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617 results on '"Visco, A."'

1. Marginal zone lymphoma international prognostic index: a unifying prognostic index for marginal zone lymphomas requiring systemic treatment

Author

Arcaini, Luca, primary, Bommier, Côme, additional, Alderuccio, Juan Pablo, additional, Merli, Michele, additional, Fabbri, Nicole, additional, Nizzoli, Maria Elena, additional, Maurer, Matthew J., additional, Tarantino, Vittoria, additional, Ferrero, Simone, additional, Rattotti, Sara, additional, Talami, Annalisa, additional, Murru, Roberta, additional, Khurana, Arushi, additional, Mwangi, Raphael, additional, Deodato, Marina, additional, Cencini, Emanuele, additional, Re, Francesca, additional, Visco, Carlo, additional, Feldman, Andrew L., additional, Link, Brian K., additional, Delamain, Marcia Torresan, additional, Spina, Michele, additional, Annibali, Ombretta, additional, Pulsoni, Alessandro, additional, Ferreri, Andrés J.M., additional, Stelitano, Caterina Cecilia, additional, Pennese, Elsa, additional, Habermann, Thomas M., additional, Marcheselli, Luigi, additional, Han, Sunwoo, additional, Reis, Isildinha M., additional, Paulli, Marco, additional, Lossos, Izidore S., additional, Cerhan, James R., additional, and Luminari, Stefano, additional

Published
2024
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2. Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors

Author

Pettinella, Francesca, primary, Mariotti, Barbara, additional, Lattanzi, Chiara, additional, Bruderek, Kirsten, additional, Donini, Marta, additional, Costa, Sara, additional, Marini, Olivia, additional, Iannoto, Giulia, additional, Gasperini, Sara, additional, Caveggion, Elena, additional, Castellucci, Monica, additional, Calzetti, Federica, additional, Bianchetto-Aguilera, Francisco, additional, Gardiman, Elisa, additional, Giani, Matteo, additional, Dusi, Stefano, additional, Cantini, Maurizio, additional, Vassanelli, Aurora, additional, Pavone, Denise, additional, Milella, Michele, additional, Pilotto, Sara, additional, Biondani, Pamela, additional, Höing, Benedikt, additional, Schleupner, Marie Carolin, additional, Hussain, Timon, additional, Hadaschik, Boris, additional, Kaspar, Cordelia, additional, Visco, Carlo, additional, Tecchio, Cristina, additional, Koenderman, Leo, additional, Bazzoni, Flavia, additional, Tamassia, Nicola, additional, Brandau, Sven, additional, Cassatella, Marco A., additional, and Scapini, Patrizia, additional

Published
2024
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3. The role of genetic testing in suspected fulminant myocarditis: A case report

Author

Mistrulli, Raffaella, primary, Micolonghi, Caterina, additional, Follesa, Federico, additional, Fabiani, Marco, additional, Pagannone, Erika, additional, D'Amati, Giulia, additional, Giordano, Carla, additional, Caroselli, Silvia, additional, Savio, Camilla, additional, Germani, Aldo, additional, Pizzuti, Antonio, additional, Visco, Vincenzo, additional, Petrucci, Simona, additional, Rubattu, Speranza, additional, Piane, Maria, additional, and Autore, Camillo, additional

Published
2023
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8. Therapeutic advances for treating memory impairments in perinatal brain injuries with implications for cerebral palsy: a systematic review and meta-analysis of preclinical studies

Author

Calado, Caio Matheus Santos da Silva, primary, Manhães-de-Castro, Raul, additional, Pereira, Sabrina da Conceição, additional, da Silva Souza, Vanessa, additional, Visco, Diego Bulcão, additional, de Silveira, Beatriz Souza, additional, de Souza, Sandra Lopes, additional, and Toscano, Ana Elisa, additional

Published
2023
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9. Immunotherapy: AUTOLOGOUS CYTOKINE-INDUCED KILLER (CIK) CELLS COMBINED WITH ANTI CD20 ANTIBODY FOR B-CELL MALIGNANCIES: FIRST REPORT ON CLINICAL FEASIBILITY

Author

Elice, F., primary, Riva, M., additional, Bernardi, M., additional, Bozza, A., additional, Cappuzzello, E., additional, Catanzaro, D., additional, Chieregato, K., additional, Dalla Pietà, A., additional, Krampera, M., additional, Merlo, A., additional, Piazza, F., additional, Sommaggio, R., additional, Tisi, M., additional, Trentin, L., additional, Visco, C., additional, Visentin, A., additional, Tosetto, A., additional, Rosato, A., additional, and Astori, G., additional

Published
2023
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11. Characteristics associated with composite surgical failure over 5 years of women in a randomized trial of sacrospinous hysteropexy with graft vs vaginal hysterectomy with uterosacral ligament suspension

Author

Richter, Holly E., primary, Sridhar, Amaanti, additional, Nager, Charles W., additional, Komesu, Yuko M., additional, Harvie, Heidi S., additional, Zyczynski, Halina M., additional, Rardin, Charles, additional, Visco, Anthony, additional, Mazloomdoost, Donna, additional, and Thomas, Sonia, additional

Published
2023
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14. Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects

Author

Cortellino, Salvatore, primary, Raveane, Alessandro, additional, Chiodoni, Claudia, additional, Delfanti, Gloria, additional, Pisati, Federica, additional, Spagnolo, Vanessa, additional, Visco, Euplio, additional, Fragale, Giuseppe, additional, Ferrante, Federica, additional, Magni, Serena, additional, Iannelli, Fabio, additional, Zanardi, Federica, additional, Casorati, Giulia, additional, Bertolini, Francesco, additional, Dellabona, Paolo, additional, Colombo, Mario P., additional, Tripodo, Claudio, additional, and Longo, Valter D., additional

Published
2022
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15. Third dose of SARS-COV2 mRNA-vaccine in liver transplant recipients: can it bridge the response gap?

Author

Montalbano, Marzia, primary, Lionetti, Raffaella, additional, Comandini, Ubaldo Visco, additional, Meschi, Silvia, additional, Agrati, Chiara, additional, Conte, Federica, additional, Puro, Vincenzo, additional, Piccolo, Paola, additional, Matusali, Giulia, additional, Grassi, Germana, additional, Mereu, Tiziana, additional, Angelone, Federica, additional, Girardi, Enrico, additional, Ettorre, Giuseppe Maria, additional, and D’Offizi, Giampiero, additional

Published
2022
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16. Does m-RNA vaccination protect from Sars-Cov2 (asymptomatic) infection in liver transplant recipients?

