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33 results on '"Testoni, P."'

4. OC.05.1 A CONTROLLED, RANDOMIZED CLINICAL TRIAL ON MANNITOL VERSUS PEG-ASC FOR BOWEL PREPARATION: EFFICACY AND SAFETY RESULTS FROM SATISFACTION STUDY

Author

Vecchi, M., primary, Tontini, G.E., additional, Fiori, G., additional, Bocus, P., additional, Cannizzaro, R., additional, Carnovali, M., additional, Cesana, B., additional, Cesaro, P., additional, Costamagna, G., additional, Di Paolo, D., additional, Elli, L., additional, Fedorishina, O., additional, Hinkel, C., additional, Jakobs, R., additional, Kashin, S., additional, Manes, G., additional, Melnikova, E., additional, Orsatti, A., additional, Ponchon, T., additional, Prada, A., additional, Radaelli, F., additional, Rimondi, A., additional, Sferrazza, S., additional, Soru, P., additional, Testoni, P., additional, Valats, J., additional, Veselov, V., additional, Spada, C., additional, and Uebel, P., additional

Published
2023
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7. Electromagnetic force mapping methods on dissimilar finite element meshes: Benchmark, discussion and outcomes

Author

Testoni, P., primary, Cau, F., additional, Combescure, D., additional, Garcia-Blanco, E., additional, Gonzalez Fernandez, M., additional, La Rovere, S., additional, Ricci, M., additional, Ordieres, J., additional, Guirao, J., additional, Portone, A., additional, Ayneto Pou, J., additional, Reccia, L., additional, Calvo-Plaza, F.J., additional, Sádaba, S., additional, and Sofianos, A., additional

Published
2022
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13. Surgical management of acute pancreatitis in Italy: lessons from a prospective multicentre study

Author

De Rai, Paolo, Zerbi, Alessandro, Castoldi, Laura, Bassi, Claudio, Frulloni, Luca, Uomo, Generoso, Gabbrielli, Armando, Pezzilli, Raffaele, Cavallini, Giorgio, Di Carlo, Valerio, Agugiaro, S., Turri, L., Bartoli, A., Barberini, F., Cavazzoni, G., Bartolo, F., Della Papa, D., Bassi, N., Massani, M., Benedetti, A., Macarri, G., Piergallini, L., Briani, G., Bartolasi, L., Bugnano, L., Buonanno, G. M., Esposito, C., Cordovana, A., Cavina, E., Seccia, M., Lippolis, P., Musco, B., Barletta, M., Chilovi, E., De Guelfi, A., Chirletti, P., Caronna, R., Scozzafava, S., Cardi, M., Cirino, E., Buffone, A., Colangelo, E., Caracino, V., Cortese, F., Casentini, A., Costamagna, G., Trincali, A., Curzio, M., Clivio, S., Segato, S., D'Alessandro, A., Ambrosiani, V., D'Ambrosio, B., Chiodo, C., Dicillo, M., Reale, L., Grandolfo, A., Fabbrucci, P., Bruscino, A., Mugnaini, P., Ferrarese, S., Ugenti, I., Forte, G. B., Rocco, P., Franzè, A., Bertelè, A., Sereni, G., Friedman, Daniele, Mariani, L., Morelli, F., Gai, V., Antro, C., Garcea, D., Gardini, A., Lucci, E., Giulianotti, P. C., Sbrana, F., Balestracci, T., Giulini, S. M., Pellizzari, A., Ronconi, M., Cimaschi, S., Grassini, M., Lacignola, S., Calandro, L., Mazzitelli, L., Costarella, S. M., Egidio, A., Mello Teggia, P., Stefano, E., Cassini, P., Modica, G., Lupo, F., Giraci, G., Mosca, F., Del Chiaro, M., Mosella, G., Benassai, G., Nanni, M., D'Aristotile, A., Negro, P., Pirazzoli, A., Rabitti, P. G., Romano, C., Gerardi, G., Troianello, B., Russello, D., Di Stefano, A., Avelli, S., Salval, N., Bellini, N., Scalon, P., Staudacher, C., Parolini, D., Strazzabosco, M., Signorelli, S., Tedeschi, U., Testoni, P. A., Masci, E., Mariani, A., Torelli, E., Garcea, M. R., Lombardi, V., Lecconi, L., Valeri, L., Presenti, L., Alessio, F., Ventrucci, M., Virzi, S., Cipolla, A., De Rai, P, Zerbi, A, Castoldi, L, Bassi, C, Frulloni, L, Uomo, G, Gabbrielli, A, Pezzilli, R, Cavallini, G, Di Carlo, V, Proinf, Aisp, and Testoni, PIER ALBERTO

