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1. A comprehensive qualitative investigation of the factors that affect surgical site infection prevention in cardiac surgery in England using observations and interviews

Author

Tanner, Judith, primary, Jones, Lyn Brierley, additional, Westwood, Nigel, additional, Rochon, Melissa, additional, Wloch, Catherine, additional, Vaja, Ricky, additional, Rogers, Luke J., additional, Dearling, Jeremy, additional, Wilson, Keith, additional, Kirmani, Bilal H., additional, Bhudia, Sunil K., additional, Rajakaruna, Cha, additional, Petrou, Mario, additional, Bailes, Louise, additional, Jawarchan, Angila, additional, Baker, Maureen, additional, and Murphy, Gavin J., additional

Published
2024
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3. Barriers and facilitators for surgical site infection surveillance for adult cardiac surgery in a high-income setting: an in-depth exploration

Author

Tanner, Judith, primary, Brierley Jones, Lyn, additional, Rochon, Melissa, additional, Westwood, Nigel, additional, Wloch, Catherine, additional, Vaja, Ricky, additional, Rogers, Luke, additional, Dearling, Jeremy, additional, Wilson, Keith, additional, Magboo, Rosalie, additional, Aujla, Hardeep, additional, Page, Sue, additional, Whiting, Penny, additional, Murphy, Gavin, additional, Brown, Colin, additional, Lamagni, Theresa, additional, and Harrington, Pauline, additional

Published
2023
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9. Protocol for direct reporting of awareness in maternity patients (DREAMY): a prospective, multicentre cohort study of accidental awareness during general anaesthesia