Author

Comandini, Ubaldo Visco, primary, Montalbano, Marzia, additional, Lionetti, Raffaella, additional, Piccolo, Paola, additional, Nesticò, Daniela, additional, Meschi, Silvia, additional, Agrati, Chiara, additional, Taibi, Chiara, additional, Vincenzi, Laura, additional, Girardi, Enrico, additional, Ettorre, Giuseppe Maria, additional, and D’Offizi, Giampiero, additional

Published
2022
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17. Immunotherapy: AUTOLOGOUS CYTOKINE-INDUCED KILLER (CIK) CELLS COMBINED WITH ANTI CD20 ANTIBODY FOR B-CELL MALIGNANCIES: FIRST REPORT ON CLINICAL FEASIBILITY

Author

F. Elice, M. Riva, M. Bernardi, A. Bozza, E. Cappuzzello, D. Catanzaro, K. Chieregato, A. Dalla Pietà, M. Krampera, A. Merlo, F. Piazza, R. Sommaggio, M. Tisi, L. Trentin, C. Visco, A. Visentin, A. Tosetto, A. Rosato, and G. Astori

Subjects
Cancer Research, Transplantation, Oncology, Immunology, Immunology and Allergy, Cell Biology, Genetics (clinical)
Published
2023

18. Controlling faecal incontinence in women by performing anal exercises with biofeedback or loperamide: a randomised clinical trial

Author

J Eric Jelovsek, Alayne D Markland, William E Whitehead, Matthew D Barber, Diane K Newman, Rebecca G Rogers, Keisha Dyer, Anthony G Visco, Gary Sutkin, Halina M Zyczynski, Benjamin Carper, Susan F Meikle, Vivian W Sung, Marie G Gantz, John Eric Jelovsek, Mathew D. Barber, Marie Fidela R. Paraiso, Mark D. Walters, Beri Ridgeway, Brooke Gurland, Massarat Zutshi, Geetha Krishnan, Ly Pung, Annette Graham, Vivian W. Sung, Deborah L. Myers, Charles R. Rardin, Cassandra Carberry, B. Star Hampton, Kyle Wohlrab, Ann S. Meers, Anthony Visco, Cindy Amundsen, Alison Weidner, Nazema Siddiqui, Amie Kawasaki, Shantae McLean, Nicole Longoria, Jessica Carrington, Niti Mehta, Ingrid Harm-Ernandes, Jennifer Maddocks, Amy Pannullo, Alayne Markland, Holly E. Richter, R. Edward Varner, Robert Holley, L. Keith Lloyd, Tracy S. Wilson, Alicia Ballard, Jeannine McCormick, Velria Willis, Nancy Saxon, Kathy Carter, Susan Meikle, Charles Nager, Michael Albo, Emily Lukacz, Cindy Furey, Patricia Riley, JoAnn Columbo, Sherella Johnson, Shawn Menefee, Karl Luber, Gouri Diwadkar, Jasmine Tan-Kim, Rebecca G. Rogers, Yuko Komesu, Gena Dunivan, Peter Jeppson, Sara Cichowski, Christy Miller, Erin Yane, Julia Middendorf, Risela Nava, Marie G. Gantz, Dennis Wallace, Amanda Shaffer, Poonam Pande, Kelly Roney, Ryan E. Whitworth, Lauren Klein Warren, Kevin A. Wilson, Brenda Hair, Kendra Glass, Daryl Matthews, James W. Pickett, Yan Tang, Tamara L. Terry, Lynda Tatum, Barbara Bibb, Jutta Thornberry, Kristin Zaterka-Baxter, Lindsay Morris, Lily Arya, Ariana Smith, Heidi Harve, Uduak Umoh Andy, Pamela Levin, Diane K. Newman, Mary Wang, Donna Thompson, Teresa Carney, Michelle Kingslee, Lorraine Flick, Halina M. Zyczynski, Pam Moalli, Jonathan Shepherd, Michael Bonidie, Steven Abo, Janet Harrison, Christopher Chermansky, Lori Geraci, Judy Gruss, Karen Mislanovich, Ellen Eline, Beth Klump, Susan E. George, William E. Whitehead, Kay Dickersin, Luohua Jiang, Missy Lavender, Kate O'Dell, Kate Ryan, Paul Tulikangas, Lan Kong, Donna McClish, Leslie Rickey, David Shade, Ashok Tuteja, and Susan Yount

Subjects
Loperamide, medicine.medical_specialty, Constipation, medicine.medical_treatment, Anal Canal, Biofeedback, Placebo, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Severity of illness, medicine, Clinical endpoint, Humans, Hepatology, business.industry, digestive, oral, and skin physiology, Gastroenterology, Biofeedback, Psychology, Exercise Therapy, Clinical trial, 030220 oncology & carcinogenesis, Physical therapy, Female, 030211 gastroenterology & hepatology, medicine.symptom, business, Fecal Incontinence, medicine.drug
Abstract

Summary Background Well designed, large comparative effectiveness trials assessing the efficacy of primary interventions for faecal incontinence are few in number. The objectives of this study were to compare different combinations of anorectal manometry-assisted biofeedback, loperamide, education, and oral placebo. Methods In this randomised factorial trial, participants were recruited from eight clinical sites in the USA. Women with at least one episode of faecal incontinence per month in the past 3 months were randomly assigned 0·5:1:1:1 to one of four groups: oral placebo plus education only, placebo plus anorectal manometry-assisted biofeedback, loperamide plus education only, and loperamide plus anorectal manometry-assisted biofeedback. Participants received 2 mg per day of loperamide or oral placebo with the option of dose escalation or reduction. Women assigned to biofeedback received six visits, including strength and sensory biofeedback training. All participants received a standardised faecal incontinence patient education pamphlet and were followed for 24 weeks after starting treatment. The primary endpoint was change in St Mark's (Vaizey) faecal incontinence severity score between baseline and 24 weeks, analysed by intention-to-treat using general linear mixed modelling. Investigators, interviewers, and outcome evaluators were masked to biofeedback assignment. Participants and all study staff other than the research pharmacist were masked to medication assignment. Randomisation took place within the electronic data capture system, was stratified by site using randomly permuted blocks (block size 7), and the sizes of the blocks and the allocation sequence were known only to the data coordinating centre. This trial is registered with ClinicalTrials.gov, number NCT02008565. Findings Between April 1, 2014, and Sept 30, 2015, 377 women were enrolled, of whom 300 were randomly assigned to placebo plus education (n=42), placebo plus biofeedback (n=84), loperamide plus education (n=88), and the combined intervention of loperamide plus biofeedback (n=86). At 24 weeks, there were no differences between loperamide versus placebo (model estimated score change −1·5 points, 95% CI −3·4 to 0·4, p=0·12), biofeedback versus education (−0·7 points, −2·6 to 1·2, p=0·47), and loperamide and biofeedback versus placebo and biofeedback (−1·9 points, −4·1 to 0·3, p=0·092) or versus loperamide plus education (−1·1 points, −3·4 to 1·1, p=0·33). Constipation was the most common grade 3 or higher adverse event and was reported by two (2%) of 86 participants in the loperamide and biofeedback group and two (2%) of 88 in the loperamide plus education group. The percentage of participants with any serious adverse events did not differ between the treatment groups. Only one serious adverse event was considered related to treatment (small bowel obstruction in the placebo and biofeedback group). Interpretation In women with normal stool consistency and faecal incontinence bothersome enough to seek treatment, we were unable to find evidence against the null hypotheses that loperamide is equivalent to placebo, that anal exercises with biofeedback is equivalent to an educational pamphlet, and that loperamide and biofeedback are equivalent to oral placebo and biofeedback or loperamide plus an educational pamphlet. Because these are common first-line treatments for faecal incontinence, clinicians could consider combining loperamide, anal manometry-assisted biofeedback, and a standard educational pamphlet, but this is likely to result in only negligible improvement over individual therapies and patients should be counselled regarding possible constipation. Funding Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Institutes of Health Office of Research on Women's Health