Subjects
Male, Time Factors, Pancreatitis, Alcoholic, medicine.medical_treatment, Acute pancreatitis, Surgery, Aged, Biliary Tract Diseases, Chi-Square Distribution, Cholangiopancreatography, Endoscopic Retrograde, Cholecystectomy, Laparoscopic, Female, Guideline Adherence, Humans, Italy, Pancreatitis, Pancreatitis, Acute Necrotizing, Practice Guidelines as Topic, Prospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Treatment Outcome, Cholecystectomy, Jejunostomy, Pancreatectomy, Practice Patterns, Physicians', Hepatology, Gastroenterology, Physician's Practice Patterns, Practice Patterns, surgery, Endoscopic Retrograde, Medicine, Cholangiopancreatography, Laparoscopic, Acute Necrotizing, Alcoholic, Prospective cohort study, health care economics and organizations, acute pancreatitis, Corrigendum, Risk assessment, medicine.medical_specialty, education, Severity of illness, Intensive care medicine, Physicians', business.industry, General surgery, Original Articles, medicine.disease, business
Abstract

OBJECTIVE: This study aimed to evaluate the surgical treatment of acute pancreatitis in Italy and to assess compliance with international guidelines. METHODS: A series of 1173 patients in 56 hospitals were prospectively enrolled and their data analysed. RESULTS: Twenty-nine patients with severe pancreatitis underwent surgical intervention. Necrosectomy was performed in 26 patients, associated with postoperative lavage in 70% of cases. A feeding jejunostomy was added in 37% of cases. Mortality was 21%. Of the patients with mild pancreatitis, 714 patients with a biliary aetiology were evaluated. Prophylactic treatment of relapses was carried out in 212 patients (36%) by cholecystectomy and in 161 using a laparoscopic approach. Preoperative endoscopic retrograde cholangiopancreatography was associated with cholecystectomy in 83 patients (39%). Forty-seven patients (22%) were treated at a second admission, with a median delay of 31 days from the onset of pancreatitis. Eighteen patients with severe pancreatitis underwent cholecystectomy 37.9 days after the first admission. There were no deaths. DISCUSSION: The results indicate poor compliance with published guidelines. In severe pancreatitis, early surgical intervention is frequently performed and enteral feeding is seldom used. Only a small number of patients with mild biliary pancreatitis undergo definitive treatment (i.e. cholecystectomy) within 4 weeks of the onset of pancreatitis.

Published
2010
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18. ITER non-axisymmetric error fields induced by its magnet system

Author

Knaster, J., primary, Amoskov, V., additional, Formisano, A., additional, Gribov, Y., additional, Lamzin, E., additional, Martone, L., additional, Maximenkova, N., additional, Mitchell, N., additional, Portone, A., additional, Sytchevsky, S., additional, and Testoni, P., additional

Published
2011
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26. Design and optimization of the 12.5T EFDA dipole magnet

Author

Portone, A., primary, Salpietro, E., additional, Bottura, L., additional, Bruzzone, P., additional, Della Corte, A., additional, Fietz, W., additional, Heller, R., additional, Raff, S., additional, Lucas, J., additional, Toral, F., additional, Rifflet, J.M., additional, and Testoni, P., additional

Published
2006
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28. Design and manufacture of the Poloidal Field Conductor Insert coil

Author

Sborchia, C., primary, Duglue, D., additional, Hurd, F., additional, Maix, R., additional, Salpietro, E., additional, Testoni, P., additional, Bessette, D., additional, Mitchell, N., additional, Okuno, K., additional, Sugimoto, M., additional, Alekseev, A., additional, and Sytnikov, V., additional

Published
2003
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29. The internal vacuum transmission lines of the ITER-like ICRH antenna project for JET

Author

Wouters, P, primary, Monakhov, I, additional, Durodié, F, additional, Baity, F, additional, Butcher, P, additional, Clay, R, additional, Fanthome, J, additional, Goulding, R.H, additional, Hellingman, P, additional, Hender, T, additional, Lamalle, P.U, additional, Mead, M, additional, Nelson, B, additional, Nightingale, M, additional, Riccardo, V, additional, Ronden, D, additional, Stakenborg, J, additional, Testoni, P, additional, Tichler, J, additional, Tigwell, P, additional, van Amerongen, F, additional, Walden, A, additional, and Walton, R, additional

Published
2003
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30. Vertical displacement event/disruption electromagnetic analysis for the ITER-FEAT vacuum vessel and in-vessel components

