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6,864 results on '"Wei, Liu"'

6. Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis

Author

Luyao, Xu, primary, Wenhai, Guo, additional, Jiaying, Dai, additional, Ya, Cheng, additional, Yun, Chen, additional, Wei, Liu, additional, Jiean, Xu, additional, Wen, Su, additional, Xiaodong, Zhang, additional, Changjun, Wang, additional, Hongzhi, Yang, additional, Jinwen, Xu, additional, and Yaxing, Zhang, additional

Published
2024
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20. In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units

Author

Zhen Yang, Bin Wang, Wei Liu, Xiaoke Li, Kaini Liang, Zejun Fan, Jiao Jiao Li, Yudi Niu, Zihao He, Hui Li, Du Wang, Jianjing Lin, Yanan Du, Jianhao Lin, and Dan Xing

Subjects
Biomaterials, Biomedical Engineering, Article, Biotechnology
Abstract

The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial, directional and controllable differentiation of mesenchymal stem cells (MSCs) into cartilage and bone compartments. Emerging organoid technology offers new opportunities for osteochondral regeneration. In this study, we developed gelatin-based microcryogels customized using hyaluronic acid (HA) and hydroxyapatite (HYP), respectively for inducing cartilage and bone regeneration (denoted as CH-Microcryogels and OS-Microcryogels) through in vivo self-assembly into osteochondral organoids. The customized microcryogels showed good cytocompatibility and induced chondrogenic and osteogenic differentiation of MSCs, while also demonstrating the ability to self-assemble into osteochondral organoids with no delamination in the biphasic cartilage-bone structure. Analysis by mRNA-seq showed that CH-Microcryogels promoted chondrogenic differentiation and inhibited inflammation, while OS-Microcryogels facilitated osteogenic differentiation and suppressed the immune response, by regulating specific signaling pathways. Finally, the in vivo engraftment of pre-differentiated customized microcryogels into canine osteochondral defects resulted in the spontaneous assembly of an osteochondral unit, inducing simultaneous regeneration of both articular cartilage and subchondral bone. In conclusion, this novel approach for generating self-assembling osteochondral organoids utilizing tailor-made microcryogels presents a highly promising avenue for advancing the field of tissue engineering.

Published
2023

46. Eutectic high entropy alloy syntactic foam

Author

Jin Meng, Yu Qiao, Tian-Wei Liu, Yuan-Yuan Tan, Fu-Hua Cao, Yan Chen, Hai-Ying Wang, and Lan-Hong Dai

Subjects
Polymers and Plastics, Mechanics of Materials, Mechanical Engineering, Materials Chemistry, Metals and Alloys, Ceramics and Composites
Published
2023

47. Laparoscopic duodenum-preserving total pancreatic-head resection versus standard pancreaticoduodenectomy for pancreatic-head intraductal papillary mucinous neoplasm

Author

Wei, Liu and Bing, Peng

Subjects
Surgery
Abstract

Currently, no literature specifically addresses the curative efficacy of laparoscopic duodenum-preserving total pancreatic head resection (LDPPHRt) in the treatment of pancreatic-head intraductal papillary mucinous neoplasm (IPMN). This study aimed to compare the short-term and long-term outcomes between LDPPHRt and laparoscopic pancreaticoduodenectomy (LPD) for pancreatic-head IPMN.We retrospectively reviewed patients undergoing LDPPHRt or LPD for pancreatic-head IPMN in our institution between September 2014 and October 2020. We collected, analyzed and compared preoperative, intraoperative, and perioperative data, including quality of life as assessed using EORTC QLQ-C30 and QLQ-PAN26 questionnaires.In total, 50 patients were incorporated into this study, which included 12 LDPPHRt patients and 38 LPD patients. Preoperative data was comparable in the two groups, and neither was there any significant difference in postoperative data. The incidence of exocrine and endocrine insufficiency was similar between the LDPPHRt and LPD groups (50% vs. 28.9%, p = 0.321; 8.3% vs. 7.9%, p = 1.000), but some differences between the two surgical procedures were apparent when evaluating postoperative quality of life. Specifically, patients in the LDPPHRt group reported higher physical functional and body image scores than the LPD group (96.1 ± 6.0 vs. 88.2 ± 13.9, p = 0.008; 65.3 ± 32.9 vs. 43.0 ± 31.4, p = 0.039), and LDPPHRt was also associated with lower digestive symptom scores (5.5 ± 12.9 vs. 28.9 ± 25.9, p = 0.004).Perioperative outcomes for LDPPHRt were comparable to those for LPD, but the quality of life after operation was better in the LDPPHRt group.

Published
2023

48. Progress in Nb-Si ultra-high temperature structural materials: A review

Author

Wei Liu, Shuai Huang, Chengtong Ye, Lina Jia, Yongwang Kang, Jiangbo Sha, Bingqing Chen, Yu Wu, and Huaping Xiong

Subjects
Polymers and Plastics, Mechanics of Materials, Mechanical Engineering, Materials Chemistry, Metals and Alloys, Ceramics and Composites
Published
2023

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