Published
2019

19. Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects

Author

Salvatore Cortellino, Alessandro Raveane, Claudia Chiodoni, Gloria Delfanti, Federica Pisati, Vanessa Spagnolo, Euplio Visco, Giuseppe Fragale, Federica Ferrante, Serena Magni, Fabio Iannelli, Federica Zanardi, Giulia Casorati, Francesco Bertolini, Paolo Dellabona, Mario P. Colombo, Claudio Tripodo, Valter D. Longo, Cortellino, Salvatore, Raveane, Alessandro, Chiodoni, Claudia, Delfanti, Gloria, Pisati, Federica, Spagnolo, Vanessa, Visco, Euplio, Fragale, Giuseppe, Ferrante, Federica, Magni, Serena, Iannelli, Fabio, Zanardi, Federica, Casorati, Giulia, Bertolini, Francesco, Dellabona, Paolo, Colombo, Mario P, Tripodo, Claudio, and Longo, Valter D

Subjects
Tumor Microenvironment, Humans, Triple Negative Breast Neoplasms, Fasting, Immunotherapy, Settore MED/08 - Anatomia Patologica, Glycolysis, nutrition, triple-negative breast cancer, CP: Cancer, CP: Immunology, fasting, fasting-mimicking diet, immunotherapy, inflammation, B7-H1 Antigen, General Biochemistry, Genetics and Molecular Biology
Abstract

Immunotherapy is improving the prognosis and survival of cancer patients, but despite encouraging out-comes in different cancers, the majority of tumors are resistant to it, and the immunotherapy combinations are often accompanied by severe side effects. Here, we show that a periodic fasting-mimicking diet (FMD) can act on the tumor microenvironment and increase the efficacy of immunotherapy (anti-PD-L1 and anti-OX40) against the poorly immunogenic triple-negative breast tumors (TNBCs) by expanding early exhausted effector T cells, switching the cancer metabolism from glycolytic to respiratory, and reducing collagen depo-sition. Furthermore, FMD reduces the occurrence of immune-related adverse events (irAEs) by preventing the hyperactivation of the immune response. These results indicate that FMD cycles have the potential to enhance the efficacy of anti-cancer immune responses, expand the portion of tumors sensitive to immuno-therapy, and reduce its side effects.

Published
2022

20. P525. Cell Type-Specific Manifestations of Cortical Thickness Heterogeneity in Schizophrenia

Author

Di Biase, Maria A., primary, Geaghan, Michael, additional, Reay, William, additional, Seidlitz, Jakob, additional, Weickert, Cynthia Shannon, additional, Green, Melissa, additional, Quidé, Yann, additional, Atkins, Joshua, additional, Lyall, Amanda, additional, Pasternak, Ofer, additional, Kubicki, Marek, additional, Rathi, Yogesh, additional, Visco, Andrew, additional, Gaunnac, Megan, additional, Lv, Jinglei, additional, Mesholam-Gately, Raquelle, additional, Lewandowski, Kathryn, additional, Holt, Daphne J., additional, Keshavan, Matcheri, additional, Pantelis, Christos, additional, Öngür, Dost, additional, Breier, Alan, additional, Cairns, Murray, additional, Shenton, Martha, additional, and Zalesky, Andrew, additional

Published
2022
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24. Rate-Dependent Deformation of Amorphous Sulfide Glass Electrolytes for Solid-State Batteries

Author

Christos E. Athanasiou, Xing Liu, Mok Yun Jin, Eugene Nimon, Steve Visco, Cholho Lee, Myounggu Park, Junnyeong Yun, Nitin P. Padture, Huajian Gao, Brian W. Sheldon, School of Mechanical and Aerospace Engineering, and Institute of High Performance Computing, A*STAR

Subjects
History, General Energy, Polymers and Plastics, Amorphous Sulfides, Mechanical engineering [Engineering], General Engineering, General Physics and Astronomy, General Materials Science, General Chemistry, Business and International Management, Industrial and Manufacturing Engineering, Contact Mechanics
Abstract

Sulfide glasses are emerging as potential electrolytes for solid-state batteries. The mechanical behavior of these materials can significantly impact cell performance, and it is thus imperative to understand their deformation and fracture mechanisms. Previous work mainly reports properties obtained under quasi-static loading conditions, but very little is known about deformation under dynamic conditions. The current investigation shows that the sulfide glass mechanical behavior is dominated by viscoplasticity, differing substantially from polycrystalline oxide and sulfide solid electrolytes. Finite element modeling indicates that the sulfide glass stiffness is high enough to maintain good contact with softer lithium metal electrodes under moderate stack pressures. The observed viscoplasticity also implies that battery operating conditions will play an important role in electro-chemo-mechanical processes that are associated with dendritic lithium penetration. In general, the rate-dependent mechanical behavior of the sulfide glass electrolytes documented here offers a new dimension for designing next-generation all-solid-state batteries. Published version The authors acknowledge financial support from SK Innovation and the National Science Foundation (DMR-2124775).

