Search

International audience; Velocities in Drake Passage from the 25-year GLORYS12 Mercator Ocean reanalysis were compared with satellite altimetry-derived surface velocities and independent in-situ velocity measurements from the DRAKE (2006-2009) and cDrake (2007-2011) experiments. GLORYS12 assimilates satellite along-track sea level anomalies and, as expected, model velocities are in rather good agreement with gridded altimetry derived velocities (r ~ 0.5, above 99% confidence level). GLORYS12 velocities also compared well with the currentmeter data from the DRAKE (in the water column) and cDrake (50 m above seafloor) experiments in terms of means and standard deviations; most correlations between the reanalysis and directly measured velocity time series were significant (r ~ 0.5 for DRAKE and r ~ 0.4 for cDrake, above 99% confidence level). We used the GLORYS12 reanalysis to examine the Antarctic Circumpolar Current (ACC) total volume transport across three sections in Drake Passage. The 25 years of the ACC total volume transport has a mean of 155 ± 3 Sv and a standard deviation of 6.7 Sv. Annual mean values span over a range of 12 Sv. The spectrum of the GLORYS12 total transport time series shows energy peaks (above 95% confidence level) at the intraseasonal, semi-annual and annual periods and no significant low-frequency variations (beyond 2 years) or trend, in agreement with previous studies. This first assessment of GLORYS12 velocities in Drake Passage is very encouraging for monitoring the regional variability of the ACC.

International audience; A palynological assemblage including the extinct araucarian dispersed pollen, Cyclusphaera scabrata, was analysed from the Achiri locality, Bolivian Altiplano. The fossil-yielding locality of Achiri is located in the Pacajes Province, La Paz Department, in the northwestern Altiplano, Bolivia. The Achiri locality is very well known by the fossil vertebrate faunas recovered from the Mauri Formation (M6). The palynological samples come from fine-grained and plant-rich lacustrine levels lower in the same unit. An age between late middle to early late Miocene? was inferred for the palynological association studied, based on local stratigraphy and radioisotopic ages obtained higher in the series. The retrieved association is mainly represented by angiosperms; although gymnosperms, bryophytes, ferns, and freshwater algae are also documented. Compositae are the most abundant group within angiosperms, and Polylepis also occurred but in low percentages. The presence of C. scabrata in the Bolivian Altiplano expands the taxon distribution outside northern South America and provides additional evidence to infer timing and distribution routes of conifers, restricted toward the tropics during the latest Neogene. Its occurrence supports a paleoelevation of no more than 2000 m for the northern area of the Altiplano in agreement with previous results. Compositae of Fenestrites type and Polylepis occur earlier in Bolivia and C. scabrata later, comparing their occurrence in miocene microfloras from low to mid-latitudes of South America.

The controlled delivery of multiple drugs from biomaterials is a timely challenge. In particular the nanocomposite approach offers a unique opportunity to combine the scaffold-forming ability and biocompatibility of hydrogels with the versatile and tunable drug release properties of micro- or nano-carriers. Here, we show that collagen-silica nanocomposites allowing for the prolonged release of two topical antibiotics are promising medicated dressings to prevent infection in wounds. For this purpose, core–shell silica particles loaded with gentamicin sulfate and sodium rifamycin were combined with concentrated collagen type I hydrogels. A dense fibrillar network of collagen exhibiting its typical periodic banding pattern and a homogenous particle distribution were observed by scanning electron microscopy. Antibiotics release from nanocomposites allowed a sustained antibacterial effect against Staphylococcus aureus over 10 days in vitro. The acute dermal irritation test performed on albino rabbit skin showed no sign of severe inflammation. The antibacterial efficiency of nanocomposites was evaluated in vivo in a model of cutaneous infection, showing a 2 log steps decrease in bacterial population when loaded systems were used. In parallel, the histological examination indicated the absence of M1 inflammatory macrophages in the wound bed after treatment. Taken together, these results illustrate the potentialities of the nanocomposite approach to develop collagen-based biomaterials with controlled dual drug delivery to prevent infection and promote cutaneous wound repair. Fil: Mebert, Andrea Mathilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Peroni, Roxana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina Fil: Illoul, Corinne. Centre National de la Recherche Scientifique; Francia Fil: Hélary, Christophe. Centre National de la Recherche Scientifique; Francia Fil: Coradin, Thibaud. Centre National de la Recherche Scientifique; Francia Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina

