7 results on '"V Saravanakumar"'
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2. SARS-CoV-2 antibody seroprevalence in India, August–September, 2020: findings from the second nationwide household serosurvey
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Shanta Dutta, Harpreet Singh Pawar, Giridhara R Babu, V. Saravanakumar, Kanwar Narain, Ezhilarasan Ilayaperumal, Sanjay Zodpey, Babu Jagjeevan, Swarup Sarkar, Srikanta Kanungo, Tekumalla Ramarao, Vijay K. Shukla, Jaya Singh Kshatri, Ashrafjit S. Chahal, Aparup Das, Balram Bhargava, Hari Bhan Singh, R Anusha, Chethana Rangaraju, Dinesh Kumar Baradwaj, Smita Asthana, Ravindra Mohan Pandey, Prashant Singh, T Sivakumar, Krithikaa Sekar, Dasarathi Das, Arlappa Nimmathota, Sampada Dipak Bangar, Kamran Zaman, M. Sunil Kumar, Sujeet Kumar Singh, R. Sabarinathan, Naman Shah, Hirawati Deval, Arshad Kalliath, K Kalaiyarasi, Kamalesh Sarkar, Muthusamy Santhosh Kumar, Seema Sahay, Rajiv Yadav, Sanket Kulkarni, Alok Kumar, Vishal Chopra, Rajeev Gupta, C. P. Girish Kumar, Rajeev K. Singh, Kiran Rade, Kangjam Rekha Devi, Shripad A. Patil, Alka Turuk, T Karunakaran, Jyothi Bhat, Annamma Jose, J P Muliyil, Kushal Singh Rathore, Shalini Singh, Tanzin Dikid, Nivethitha N Krishnan, A.R. Nirmala, Hemalatha Rajkumar, G G J Naga Lakshmi, Shashi Kant, Avula Laxmaiah, Major Madhukar, Pradeep Das, Amarendra Mahapatra, Manoj V Murhekar, Gaurav Raj Dwivedi, Pushpendra Singh, Jeromie Wesley Vivian Thangaraj, Sarang Dhatrak, Tanu Anand, K Kiran, Gurudayal S Toteja, Ankit Viramgami, Rakesh Balachandar, Ganta Venkata Prasad, Sauvik Dasgupta, Samiran Panda, Ashok Kumar Pandey, Sanghamitra Pati, Suman Sundar Mohanty, Dantuluri Sheethal Varma, S. Muhammad Salim Khan, Vimith Cheruvathoor Wilson, Mariya Amin Qurieshi, Anshuman Chaudhury, Sriram Selvaraju, Alok Kumar Deb, Avi Kumar Bansal, Tarun Bhatnagar, D C S Reddy, Himanshu Chauhan, Rushikesh Andhalkar, Ashwini Yadav, Inaamul Haq, Falguni Debnath, Rajni Kant, Josephine Pradhan, Anindya Mitra, Somashekar Narasimhaiah, Ramesh Kumar Sangwan, Raman R. Gangakhedkar, Aakash Shrivastava, VG Vinoth Kumar, Ramesh Chandra Jha, Aby Robinson, and K. Nagbhushanam
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Adult ,Male ,Adolescent ,Coronavirus disease 2019 (COVID-19) ,Cross-sectional study ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,030231 tropical medicine ,Population ,India ,Antibodies, Viral ,03 medical and health sciences ,0302 clinical medicine ,Seroepidemiologic Studies ,Prevalence ,Humans ,Medicine ,Seroprevalence ,030212 general & internal medicine ,Occupations ,Child ,education ,education.field_of_study ,biology ,SARS-CoV-2 ,business.industry ,COVID-19 ,Articles ,General Medicine ,Middle Aged ,Serum samples ,Cross-Sectional Studies ,Immunoglobulin G ,biology.protein ,Female ,Antibody ,Rural area ,business ,Demography - Abstract
BACKGROUND: The first national severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey in India, done in May-June, 2020, among adults aged 18 years or older from 21 states, found a SARS-CoV-2 IgG antibody seroprevalence of 0·73% (95% CI 0·34-1·13). We aimed to assess the more recent nationwide seroprevalence in the general population in India. METHODS: We did a second household serosurvey among individuals aged 10 years or older in the same 700 villages or wards within 70 districts in India that were included in the first serosurvey. Individuals aged younger than 10 years and households that did not respond at the time of survey were excluded. Participants were interviewed to collect information on sociodemographics, symptoms suggestive of COVID-19, exposure history to laboratory-confirmed COVID-19 cases, and history of COVID-19 illness. 