Published
2022

25. Characteristics associated with composite surgical failure over 5 years of women in a randomized trial of sacrospinous hysteropexy with graft vs vaginal hysterectomy with uterosacral ligament suspension

Author

Holly E. Richter, Amaanti Sridhar, Charles W. Nager, Yuko M. Komesu, Heidi S. Harvie, Halina M. Zyczynski, Charles Rardin, Anthony Visco, Donna Mazloomdoost, and Sonia Thomas

Subjects
Treatment Outcome, Gynecologic Surgical Procedures, Ligaments, Uterine Prolapse, Hysterectomy, Vaginal, Humans, Obstetrics and Gynecology, Female, Obesity, Pelvic Organ Prolapse
Abstract

Among women with symptomatic uterovaginal prolapse undergoing vaginal surgery in the Vaginal hysterectomy with Native Tissue Vault Suspension vs Sacrospinous Hysteropexy with Graft Suspension (Study for Uterine Prolapse Procedures Randomized Trial) trial, sacrospinous hysteropexy with graft (hysteropexy) resulted in a lower composite surgical failure rate than vaginal hysterectomy with uterosacral suspension over 5 years.This study aimed to identify factors associated with the rate of surgical failure over 5 years among women undergoing sacrospinous hysteropexy with graft vs vaginal hysterectomy with uterosacral suspension for uterovaginal prolapse.This planned secondary analysis of a comparative effectiveness trial of 2 transvaginal apical suspensions (NCT01802281) defined surgical failure as either retreatment of prolapse, recurrence of prolapse beyond the hymen, or bothersome prolapse symptoms. Baseline clinical and sociodemographic factors for eligible participants receiving the randomized surgery (N=173) were compared across categories of failure (≤1 year,1 year, and no failure) with rank-based tests. Factors with adequate prevalence and clinical relevance were assessed for minimally adjusted bivariate associations using piecewise exponential survival models adjusting for randomized apical repair and clinical site. The multivariable model included factors with bivariate P.2, additional clinically important variables, apical repair, and clinical site. Backward selection determined final retained risk factors (P.1) with statistical significance evaluated by Bonferroni correction (P.005). Final factors were assessed for interaction with type of apical repair at P.1. Association is presented by adjusted hazard ratios and further illustrated by categorization of risk factors.In the final multivariable model, body mass index (increase of 5 kg/mObesity and duration of prolapse symptoms have been determined as risk factors associated with surgical failure over 5 years from transvaginal prolapse repair, regardless of approach. Providers and patients should consider these modifiable risk factors when discussing treatment plans for bothersome prolapse.

Published
2023

26. High prevalence of asymptomatic SARS-CoV-2 infection in a cohort of liver transplant recipients in central Italy

Author

Visco-Comandini, Ubaldo, primary, Castilletti, Concetta, additional, Lionetti, Raffaella, additional, Meschi, Silvia, additional, Montalbano, Marzia, additional, Rianda, Alessia, additional, Taibi, Chiara, additional, Sorace, Chiara, additional, Guglielmo, Nicola, additional, Piccolo, Paola, additional, Paci, Paola, additional, Ettorre, Giuseppe Maria, additional, and Gianpiero, D'Offizi, additional

Published
2022
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27. Liver transplantation from active COVID-19 donors: A lifesaving opportunity worth grasping?

Author

Romagnoli, Renato, primary, Gruttadauria, Salvatore, additional, Tisone, Giuseppe, additional, Maria Ettorre, Giuseppe, additional, De Carlis, Luciano, additional, Martini, Silvia, additional, Tandoi, Francesco, additional, Trapani, Silvia, additional, Saracco, Margherita, additional, Luca, Angelo, additional, Manzia, Tommaso Maria, additional, Visco Comandini, Ubaldo, additional, De Carlis, Riccardo, additional, Ghisetti, Valeria, additional, Cavallo, Rossana, additional, Cardillo, Massimo, additional, and Grossi, Paolo Antonio, additional

Published
2021
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28. Actuation crosstalk in free-falling systems: Torsion pendulum results for the engineering model of the LISA pathfinder gravitational reference sensor

Author

Antonella Cavalleri, Aniello Grado, N. Finetti, Mauro Hueller, Massimo Bassan, L. Di Fiore, F. Garufi, Massimo Visco, Leopoldo Milano, R. De Rosa, Y. Minenkov, Ruggero Stanga, W. J. Weber, F. De Marchi, Rita Dolesi, M. De Laurentis, L. Marconi, Daniele Vetrugno, Giuseppe Pucacco, S. Vitale, Bassan, M., Cavalleri, A., De Laurentis, M., De Marchi, F., De Rosa, Rosario., Di Fiore, L., Dolesi, R., Finetti, N., Garufi, F., Grado, A., Hueller, M., Marconi, L., Milano, L., Minenkov, Y., Pucacco, G., Stanga, R., Vetrugno, D., Visco, M., Vitale, S., and Weber, W. J.

Subjects
Physics, LISA, 010308 nuclear & particles physics, Acoustics, Settore FIS/01 - Fisica Sperimentale, Actuation, Astrophysics::Instrumentation and Methods for Astrophysics, Torsion pendulum, Astronomy and Astrophysics, Control force, 01 natural sciences, Gravitation, Crosstalk, Free falling, Pathfinder, Classical mechanics, Torsion pendulum clock, 0103 physical sciences, Inertial motion, Reference sensor, Torque, 010306 general physics, Inertial motion, Crosstalk, Torsion pendulum, LISA, Actuation
Abstract

In this paper we report on measurements on actuation crosstalk, relevant to the gravitational reference sensors for LISA Pathfinder and LISA. In these sensors, a Test Mass (TM) falls freely within a system of electrodes used for readout and control. These measurements were carried out on ground with a double torsion pendulum that allowed us to estimate both the torque injected into the sensor when a control force is applied and, conversely, the force leaking into the translational degree of freedom due to the applied torque.The values measured on our apparatus (the engineering model of the LISA Pathfinder sensor) agree to within 0.2% (over a maximum measured crosstalk of 1%) with predictions of a mathematical model when measuring force to torque crosstalk, while it is somewhat larger than expected (up to 3.5%) when measuring torque to force crosstalk. However, the values in the relevant range, i.e. when the TM is well centered ( ± 10 µm) in the sensor, remain smaller than 0.2%, satisfying the LISA Pathfinder requirements.