Sediment deposits formed mainly under the influence of bottom currents (contourites) are widely used as high-resolution archives for reconstructing past ocean conditions. However, the driving processes of Contourite Depositional Systems (CDS) are not entirely understood. The aim of this study is to establish a clearer link between contourite features and the oceanographic processes that form them. The morphosedimentary characteristics of a large CDS were analysed together with the current dynamics along the northern Argentine continental margin. This study combines multibeam bathymetry, seismo-acoustic data, sediment samples, vessel-mounted Acoustic Doppler Current Profiler (VM-ADCP) data and numerical modelling of ocean currents. The contouritic features include large contourite terraces (La Plata Terrace, Ewing Terrace) and an abraded surface connecting the terraces, as well as smaller erosional and depositional features like moats, erosion surfaces on the Ewing Terrace, sediment waves and contourite drifts. Measured and modelled near-bottom currents are vigorous (up to 63 cm/s at 150–200 m above the seafloor) where abraded surfaces and moats are present, and relatively weak (below 30 cm/s) on the La Plata Terrace and the Ewing Terrace. Generally, bottom currents follow the upper and middle slope morphology. Decreasing velocity of water masses flowing northward leads to less erosion and finer sediment deposits. ADCP data and the hydrodynamic model show the formation of eddies near the seafloor which probably lead to the small erosion surfaces on the Ewing Terrace, even though it is mainly a depositional environment. Overall, this study contributes to a better understanding of the formation of CDS and can help future reconstructions of past ocean conditions based on sedimentary structures.

International audience; Aseptic loosening and bacterial infections are the two main causes of failure for metallic implants used for joint replacement. A coating that is both bioactive and possesses antimicrobial properties may address such shortcomings and improve the performance of the implant. We have sought to study the properties of combining hydroxyapatite-based nanoparticles or coatings with baicalein, a plant-extracted molecule with both antibacterial and antioxidant properties. (B-type) carbonated hydroxyapatite nanoparticles prepared by a chemical wet method could subsequently adsorbed by soaking in a baicalein solution. The amount of adsorbed baicalein was determined to be 63 mg.g-1 by thermogravimetric measurements. In a second approach, baicalein was adsorbed on a biomimetic calcium-deficient hydroxyapatite planar coating (12 μm thick) deposited on Ti6Al4V alloy from an aqueous solution of calcium, phosphate, sodium and magnesium salts. Soaking of the hydroxyapatite coated on titanium alloy in a baicalein solution induced partial dissolution/remodeling of the upper surface of the coating. However, the observed remodeling of the surface was much more pronounced in the presence of a baicalein solution, compared to pure water. The presence of adsorbed baicalein on the HAp layer, although it could not be precisely quantified, was assessed by XPS and fluorescence analysis. Planar coatings exhibited significant antibacterial properties against Staphylococcus epidermidis. Baicalein-modified nanoparticles exhibited significant antioxidant properties. These results illustrate the potential of hydroxyapatite used as a carrier for natural biologically-active molecules and also discuss the challenges associated with their applications as antibacterial agents.

The Agua de la Mula Member of the Agrio Formation, comprises marine deposits accumulated in a mixed carbonate-siliciclastic outer ramp during the late Hauterivian. An innovative multi-proxy study that includes sedimentological, geochemical and paleobiological data from the El Portón section were combined in order to constrain the environmental context. Two major sedimentary cycles have been recognised (TST-HST) reflecting the position of both distal and proximal sediments within the depositional system. The distal outer ramp deposits (FA1) are predominantly characterised by carbonate-bearing mudstones, with TOC content up to 4.43 wt% TOC (average 1.62 wt%) and Type II marine-derived amorphous organic matter. The high TOC could be reflecting enhanced bioproductivity during periods of decreased salinity as mirrored by peaks of Micrantholithus, and reduced dilution by siliciclastic material in a distal setting. Conversely, the proximal outer ramp succession (FA2) shows a higher siliciclastic pattern, along with the terrestrial organic matter signal (Type II-III kerogen) and TOC content around 1 wt% (average 1.05 wt%). In this interval primary production is associated with more stable conditions and stratified water, as reflected in peaks of Nannoconus. These conditions allowed a greater diversity and high abundances of calcareous nannofossil assemblages. Fil: Omarini Fernández, Julieta. Universidad Nacional de Río Negro. Sede Alto Valle. Instituto de Investigaciones en Paleobiología y Geología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina Fil: Lescano, Marina Aurora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina Fil: Odino Barreto, Andrea Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; Argentina Fil: Campetella, Débora Mical. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Universidad Nacional de Río Negro. Sede Alto Valle. Instituto de Investigaciones en Paleobiología y Geología; Argentina Fil: Tunik, Maisa Andrea. Universidad Nacional de Río Negro. Sede Alto Valle. Instituto de Investigaciones en Paleobiología y Geología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina Fil: Garban Gonzalez, Grony José. Dtp Laboratorios Srl; Argentina. Universidad Central de Venezuela; Venezuela Fil: Brea, Fabián. YPF - Tecnología; Argentina Fil: Erra, Georgina. YPF - Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina Fil: Aguirre Urreta, María Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina Fil: Martinez, Mathieu. Universite de Rennes I; Francia

