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Start Over Author "Varricchio, E." Publisher elsevier bv
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10. Orexin 1 receptor in the seminiferous tubules of boar testis: An immunohistochemical study

Author

L. Maruccio, Ettore Varricchio, Finizia Russo, Paolo de Girolamo, Antonio Calamo, Russo, F, Maruccio, Lucianna, Calamo, Antonio, DE GIROLAMO, Paolo, and Varricchio, E.

Subjects
Male, endocrine system, medicine.medical_specialty, Histology, BOAR, Sus scrofa, Cell Biology, General Medicine, Seminiferous Tubules, Biology, Immunohistochemistry, Orexin receptor, Orexin, Orexin-A, Endocrinology, medicine.anatomical_structure, Orexin Receptors, Internal medicine, medicine, Animals, Receptor, Germ cell, Testosterone
Abstract

Orexin receptor 1 (OX₁R) and orexin receptor 2 (OX₂R) are two G-protein-coupled receptors that bind their ligands, orexin A (OXA) and B (OXB), with different affinities. The male genital system represents an important target for OXA, which appears to play a role in the control of steroidogenesis and germ cell development in the testis. It is known that among domestic breeding animals, in the boar the number of Leydig cells is very high and OXA appears to have stimulatory activity on testosterone production. In this study, we aimed to evaluate the presence of OX₁R in the boar testis in order to extend our knowledge concerning the distribution and a potential functional role of the orexinergic system in the male reproductive tract of farm animals. The presence of OX₁R immunopositive cells in seminiferous tubules of the boar testis enables us to hypothesize a possible role of OXA on male germ cells cycle in pig. Further investigations, involving functional and ultrastructural analysis, may contribute to our understanding of the role of orexins in the boar genital system.

Published
2014
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