Published
2018

29. Defining mechanisms of recurrence following apical prolapse repair based on imaging criteria

Author

Bowen, Shaniel T., primary, Moalli, Pamela A., additional, Abramowitch, Steven D., additional, Lockhart, Mark E., additional, Weidner, Alison C., additional, Ferrando, Cecile A., additional, Nager, Charles W., additional, Richter, Holly E., additional, Rardin, Charles R., additional, Komesu, Yuko M., additional, Harvie, Heidi S., additional, Mazloomdoost, Donna, additional, Sridhar, Amaanti, additional, Gantz, Marie G., additional, Albo, Michael E., additional, Alperin, Marianna, additional, Columbo, Joann, additional, Curry, Jodi, additional, Ferrante, Kimberly, additional, Herrala, Kyle, additional, Johnson, Sherella, additional, Kirby, Anna C., additional, Lukacz, Emily S., additional, Ruppert, Erika, additional, Wasenda, Erika, additional, Diwadkar, Gouri B., additional, Dyer, Keisha Y., additional, Mackinnon, Linda M., additional, Menefee, Shawn A., additional, Tan-Kim, Jasmine, additional, Zazueta-Damian, Gisselle, additional, Amundsen, Cindy, additional, Bruton, Yasmeen, additional, Coleman-Taylor, Notorious, additional, Gilliam, Robin, additional, Harris, Acacia, additional, Hayes, Akira, additional, Kawasaki, Amie, additional, Longoria, Nicole, additional, McLean, Shantae, additional, Raynor, Mary, additional, Siddiqui, Nazema, additional, Visco, Anthony G., additional, Ballard, Alicia, additional, Carter, Kathy, additional, Ellington, David, additional, Patel, Sunita, additional, Saxon, Nancy, additional, Varner, R. Edward, additional, Willis, Velria, additional, Carberry, Cassandra, additional, Douglas, Samantha, additional, Hampton, B. Star, additional, Korbly, Nicole, additional, Meers, Ann S., additional, Myers, Deborah L., additional, Sung, Vivian W., additional, Viscione, Elizabeth-Ann, additional, Wohlrab, Kyle, additional, Box, Karen, additional, Dunivan, Gena, additional, Jeppson, Peter, additional, Middendorf, Julia, additional, Rogers, Rebecca G., additional, Arya, Lily, additional, Andy, Uduak, additional, Butler, Norman, additional, Cain, Doris, additional, Carney, Teresa, additional, Flick, Lorraine, additional, Desai Khanijow, Kavita, additional, Kingslee, Michelle, additional, Lee, Daniel, additional, O’Donnell, Patricia, additional, Smith, Ariana, additional, Thompson, Donna, additional, Bonidie, Michael, additional, Gruss, Judy, additional, Lowder, Jerry, additional, Shepherd, Jonathan, additional, Sutkin, Gary, additional, Zyczynski, Halina M., additional, Barber, Matthew, additional, Dastoli, Kathleen, additional, Edington, Maryori, additional, Graham, Annette, additional, Krishnan, Geetha, additional, Jelovsek, Eric, additional, Paraiso, Marie Fidela R., additional, Pung, Ly, additional, Ferrando, Cecile, additional, Walters, Mark, additional, Meikle, Susan, additional, Burd, Andrew, additional, Burdekin, Kate, additional, Glass, Kendra, additional, Grant, Tracey, additional, Grey, Scott, additional, Ham, Michael, additional, Pickett, James, additional, Wallace, Dennis, additional, Whitworth, Ryan, additional, Shaffer, Amanda, additional, and Swankie, Taylor, additional

Published
2021
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30. Virtual high-throughput screens identifying hPK-M2 inhibitors: Exploration of model extrapolation

Author

Lyndsey N. Schmucker, Donald P. Visco, and Jonathan J. Chen

Subjects
Models, Molecular, 0301 basic medicine, Quantitative structure–activity relationship, Computer science, Pyruvate Kinase, Drug Evaluation, Preclinical, Extrapolation, Quantitative Structure-Activity Relationship, Computational biology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Humans, Enzyme Inhibitors, Throughput (business), Training set, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Initial screen, Organic Chemistry, Experimental validation, Warburg effect, High-Throughput Screening Assays, Computational Mathematics, 030104 developmental biology, 030220 oncology & carcinogenesis
Abstract

Glycolysis with PK-M2 occurs typically in anaerobic conditions and atypically in aerobic conditions, which is known as the Warburg effect. The Warburg effect is found in many oncogenic situations and is believed to provide energy and biomass for oncogenesis to persist. The work presented targets human PK-M2 (hPK-M2) in a virtual high-throughput screen to identify new inhibitors and leads for further study. In the initial screen, one of the 12 candidates selected for experimental validation showed biological activity (hit-rate = 8.13%). In the second screen with retrained models, six of 11 candidates selected for experimental validation showed biological activity (hit-rate: 54.5%). Additionally, four different scaffolds were identified for further analysis when examining the tested candidates and compounds in the training data. Finally, extrapolation was necessary to identify a sufficient number of candidates to test in the second screen. Examination of the results suggested stepwise extrapolation to maximize efficiency.

Published
2019

33. Effect of sacrospinous hysteropexy with graft vs vaginal hysterectomy with uterosacral ligament suspension on treatment failure in women with uterovaginal prolapse: 5-year results of a randomized clinical trial

Author

Nager, Charles W., primary, Visco, Anthony G., additional, Richter, Holly E., additional, Rardin, Charles R., additional, Komesu, Yuko, additional, Harvie, Heidi S., additional, Zyczynski, Halina M., additional, Paraiso, Marie Fidela R., additional, Mazloomdoost, Donna, additional, Sridhar, Amaanti, additional, and Thomas, Sonia, additional

Published
2021
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35. Efficacy of R-COMP in comparison to R-CHOP in patients with DLBCL: A systematic review and single-arm metanalysis

Author

Visco, Carlo, primary, Pregnolato, Francesca, additional, Ferrarini, Isacco, additional, De Marco, Beatrice, additional, Bonuomo, Valentina, additional, Sbisà, Eugenio, additional, Fraenza, Costanza, additional, Bernardelli, Andrea, additional, Tanasi, Ilaria, additional, Quaglia, Francesca Maria, additional, and Krampera, Mauro, additional

Published
2021
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38. P525. Cell Type-Specific Manifestations of Cortical Thickness Heterogeneity in Schizophrenia

Author

Maria A. Di Biase, Michael Geaghan, William Reay, Jakob Seidlitz, Cynthia Shannon Weickert, Melissa Green, Yann Quidé, Joshua Atkins, Amanda Lyall, Ofer Pasternak, Marek Kubicki, Yogesh Rathi, Andrew Visco, Megan Gaunnac, Jinglei Lv, Raquelle Mesholam-Gately, Kathryn Lewandowski, Daphne J. Holt, Matcheri Keshavan, Christos Pantelis, Dost Öngür, Alan Breier, Murray Cairns, Martha Shenton, and Andrew Zalesky

Subjects
Biological Psychiatry
Published
2022

39. Valve-in-Valve With Allegra Implantation in Failed Direct Flow Transcatheter Heart Valve

Author

Francesco Ancona, Saud Khawaja, Nicola Buzzatti, Eustachio Agricola, Matteo Montorfano, Alessandro Beneduce, Luca A. Ferri, Marco Ancona, Anna Palmisano, Barbara Bellini, Francesco Moroni, Antonio Esposito, Emanuele Visco, RT Vittorio Romano, Ancona, M. B., Visco, E., Khawaja, S., Romano, V., Moroni, F., Ferri, L., Bellini, B., Beneduce, A., Ancona, F., Agricola, E., Buzzatti, N., Palmisano, A., Esposito, A., and Montorfano, M.