3-5 mL of venous blood was collected from each participant and blood samples were tested using the Abbott SARS-CoV-2 IgG assay. Seroprevalence was estimated after applying the sampling weights and adjusting for clustering and assay characteristics. We randomly selected one adult serum sample from each household to compare the seroprevalence among adults between the two serosurveys. FINDINGS: Between Aug 18 and Sept 20, 2020, we enrolled and collected serum samples from 29â082 individuals from 15â613 households. The weighted and adjusted seroprevalence of SARS-CoV-2 IgG antibodies in individuals aged 10 years or older was 6·6% (95% CI 5·8-7·4). Among 15â084 randomly selected adults (one per household), the weighted and adjusted seroprevalence was 7·1% (6·2-8·2). Seroprevalence was similar across age groups, sexes, and occupations. Seroprevalence was highest in urban slum areas followed by urban non-slum and rural areas. We estimated a cumulative 74·3 million infections in the country by Aug 18, 2020, with 26-32 infections for every reported COVID-19 case. INTERPRETATION: Approximately one in 15 individuals aged 10 years or older in India had SARS-CoV-2 infection by Aug 18, 2020. The adult seroprevalence increased approximately tenfold between May and August, 2020. Lower infection-to-case ratio in August than in May reflects a substantial increase in testing across the country. FUNDING: Indian Council of Medical Research.
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- 2021
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3. Measles and Rubella Seroprevalence to Evaluate the Impact of the Mass Vaccination Campaigns in India: Pre-And Post- Cross-Sectional Household Serosurveys in Four Indian Districts, 2018-2020
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Manoj V. Murhekar, Nivedita Gupta, Alvira Z. Hasan, Santhosh Kumar Muthusamy, V. Saravanakumar, Christine Prosperi, Gajanan Sapkal, Jeromie Wesley Vivian Thangaraj, Ojas Kaduskar, Vaishali Bhatt, Gururaj Deshpande, Ullas Padinjaremattathil Thankappan, Avi Kumar Bansal, Sanjay L. Chauhan, Gagandeep Singh Grover, Arun Kumar Jain, Ragini N. Kulkarni, Santanu Kumar Sharma, Itta K. Chaaithanya, Sanchit Kharwal, Sunil K. Mishra, Neha R. Salvi, Sandeep Sharma, Nilanju Sarmah, R. Sabarinathan, Augustine Duraiswamy, Sudha Rani D, K. Kanagasabai, Abhishek Lachyan, Poonam Gawali, Mitali Kapoor, Arpit Kumar Shrivastava, Saurabh Kumar Chonker, Bipin Tilekar, V Tandale, Mohammad Ahmad, Lucky Sangal, Amy K. Winter, Sanjay M. Mehendale, William J. Moss, and Kyla Hayford
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- 2022
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4. SARS-CoV-2 Sero-Prevalence Among General Population and Healthcare Workers in India, December 2020 - January 2021
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Kiran Rade, Somashekar Narasimhaiah, Gaurav Raj Dwivedi, D. Elantamilan, Muthusamy Santhosh Kumar, Debdutta Bhattacharya, Niraj Kumar, R. Sabarinathan, M. Sunil Kumar, Krishna Pandey, Seema Sahay, Suresh Yadav, Rakesh Balachandar, Jeromie Wesley Vivian Thangaraj, Samiran Panda, Vishal Chopra, Gangeti Gandhi Jayanthi Naga Lakshmi, Virendra Kumar, Shripad A. Patil, Hemalatha Rajkumar, Chethana Rangaraju, Kanwar Narain, Kamran Zaman, Anindya Mitra, Amit Chakrabarti, Nivetha Srinivasan, Dinesh Kumar Baradwaj, Jyotirmayee Turuk, A.M. Khan, Tekumalla Ramarao, Pushpendra Singh, Amit Kumar, R S Dhaliwal, Shalini Singh, Vimith Cheruvathoor Wilson, Rajni Kant, Ashok Kumar Pandey, Srikanta Kanungo, Anshuman Chaudhury, Smita