedo Cardoso, Karen Jansen, Thaíse Campos Mondin, Ricardo Azevedo da Silva, and Pedro Vieira da Silva Magalhães
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Adult ,Male ,medicine.medical_specialty ,Bipolar Disorder ,Substance-Related Disorders ,Cross-sectional study ,Health Status ,Comorbidity ,Young Adult ,mental disorders ,Prevalence ,medicine ,Humans ,Bipolar disorder ,Cognitive skill ,Young adult ,Social Behavior ,Psychiatry ,Mini-international neuropsychiatric interview ,Neuropsychology ,medicine.disease ,Substance abuse ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Female ,Psychology ,Brazil ,Clinical psychology - Abstract
Aim: To assess the functional impairment of young adults with bipolar disorder with substance abuse/ dependence comorbidity. Method: Cross-sectional study within a community sample. Bipolar Disorder was assessed by qualified psychologists using The Mini International Neuropsychiatric Interview – PLUS (MINI-PLUS). Substance abuse and dependence was assessed using the “Alcohol, Smoking and Substance Involvement Screening Test” (ASSIST). Functional impairment was assessed using the Functional Assessment Short Test (FAST). Results: The sample included 1259 young adults. The prevalence of Bipolar Disorder (BD) without Substance Abuse/Dependence (SAD) comorbidity was 5.9% (n ¼74), and the prevalence of bipolar disorder with substance abuse/dependence comorbidity was 1.4% (n¼17). Both groups showed higher impairment in overall functioning, interpersonal relationship, and leisure time as compared to controls. In addition, BDþSAD showed higher impairment in the cognitive functioning domain of FAST. Limitation: A battery of neuropsychological tests was not performed. Conclusion: Functional impairment is associated with BD, independently of substance abuse or dependence. In addition, BDþSAD present a more severe impairment in the cognitive domain of FAST as compared to controls. & 2015 Published by Elsevier B.V.
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- 2015
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