Author

P.M. Odor, S. Bampoe, D.N. Lucas, S.R. Moonesinghe, J. Andrade, J.J. Pandit, Alicja A'Court, Dina Abdel-Gadir, Ayman Abdu, Caroline Abisogun, Zainab Aboud, Judith Abrams, Andrea Ackerman, Christine Adamso, Rachel Addison, Adedayo Adeyeye, Rachel Adler, Maame Aduse-Poku, Siddharth Adyanthaya, Najmiah Ahmad, Dabeeruddeen Ahmed, Atif Ahmed, Bucky Akindele, Olubukola Akindele, Sonia Akrimi, Samar Al-Rawi, Yousif Ali, Jo Allam, Alisha Allana, Kellie Allen, Orlanda Allen, Natasha Amaradasa, Lareina Amarasekara, Freda Amoakwa-adu, Padmanabhan Anandageetha, Suresh Anandakrishnan, Rathai Anandanadesan, Michelle Anderson, Simon Apps, Audrey Aquilina, Gill Arbane, Alice Arch, Sarah Armstrong, Rita Arya, Gloria Ashiru, Keri Ashpole, Claire Atkinson, Francesca Atkinson, Elizabeth Auer, Ben Avery, Maite Babio-Galan, Hareth Bader, George Badham, Subha Bagchi, Sarah Bailey, Yolanda Baird, Cristina Balaka, Melissa Baldwin, Paul Balfour, Shreya Bali, Samantha Banks, Philip Barclay, Lucy Barnes, Thomas Barnes, Niraj Barot, Stephen Barrett, Venetia Barrett, Kate Barrett, Louise Bates, Katherine Batte, Beki Baytug, Mona Behravesh, Suzanne Bell, Raul Benloch, Richard Bentley, Jennifer Berg, Charlotte Berwick, Richard Berwick, Rashmi Bhadange, Sanjoy Bhattacharyya, Egidija Bielskute, Sian Birch, Scott Bird, Ruth Bird, William Birts, Becky Black, Tatyana Blagova, Holly Blake, Oliver Blightman, Susara Blunden, Richard Bolton, Caroline Borkett-Jones, John Boselli, Manuella Bowen, Ruth Bowen, James Bowye, Henry Boyle, Zameen Brar, Jo Bray, Samantha Brayshaw, Catherine Bressington, Alison Brewer, Naomi Brice, Laura Bridge, James Briscoe, Sonia Brocklesby, Harry Brown, Sarah Brown, Derek Brunnen, Keshavareddy Burijintichenna, Sara Burnard, Agnieszka Burtt, Victoria Buswell, Hannah Bykar, Matthew Cairney, Clare Calvert, Laura Camarasa, Natasha Campbell, Frederick Campbell-Jones, Jane Cantliffe, William Carrol, Joanna Carvalho, Catherine Cashell, Sarah Cassie, Kadu Cassim, Marika Chandler, Rachel Chapman, Robert Charles, Ping Chen, Deanne Cheyne, Kiran Chima, Floju Chin, Radu Chirvasuta, Martin Shao Chong, Sadia Choudhury, Priyakam Chowdhury, Tracey Christmas, Shilpa Chughwani, Sarah Ciechanowicz, Emma Clarey, Rob Coe, Jolyon Cohen, Nicholas Coker, Karen Collins, Lauren Collis, Jasna Comar, Marianne Conroy, Kathy Constantin, Jeremy Corfe, Elaine Coulborn, Vanessa Cowie, Rachel Crone, James Cronin, Jennifer Crooks, Nicola Crowther, Elizabeth Crowther, Carina Cruz, Alexa Curtis, Sarah Curtis, Sam Curtis, Adrian Dabrowicz, Nick Daines, Viral Dalal, Peter Dannatt, Dinesh Das, Jennifer Dash, Katherine Davidson, Sarah Davies, Yvette Davis, James Dawson, Jonathan Dean, Caroline Dean, Jane Denman, Neel Desai, Preeti Dewan, Sarah Dimont, Clare Donovan, Mano Doraiswami, Kate Doughty, Jamie Douglass, Michelle Dower, Samantha Downing, Wendy Duberry, Emily Duckham, Lucy Dudgeon, Stephanie Dukes, Leigh Dunn, Venkat Duraiswamy, Anthony O' Dwyer, Kristyn Dyer, Suresh Eapen, Mark Earl, Sally Eason, Kylie-Ellen Edwards, Zara Edwards, Osinachi Egole, John Ekpa, Olivia El-Amin, Kariem El-Boghdadly, Okba Elbasir, James Eldridge, Laura Elgie, Matt Ellington, Katharine Elliott, Justine Elliott, Mohamed Elmi, Ramy Elnoumeir, Eunice Emeakaraoha, Matt Evans, Mary Everett, Philippa Fabb, Hadia Farooq, Rohan Farrimond, Fiona Faulds, Erik Fawcett, Andrew Feneley, Dinushi Fernando, Janis Ferns, Claire Finlay, Simon Fitzgerald, Doireann O'Flaherty, Mark Fleet, Lydia Fletcher, Vanessa Fludder, Terri Follet, Jane Forbes, Mark Forth, Greg Foster, John Francis, Kate Fraser, Lauren Friedman, Luca Fruggeri, Laura Fulton, Sam Funnell, Amit Gadre, Ajay Gandhi, Harriet Gardiner, Zoe Garner, Gráinne Garvey, Tom Gately, Richard George, Siobhan Gillespie, Stephanie Glover, Jennifer Goddard, Ben Goodman, Tarikere Gopal, George Graham, David Green, Denise Griffin, Jessica Griffith, Stephanie Grigsby, Julie Grindey, Huw Griffiths, Jonathan Groome, Christine Grother, Gabrielle Grounds, Alice Groves, Abhik Guha, Amila Gunawardhana, Aman Gupta, Rekha Gupta, James Gutsell, Richard Haddon, Dina Hadi, Nicola Hadjipavlou, Henry Hammerbeck, Laura Hammon, Sarah Hammond, Hampesh Hampanna, Holly Hancock, Hemantha Handapangoda, Yumna Haroon-Mowahed, Dawn Harpham, Grant Harris, Abigail Harrison, Divya Harshan, Andrew Hartopp, Eoin Harty, Nick Haslam, Gemma Hawkins, Edith Hawkins, Sarah Hawksey, Carole Hays, Tracy Hazelton, Andrew Heavyside, Chibuzo Hemeson, Katrina Henderson, Oliver Henry, Lara Herbert, Nikki Higgins, James Hilton, Claire Hindmoor, Rachael Hitchcock, Laura Hobbs, Michele Homsy, Cassandra Honeywell, Nazima Hoque, Kirsty House, Ryan Howle, Amanda Tiller, Matthew Huniak, Jeremy Hunte, Tauqeer Husain, Coralie Huson, Catriona Hussain, Tawhida Hussain, Zainab Hussein, Jeremy Hyams, Eleanor Hyde, Marina Iaverdino, Alex Ignacka, Erin Innes, Stefanos Ioannidis, Rehana Iqbal, Fahja Ismail, Jenny Jackson, Michael Jackson, Guy Jackson, Robyn Jacobs, Poonam Jadhav, Aisha Jalaly, Lorraine James, Monica James, Surekha Jani, Chandran Jeganathan, Claire Joannides, Robert Johnson, Thosa Johnson, Carolyn Johnston, Reeanne Jones, Tom Jones, Miran Kadr, Rasmeet Kainth, Jenna Kane, Rafiq Kanji, Sunil Kannanparambil, Girish Kar, Theanalli Kasianandan, Husam Kaskos, Lisa Kavanagh, Richard Kaye, Leith Kelliher, Serena Kelliot, Jemma Kelly, Jenna Kelly, Carol Kenyon, Laura Kessack, Samuel Kestner, Mohammed Khaku, Sophia Khaleeq, Pervaz Khan, Sabeen Khan, Usamah Kidwai, Christopher King, Helen King, Elizabeth Kingston, Waisun Kok, Rebekka Konig, Zheyna Konstantinova, Priya Krishnan, Justin Kua, Kavitha Kuntumalla, Emira Kursumovic, Krzysztof Kurzatkowski, Hariprasad Kuttambakam, Katherine Lane, Sophie Lane, Andrew Langton, Hamad Latif, Norlan Lau, Shyam Laxman, Helen Laycock, Rachel Lee, Silvia Leonardi, Karen Light, Heidi Lightfoot, Shuang Liu, Sanduni Liyanage, Jessica Lowe, Nuala