Subjects
valve-in-valve, medicine.medical_specialty, Transcatheter aortic, business.industry, medicine.medical_treatment, Hemodynamics, 030204 cardiovascular system & hematology, medicine.disease, Direct flow, Valve in valve, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Valve replacement, direct flow, Internal medicine, Heart failure, Aortic valve surgery, medicine, Cardiology, Allegra, 030212 general & internal medicine, Heart valve, Cardiology and Cardiovascular Medicine, business
Abstract

An 87-year-old man with a history of transcatheter aortic valve replacement with a 6-year-old 27-mm Direct Flow bioprosthesis (Direct Flow Medical, Santa Rosa, California), presented with heart failure. Echocardiography showed normal transcatheter heart valve (THV) leaflets with no obstruction (mean

Published
2020

41. PROGNOSTIC VALUE OF RIGHT VENTRICULAR SYSTOLIC PRESSURE (RVSP) IN PATIENTS HOSPITALIZED WITH HEART FAILURE

Author

Majmundar, Monil M., primary, Kansara, Tikal, additional, Park, Hansang, additional, Lenik, Joanna, additional, Gapuz, Kristine, additional, Khan, Nazia, additional, Quesada, Fernando, additional, Ghosh, Kuldeep, additional, Shah, Palak, additional, Kumar, Ashish, additional, Doshi, Rajkumar, additional, Mene-Afejuku, Tuoyo, additional, Patel, Harsh, additional, Thakkar, Samarthkumar, additional, Chaudhari, Shobhana, additional, Mushiyev, Savi, additional, and Visco, Ferdinand, additional

Published
2021
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42. Meta-Analysis of Transcatheter Aortic Valve Implantation in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valve

Author

Majmundar, Monil, primary, Kumar, Ashish, additional, Doshi, Rajkumar, additional, Shah, Palak, additional, Arora, Shilpkumar, additional, Shariff, Mariam, additional, Adalja, Devina, additional, Visco, Ferdinand, additional, Amin, Hossam, additional, Vallabhajosyula, Saraschandra, additional, Gullapalli, Nageshwara, additional, Kapadia, Samir R., additional, Kalra, Ankur, additional, and Panaich, Sidakpal S., additional

Published
2021
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43. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Mondi, Annalisa, primary, Lorenzini, Patrizia, additional, Castilletti, Concetta, additional, Gagliardini, Roberta, additional, Lalle, Eleonora, additional, Corpolongo, Angela, additional, Valli, Maria Beatrice, additional, Taglietti, Fabrizio, additional, Cicalini, Stefania, additional, Loiacono, Laura, additional, Di Gennaro, Francesco, additional, D’Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Antinori, Andrea, additional, Zito, Sara, additional, Abbonizio, Maria Alessandra, additional, Abdeddaim, Amina, additional, Agostini, Elisabetta, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonica, Maria Assunta, additional, Antonini, Mario, additional, Bartoli, Tommaso Ascoli, additional, Baldini, Francesco, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Bellagamba, Rita, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Biava, Gianluigi, additional, Bibas, Michele, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Boumis, Evangelo, additional, Branca, Marta, additional, Buonomo, Rosanna, additional, Busso, Donatella, additional, Camici, Marta, additional, Campioni, Paolo, additional, Canichella, Flaminia, additional, Capone, Alessandro, additional, Caporale, Cinzia, additional, Caraffa, Emanuela, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Cataldo, Adriana, additional, Cerilli, Stefano, additional, Cerva, Carlotta, additional, Chiappini, Roberta, additional, Chinello, Pierangelo, additional, Cianfarani, Maria Assunta, additional, Ciaralli, Carmine, additional, Cimaglia, Claudia, additional, Cinicola, Nicola, additional, Ciotti, Veronica, additional, Colavita, Francesca, additional, Cristofaro, Massimo, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, De Angelis, Alessia, additional, De Angelis, Giada, additional, De Palo, Maria Grazia, additional, De Zottis, Federico, additional, Di Bari, Virginia, additional, Di Lorenzo, Rachele, additional, Di Stefano, Federica, additional, Donno, Davide, additional, Evangelista, Francesca, additional, Faraglia, Francesca, additional, Farina, Anna, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Fusetti, Matteo, additional, Galati, Vincenzo, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Gaviano, Ilaria, additional, Tekle, Saba Gebremeskel, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Granata, Guido, additional, Greci, Maria Cristina, additional, Grilli, Elisabetta, additional, Grisetti, Susanna, additional, Gualano, Gina, additional, Iacomi, Fabio, additional, Iaconi, Marta, additional, Iannicelli, Giuseppina, additional, Inversi, Carlo, additional, Lamanna, Maria Elena, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Libertone, Raffaella, additional, Lionetti, Raffaella, additional, Liuzzi, Giuseppina, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Maffongelli, Gaetano, additional, Marani, Alessandra, additional, Marchioni, Luisa, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Mastrobattista, Annelisa, additional, Mastrorosa, Ilaria, additional, Matusali, Giulia, additional, Mazzotta, Valentina, additional, Mencarini, Paola, additional, Meschi, Silvia, additional, Messina, Francesco, additional, Micarelli, Sibiana, additional, Mogavero, Giulia, additional, Mondi, Annalisa, additional, Montalbano, Marzia, additional, Montaldo, Chiara, additional, Mosti, Silvia, additional, Murachelli, Silvia, additional, Musso, Maria, additional, Nardi, Michela, additional, Navarra, Assunta, additional, Nocioni, Martina, additional, Noto, Pasquale, additional, Noto, Roberto, additional, Oliva, Alessandra, additional, Onnis, Ilaria, additional, Ottou, Sandrine, additional, Palazzolo, Claudia, additional, Pallini, Emanuele, additional, Palombi, Giulio, additional, Pareo, Carlo, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Penna, Giovanna, additional, Petrecchia, Antonella, additional, Petrone, Ada, additional, Pianura, Elisa, additional, Pinnetti, Carmela, additional, Pisciotta, Maria, additional, Piselli, Pierluca, additional, Pittalis, Silvia, additional, Pontarelli, Agostina, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Ramazzini, Paolo Migliorisi, additional, Rianda, Alessia, additional, Rinonapoli, Gabriele, additional, Rosati, Silvia, additional, Rubino, Dorotea, additional, Rueca, Martina, additional, Ruggeri, Alberto, additional, Sacchi, Alessandra, additional, Sampaolesi, Alessandro, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarabello, Alessandra, additional, Scarcia, Silvana, additional, Schininà, Vincenzo, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Strano, Giacomo, additional, Taibi, Chiara, additional, Taloni, Giorgia, additional, Nardi, Tetaj, additional, Tonnarini, Roberto, additional, Topino, Simone, additional, Tozzi, Martina, additional, Vairo, Francesco, additional, Vergori, Alessandra, additional, Vincenzi, Laura, additional, Visco-Comandini, Ubaldo, additional, Vita, Serena, additional, Vittozzi, Pietro, additional, Zaccarelli, Mauro, additional, and Zanetti, Antonella, additional

