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In Germany strong efforts have been made within the last years to develop new methods for human biomonitoring (HBM). The German Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB) and the German Chemical Industry Association e. V. (VCI) cooperate since 2010 to increase the knowledge on the internal exposure of the general population to chemicals. The projects aim is to promote human biomonitoring by developing new analytical methods Key partner of the cooperation is the German Environment Agency (UBA) which has been entrusted with the scientific coordination. Another key partner is the “HBM Expert Panel” which each year puts together a list of chemicals of interest to the project from which the Steering Committee of the project choses up to five substances for which method development will be started. Emphasis is placed on substances with either a potential health relevance or on substances to which the general population is potentially exposed to a considerable extent. The HBM Expert Panel also advises on method development. Once a method is developed, it is usually first applied to about 40 non-occupationally exposed individuals. A next step is applying the methods to different samples. Either, if the time trend is of major interest, to samples from the German Environmental Specimen Bank, or, in case exposure sources and distribution of exposure levels in the general population are the focus, the new methods are applied to samples from children and adolescents from the population representative 5th German Environmental Survey (GerES V). Results are expected in late 2018. This article describes the challenges faced during method development and solutions found. An overview presents the 34 selected substances, the 14 methods developed and the 7 HBM-I values derived in the period from 2010 to mid 2016.