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9 results on '"Tan Qiuping"'

4. Optimization of loop-mediated isothermal amplification (LAMP) assay for robust visualization in SARS-CoV-2 and emerging variants diagnosis

Author

Luo, Zhen, primary, Ye, Chunhong, additional, Xiao, Heng, additional, Yin, Jialing, additional, Liang, Yicong, additional, Ruan, Zhihui, additional, Luo, Danju, additional, Gao, Daolong, additional, Tan, Qiuping, additional, Li, Yongkui, additional, Zhang, Qiwei, additional, Liu, Weiyong, additional, and Wu, Jianguo, additional

Published
2022
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5. Sericin and sericin-derived peptide alleviate viral pathogenesis in mice though inhibiting lactate production and facilitating antiviral response

Author

Li, Yongkui, primary, Huang, Ying, additional, Pan, Pan, additional, Che, Xu, additional, Zhang, Yaru, additional, Zhang, Yeshun, additional, Amal, Algahtany, additional, Li, Xin, additional, Niu, Wenjing, additional, Luo, Nachuan, additional, Zhang, Wen, additional, Gao, Daolong, additional, Tan, Qiuping, additional, Zhang, Qiwei, additional, Xing, Xiwen, additional, Luo, Zhen, additional, and Wu, Jianguo, additional

Published
2021
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7. BTB-TAZ Domain Protein PpBT3 modulates peach bud endodormancy by interacting with PpDAM5

Author

Zhang, Xinhao, primary, Shen, Hongyan, additional, Wen, Binbin, additional, Li, Sen, additional, Xu, Chen, additional, Gai, Yu, additional, Meng, Xiangguang, additional, He, Huajie, additional, Wang, Ning, additional, Li, Dongmei, additional, Chen, Xiude, additional, Xiao, Wei, additional, Fu, Xiling, additional, Tan, Qiuping, additional, and Li, Ling, additional

Published
2021
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8. Sericin and sericin-derived peptide alleviate viral pathogenesis in mice though inhibiting lactate production and facilitating antiviral response

Author

Yaru Zhang, Wen Zhang, Yongkui Li, Qiwei Zhang, Xu Che, Daolong Gao, Luo Nachuan, Yeshun Zhang, Xin Li, Tan Qiuping, Huang Ying, Jianguo Wu, Pan Pan, Algahtany Amal, Wenjing Niu, Xing Xiwen, and Zhen Luo

Subjects
Innate immune system, biology, Chemistry, Cell growth, Cell, Inflammation, biology.organism_classification, Sericin, Cell biology, medicine.anatomical_structure, Immune system, Vesicular stomatitis virus, medicine, General Materials Science, medicine.symptom, Cell adhesion
Abstract

Sericin, a bioactive protein forming the outer layer of silk, promotes cell proliferation and cell adhesion, inhibits inflammation, and provides nutrition. Here, we obtain endotoxin-free sericin and explore its potential property in antiviral activity towards infectious diseases. In vesicular stomatitis virus (VSV) infection model, pre-treatment with sericin obviously inhibits VSV replication and reduces organ injury in infected mice. Further studies reveal that pre-incubating cells with sericin results in suppressing the infections of VSV and Enterovirus 71 (EV71) in infected cells. More evidences show that upon virus infection, the levels of interferons (IFNs) are significantly elevated in the cells pre-incubated with sericin as compared to untreated cells, indicating that sericin promotes virus-induced antiviral immune responses. Mechanistically, sericin attenuates cell glycolysis rate and reduces lactate production. Low level of lactate benefitting from sericin treatment facilitates the RIG-I-MAVS signaling pathway to initiate interferon activation. Notably, like sericin, a sericin-derived peptide F5-SP shares the same functions to exert antiviral activity both in vitro and in vivo. Therefore, we report that sericin and sericin-derived peptide F5-SP enhance antiviral innate immune response through inhibiting lactate production, which discovers a promising biomedical application of sericin in the prevention and treatment of viral infectious diseases.

Published
2021
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