Asthana, Amarendra Mahapatra, Manoj V Murhekar, Rajiv Yadav, Ganta Venkata Prasad, Nandan Kumar Mishra, C. P. Girish Kumar, Ramesh Kumar Hudda, Shanta Dutta, Aby Robinson, D C S Reddy, Chandrasekaran Padmapriyadarshini, Vijay K. Shukla, Babu Jagjeevan, Jaya Singh Kshatri, Dantuluri Sheethal Varma, Nimmathota Arlappa, K. Nagbhushanam, Alok Kumar Deb, Jyothi Bhat, Hirawati Deval, Alka Turuk, Pravin Bharti, Arshad Kalliath, Balram Bhargava, S. Muhammad Salim Khan, Hari Bhan Singh, Dasarathi Das, Avula Laxmaiah, Sriram Selvaraju, V. Saravanakumar, Tarun Bhatnagar, Nivethitha N Krishnan, K. Arunraj, Inaamul Haq, A.R. Nirmala, Major Madhukar, Y.K. Sharma, Ashrafjit S. Chahal, Aparup Das, Krithikaa Sekar, Surabhi Yadav, Mariya Amin Qurieshi, Ganesh Mehta, Rakesh Dayal, Vikas Dhikav, Kangjam Rekha Devi, Sirasanambatti Devarajulu Reddy, Ankit Viramgami, Sanghamitra Pati, Prashant Singh, Sampada Dipak Bangar, Rajeev K. Singh, Rushikesh Andhalkar, Prathiksha Giridharan, Debjit Chakraborty, Avi Kumar Bansal, Sarang Dhatrak, and Rochak Saxena
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medicine.medical_specialty ,education.field_of_study ,business.industry ,Public health ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,education ,Population ,Epidemiology ,Pandemic ,Health care ,medicine ,Seroprevalence ,Rural area ,business ,Demography - Abstract
Background: Repeated cross-sectional serosurveys in the same geographic area establish the trend of the evolving pandemic. We present the findings of the third round of a national serosurvey to estimate the seroprevalence of SARS-CoV-2 infection among the general population and health care workers of India. Methods: We conducted the third population-based serosurvey between Dec 18, 2020 and Jan 6, 2021 in the same 700 villages or wards from 70 districts in 21 states across India, which were selected for the first and second serosurveys. We enrolled from each district, at least 400 individuals aged ≥ 10 years from general population and 100 HCWs from sub-district level public health facilities. Serum samples from general population were tested for the presence of IgG antibodies against nucleocapsid (N) and spike protein (S1-RBD) of SARS-CoV-2 using the Abbott and Siemens assays respectively, whereas sera from HCWs were tested for anti-S1-RBD. For general population, sera positive for either of the antibodies were considered positive, while sera positive for anti-S1-RBD were considered as positive for HCW. Weighted seroprevalence estimates were adjusted for sensitivity and specificity of respective assays. Findings: Of the 28,598 sera from general population, 4585 (16%) had IgG antibodies against N, 6647 (23.2%) against S1-RBD and 7436 (26%) against either. The weighted and assay characteristic adjusted seroprevalence against either of the antibodies was 24.1 (95%CI: 23.0% to 25.3%). Seroprevalence was lower in rural areas (21.4%, 95% CI: 20.3% to 22.6%) compared to urban non-slum (29.4%, 95% CI: 26.9% - 32.1%) and slum areas (34.6%, 95% CI: 31.0% to 38.3%). Among 7385 HCWs, the seroprevalence of anti-S1-RBD IgG antibodies was 25.6% (95% CI: 23.5% to 27.8%). Interpretation: Nearly one in four individuals aged 10 years or older from general population as well as HCWs were exposed to SARS-CoV-2 by December 2020 amounting to 271 million infections in India. Funding Statement: Indian Council of Medical Research Declaration of Interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare no competing interests Ethics Approval Statement: The project was approved by Institutional Human Ethics Committee at ICMR-National Institute of Epidemiology.