International audience; In this study, we used Dielectric Barrier Discharge (DBD) Plasma Actuators to control and pulse two-dimensional free air micro-jets at low Reynolds numbers (Re < 200), avoiding the use of mobile and mechanical devices such as, for example, valves. We performed experimental measurements and visualizations to characterize the effect of different DBD burst frequencies (1 Hz to 80 Hz) and different DBD applied voltages, on both the external and internal flows. Preliminary results show an increase in the external flow rate (20 %) and a promising and effective method to pulse micro-jets at these frequencies.

In this work the transient liquid phase bonding process was successfully used to join seamless carbon steel tubes using an amorphous Fe–B–Si foil as interlayer. The tubes were aligned with their butted surfaces in contact with the interlayer and the entire assembly was heated by means of an induction furnace under a reducing atmosphere. The temperature was raised to the process temperature (≈1300 °C) and then held for 7 min. The joining process was performed under a pressure of 5 MPa. The joined tubes microstructures were characterized by direct observations – scanning electron microscopy – and diffraction techniques – electron backscatter diffraction. Chemical analysis was performed by electron probe microanalysis. The joint region (JR) presents only ferrite grains - in contrast with the heat affected zone (HAZ) and the base metal (BM), whose microstructures consist of ferrite and cementite. Si content at the JR was precisely determined by chemical profiling, showing higher concentrations of Si compared with the HAZ and BM. These results are in accordance with the fact that the cementite is unable to form in Si enriched zones. Also, ferrite grains at the JR present high-angle grain boundaries with respect to the grains of the HAZ. Tensile tests show that the joined tubes failed away from the bond, at the HAZ, and reached 96% of the ultimate tensile strength of the BM, in the as-bonded condition. Microindentation hardness profiles across the bonding zone are in agreement with the observed microstructures at the different zones of the bond region. Fil: Di Luozzo, Nicolás. Institut Politechnique de Grenoble; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; Argentina. Universidad de Buenos Aires. Facultad de Ingenieria. Departamento de Fisica. Laboratorio de Sólidos Amorfos; Argentina Fil: Doisneau, Béatrice. Institut Politechnique de Grenoble; Francia Fil: Boudard, Miguel Santiago. Institut Politechnique de Grenoble; Francia Fil: Fontana, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; Argentina. Universidad de Buenos Aires. Facultad de Ingenieria. Departamento de Fisica. Laboratorio de Sólidos Amorfos; Argentina Fil: Arcondo, Bibiana Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; Argentina. Universidad de Buenos Aires. Facultad de Ingenieria. Departamento de Fisica. Laboratorio de Sólidos Amorfos; Argentina

International audience; We address the description of the tropicalization of families of rational varieties under parametrizations with prescribed support, via curve valuations. We recover and extend results by Sturmfels, Tevelev and Yu for generic coefficients, considering rational parametrizations with non-trivial denominator. The advantage of our point of view is that it can be generalized to deal with non-generic parametrizations. We provide a detailed analysis of the degree of the closed image, based on combinatorial conditions on the relative positions of the supports of the polynomials defining the parametrization. We obtain a new formula and finer bounds on the degree, when the supports of the polynomials are different. We also present a new formula and bounds for the order at the origin in case the closed image is a hypersurface.