Author

Miki, N, primary, Verrecchia, M, additional, Barabaschi, P, additional, Belov, A, additional, Chiocchio, S, additional, Elio, F, additional, Ioki, K, additional, Kikuchi, S, additional, Kokotkov, V, additional, Ohmori, J, additional, Roccella, M, additional, Sonato, P, additional, Testoni, P, additional, and Utin, Y, additional

Published
2001
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31. Treatment with rapamycin can restore regulatory T-cell function in IPEX patients

Author

Pier Alberto Testoni, Rosalia Curto, Federica Barzaghi, Olaf Neth, Maria Grazia Roncarolo, Alessandro Aiuti, Francesca Tucci, Claudia Sartirana, Laura Passerini, Rosa Bacchetta, Vito Lampasona, Graziano Barera, Daniele Zama, Maria Pia Cicalese, Elena Bazzigaluppi, Manfred Hoenig, Ansgar Schulz, Alberto Mariani, Sven Olek, Luca Albarello, Ivana Rabbone, Emanuele Bosi, Markus G. Seidel, Passerini, L., Barzaghi, F., Curto, R., Sartirana, C., Barera, G., Tucci, F., Albarello, L., Mariani, A., Testoni, P. A., Bazzigaluppi, E., Bosi, E., Lampasona, V., Neth, O., Zama, D., Hoenig, M., Schulz, A., Seidel, M. G., Rabbone, I., Olek, S., Roncarolo, M. G., Cicalese, M. P., Aiuti, A., Bacchetta, R., Passerini L., Barzaghi F., Curto R., Sartirana C., Barera G., Tucci F., Albarello L., Mariani A., Testoni P.A., Bazzigaluppi E., Bosi E., Lampasona V., Neth O., Zama D., Hoenig M., Schulz A., Seidel M.G., Rabbone I., Olek S., Roncarolo M.G., Cicalese M.P., Aiuti A., and Bacchetta R.

Subjects
Male, 0301 basic medicine, regulatory T cell, medicine.medical_treatment, Hematopoietic stem cell transplantation, Lymphocyte Activation, medicine.disease_cause, T-Lymphocytes, Regulatory, regulatory T cells, Autoimmunity, Immunosuppressive Agent, 0302 clinical medicine, Cell Movement, IPEX, Immunology and Allergy, Sirolimu, Child, Cells, Cultured, autoimmunity, FOXP3, Forkhead Transcription Factors, Genetic Diseases, X-Linked, hemic and immune systems, EBI3, Regulatory T cells, suppression, Minor Histocompatibility Antigen, medicine.anatomical_structure, Immune System Diseases, mTOR, Immunosuppressive Agents, Human, Diarrhea, Ebi3, Immune System Disease, Regulatory T cell, Immunology, chemical and pharmacologic phenomena, Minor Histocompatibility Antigens, 03 medical and health sciences, TIGIT, Glucocorticoid-Induced TNFR-Related Protein, Immune Tolerance, medicine, Humans, GITR, Sirolimus, rapamycin, business.industry, Interleukins, Forkhead Transcription Factor, Interleukin, IPEX syndrome, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, Gene Expression Regulation, CTLA-4, Mutation, Cancer research, business, 030215 immunology
Abstract

[Background] Immune-dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a lethal disease caused by mutations in a transcription factor critical for the function of thymus-derived regulatory T (Treg) cells (ie, FOXP3), resulting in impaired Treg function and autoimmunity. At present, hematopoietic stem cell transplantation is the therapy of choice for patients with IPEX syndrome. If not available, multiple immunosuppressive regimens have been used with poor disease-free survival at long-term follow-up. Rapamycin has been shown to suppress peripheral T cells while sparing Treg cells expressing wild-type FOXP3, thereby proving beneficial in the clinical setting of immune dysregulation. However, the mechanisms of immunosuppression selective to Treg cells in patients with IPEX syndrome are unclear., [Objective] We sought to determine the cellular and molecular basis of the clinical benefit observed under rapamycin treatment in 6 patients with IPEX syndrome with different FOXP3 mutations., [Methods] Phenotype and function of FOXP3-mutated Treg cells from rapamycin-treated patients with IPEX syndrome were tested by flow cytometry and in vitro suppression assays, and the gene expression profile of rapamycin-conditioned Treg cells by droplet-digital PCR., [Results] Clinical and histologic improvements in patients correlated with partially restored Treg function, independent of FOXP3 expression or Treg frequency. Expression of TNF-receptor-superfamily-member 18 (TNFRSF18, glucocorticoid-induced TNF-receptor–related) and EBV-induced-3 (EBI3, an IL-35 subunit) in patients’ Treg cells increased during treatment as compared with that of Treg cells from untreated healthy subjects. Furthermore inhibition of glucocorticoid-induced TNF-receptor–related and Ebi3 partially reverted in vitro suppression by in vivo rapamycin-conditioned Treg cells., [Conclusions] Rapamycin is able to affect Treg suppressive function via a FOXP3-independent mechanism, thus sustaining the clinical improvement observed in patients with IPEX syndrome under rapamycin treatment.