Lucas, Miyoba Lungu, Marianne Lunn, Heather Lynes, Kishore Machavarapu, Matthew Mackenzie, Jonathan Major, Victoria Male, Zain Malik, Katarina Manso, Myrna Maquinana, Katarzyna Marciniak, Lizzie Maronge, Chris Marsh, Carmela Martella, Nicki Martin, Nicole Martins, Jaspreet Marway, Louisa Mason, Lucy Mason, Nadia Masood, James Masters, Matthew Maton-Howarth, Francesca Mazzola, Tamsin McAllister, Rachel McCarthy, Claire McCormick, Sharon McCready, Steffan McDougall, Lorna Mcewan, Jon McGarry, Helen McKevitt, Stephanie Mckinley, Anna Mckskeane, Eloise McMaster, Martina McMonagle, Helen McNamara, Hannah McPhee, Laura McRae, Dee Mead, Emma Meadows, Madhur Mehta, Joanne Meikle, Yavor Metodiev, Chloe Michael, Victoria Millar, Sarah Miller, Gregg Miller, Sezanne Milne, Kostas Miltsios, Lucia Misquita, Simone Misquita, Manasi Mittal, Mohamed Mohamed, Katherine Powell Monaghan, Joanna Monk, Alexandra Monkhouse, David Monks, Laura Montague, Angela Moon, Jennifer Moran, Annette Moreton, Endaf Morgan, Oliver Morgan, Danny Morland, Monica Morosan, Kimberley Morris, Andrea Morris, Clare Moser, Manulella Mount, Carol Muir, McDonald Mupudzi, Mayur Murali, Iona Murdoch, Heather Murray, Theresa Murray, Karen Murrell, Girish Narasimha Murthy, Diana Neeley, Hannah Nei, Kerry Neil, Tara Nejim, Mark Nel, Anne Nicholson, Angela Nicklin, Catherine Nolan, Tracey Nolan, Eveliina Nurmi, Bridie O'Neill, Christie Oakes, Neil Oakes, Maria Ochoa-Ferraro, Nike Odeleye, Katy Oliver, Mark Oliver, Julie Onslow, Desire Onwochei, Thomas Oommen, Tim Orr, Osato Osagie, Hannah Osborn, Jennie Overend, Hazel Owston, Emma Pack, Pulak Padhi, Prabvathy Palani, Rajesh Pandey, Dhruti Pandya, Navjot Panesar, Con Papageorgiou, Georgios Papanastasiou, Costas Papoutsos, Suji Pararajasingham, James Parry, Hasita Patel, Jaishel Patel, Jiten Patel, Kaumudi Patel, Kiran Patel, Mitul Patel, Reshma Patel, Ruchira Patel, Nimisha Patel, Sangeeta Pathak, Fiona Pearson, Viktorija Peciulene, Beth Peers, Benjamin Peirce, Stacey Pepper, Jasmina Perinpanayagam, Hollie Perry, Nadya Petrova, Trudie Phillips, Sioned Phillips, Leonidas Phylactides, Felicity Pilkington, James Plumb, Evangelia Poimenidi, Anna Sau Kuk Poon, Thomas Potter, Una Poultney, Lucy Powell, Andrew Prenter, Katie Preston, Anna Price, Naomi Pritchard, Jenny Pullen, Manishi Purohit, Charlotte Quamina, Jibran Qureshi, Zahra Rajput, Stephen Ramage, Tamilselvi Ramanathan, Upeka Ranasinghe, Kalum Ranatunga, Abby Rand, Seema Randive, Desikan Rangarajan, Chandana Rao, Sambasiva Rao Pelluri, Antony Ratnasingham, Jamil Razzaque, Anuvidya Reddy, Katie Redington, Emma Reel, Peter Remeta, Francesca Ricco, Anna Riccoboni, Polly Rice, Mel Rich, Nicole Richards, Joanne Riches, Simon Ripoll, Fleur Roberts, Kitty Roberts, Kay Robins, Susie Robinson, Samantha Roche, Maria Rojo, Milena Carmela Romano, Hilary Rosser, Lindsay Roughley, Catriona Routley, Christine Rowley, Pallab Rudra, Robin Russell, Christine Ryan, Chloe Saad, Abtin Sadeghi, Armorel Salberg, Matt Samuel, Rebecca Samuels, Suresh Sanapala, Seliat Sanusi, Sarbpreet Sarao, Sathyabhama Sathyabhama, Zoe Saunders, Bernadetta Sawarzynska-ryszka, Panagiota Sceales, Penny Sceales, Natasha Schumacher, Nuala Schwartz, Claudia Sellers, Heather Sellers, Jessica Sellick, Soumen Sen, Dhaneesha Senaratne, Sarah Senbeto, Dineth Seneviratna, Thunga Setty, Raj Shah, Sonia Shah, James Shambly, Saju Sharafudeen. Imran Sharieff, Laurence Sharifi, Lisa Sharpe, Michael Shaw, Ian Sheldrake, Priya Shinde, Adam Shonfeld. Jonathon Short, Julian Siah, Sheena Sibug. Omar Siddique, Sara Siew, Matthew Simpson, Georgina Singleton, Kathryn Sinha, Aneeta Sinha, Matthew Sinnott, Harry Sivadhas, Sivanth Sivakumar, Boopathi Sivarajan, Sinduja Sivarajan, Chris Skeoch, Samuel Slade, Paul Slater, Camilla Smith, Carys Smith, Christopher Smith, James Smith, Lorraine Smith, Annika Smith, Edward Smith, Ruth Smith, Sue Smith, Tim Smith, Helen Smithers, Sue Smolen, Claire Smyth, Toni Snel, Carol Snipe, Sam Soltanifar, Nilesh Sonawane, Andal Soundararaja, Emily Spence, Mark Spiliopoulos, Chhavi Srivastava, Karen Stacey, Helena Stafford, Nikki Staines, Richard Stead, Emma Stevens, Alex Stilwell, Gary Stocks, Aaron Stokes, Christopher Stone, Ben Straughan, Vanitha Subbarathnam, Srinath Sudunagunta, Pervez Sultan, Puvan Suppiah, Priyanka Surve, Angus Sutherland, Rob Swanton, Claire Swarbrick, Amy Swinson, Eleni Syrrakou, Shahrzad Tadbiri, Preetam Tamhane, Perumal Tamilselvan, Andrew Tan, Shamil Tanna, Hayley Tarft, Laura Tarry, Ian Taylor, Suzanne Taylor, Julie Tebbot, Svetlana Theron, Megan Thomas, Sarah Todd, Hermione Tolliday, Charlotte Topham, Nicholas Tovell, Martyn Traves, Dawn Trodd, Aseem Tufchi, Katie Turley, Marc Turnbull, Chris Turnbull, Oliver Turner, William Turner, Sharon Turney, Eleanor Tyagi, David Uncles, Vanessa Unsworth, Pradnya Vadnere, Rama Varadan, Vik Vasishta, Andrew Veal, Lalitha Vedham, Jessica Venkaya, Miriam Verghese, Icel Veronica, Dinesh Vidanagamage, Rachel Vincent, Vinodhan Vyapury, Harris Wain, Fiona Walbridge, Elaine Walker, Pete Walsh, Eleanor Walshe, Michelle Walters, Yize Wan, Cherry Wang, Kavita Wankhade, Gareth Waters, Christopher Watts, Alex Webber, Tom Wedgwood, Michael Wee, Susan Wellstead, Alison White, Michael Whitear, Lucy Whitefield, Sarah Wilkinson, Lauren Williams, Rhys Williams, Dawn Wilson, Samantha Wilson, Katie Wimble, Elaine Winkley, Luke Winslow, Paul Winwright, Karolina Wloch, Gideon Wong, Hannah Wong, Jan Man Wong, Tim Wood, Sarah Wray, Ian Wrench, James Wu, Kynn Wynn, Yeng Yap, Chia Kuan Yeow, Emily Young, Alex Yusaf, Saeed Uz Zafar, Darius Zeinali, Sheldon Zhang, Sarvesh Zope, Liana Zucco, Sibtain Anwar, Nadia Blunt, John Cronin, Vimal Grover, Kate Grailey, Martin Grey, David Highton, Phil Hopkins, Harriet Kemp, Queenie Lo, Daniel Martin, Clare Morkane, James O'Carroll, Charles Oliver, Benjamin Post, Anil Visram, and Alex Wickham