A new method to detect salient pieces of boundaries in an image is presented. After detecting perceptually meaningful level lines, periodic binary sequences are built by labeling each point in close curves as salient or non-salient. We propose a general and automatic method to detect meaningful subsequences within these binary sequences. Experimental results show its good performance, when tested with different saliency criteria, such as contrast, regularity, and the combination of both. HighlightsWe present a new method to detect salient pieces of boundaries in an image.After detecting meaningful level lines, we label each point as salient/non- salient.We propose a method to detect meaningful subsequences within these binary sequences.The method is general and automatic.The method shows good performance, when tested with different saliency criteria.

International audience; Crime is the result of a rational distinctive balance between the benefits and costs of an illegal act. This idea was proposed by Becker more than forty years ago (Becker (1968) [1]). In this paper, we simulate a simple artificial society, in which agents earn fixed wages and can augment (or lose) wealth as a result of a successful (or not) act of crime. The probability of apprehension depends on the gravity of the crime, and the punishment takes the form of imprisonment and fines. We study the costs of the law enforcement system required for keeping crime within acceptable limits, and compare it with the harm produced by crime. A sharp phase transition is observed as a function of the probability of punishment, and this transition exhibits a clear hysteresis effect, suggesting that the cost of reversing a deteriorated situation might be much higher than that of maintaining a relatively low level of delinquency. Besides, we analyze economic consequences that arise from crimes under different scenarios of criminal activity and probabilities of apprehension.

International audience; Silver-containing chalcogenide glasses are of considerable interest for applications in optical and electrical recordings and as solid electrolytes. Therefore, insight in their structural properties is important. A neutron thermodiffraction study of Agx(Ge0.25Se0.75)100-x glasses with x = 15 and 25 at.% was carried out. The amorphous samples were heated in situ from room temperature up to 350 °C, while the neutron diffraction spectra were collected every degree. For both glasses the Ag8GeSe6 phase appeared first, followed by the crystallization of GeSe2. The crystallization process for the Ag-rich glass was more complex with the appearance of a non-identified third phase. Rietveld refinement helped us in studying the evolution of the lattice constants of each phase upon heating.

Films of nominal composition Ge 28 Se 60 Sb 12 were deposited on microscope slides by pulsed laser deposition (PLD), using either bulk or powdered glassy targets and a Nd:YAG laser ( λ =266 nm). The films with thickness comprised between 400 and 800 nm showed a smooth and dense morphology. They were homogeneous in composition all over the samples with a composition somewhat deficient in selenium compared to the nominal one: Ge 28.1±0.3 Se 56.1±0.1 Sb 15.8±0.2 and Ge 29.0±0.3 Se 55.5±0.1 Sb 15.5±0.2 for films obtained from powdered glassy targets and bulk targets, respectively. The optical characteristics of the films were extracted from the transmission spectra recorded between 250 and 2500 nm. In particular, the refractive index at 1.5 μm was found to be 2.75±0.03, close to that of the bulk glass, as expected for dense films. The decrease in the optical band gap and the increase in the Urbach absorption edge with the film thickness were attributed to an increase in disorder.

We present a deterministic algorithm for computing all irreducible factors of degree $\le d$ of a given bivariate polynomial $f\in K[x,y]$ over an algebraic number field $K$ and their multiplicities, whose running time is polynomial in the bit length of the sparse encoding of the input and in $d$. Moreover, we show that the factors over $\Qbarra$ of degree $\le d$ which are not binomials can also be computed in time polynomial in the sparse length of the input and in $d$., 20 pp, Latex 2e. We learned on January 23th, 2006, that a multivariate version of Theorem 1 had independently been achieved by Erich Kaltofen and Pascal Koiran

International audience; BACKGROUND: Systems biology leveraging multi-OMICs technologies, is rapidly advancing development of precision therapies and matching patients to targeted therapies, leading to improved responses. A new pillar of precision oncology lies in the power of chemogenomics to discover drugs that sensitizes malignant cells to other therapies. Here, we test a chemogenomic approach using epigenomic inhibitors (epidrugs) to reset patterns of gene expression driving the malignant behavior of pancreatic tumors. METHODS: We tested a targeted library of ten epidrugs targeting regulators of enhancers and super-enhancers on reprogramming gene expression networks in seventeen patient-derived primary pancreatic cancer cell cultures (PDPCCs), of both basal and classical subtypes. We subsequently evaluated the ability of these epidrugs to sensitize pancreatic cancer cells to five chemotherapeutic drugs that are clinically used for this malignancy. FINDINGS: To comprehend the impact of epidrug priming at the molecular level, we evaluated the effect of each epidrugs at the transcriptomic level of PDPCCs. The activating epidrugs showed a higher number of upregulated genes than the repressive epidrugs (χ(2) test p-value

