85 results on '"Whisstock, James C"'
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2. Fragment-based and structure-guided discovery of perforin inhibitors
3. OpenFIBSEM: A universal API for FIBSEM control
4. TcpA from the Clostridium perfringens plasmid pCW3 is more closely related to the DNA translocase FtsK than to coupling proteins
5. Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential
6. Oxygen Plasma Focused Ion Beam: Optimised Beam Chemistry to Improve the Throughput of FIB/SEM Tomography on Biological Samples
7. Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface
8. Mapping the binding site of C1-inhibitor for polyanion cofactors
9. Automated cryo-lamella preparation for high-throughput in-situ structural biology
10. Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes
11. Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding
12. Perforin—A key (shaped) weapon in the immunological arsenal
13. Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice
14. Antibodies: From novel repertoires to defining and refining the structure of biologically important targets
15. Giant MACPF/CDC pore forming toxins: A class of their own
16. Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding
17. Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes
18. The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells
19. Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development
20. Capturing embryonic development from metamorphosis: how did the terminal patterning signalling pathway of Drosophila evolve?
21. Reconciling the Structural Attributes of Avian Antibodies
22. The Perforin Pore Facilitates the Delivery of Cationic Cargos
23. The Three-dimensional Structure of the Extracellular Adhesion Domain of the Sialic Acid-binding Adhesin SabA from Helicobacter pylori
24. New insights into the structure and function of the plasminogen/plasmin system
25. A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
26. The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome.
27. The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome
28. A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4
29. The zymogen form of the catalytic region of the complement protease, C1s, is stabilized into a form unable to interact with substrates and cofactors
30. The Extracellular Protein Factor Epf from Streptococcus pyogenes Is a Cell Surface Adhesin That Binds to Cells through an N-terminal Domain Containing a Carbohydrate-binding Module
31. X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP
32. Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death
33. The X-ray Crystal Structure of Full-Length Human Plasminogen
34. S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction
35. Protection from Endogenous Perforin: Glycans and the C Terminus Regulate Exocytic Trafficking in Cytotoxic Lymphocytes
36. Serpins flex their muscle. I. PUTTING THE CLAMPS ON PROTEOLYSIS IN DIVERSE BIOLOGICAL SYSTEMS.
37. Serpins Flex Their Muscle
38. Serpins Flex Their Muscle
39. Maspin (SERPINB5) Is an Obligate Intracellular Serpin
40. Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials
41. Structural determinants of GAD antigenicity
42. Structural Mechanisms of Inactivation in Scabies Mite Serine Protease Paralogues
43. The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly
44. A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2
45. The Crystal Structure of DehI Reveals a New α-Haloacid Dehalogenase Fold and Active-Site Mechanism
46. A Structural Basis for Loop C-Sheet Polymerization in Serpins
47. Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
48. DNA Accelerates the Inhibition of Human Cathepsin V by Serpins
49. Aeropin from the Extremophile Pyrobaculum aerophilum Bypasses the Serpin Misfolding Trap
50. SERPINB11 Is a New Noninhibitory Intracellular Serpin
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