Subjects
Adult, One year follow up, Trial protocol, Guidelines as Topic, Anesthesia, General, Intraoperative Awareness, Cohort Studies, Interviews as Topic, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, Anesthesia, Obstetrical, Humans, Medicine, General anaesthesia, Prospective Studies, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics and Gynecology, medicine.disease, United Kingdom, Anesthesiology and Pain Medicine, Accidental, Cohort, Structured interview, Female, Medical emergency, business, Surgical patients, Cohort study
Abstract

Background Accidental awareness during general anaesthesia (AAGA) is a complex and rare outcome to investigate in surgical patient populations, particularly obstetric patients. We report the protocol of the Direct Reporting of Awareness in Maternity patients (DREAMY) study, illustrating how the research was designed to address practical and methodological challenges for investigating AAGA in an obstetric cohort. Methods This is the trial protocol of a prospective, multicentre cohort study of patients undergoing obstetric surgery under general anaesthesia. Accidental awareness during general anaesthesia will be detected using three repetitions of standardised direct questioning over 30 days, with responses indicating memories during general anaesthesia verified using structured interviews. Reports will be adjudicated, then classified, in accordance with pre-defined and pre-validated structures, including the Michigan Awareness Classification tool. Quantitative data will be collected on general anaesthesia conduct for all participants. This descriptive study is being conducted in England and aims to recruit a minimum of 2015 patients. Results The DREAMY study was prospectively registered (ClinicalTrials.gov Identifier: NCT03100396) and ethical approval granted. Participant recruitment began in May 2017 and one year follow up concluded in August 2019. Publication of the results is anticipated in 2020. Conclusions The DREAMY study will provide data on incidence, experience and implications of AAGA for obstetric patients, using a robust methodology that will reliably detect and translate subjective AAGA reports into objective outcomes. In addition, the study is expected to improve vigilance for AAGA in participating hospitals and encourage adoption of recommendations for support of patients experiencing AAGA.

Published
2020
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10. Development of Malignancy-Risk Gene Signature Assay for Predicting Breast Cancer Risk

Author

Richard G. Roetzheim, Christine Laronga, Dung-Tsa Chen, Marek Wloch, Tania Mesa, Jiannong Li, Sean J. Yoder, M. Catherine Lee, James Sun, and Weihong Sun

Subjects
Adult, Oncology, Breast biopsy, medicine.medical_specialty, Biopsy, Concordance, Breast Neoplasms, Malignancy, Risk Assessment, Article, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Predictive Value of Tests, Internal medicine, Biomarkers, Tumor, medicine, Humans, Breast, Aged, Framingham Risk Score, Receiver operating characteristic, medicine.diagnostic_test, business.industry, Gene Expression Profiling, Middle Aged, Gene signature, medicine.disease, ROC Curve, Tissue Array Analysis, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Surgery, Transcriptome, business, Follow-Up Studies
Abstract

Background Breast cancer (BC) risk assessment models are statistical estimates based on patient characteristics. We developed a gene expression assay to assess BC risk using benign breast biopsy tissue. Methods A NanoString-based malignancy risk (MR) gene signature was validated for formalin-fixed paraffin-embedded (FFPE) tissue. It was applied to FFPE benign and BC specimens obtained from women who underwent breast biopsy, some of whom developed BC during follow-up to evaluate diagnostic capability of the MR signature. BC risk was calculated with MR score, Gail risk score, and both tests combined. Logistic regression and receiver operating characteristic curves were used to evaluate these 3 models. Results NanoString MR demonstrated concordance between fresh frozen and FFPE malignant samples (r = 0.99). Within the validation set, 563 women with benign breast biopsies from 2007 to 2011 were identified and followed for at least 5 y; 50 women developed BC (affected) within 5 y from biopsy. Three groups were compared: benign tissue from unaffected and affected patients and malignant tissue from affected patients. Kruskal–Wallis test suggested difference between the groups (P = 0.09) with trend in higher predicted MR score for benign tissue from affected patients before development of BC. Neither the MR signature nor Gail risk score were statistically different between affected and unaffected patients; combining both tests demonstrated best predictive value (AUC = 0.71). Conclusions FFPE gene expression assays can be used to develop a predictive test for BC. Further investigation of the combined MR signature and Gail Model is required. Our assay was limited by scant cellularity of archived breast tissue.

Published
2020
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12. Innovative method for the preparation of catalytic surfaces: The application of microorganisms for the deposition of nanoparticles on supports

Author

Golda-Cepa, Monika, primary, Pajerski, Wojciech, additional, Duch, Joanna, additional, Jarosz, Magdalena, additional, Indyka, Paulina, additional, Pawlyta, Miroslawa, additional, Ochonska, Dorota, additional, Brzychczy-Wloch, Monika, additional, Sojka, Zbigniew, additional, and Kotarba, Andrzej, additional

Published
2021
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13. PCL and PCL/bioactive glass biomaterials as carriers for biologically active polyphenolic compounds: Comprehensive physicochemical and biological evaluation

Author

Dziadek, Michal, primary, Dziadek, Kinga, additional, Checinska, Kamila, additional, Zagrajczuk, Barbara, additional, Golda-Cepa, Monika, additional, Brzychczy-Wloch, Monika, additional, Menaszek, Elzbieta, additional, Kopec, Aneta, additional, and Cholewa-Kowalska, Katarzyna, additional

Published
2021
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16. Fasting Hyperglycemia and Long-term Outcome in Patients with Acute Ischemic Stroke Treated with Mechanical Thrombectomy

Author

Wnuk, Marcin, primary, Popiela, Tadeusz, additional, Drabik, Leszek, additional, Brzegowy, Pawel, additional, Lasocha, Bartosz, additional, Wloch-Kopec, Dorota, additional, Pulyk, Roman, additional, Jagiella, Jeremiasz, additional, Wiacek, Marcin, additional, Kaczorowski, Rafal, additional, Bartosik-Psujek, Halina, additional, and Slowik, Agnieszka, additional

Published
2020
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17. Protocol for direct reporting of awareness in maternity patients (DREAMY): a prospective, multicentre cohort study of accidental awareness during general anaesthesia