Graphical abstract, Globin-coupled sensors (GCS) usually consist of three domains: a sensor/globin, a linker, and a transmitter domain. The globin domain (GD), activated by ligand binding and/or redox change, induces an intramolecular signal transduction resulting in a response of the transmitter domain. Depending on the nature of the transmitter domain, GCSs can have different activities and functions, including adenylate and di-guanylate cyclase, histidine kinase activity, aerotaxis and/or oxygen sensing function. The gram-negative delta-proteobacterium Geobacter sulfurreducens expresses a protein with a GD covalently linked to a four transmembrane domain, classified, by sequence similarity, as GCS (GsGCS). While its GD is fully characterized, not so its transmembrane domain, which is rarely found in the globin superfamily. In the present work, GsGCS was characterized spectroscopically and by native ion mobility-mass spectrometry in combination with cryo-electron microscopy. Although lacking high resolution, the oligomeric state and the electron density map were valuable for further rational modeling of the full-length GsGCS structure. This model demonstrates that GsGCS forms a transmembrane domain-driven tetramer with minimal contact between the GDs and with the heme groups oriented outward. This organization makes an intramolecular signal transduction less likely. Our results, including the auto-oxidation rate and redox potential, suggest a potential role for GsGCS as redox sensor or in a membrane-bound e−/H+ transfer. As such, GsGCS might act as a player in connecting energy production to the oxidation of organic compounds and metal reduction. Database searches indicate that GDs linked to a four or seven helices transmembrane domain occur more frequently than expected.

International audience; Consumer demands for healthier foods are constantly on the rise and results in the diversification of sources such as vegetable oils. Chia oil is a relevant source of alpha-linolenic acid. One of the targeted applications is the inclusion of chia oil in emulsified form in beverages where it is necessary to obtain stable submicron emulsions, acting as carrier of nutrients such as lipids. In the present work, high-pressure homogenization was employed to produce emulsions (10% chia oil) with small oil droplets (300 nm), formulated with different emulsifiers (beta-lacto-globulin (BLG), lecithin and Tween 80). These emulsions were submitted to a dynamic in vitro digestion (DIDGI) to better understand the main mechanisms involved in the process of lipolysis, in order to design systems that may allow the modulation of the digestive action of lipases, thus ensuring the maximum bioaccessibility of the lipids. This device mimics part of the transient biochemical conditions as well as the flow of foods through the different compartments occurring in the real digestion. Significant differences were observed in the lipolysis during the gastric phase. BLG emulsions reached a lipolysis degree of 30%. Lecithin-stabilized emulsions behave similarly to BLG ones during the first 90 min but lipolysis levelled off further similar to 20%. Finally, Tween-80-stabilized emulsions remained almost undigested (around 2%). No significant differences were noticed in duodenum and distal small intestine, irrespective of the emulsifier employed. After digestion, the fatty acid bioaccessibility was higher with BLG as emulsifier.

The onset of the movement of particles placed on a horizontal rough surface subject to a vertical sinusoidal vibration is investigated through tracking experiments, theoretical analysis, and numerical simulations. The frequency of vibration needed to move particles decays exponentially with the amplitude of the oscillatory input. This behavior is explained through a simple mechanism in which a forced damped harmonic oscillator with a spring constant represents all the interactions between the particle and the surface. The numerical results compare well with experimental data, demonstrating that the forces included in the numerical calculations suitably account for the main particle response, even though the complexity of the surface is not fully taken into account. Describing the way in which frequency varies with amplitude could be relevant to technological applications such as cleaning of material surfaces. Fil: Valenzuela Aracena, Karina de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina Fil: Benito, Jesica Gisele. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina Fil: Oger, Luc. Universite de Rennes I; Francia Fil: Ippolito, Irene Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina Fil: Uñac, Rodolfo Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina Fil: Vidales, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina

This paper builds a time series for vacancies in Argentina and shows the path of the Beveridge curve during the period 2000-2018. We use a novel dataset from a survey that collects vacancy postings since 2008 and combine it with a print help-wanted index published from 2000 through 2014. We present, as a result, a job vacancy series long enough to cover six recessions in addition to the 2001 crisis.