Published
2021
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45. The Fibrosis-4 index is associated with Intensive Care Unit (ICU) admission in middle-aged patients with COVID-19

Author

Biliotti, E., primary, Piselli, P., additional, Visco Comandini, U., additional, Lionetti, R., additional, Taibi, C., additional, Vincenzi, L., additional, Moghazi, S. Al, additional, Antinori, A., additional, Caraffa, E., additional, Cimaglia, C., additional, Marchioni, L., additional, Mariano, A., additional, Mastrorosa, I., additional, Mosti, S., additional, Navarra, A., additional, Nicastri, E., additional, Palmieri, F., additional, Girardi, E., additional, D'Offizi, G., additional, and Study Group, ReCOVeRI, additional

Published
2021
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46. Bounded Rationality and Expectations in Economics

Author

Giordano Zevi and Ignazio Visco

Subjects
Empirical research, Economic agents, Economics, Survey data collection, Positive economics, Degree (music), Bounded rationality
Abstract

Starting from Simon’s bounded rationality notion, in this study we consider some of the links between concepts of bounded rationality and the approaches followed by economists in their analysis of the role played by economic agents’ expectations in driving the evolution of the economy through time. We argue that the degree of attention devoted to the formation of expectations by the macroeconomic theory has followed high and low cycles. In recent years, the increasing availability of survey data and the failings of models based on purely rational representative agents have prompted renewed interest in inquiries into the direct measurement of expectations and empirical studies of their formation. The intellectual legacy of Herbert Simon provides a useful guide for both these activities.

Published
2020

47. Problems with interpreting troponins in chronic kidney disease patients for ruling out acute coronary syndrome

Author

Craig Basman, Ferdinand Visco, Monil Majmundar, and Tikal Kansara

Subjects
medicine.medical_specialty, Acute coronary syndrome, Chest pain, Sensitivity and Specificity, 03 medical and health sciences, 0302 clinical medicine, Troponin T, medicine, Humans, Acute Coronary Syndrome, Renal Insufficiency, Chronic, Intensive care medicine, Pathological, biology, business.industry, Troponin I, 030208 emergency & critical care medicine, General Medicine, Emergency department, medicine.disease, Troponin, Triage, Emergency Medicine, biology.protein, medicine.symptom, business, Kidney disease
Abstract

Chest pain is one of the most common reasons for emergency department visits worldwide, and troponins play a central role in diagnosing acute coronary syndrome (ACS) in these patients. Hence, the tests for these molecules are imperative in triage for ACS. Presently, multiple high-sensitivity troponin tests are available, including those for troponin T and I. However, in the presence of physiological and pathological alterations such as chronic kidney disease (CKD) and muscle dysfunction, these tests lose their sensitivity and specificity, especially if not interpreted in the right clinical background. Further, no guidelines exist for interpreting the results in patients with CKD. We identified studies that compared the relative efficacy, sensitivity, and specificity of tests for troponin T and I in patients with CKD to understand the practical problems in the clinical interpretation of these results in the specific setting of CKD and highlight the measures to be taken into consideration.

Published
2021

48. Defining mechanisms of recurrence following apical prolapse repair based on imaging criteria

Author

Shaniel T. Bowen, Pamela A. Moalli, Steven D. Abramowitch, Mark E. Lockhart, Alison C. Weidner, Cecile A. Ferrando, Charles W. Nager, Holly E. Richter, Charles R. Rardin, Yuko M. Komesu, Heidi S. Harvie, Donna Mazloomdoost, Amaanti Sridhar, Marie G. Gantz, Michael E. Albo, Marianna Alperin, Joann Columbo, Jodi Curry, Kimberly Ferrante, Kyle Herrala, Sherella Johnson, Anna C. Kirby, Emily S. Lukacz, Erika Ruppert, Erika Wasenda, Gouri B. Diwadkar, Keisha Y. Dyer, Linda M. Mackinnon, Shawn A. Menefee, Jasmine Tan-Kim, Gisselle Zazueta-Damian, Cindy Amundsen, Yasmeen Bruton, Notorious Coleman-Taylor, Robin Gilliam, Acacia Harris, Akira Hayes, Amie Kawasaki, Nicole Longoria, Shantae McLean, Mary Raynor, Nazema Siddiqui, Anthony G. Visco, Alicia Ballard, Kathy Carter, David Ellington, Sunita Patel, Nancy Saxon, R. Edward Varner, Velria Willis, Cassandra Carberry, Samantha Douglas, B. Star Hampton, Nicole Korbly, Ann S. Meers, Deborah L. Myers, Vivian W. Sung, Elizabeth-Ann Viscione, Kyle Wohlrab, Karen Box, Gena Dunivan, Peter Jeppson, Julia Middendorf, Rebecca G. Rogers, Lily Arya, Uduak Andy, Norman Butler, Doris Cain, Teresa Carney, Lorraine Flick, Kavita Desai Khanijow, Michelle Kingslee, Daniel Lee, Patricia O’Donnell, Ariana Smith, Donna Thompson, Michael Bonidie, Judy Gruss, Jerry Lowder, Jonathan Shepherd, Gary Sutkin, Halina M. Zyczynski, Matthew Barber, Kathleen Dastoli, Maryori Edington, Annette Graham, Geetha Krishnan, Eric Jelovsek, Marie Fidela R. Paraiso, Ly Pung, Cecile Ferrando, Mark Walters, Susan Meikle, Andrew Burd, Kate Burdekin, Kendra Glass, Tracey Grant, Scott Grey, Michael Ham, James Pickett, Dennis Wallace, Ryan Whitworth, Amanda Shaffer, and Taylor Swankie

