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To investigate the value of CD64 in the early diagnosis of intracranial infection after craniocerebral surgery.93 patients who met the inclusion and exclusion criteria after neurosurgery in Lianyungang First people 's Hospital and Lianyungang Second People 's Hospital were admitted and divided into experimental group with intracranial infection(n=32) and uninfected control group according to the results of cerebrospinal fluid (CSF) culture (n=61). Performed relevant statistical analysis and draw ROC curve and calculated area under the curve (AUC).The sensitivity and specificity of the CD64, CRP and WBC counts were 84.38% and 86.89%, 78.13% and 75.41%, 75.00% and 67.21% respectively, the AUC were 0.912,0.858 and 0.851. the accuracy was the highest when the three diagnosis were combined, reaching 93.75%, the AUC could reach 0.948.Serum CD64, CRP and WBC count in the diagnosis of intracranial infection after cranio-cerebral surgery were significant. CD64 was more valuable than the others. the diagnostic efficiency could be improved when CD64, CRP and WBC count were combined.