International audience; New high-resolution airborne magnetic data of Uruguay allowed constructing new maps concerning the spatial distribution of dyke swarms, main faults and other magnetic bodies, which compose the Uruguayan Shield. We combined geophysical analyses (vertical derivatives, upward continuation, Euler deconvolution), structural analyses of the magnetic maps and previous geological data in order to discriminate the main structural features of the Uruguayan Shield and contribute to a better understanding of its tectonic evolution. The magnetic maps revealed several outstanding features in the Uruguayan Shield. The Paleoproterozoic dyke swarm is larger, denser, more widespread and complex than originally thought, suggesting a possible plume origin. In addition, a new Mesozoic dyke swarm, as complex as the previous one, was identified crosscutting the Paleoproterozoic dyke swarm and the Neoproterozoic orogenic structures. Moreover, this swarm is connected to volcanic calderas in the Merín basin, and shows displacements along Neoproterozoic shear zones, in the magnetic maps, revealing its brittle reactivation during Mesozoic times. The new observations clarify how Proterozoic basement structures controlled the development of the Mesozoic rift. Paleoproterozoic dyke swarms were reactivated as normal faults and Neoproterozoic structures hindered the rift growth, deflecting the deformation in transcurrent movements. Meanwhile, the Mesozoic dyke swarm was developed in a perpendicular direction to the Neoproterozoic structures. Moreover, these findings contradict the current rift model for Uruguay and rise a new model in which the Mesozoic rift developed as two rift basins connected by a central transfer zone, generated by the reactivation of Dom Feliciano Belt structures, between the Sierra Ballena and Sarandí del Yí Shear Zones.

There is a growing appreciation that the environmental conditions that we call space weather impact the technological infrastructure that powers the coupled economies around the world. With that comes the need to better shield society against space weather by improving forecasts, environmental specifications, and infrastructure design. [...] advanced understanding of space weather requires a coordinated international approach to effectively provide awareness of the processes within the Sun-Earth system through observation-driven models. This roadmap prioritizes the scientific focus areas and research infrastructure that are needed to significantly advance our understanding of space weather of all intensities and of its implications for society. Advancement of the existing system observatory through the addition of small to moderate state-of-the-art capabilities designed to fill observational gaps will enable significant advances. Such a strategy requires urgent action: key instrumentation needs to be sustained, and action needs to be taken before core capabilities are lost in the aging ensemble. We recommend advances through priority focus (1) on observation-based modeling throughout the Sun-Earth system, (2) on forecasts more than 12 hrs ahead of the magnetic structure of incoming coronal mass ejections, (3) on understanding the geospace response to variable solar-wind stresses that lead to intense geomagnetically-induced currents and ionospheric and radiation storms, and (4) on developing a comprehensive specification of space climate, including the characterization of extreme space storms to guide resilient and robust engineering of technological infrastructures. The roadmap clusters its implementation recommendations by formulating three action pathways, and outlines needed instrumentation and research programs and infrastructure for each of these. [...], In press for Advances of Space Research: an international roadmap on the science of space weather, commissioned by COSPAR and ILWS (63 pages and 4 figures)

Reactive oxygen species (ROS), such as free radicals and peroxides, are environmental trace pollutants potentially associated with asthma and airways inflammation. These compounds are often not detected in indoor air due to sampling and analytical limitations. This study developed and validated an experimental method to sample, identify and quantify ROS in indoor air using fluorescent probes. Tests were carried out simultaneously using three different probes: 2′,7′-dichlorofluorescin (DCFH) to detect a broad range of ROS, Amplex ultra Red® (AuR) to detect peroxides, and terephthalic acid (TPA) to detect hydroxyl radicals (HO•). For each test, air samples were collected using two impingers in series kept in an ice bath, containing each 10 mL of 50 mM phosphate buffer at pH 7.2. In tests with TPA, that probe was also added to the buffer prior to sampling; in the other two tests, probes and additional reactants were added immediately after sampling. The concentration of fluorescent byproducts was determined fluorometrically. Calibration curves were developed by reacting DCFH and AuR with known amounts of H2O2, and using known amounts of 2-hydroxyterephthalic acid (HTPA) for TPA. Low detection limits (9-13 nM) and quantification limits (18-22 nM) were determined for all three probes, which presented a linear response in the range 10-500 nM for AuR and TPA, and 100-2000 nM for DCFH. High collection efficiency (CE) and recovery efficiency (RE) were observed for DCFH (CE=RE=100%) and AuR (CE=100%; RE=73%) by sampling from a laboratory-developed gas phase H2O2 generator. Interference of co-occurring ozone was evaluated and quantified for the three probes by sampling from the outlet of an ozone generator. The method was demonstrated by sampling air emitted by two portable air cleaners: a strong ozone generator (AC1) and a plasma generator (AC2). High ozone levels emitted by AC1 did not allow for simultaneous determination of ROS levels due to high background levels associated with ozone decomposition in the buffer. However, emitted ROS were quantified at the outlet of AC2 using two of the three probes. With AuR, the concentration of peroxides in air emitted by the air cleaner was 300 ppt of H2O2 equivalents. With TPA, the HO• concentration was 47 ppt. This method is best suited to quantify ROS in the presence of low ozone levels. Fil: Montesinos, Victor Nahuel. Comisión Nacional de Energía Atómica. Gerencia del Área de Seguridad Nuclear y Ambiente. Gerencia de Química (CAC); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina Fil: Sleiman, Mohamad. Clermont Université; Francia. Lawrence Berkeley National Laboratory. Environmental Energy Technologies División. Indoor Environment Group; Estados Unidos. Centre National de la Recherche Scientifique; Francia Fil: Cohn, Sebastian. Lawrence Berkeley National Laboratory. Environmental Energy Technologies División. Indoor Environment Group; Estados Unidos Fil: Litter, Marta Irene. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Seguridad Nuclear y Ambiente. Gerencia de Química (CAC); Argentina Fil: Destaillats, Hugo. Lawrence Berkeley National Laboratory. Environmental Energy Technologies División. Indoor Environment Group; Estados Unidos

ZnO nanorods (NRs) were grown on fluorine doped tin oxide (FTO) substrates at low temperatures (90 °C) from Zn2+ precursors in alkaline media previously seeded with ZnO nanoparticles. These were deposited onto the FTO substrate heated at 350 °C by spray pyrolysis of a Zn acetate solution in a water ethanol mixture. The structure of seeds was tuned by the ethanol to water ratio, Γ, which controls the solvent evaporation rate of drops impinging the substrate. From a detailed characterization using a combination of scanning electron microscopy, X-ray diffraction, UV-visible absorption and cathodoluminescence spectroscopies, the dependence of the morphology and optical properties of the ZnO NRs on the seeding conditions was demonstrated. NRs grown on seeds deposited from solutions with Γ in the 0.03-0.06 range - i.e. when the surface excess of ethanol in the water-ethanol mixture has a maximum - show thinner average diameters and stacking faults due to the presence of zinc blende domains embedded into an overall wurtzite NR. They furthermore exhibit blue-shifted near band edge emission peak and a high deep level emission in cathodoluminescence. All these findings support the use of spray pyrolysis as a simple and reproducible way to control the seeds deposition, influencing the growth, the structure and the optical properties of the final ZnO NRs. Fil: Rodríguez, Juan. Universidad Nacional de Ingeniería; Perú Fil: Feuillet, Guy. CEA Grenoble; Francia Fil: Donatini, Fabrice. Université Grenoble Alpes; Francia. Centre National de la Recherche Scientifique. Institut Néel; Francia Fil: Onna, Diego Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina Fil: Sanchez, Luis. Universidad Nacional de Ingeniería; Perú Fil: Candal, Roberto Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina Fil: Marchi, María Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Microscopías Avanzadas; Argentina Fil: Aldabe, Sara Alfonsina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina Fil: Chandezon, Frédéric. Université Grenoble Alpes; Francia. Centre National de la Recherche Scientifique; Francia