Author

Odor, P.M., primary, Bampoe, S., additional, Lucas, D.N., additional, Moonesinghe, S.R., additional, Andrade, J., additional, Pandit, J.J., additional, A'Court, Alicja, additional, Abdel-Gadir, Dina, additional, Abdu, Ayman, additional, Abisogun, Caroline, additional, Aboud, Zainab, additional, Abrams, Judith, additional, Ackerman, Andrea, additional, Adamso, Christine, additional, Addison, Rachel, additional, Adeyeye, Adedayo, additional, Adler, Rachel, additional, Aduse-Poku, Maame, additional, Adyanthaya, Siddharth, additional, Ahmad, Najmiah, additional, Ahmed, Dabeeruddeen, additional, Ahmed, Atif, additional, Akindele, Bucky, additional, Akindele, Olubukola, additional, Akrimi, Sonia, additional, Al-Rawi, Samar, additional, Ali, Yousif, additional, Allam, Jo, additional, Allana, Alisha, additional, Allen, Kellie, additional, Allen, Orlanda, additional, Amaradasa, Natasha, additional, Amarasekara, Lareina, additional, Amoakwa-adu, Freda, additional, Anandageetha, Padmanabhan, additional, Anandakrishnan, Suresh, additional, Anandanadesan, Rathai, additional, Anderson, Michelle, additional, Apps, Simon, additional, Aquilina, Audrey, additional, Arbane, Gill, additional, Arch, Alice, additional, Armstrong, Sarah, additional, Arya, Rita, additional, Ashiru, Gloria, additional, Ashpole, Keri, additional, Atkinson, Claire, additional, Atkinson, Francesca, additional, Auer, Elizabeth, additional, Avery, Ben, additional, Babio-Galan, Maite, additional, Bader, Hareth, additional, Badham, George, additional, Bagchi, Subha, additional, Bailey, Sarah, additional, Baird, Yolanda, additional, Balaka, Cristina, additional, Baldwin, Melissa, additional, Balfour, Paul, additional, Bali, Shreya, additional, Banks, Samantha, additional, Barclay, Philip, additional, Barnes, Lucy, additional, Barnes, Thomas, additional, Barot, Niraj, additional, Barrett, Stephen, additional, Barrett, Venetia, additional, Barrett, Kate, additional, Bates, Louise, additional, Batte, Katherine, additional, Baytug, Beki, additional, Behravesh, Mona, additional, Bell, Suzanne, additional, Benloch, Raul, additional, Bentley, Richard, additional, Berg, Jennifer, additional, Berwick, Charlotte, additional, Berwick, Richard, additional, Bhadange, Rashmi, additional, Bhattacharyya, Sanjoy, additional, Bielskute, Egidija, additional, Birch, Sian, additional, Bird, Scott, additional, Bird, Ruth, additional, Birts, William, additional, Black, Becky, additional, Blagova, Tatyana, additional, Blake, Holly, additional, Blightman, Oliver, additional, Blunden, Susara, additional, Bolton, Richard, additional, Borkett-Jones, Caroline, additional, Boselli, John, additional, Bowen, Manuella, additional, Bowen, Ruth, additional, Bowye, James, additional, Boyle, Henry, additional, Brar, Zameen, additional, Bray, Jo, additional, Brayshaw, Samantha, additional, Bressington, Catherine, additional, Brewer, Alison, additional, Brice, Naomi, additional, Bridge, Laura, additional, Briscoe, James, additional, Brocklesby, Sonia, additional, Brown, Harry, additional, Brown, Sarah, additional, Brunnen, Derek, additional, Burijintichenna, Keshavareddy, additional, Burnard, Sara, additional, Burtt, Agnieszka, additional, Buswell, Victoria, additional, Bykar, Hannah, additional, Cairney, Matthew, additional, Calvert, Clare, additional, Camarasa, Laura, additional, Campbell, Natasha, additional, Campbell-Jones, Frederick, additional, Cantliffe, Jane, additional, Carrol, William, additional, Carvalho, Joanna, additional, Cashell, Catherine, additional, Cassie, Sarah, additional, Cassim, Kadu, additional, Chandler, Marika, additional, Chapman, Rachel, additional, Charles, Robert, additional, Chen, Ping, additional, Cheyne, Deanne, additional, Chima, Kiran, additional, Chin, Floju, additional, Chirvasuta, Radu, additional, Shao Chong, Martin, additional, Choudhury, Sadia, additional, Chowdhury, Priyakam, additional, Christmas, Tracey, additional, Chughwani, Shilpa, additional, Ciechanowicz, Sarah, additional, Clarey, Emma, additional, Coe, Rob, additional, Cohen, Jolyon, additional, Coker, Nicholas, additional, Collins, Karen, additional, Collis, Lauren, additional, Comar, Jasna, additional, Conroy, Marianne, additional, Constantin, Kathy, additional, Corfe, Jeremy, additional, Coulborn, Elaine, additional, Cowie, Vanessa, additional, Crone, Rachel, additional, Cronin, James, additional, Crooks, Jennifer, additional, Crowther, Nicola, additional, Crowther, Elizabeth, additional, Cruz, Carina, additional, Curtis, Alexa, additional, Curtis, Sarah, additional, Curtis, Sam, additional, Dabrowicz, Adrian, additional, Daines, Nick, additional, Dalal, Viral, additional, Dannatt, Peter, additional, Das, Dinesh, additional, Dash, Jennifer, additional, Davidson, Katherine, additional, Davies, Sarah, additional, Davis, Yvette, additional, Dawson, James, additional, Dean, Jonathan, additional, Dean, Caroline, additional, Denman, Jane, additional, Desai, Neel, additional, Dewan, Preeti, additional, Dimont, Sarah, additional, Donovan, Clare, additional, Doraiswami, Mano, additional, Doughty, Kate, additional, Douglass, Jamie, additional, Dower, Michelle, additional, Downing, Samantha, additional, Duberry, Wendy, additional, Duckham, Emily, additional, Dudgeon, Lucy, additional, Dukes, Stephanie, additional, Dunn, Leigh, additional, Duraiswamy, Venkat, additional, O' Dwyer, Anthony, additional, Dyer, Kristyn, additional, Eapen, Suresh, additional, Earl, Mark, additional, Eason, Sally, additional, Edwards, Kylie-Ellen, additional, Edwards, Zara, additional, Egole, Osinachi, additional, Ekpa, John, additional, El-Amin, Olivia, additional, El-Boghdadly, Kariem, additional, Elbasir, Okba, additional, Eldridge, James, additional, Elgie, Laura, additional, Ellington, Matt, additional, Elliott, Katharine, additional, Elliott, Justine, additional, Elmi, Mohamed, additional, Elnoumeir, Ramy, additional, Emeakaraoha, Eunice, additional, Evans, Matt, additional, Everett, Mary, additional, Fabb, Philippa, additional, Farooq, Hadia, additional, Farrimond, Rohan, additional, Faulds, Fiona, additional, Fawcett, Erik, additional, Feneley, Andrew, additional, Fernando, Dinushi, additional, Ferns, Janis, additional, Finlay, Claire, additional, Fitzgerald, Simon, additional, O'Flaherty, Doireann, additional, Fleet, Mark, additional, Fletcher, Lydia, additional, Fludder, Vanessa, additional, Follet, Terri, additional, Forbes, Jane, additional, Forth, Mark, additional, Foster, Greg, additional, Francis, John, additional, Fraser, Kate, additional, Friedman, Lauren, additional, Fruggeri, Luca, additional, Fulton, Laura, additional, Funnell, Sam, additional, Gadre, Amit, additional, Gandhi, Ajay, additional, Gardiner, Harriet, additional, Garner, Zoe, additional, Garvey, Gráinne, additional, Gately, Tom, additional, George, Richard, additional, Gillespie, Siobhan, additional, Glover, Stephanie, additional, Goddard, Jennifer, additional, Goodman, Ben, additional, Gopal, Tarikere, additional, Graham, George, additional, Green, David, additional, Griffin, Denise, additional, Griffith, Jessica, additional, Grigsby, Stephanie, additional, Grindey, Julie, additional, Griffiths, Huw, additional, Groome, Jonathan, additional, Grother, Christine, additional, Grounds, Gabrielle, additional, Groves, Alice, additional, Guha, Abhik, additional, Gunawardhana, Amila, additional, Gupta, Aman, additional, Gupta, Rekha, additional, Gutsell, James, additional, Haddon, Richard, additional, Hadi, Dina, additional, Hadjipavlou, Nicola, additional, Hammerbeck, Henry, additional, Hammon, Laura, additional, Hammond, Sarah, additional, Hampanna, Hampesh, additional, Hancock, Holly, additional, Handapangoda, Hemantha, additional, Haroon-Mowahed, Yumna, additional, Harpham, Dawn, additional, Harris, Grant, additional, Harrison, Abigail, additional, Harshan, Divya, additional, Hartopp, Andrew, additional, Harty, Eoin, additional, Haslam, Nick, additional, Hawkins, Gemma, additional, Hawkins, Edith, additional, Hawksey, Sarah, additional, Hays, Carole, additional, Hazelton, Tracy, additional, Heavyside, Andrew, additional, Hemeson, Chibuzo, additional, Henderson, Katrina, additional, Henry, Oliver, additional, Herbert, Lara, additional, Higgins, Nikki, additional, Hilton, James, additional, Hindmoor, Claire, additional, Hitchcock, Rachael, additional, Hobbs, Laura, additional, Homsy, Michele, additional, Honeywell, Cassandra, additional, Hoque, Nazima, additional, House, Kirsty, additional, Howle, Ryan, additional, Tiller, Amanda, additional, Huniak, Matthew, additional, Hunte, Jeremy, additional, Husain, Tauqeer, additional, Huson, Coralie, additional, Hussain, Catriona, additional, Hussain, Tawhida, additional, Hussein, Zainab, additional, Hyams, Jeremy, additional, Hyde, Eleanor, additional, Iaverdino, Marina, additional, Ignacka, Alex, additional, Innes, Erin, additional, Ioannidis, Stefanos, additional, Iqbal, Rehana, additional, Ismail, Fahja, additional, Jackson, Jenny, additional, Jackson, Michael, additional, Jackson, Guy, additional, Jacobs, Robyn, additional, Jadhav, Poonam, additional, Jalaly, Aisha, additional, James, Lorraine, additional, James, Monica, additional, Jani, Surekha, additional, Jeganathan, Chandran, additional, Joannides, Claire, additional, Johnson, Robert, additional, Johnson, Thosa, additional, Johnston, Carolyn, additional, Jones, Reeanne, additional, Jones, Tom, additional, Kadr, Miran, additional, Kainth, Rasmeet, additional, Kane, Jenna, additional, Kanji, Rafiq, additional, Kannanparambil, Sunil, additional, Kar, Girish, additional, Kasianandan, Theanalli, additional, Kaskos, Husam, additional, Kavanagh, Lisa, additional, Kaye, Richard, additional, Kelliher, Leith, additional, Kelliot, Serena, additional, Kelly, Jemma, additional, Kelly, Jenna, additional, Kenyon, Carol, additional, Kessack, Laura, additional, Kestner, Samuel, additional, Khaku, Mohammed, additional, Khaleeq, Sophia, additional, Khan, Pervaz, additional, Khan, Sabeen, additional, Kidwai, Usamah, additional, King, Christopher, additional, King, Helen, additional, Kingston, Elizabeth, additional, Kok, Waisun, additional, Konig, Rebekka, additional, Konstantinova, Zheyna, additional, Krishnan, Priya, additional, Kua, Justin, additional, Kuntumalla, Kavitha, additional, Kursumovic, Emira, additional, Kurzatkowski, Krzysztof, additional, Kuttambakam, Hariprasad, additional, Lane, Katherine, additional, Lane, Sophie, additional, Langton, Andrew, additional, Latif, Hamad, additional, Lau, Norlan, additional, Laxman, Shyam, additional, Laycock, Helen, additional, Lee, Rachel, additional, Leonardi, Silvia, additional, Light, Karen, additional, Lightfoot, Heidi, additional, Liu, Shuang, additional, Liyanage, Sanduni, additional, Lowe, Jessica, additional, Lucas, Nuala, additional, Lungu, Miyoba, additional, Lunn, Marianne, additional, Lynes, Heather, additional, Machavarapu, Kishore, additional, Mackenzie, Matthew, additional, Major, Jonathan, additional, Male, Victoria, additional, Malik, Zain, additional, Manso, Katarina, additional, Maquinana, Myrna, additional, Marciniak, Katarzyna, additional, Maronge, Lizzie, additional, Marsh, Chris, additional, Martella, Carmela, additional, Martin, Nicki, additional, Martins, Nicole, additional, Marway, Jaspreet, additional, Mason