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- 2021
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5. SARS-CoV-2 Sero-Prevalence among General Population and Healthcare Workers in India, December 2020 - January 2021
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Manoj V. Murhekar, Tarun Bhatnagar, Jeromie Wesley Vivian Thangaraj, V. Saravanakumar, Muthusamy Santhosh Kumar, Sriram Selvaraju, Kiran Rade, Girish Kumar CP, R. Sabarinathan, Alka Turuk, Smita Asthana, Rakesh Balachandar, Sampada Dipak Bangar, Avi Kumar Bansal, Vishal Chopra, Dasarathi Das, Alok Kumar Deb, Kangjam Rekha Devi, Vikas Dhikav, Gaurav Raj Dwivedi, S. Muhammad Salim Khan, M. Sunil Kumar, Avula Laxmaiah, Major Madhukar, Amarendra Mahapatra, Chethana Rangaraju, Jyotirmayee Turuk, Rajiv Yadav, Rushikesh Andhalkar, K. Arunraj, Dinesh Kumar Baradwaj, Pravin Bharti, Debdutta Bhattacharya, Jyothi Bhat, Ashrafjit S. Chahal, Debjit Chakraborty, Anshuman Chaudhury, Hirawati Deval, Sarang Dhatrak, Rakesh Dayal, D. Elantamilan, Prathiksha Giridharan, Inaamul Haq, Ramesh Kumar Hudda, Babu Jagjeevan, Arshad Kalliath, Srikanta Kanungo, Nivethitha N. Krishnan, Jaya Singh Kshatri, Alok Kumar, Niraj Kumar, V.G. Vinoth Kumar, Gangeti Gandhi Jayanthi Naga Lakshmi, Ganesh Mehta, Nandan Kumar Mishra, Anindya Mitra, K. Nagbhushanam, Arlappa Nimmathota, A.R. Nirmala, Ashok Kumar Pandey, Ganta Venkata Prasad, Mariya Amin Qurieshi, Sirasanambatti Devarajulu Reddy, Aby Robinson, Seema Sahay, Rochak Saxena, Krithikaa Sekar, Vijay Kumar Shukla, Hari Bhan Singh, Prashant Kumar Singh, Pushpendra Singh, Rajeev Singh, Nivetha Srinivasan, Dantuluri Sheethal Varma, Ankit Viramgami, Vimith Cheruvathoor Wilson, Surabhi Yadav, Suresh Yadav, Kamran Zaman, Amit Chakrabarti, Aparup Das, R.S. Dhaliwal, Shanta Dutta, Rajni Kant, A M Khan, Kanwar Narain, Somashekar Narasimhaiah, Chandrasekaran Padmapriyadarshini, Krishna Pandey, Sanghamitra Pati, Shripad Patil, Hemalatha Rajkumar, Tekumalla Ramarao, Y.K. Sharma, Shalini Singh, Samiran Panda, D.C.S. Reddy, Balram Bhargava, and ICMR Serosurveillance Group
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- 2021
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6. SARS-CoV-2 Antibody Prevalence in India: Findings from the Second Nationwide Household Serosurvey, August - September 2020
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Jaya Singh Kshatri, Balram Bhargava, Muthusamy Santhosh Kumar, R. Sabarinathan, Naman Shah, Srikanta Kanungo, Gaurav Raj Dwivedi, Mariya Amin Qurieshi, Kangjam Rekha Devi, V. Saravanakumar, Falguni Debnath, Ganta Venkata Prasad, Ashrafjit S. Chahal, Ankit Viramgami, Pushpendra Singh, Arshad Kalliath, Alka Turuk, Kiran Rade, Krithikaa Sekar, Jeromie Wesley Vivian Thangaraj, Rakesh Balachandar, Dantuluri Sheethal Varma, Ramesh Kumar Sangwan, Samiran Panda, Gangeti Gandhi Jayanthi Naga Lakshmi, C. P. Girish Kumar, Vijay K. Shukla, Inaamul Haq, A.R. Nirmala, Major Madhukar, Smita Asthana, Anindya Mitra, Sriram Selvaraju, Tarun Bhatnagar, Avula Laxmaiah, M. Sunil Kumar, Seema Sahay, Vishal Chopra, Prashant Singh, Sampada Dipak Bangar, Devarajulu Reddy, Dasarathi Das, Amarendra Mahapatra, Manoj V Murhekar, Suman Sundar Mohanty, Alok Kumar Deb, Chethana Rangaraju, Dinesh Kumar Baradwaj, S. Muhammad Salim Khan, Jyothi Bhat, Avi Kumar Bansal, and Rajeev K. Singh