The reaction of copper acetate with 3,4,5-tri(ethoxy)benzoic acid leads to the formation of dodecakis((μ-(3,4,5-tri(ethoxy))benzoato- κ2O:O′)-hexa(copper(II)), [Cu6(O 2C≡C6H2(OCH2CH 3)3)12]. The new compound crystallizes in the triclinic system, space group P1̄ with Z = 2, solvated by disordered cyclohexane molecules. The Cu(II) ions are placed in O5 pentacoordinated environments provided by four carboxylate oxygen atoms in a pseudo square planar arrangement and a fifth oxygen atom that belongs to a more distant carboxylate group in the axial position. The Cu(II) centers occupy the corners of a trigonal antiprism. A carboxylato network links each copper center with other four, providing potential paths for exchange coupling between the Cu(II) centers. Variable temperature magnetic susceptibility measurements show a maximum at 8 K. An analysis based on the spin-Hamiltonian formalism and DFT-based broken symmetry computations provides insight into the magnetic exchange interactions between the metal centers. Fil: Castro, Maria Ana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Química Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina Fil: Rusjan, Marcia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Química Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina Fil: Vega, Daniel Roberto. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina. Comisión Nacional de Energía Atómica; Argentina Fil: Peña, Octavio. Universite de Rennes I. Institut Des Sciences Chimiques de Rennes.; Francia Fil: Weyhermüller, Thomas. Institut Max Planck fuer Bioanorganische Chemie; Alemania Fil: Cukiernik, Fabio Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina Fil: Slep, Leonardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina

After a preliminary analysis of the low-frequency data collected with the electric antenna of the Permittivity, Wave and Altimetry (PWA) experiment onboard the Huygens Probe that landed on Titan on 14 January, 2005, it was anticipated in a previous article [Béghin et al., 2007. A Schumann-like resonance on Titan driven by Saturn's magnetosphere possibly revealed by the Huygens Probe. Icarus, 191, 251–266] that the Extremely Low-Frequency (ELF) signal at around 36 Hz observed throughout the descent, might have been generated in the upper ionosphere of Titan, driven by a plasma instability mechanism associated with the co-rotating Kronian plasma flow. The involved process was proposed as the most likely source of a Schumann resonance in the moon's atmospheric cavity, the second eigenmode of which is actually found by models to occur at around 36 Hz. In this paper, we present a thorough analysis of this signal based upon the Huygens Probe attitude data deduced from the Descent Imager Spectral Radiometer (DISR), and relevant measurements obtained from the Radio Plasma Wave Science (RPWS) experiment and from the magnetometer (MAG) onboard Cassini orbiter during flybys of Titan. We have derived several coherent characteristics of the signal which confirm the validity of the mechanism initially proposed and provide new and significant insights about such a unique type of Schumann resonance in the solar system. Indeed, the 36 Hz signal contains all the characteristics of a polarized wave, with the measured electric field horizontal component modulated by the antenna rotation, and an altitude profile in agreement with a Longitudinal Section Electric (LSE) eigenmode of the atmospheric cavity. In contrast to Earth's conditions where the conventional Transverse Magnetic mode is considered, the LSE mode appears to be the only one complying with the observations and the unexpected peculiar conditions on Titan. These conditions are essentially the lack of any lightning activity that can be ascertained from Cassini observations, the presence of an ionized layer centered around 62 km altitude that was discovered by the PWA instrumentation, and the existence of a subsurface conducting boundary which is mandatory for trapping ELF waves. A simple theoretical model derived from our analysis places tentatively consequential constraints on the conductivity profile in the lower ionosphere. It is also consistent with the presence of a conductive water ocean below an icy crust some tens of kilometers thick. Fil: Béghin, C.. Universite d’Orleans; Francia Fil: Canu, P.. Universite de Versailles-Saint Quentin en Yvelines; Francia Fil: Karkoschka, E.. University of Arizona; Estados Unidos Fil: Sotin, C.. California Institute Of Technology; Estados Unidos Fil: Bertucci, Cesar. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; Argentina Fil: Kurth, W. S.. University of Iowa; Estados Unidos Fil: Berthelier, J. J.. Institut Pierre Simon Laplace; Francia Fil: Grard, R.. European Space Agency; Países Bajos Fil: Hamelin, M.. Institut Pierre Simon Laplace; Francia Fil: Schwingenschuh, K.. Austrian Academy of Sciences; Austria Fil: Simões, F.. Institut Pierre Simon Laplace; Francia