, Louisa, additional, Mason, Lucy, additional, Masood, Nadia, additional, Masters, James, additional, Maton-Howarth, Matthew, additional, Mazzola, Francesca, additional, McAllister, Tamsin, additional, McCarthy, Rachel, additional, McCormick, Claire, additional, McCready, Sharon, additional, McDougall, Steffan, additional, Mcewan, Lorna, additional, McGarry, Jon, additional, McKevitt, Helen, additional, Mckinley, Stephanie, additional, Mckskeane, Anna, additional, McMaster, Eloise, additional, McMonagle, Martina, additional, McNamara, Helen, additional, McPhee, Hannah, additional, McRae, Laura, additional, Mead, Dee, additional, Meadows, Emma, additional, Mehta, Madhur, additional, Meikle, Joanne, additional, Metodiev, Yavor, additional, Michael, Chloe, additional, Millar, Victoria, additional, Miller, Sarah, additional, Miller, Gregg, additional, Milne, Sezanne, additional, Miltsios, Kostas, additional, Misquita, Lucia, additional, Misquita, Simone, additional, Mittal, Manasi, additional, Mohamed, Mohamed, additional, Powell Monaghan, Katherine, additional, Monk, Joanna, additional, Monkhouse, Alexandra, additional, Monks, David, additional, Montague, Laura, additional, Moon, Angela, additional, Moran, Jennifer, additional, Moreton, Annette, additional, Morgan, Endaf, additional, Morgan, Oliver, additional, Morland, Danny, additional, Morosan, Monica, additional, Morris, Kimberley, additional, Morris, Andrea, additional, Moser, Clare, additional, Mount, Manulella, additional, Muir, Carol, additional, Mupudzi, McDonald, additional, Murali, Mayur, additional, Murdoch, Iona, additional, Murray, Heather, additional, Murray, Theresa, additional, Murrell, Karen, additional, Narasimha Murthy, Girish, additional, Neeley, Diana, additional, Nei, Hannah, additional, Neil, Kerry, additional, Nejim, Tara, additional, Nel, Mark, additional, Nicholson, Anne, additional, Nicklin, Angela, additional, Nolan, Catherine, additional, Nolan, Tracey, additional, Nurmi, Eveliina, additional, O'Neill, Bridie, additional, Oakes, Christie, additional, Oakes, Neil, additional, Ochoa-Ferraro, Maria, additional, Odeleye, Nike, additional, Oliver, Katy, additional, Oliver, Mark, additional, Onslow, Julie, additional, Onwochei, Desire, additional, Oommen, Thomas, additional, Orr, Tim, additional, Osagie, Osato, additional, Osborn, Hannah, additional, Overend, Jennie, additional, Owston, Hazel, additional, Pack, Emma, additional, Padhi, Pulak, additional, Palani, Prabvathy, additional, Pandey, Rajesh, additional, Pandya, Dhruti, additional, Panesar, Navjot, additional, Papageorgiou, Con, additional, Papanastasiou, Georgios, additional, Papoutsos, Costas, additional, Pararajasingham, Suji, additional, Parry, James, additional, Patel, Hasita, additional, Patel, Jaishel, additional, Patel, Jiten, additional, Patel, Kaumudi, additional, Patel, Kiran, additional, Patel, Mitul, additional, Patel, Reshma, additional, Patel, Ruchira, additional, Patel, Nimisha, additional, Pathak, Sangeeta, additional, Pearson, Fiona, additional, Peciulene, Viktorija, additional, Peers, Beth, additional, Peirce, Benjamin, additional, Pepper, Stacey, additional, Perinpanayagam, Jasmina, additional, Perry, Hollie, additional, Petrova, Nadya, additional, Phillips, Trudie, additional, Phillips, Sioned, additional, Phylactides, Leonidas, additional, Pilkington, Felicity, additional, Plumb, James, additional, Poimenidi, Evangelia, additional, Sau Kuk Poon, Anna, additional, Potter, Thomas, additional, Poultney, Una, additional, Powell, Lucy, additional, Prenter, Andrew, additional, Preston, Katie, additional, Price, Anna, additional, Pritchard, Naomi, additional, Pullen, Jenny, additional, Purohit, Manishi, additional, Quamina, Charlotte, additional, Qureshi, Jibran, additional, Rajput, Zahra, additional, Ramage, Stephen, additional, Ramanathan, Tamilselvi, additional, Ranasinghe, Upeka, additional, Ranatunga, Kalum, additional, Rand, Abby, additional, Randive, Seema, additional, Rangarajan, Desikan, additional, Rao, Chandana, additional, Rao Pelluri, Sambasiva, additional, Ratnasingham, Antony, additional, Razzaque, Jamil, additional, Reddy, Anuvidya, additional, Redington, Katie, additional, Reel, Emma, additional, Remeta, Peter, additional, Ricco, Francesca, additional, Riccoboni, Anna, additional, Rice, Polly, additional, Rich, Mel, additional, Richards, Nicole, additional, Riches, Joanne, additional, Ripoll, Simon, additional, Roberts, Fleur, additional, Roberts, Kitty, additional, Robins, Kay, additional, Robinson, Susie, additional, Roche, Samantha, additional, Rojo, Maria, additional, Carmela Romano, Milena, additional, Rosser, Hilary, additional, Roughley, Lindsay, additional, Routley, Catriona, additional, Rowley, Christine, additional, Rudra, Pallab, additional, Russell, Robin, additional, Ryan, Christine, additional, Saad, Chloe, additional, Sadeghi, Abtin, additional, Salberg, Armorel, additional, Samuel, Matt, additional, Samuels, Rebecca, additional, Sanapala, Suresh, additional, Sanusi, Seliat, additional, Sarao, Sarbpreet, additional, Sathyabhama, Sathyabhama, additional, Saunders, Zoe, additional, Sawarzynska-ryszka, Bernadetta, additional, Sceales, Panagiota, additional, Sceales, Penny, additional, Schumacher, Natasha, additional, Schwartz, Nuala, additional, Sellers, Claudia, additional, Sellers, Heather, additional, Sellick, Jessica, additional, Sen, Soumen, additional, Senaratne, Dhaneesha, additional, Senbeto, Sarah, additional, Seneviratna, Dineth, additional, Setty, Thunga, additional, Shah, Raj, additional, Shah, Sonia, additional, Shambly, James, additional, Sharafudeen. Imran