1. Prognostic value of MAGE-A9 expression in patients with colorectal cancer
- Author
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Yiping Li, Zhaoqin Zhang, Jing Yang, Yan Zhang, Yuanhui Gu, Jichi Ma, Tao Wu, and Wei-Peng Zhan
- Subjects
Adult ,Male ,0301 basic medicine ,Oncology ,endocrine system ,medicine.medical_specialty ,Pathology ,Stromal cell ,Colorectal cancer ,03 medical and health sciences ,0302 clinical medicine ,Western blot ,Antigen ,Antigens, Neoplasm ,Internal medicine ,Biomarkers, Tumor ,Humans ,Medicine ,neoplasms ,Survival rate ,Testicular cancer ,Aged ,Hepatology ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Middle Aged ,Prognosis ,medicine.disease ,digestive system diseases ,Neoplasm Proteins ,Survival Rate ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer cell ,Immunohistochemistry ,Female ,Colorectal Neoplasms ,business - Abstract
MAGE-A9 is a novel member of the melanoma-associated antigen (MAGE) family and is expressed in testicular cancer. The present study investigated MAGE-A9 expression as a potential biomarker in colorectal cancer (CRC). Immunohistochemical analysis was used to determine the expression of MAGE-A9 in 201 cases CRC tissues. We used quantitative real-time polymerase chain reaction (RT-PCR) and western blot analysis to further verify the results. The correlation between MAGE-A9 expression, clinicopathological features and prognosis of CRC patients was analyzed. The results showed that MAGE-A9 was predominantly localized in the cytoplasm of cancer cells and stromal cells. Compared to normal adjacent tissues, the high expression rate of MAGE-A9 in CRC tissues was significantly increased (P
- Published
- 2016