Published
2020

32. White Paper of Italian Gastroenterology: Delivery of services for digestive diseases in Italy: Weaknesses and strengths

Author

Giovanni Ferrini, Antonietta Bianco, Paolo Ravelli, Michele Cicala, Aurora Bortoli, Renato Cannizzaro, Piero Leo, Emanuele Meroni, Paolo Spolaore, Gianni Gatto, Manola Lisiero, Filippo Antonini, Angelo Zullo, Antonio Balzano, Sabrina Bianchi, Emanuele Scafato, Giancarlo Spinzi, Lucio Amitrano, Luca Frulloni, Renzo Gullotta, Eugenio Brunelli, O. Triossi, Italo Sorrentini, Mario Marini, Diego Fregonese, Paolo Borro, Danilo Badiali, Giovanni Sansoè, R. Cuppone, Enrico Corazziari, Luciana Framarin, L.M. Montalbano, P. Brosolo, T. Federici, Gianni Testino, Alessandro Sumberaz, Attilio Solinas, A. Salmi, Renato Marin, L. Buri, Ivo Boskovski, Italo Stroppa, Ivano Lorenzini, Giovanni Di Matteo, Salvatore Cucchiara, Ilaria Tarantino, Cesare Hassan, Nicola Muscatiello, Giovanni M. Claar, Stefano Bellentani, Luca Barresi, Francesco Guardascione, Mario Del Piano, Mario Angelico, Luigi Vilardo, Paolo Usai-Satta, Luigi Pasquale, G. Scarpulla, Santino Marchi, Roberto Penagini, Vincenzo Gallo, Luigi Familiari, Francesco Cupella, Livio Cipolletta, Egiziano Peruzzi, Gianfranco Delle Fave, Salvatore Adamo, Luca Elli, S. Crotta, Maurizio Zilli, Antonio Cilona, Bastianello Germanà, Francesco Pallone, Leonardo Tammaro, P. Fracasso, Fabio Pace, Giovanni de Pretis, Alfredo Di Leo, Pietro Familiari, Giorgio Frosini, Giuseppe Milazzo, Maria Teresa Bardella, Michele Di Cillo, Fausto Chilovi, Enrico Ciliberto, Floriano Rosina, Alessandro Zambelli, Franco Bazzoli, Maria Rendina, Francesco Ridolfi, Franco Radaelli, Massimo Conio, Massimiliano Biagini, Massimo Bellini, Claudio De Angelis, Maria Caterina Parodi, Guido Costamagna, Pietro Fusaroli, Gioacchino Leandro, Pier Alberto Testoni, Piero Loriga, Ornella Ancarani, Giacomo Germani, Fabio Farinati, Giancarlo Caletti, Sergio Morini, Carlo Gemme, Antonio Benedetti, Adriano Lauri, Gianmarco Fava, Mauro Borzio, Mario Traina, Marcello Ingrosso, Amuso M, Giampiero Macarri, Rosa Filiberti, A. Marino, Cinzia Quondamcarlo, Francesco Bortoluzzi, L. Piazzi, Raffaele Manta, Salvatore De Stefano, Rita Conigliaro, Michele De Boni, Andrea Ederle, Clara Virgilio, Marco Soncini, Mario Cottone, G.C. Sturniolo, Anna Kohn, Maurizia Rossana Brunetto, Matteo Neri, Elisabetta Buscarini, Nicola D'Imperio, Gennaro D'Amico, Patrizia Burra, Antonio Craxì, S. Peralta, Alessandro Natali, Giuseppe Del Favero, Giovanni Actis, Andrea Nucci, Dario Conte, Stefano Fagiuoli, Santo Monastra, Fabrizio Magnolfi, Buscarini, E, Conte, D, Cannizzaro, R, Bazzoli, F, De Boni, M, Delle Fave, G, Farinati, F, Ravelli, P, Testoni, P, Lisiero, M, Spolaore, P, Fagiuoli, S, Testoni, PIER ALBERTO, Italian Association of Hospital, Gastroenterologist, Endoscopists, Italian Society of, Endoscopy, Italian Society of, Gastroenterology, Buscarini E, Conte D, Cannizzaro R, Bazzoli F, De Boni M, Fave GD, Farinati F, Ravelli P, Testoni PA, Lisiero M, Spolaore P, Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO), Italian Society of Endoscopy (SIED), Italian Society of Gastroenterology (SIGE): [.., Pietro Fusaroli, and ]