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medicine.medical_specialty ,education.field_of_study ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Population ,Informed consent ,Epidemiology ,medicine ,Seroprevalence ,Urban slum ,Rural area ,Antibody prevalence ,education ,business ,Demography - Abstract
Background: The first round of national serosurvey in India was conducted in May-June 2020 among adults from 21 States. The second serosurvey was conducted in August-September 2020 to estimate the nationwide seroprevalence for SARS-CoV-2 infection in the general population aged ten years and above. Methods: The household serosurvey was conducted among individuals aged ten years and above in the same 700 villages and wards from 70 districts selected during the first serosurvey. Blood samples were tested using the Abbott SARS-CoV-2 IgG assay. Seroprevalence was estimated after applying the sampling weights and adjusting for clustering and assay characteristics. In order to compare the adult seroprevalence between the two surveys, we randomly selected one adult serum sample from each household. Findings: The weighted and adjusted prevalence of infection among 29,082 individuals aged ten years and above was 6·6% (95% CI: 5·8% - 7·4%). The seroprevalence among adults was 7·1% (95% CI: 6·2% – 8·2%). Seroprevalence was similar across age groups, sex, and occupation. Seroprevalence was highest in urban slum areas followed by urban non-slum and rural areas. We estimated a cumulative 74·3 million infections in the country, with 26 – 32 infections for every reported COVID-19 case by August 2020. Interpretation: Nearly one in 15 individuals aged ten years and above had SARS-CoV-2 infection by August 2020. The adult seroprevalence increased ten times between May and August 2020. Lower infection to case ratio in August compared to May reflects a substantial increase in testing across the country. Funding: The study was funded by the Indian Council of Medical Research, New Delhi, India. The study sponsor was involved in reviewing the study design, writing of the manuscript and the decision to submit the paper for publication. Declaration of Interests: The authors declare no competing interests. Ethics Approval Statement: The authors obtained written informed consent from individuals aged 18 years and older. We obtained assent from children aged between 10–17 years, and written informed consent from their parents or guardians prior to the survey. The Central Ethics Committee of Health Research of Indian Council of Medical Research and the Institutional Human Ethics Committee of ICMR-National Institute of Epidemiology, Chennai approved the study protocol.
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- 2020
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7. Microhair on the adaxial leaf surface of salt secreting halophytic Oryza coarctata Roxb. show distinct morphotypes: Isolation for molecular and functional analysis
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Rajakani, Raja, primary, Sellamuthu, Gothandapani, additional, V, Saravanakumar, additional, S, Kannappan, additional, Shabala, Lana, additional, Meinke, Holger, additional, Chen, Zhonghua, additional, Zhou, Meixue, additional, Parida, Ajay, additional, Shabala, Sergey, additional, and Venkataraman, Gayatri, additional
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- 2019
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