Subjects
medicine.medical_specialty, Uterosacral ligament, Article, Introitus, Pelvis, symbols.namesake, Gynecologic Surgical Procedures, Imaging, Three-Dimensional, Recurrence, Uterine Prolapse, Hysterectomy, Vaginal, medicine, Humans, Treatment Failure, Fisher's exact test, Aged, Surgical repair, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Magnetic resonance imaging, Middle Aged, Magnetic Resonance Imaging, Confidence interval, Surgery, medicine.anatomical_structure, Hymen, symbols, Vagina, Female, business
Abstract

Background Prolapse recurrence after transvaginal surgical repair is common; however, its mechanisms are ill-defined. A thorough understanding of how and why prolapse repairs fail is needed to address their high rate of anatomic recurrence and to develop novel therapies to overcome defined deficiencies. Objective This study aimed to identify mechanisms and contributors of anatomic recurrence after vaginal hysterectomy with uterosacral ligament suspension (native tissue repair) vs transvaginal mesh (VM) hysteropexy surgery for uterovaginal prolapse. Study Design This multicenter study was conducted in a subset of participants in a randomized clinical trial by the Eunice Kennedy Shriver National Institute of Child Health and Human Development Pelvic Floor Disorders Network. Overall, 94 women with uterovaginal prolapse treated via native tissue repair (n=48) or VM hysteropexy (n=46) underwent pelvic magnetic resonance imaging at rest, maximal strain, and poststrain rest (recovery) 30 to 42 months after surgery. Participants who desired reoperation before 30 to 42 months were imaged earlier to assess the impact of the index surgery. Using a novel 3-dimensional pelvic coordinate system, coregistered midsagittal images were obtained to assess study outcomes. Magnetic resonance imaging–based anatomic recurrence (failure) was defined as prolapse beyond the hymen. The primary outcome was the mechanism of failure (apical descent vs anterior vaginal wall elongation), including the frequency and site of failure. Secondary outcomes included displacement of the vaginal apex and perineal body and change in the length of the anterior wall, posterior wall, vaginal perimeter, and introitus of the vagina from rest to strain and rest to recovery. Group differences in the mechanism, frequency, and site of failure were assessed using the Fisher exact tests, and secondary outcomes were compared using Wilcoxon rank-sum tests. Results Of the 88 participants analyzed, 37 (42%) had recurrent prolapse (VM hysteropexy, 13 of 45 [29%]; native tissue repair, 24 of 43 [56%]). The most common site of failure was the anterior compartment (VM hysteropexy, 38%; native tissue repair, 92%). The primary mechanism of recurrence was apical descent (VM hysteropexy, 85%; native tissue repair, 67%). From rest to strain, failures (vs successes) had greater inferior displacement of the vaginal apex (difference, −12 mm; 95% confidence interval, −19 to −6) and perineal body (difference, −7 mm; 95% confidence interval, −11 to −4) and elongation of the anterior vaginal wall (difference, 12 mm; 95% confidence interval, 8–16) and vaginal introitus (difference, 11 mm; 95% confidence interval, 7–15). Conclusion The primary mechanism of prolapse recurrence following vaginal hysterectomy with uterosacral ligament suspension or VM hysteropexy was apical descent. In addition, greater inferior descent of the vaginal apex and perineal body, lengthening of the anterior vaginal wall, and increased size of the vaginal introitus with strain were associated with anatomic failure. Further studies are needed to provide additional insight into the mechanism by which these factors contribute to anatomic failure.

Published
2021

49. Early life fluoxetine treatment causes long-term lean phenotype in skeletal muscle of rats exposed to maternal lard-based high-fat diet

Author

Visco, Diego Bulcão, primary, Manhães-de-Castro, Raul, additional, da Silva, Márcia Maria, additional, Dantas-Alves, Jakssuel Sebastion, additional, Costa-de-Santana, Bárbara J.R., additional, Braz, Glauber Rudá Feitoza, additional, da Silva, Aline Isabel, additional, Lagranha, Cláudia Jacques, additional, and Toscano, Ana Elisa, additional

Published
2020
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50. Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study

Author

Passamonti, Francesco, primary, Cattaneo, Chiara, additional, Arcaini, Luca, additional, Bruna, Riccardo, additional, Cavo, Michele, additional, Merli, Francesco, additional, Angelucci, Emanuele, additional, Krampera, Mauro, additional, Cairoli, Roberto, additional, Della Porta, Matteo Giovanni, additional, Fracchiolla, Nicola, additional, Ladetto, Marco, additional, Gambacorti Passerini, Carlo, additional, Salvini, Marco, additional, Marchetti, Monia, additional, Lemoli, Roberto, additional, Molteni, Alfredo, additional, Busca, Alessandro, additional, Cuneo, Antonio, additional, Romano, Alessandra, additional, Giuliani, Nicola, additional, Galimberti, Sara, additional, Corso, Alessandro, additional, Morotti, Alessandro, additional, Falini, Brunangelo, additional, Billio, Atto, additional, Gherlinzoni, Filippo, additional, Visani, Giuseppe, additional, Tisi, Maria Chiara, additional, Tafuri, Agostino, additional, Tosi, Patrizia, additional, Lanza, Francesco, additional, Massaia, Massimo, additional, Turrini, Mauro, additional, Ferrara, Felicetto, additional, Gurrieri, Carmela, additional, Vallisa, Daniele, additional, Martelli, Maurizio, additional, Derenzini, Enrico, additional, Guarini, Attilio, additional, Conconi, Annarita, additional, Cuccaro, Annarosa, additional, Cudillo, Laura, additional, Russo, Domenico, additional, Ciambelli, Fabrizio, additional, Scattolin, Anna Maria, additional, Luppi, Mario, additional, Selleri, Carmine, additional, Ortu La Barbera, Elettra, additional, Ferrandina, Celestino, additional, Di Renzo, Nicola, additional, Olivieri, Attilio, additional, Bocchia, Monica, additional, Gentile, Massimo, additional, Marchesi, Francesco, additional, Musto, Pellegrino, additional, Federici, Augusto Bramante, additional, Candoni, Anna, additional, Venditti, Adriano, additional, Fava, Carmen, additional, Pinto, Antonio, additional, Galieni, Piero, additional, Rigacci, Luigi, additional, Armiento, Daniele, additional, Pane, Fabrizio, additional, Oberti, Margherita, additional, Zappasodi, Patrizia, additional, Visco, Carlo, additional, Franchi, Matteo, additional, Grossi, Paolo Antonio, additional, Bertù, Lorenza, additional, Corrao, Giovanni, additional, Pagano, Livio, additional, and Corradini, Paolo, additional

Published
2020
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