Subjects
Male, Gastrointestinal Diseases, Treatment outcome, Diseases, Medical care, Gastroenterology, Cancer, Digestive diseases, Emergency, Gastrointestinal bleeding, Hospital discharge record, Hospital stay, Mortality, Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Emergencies, Female, Gastrointestinal Hemorrhage, Health Planning, Health Services, Health Services Needs and Demand, Hospital Mortality, Hospital Units, Humans, Incidence, Infant, Infant, Newborn, Italy, Length of Stay, Middle Aged, Prevalence, Societies, Medical, Treatment Outcome, Young Adult, Health services, White paper, Digestive disease, italy, 80 and over, Medicine, Hepatology, Settore MED/12 - Gastroenterologia, Incidence (epidemiology), Digestive diseases Emergency Gastroenterology Gastrointestinal bleeding Hospital discharge record Hospital stay Mortality, Christian ministry, gastroenterology, medicine.medical_specialty, Case mix index, Medical, Internal medicine, Cancer, Digestive diseases, Emergency, Gastroenterology, Gastrointestinal bleeding, Hospital discharge record, Hospital stay, Mortality, Preschool, business.industry, Newborn, Societies, business
Abstract

In 2011 the three major Italian gastroenterological scientific societies (AIGO, the Italian Society of Hospital Gastroenterologists and Endoscopists; SIED, the Italian Society of Endoscopy; SIGE, the Italian Society of Gastroenterology) prepared their official document aimed at analysing medical care for digestive diseases in Italy, on the basis of national and regional data (Health Ministry and Lombardia, Veneto, Emilia-Romagna databases) and to make proposals for planning of care. Digestive diseases were the first or second cause of hospitalizations in Italy in 1999–2009, with more than 1,500,000 admissions/year; however only 5–9% of these admissions was in specialized Gastroenterology units. Reported data show a better outcome in Gastroenterology Units than in non-specialized units: shorter average length of stay, in particular for admissions with ICD-9-CM codes proxying for emergency conditions (6.7 days versus 8.4 days); better case mix (higher average diagnosis-related groups weight in Gastroenterology Units: 1 vs 0.97 in Internal Medicine units and 0.76 in Surgery units); lower inappropriateness of admissions (16–25% versus 29–87%); lower in-hospital mortality in urgent admissions (2.2% versus 5.1%); for patients with urgent admissions due to gastrointestinnal haemorrhage, in-hospital mortality was 2.3% in Gastroenterology units versus 4.0% in others. The present document summarizes the scientific societies’ official report, which constitutes the “White paper of Italian Gastroenterology”

Published
2014

33. ITER non-axisymmetric error fields induced by its magnet system

Author

Y. Gribov, Juan Knaster, P. Testoni, Neil Mitchell, V. Amoskov, E. Lamzin, Alessandro Formisano, S. E. Sytchevsky, N. Maximenkova, Alfredo Portone, L. Martone, Knaster, J., Amoskov, V., Formisano, Alessandro, Gribov, Y., Martone, Raffaele, Maximenkova, N., Mitchell, N., Portone, A., Sychevski, S., and Testoni, P.

Subjects
Physics, Tokamak, Mechanical Engineering, Plasma, Magnetic field, law.invention, Computational physics, Nuclear magnetic resonance, Nuclear Energy and Engineering, Electromagnetic coil, law, Harmonics, Magnet, General Materials Science, Plasma stability, Flattop, Civil and Structural Engineering
Abstract

Error fields in Tokamaks are small departures of the exact axisymmetry of the ideal magnetic field configuration. Their reduction beyond a threshold value by the error field correction coils is essential since sufficiently large static error fields lead to discharge disruption. The error fields are originated not only by coils fabrication and installation alignment tolerances, joints and busbars but also due to the presence of ferromagnetic elements. The start of plasma current flattop with relatively low plasma density is considered as a critical state of the 15 MA scenario for the onset of locked modes causing disruptions. A figure of merit, the ‘3-mode’ criterion, based on the lowest error field harmonics [(1,1); (2,1); (3,1)] was chosen to assess the error fields expected in ITER. Analysis performed last years in an independent way by CREATE (EU) and Efremov Inst. (RF) groups has allowed a deep understanding of the error fields induced by all the possible sources. Both groups were successfully benchmarked with the estimation of the error fields induced by a given deformed shape of a TF coil obtaining a perfect match of the results up to 2 orders of magnitude smaller than the defined threshold of B3-mode/Bto [1] ).

Published
2011

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