Sharieff, Saju, additional, Sharifi, Laurence, additional, Sharpe, Lisa, additional, Shaw, Michael, additional, Sheldrake, Ian, additional, Shinde, Priya, additional, Shonfeld. Jonathon Short, Adam, additional, Siah, Julian, additional, Sibug. Omar Siddique, Sheena, additional, Siew, Sara, additional, Simpson, Matthew, additional, Singleton, Georgina, additional, Sinha, Kathryn, additional, Sinha, Aneeta, additional, Sinnott, Matthew, additional, Sivadhas, Harry, additional, Sivakumar, Sivanth, additional, Sivarajan, Boopathi, additional, Sivarajan, Sinduja, additional, Skeoch, Chris, additional, Slade, Samuel, additional, Slater, Paul, additional, Smith, Camilla, additional, Smith, Carys, additional, Smith, Christopher, additional, Smith, James, additional, Smith, Lorraine, additional, Smith, Annika, additional, Smith, Edward, additional, Smith, Ruth, additional, Smith, Sue, additional, Smith, Tim, additional, Smithers, Helen, additional, Smolen, Sue, additional, Smyth, Claire, additional, Snel, Toni, additional, Snipe, Carol, additional, Soltanifar, Sam, additional, Sonawane, Nilesh, additional, Soundararaja, Andal, additional, Spence, Emily, additional, Spiliopoulos, Mark, additional, Srivastava, Chhavi, additional, Stacey, Karen, additional, Stafford, Helena, additional, Staines, Nikki, additional, Stead, Richard, additional, Stevens, Emma, additional, Stilwell, Alex, additional, Stocks, Gary, additional, Stokes, Aaron, additional, Stone, Christopher, additional, Straughan, Ben, additional, Subbarathnam, Vanitha, additional, Sudunagunta, Srinath, additional, Sultan, Pervez, additional, Suppiah, Puvan, additional, Surve, Priyanka, additional, Sutherland, Angus, additional, Swanton, Rob, additional, Swarbrick, Claire, additional, Swinson, Amy, additional, Syrrakou, Eleni, additional, Tadbiri, Shahrzad, additional, Tamhane, Preetam, additional, Tamilselvan, Perumal, additional, Tan, Andrew, additional, Tanna, Shamil, additional, Tarft, Hayley, additional, Tarry, Laura, additional, Taylor, Ian, additional, Taylor, Suzanne, additional, Tebbot, Julie, additional, Theron, Svetlana, additional, Thomas, Megan, additional, Todd, Sarah, additional, Tolliday, Hermione, additional, Topham, Charlotte, additional, Tovell, Nicholas, additional, Traves, Martyn, additional, Trodd, Dawn, additional, Tufchi, Aseem, additional, Turley, Katie, additional, Turnbull, Marc, additional, Turnbull, Chris, additional, Turner, Oliver, additional, Turner, William, additional, Turney, Sharon, additional, Tyagi, Eleanor, additional, Uncles, David, additional, Unsworth, Vanessa, additional, Vadnere, Pradnya, additional, Varadan, Rama, additional, Vasishta, Vik, additional, Veal, Andrew, additional, Vedham, Lalitha, additional, Venkaya, Jessica, additional, Verghese, Miriam, additional, Veronica, Icel, additional, Vidanagamage, Dinesh, additional, Vincent, Rachel, additional, Vyapury, Vinodhan, additional, Wain, Harris, additional, Walbridge, Fiona, additional, Walker, Elaine, additional, Walsh, Pete, additional, Walshe, Eleanor, additional, Walters, Michelle, additional, Wan, Yize, additional, Wang, Cherry, additional, Wankhade, Kavita, additional, Waters, Gareth, additional, Watts, Christopher, additional, Webber, Alex, additional, Wedgwood, Tom, additional, Wee, Michael, additional, Wellstead, Susan, additional, White, Alison, additional, Whitear, Michael, additional, Whitefield, Lucy, additional, Wilkinson, Sarah, additional, Williams, Lauren, additional, Williams, Rhys, additional, Wilson, Dawn, additional, Wilson, Samantha, additional, Wimble, Katie, additional, Winkley, Elaine, additional, Winslow, Luke, additional, Winwright, Paul, additional, Wloch, Karolina, additional, Wong, Gideon, additional, Wong, Hannah, additional, Man Wong, Jan, additional, Wood, Tim, additional, Wray, Sarah, additional, Wrench, Ian, additional, Wu, James, additional, Wynn, Kynn, additional, Yap, Yeng, additional, Kuan Yeow, Chia, additional, Young, Emily, additional, Yusaf, Alex, additional, Uz Zafar, Saeed, additional, Zeinali, Darius, additional, Zhang, Sheldon, additional, Zope, Sarvesh, additional, Zucco, Liana, additional, Anwar, Sibtain, additional, Blunt, Nadia, additional, Cronin, John, additional, Grover, Vimal, additional, Grailey, Kate, additional, Grey, Martin, additional, Highton, David, additional, Hopkins, Phil, additional, Kemp, Harriet, additional, Lo, Queenie, additional, Martin, Daniel, additional, Morkane, Clare, additional, O'Carroll, James, additional, Oliver, Charles, additional, Post, Benjamin, additional, Visram, Anil, additional, and Wickham, Alex, additional

Published
2020
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20. Large-scale manufacturing of ultra-strong, strain-responsive poly(lactic acid)-based nanocomposites reinforced with cellulose nanocrystals

Author

Shiyu Geng, Kristiina Oksman, Daniela Wloch, and Natalia Herrera

Subjects
Toughness, Nanocomposite, Materials science, General Engineering, Biomaterial, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Ultimate tensile strength, Ceramics and Composites, Surface modification, Extrusion, Crystallite, Composite material, 0210 nano-technology, Glass transition
Abstract

Developing materials from renewable resources to produce nanocomposites with satisfactory mechanical properties is a vital progress in today's society, and meanwhile, the widespread use of these nanocomposites needs to be enabled through large-scale manufacturing. Herein, ultra-strong nanocomposites with an aligned structure that consisted of bio-based, biodegradable poly(lactic acid) (PLA) and cellulose nanocrystals are demonstrated, and these nanocomposites can be manufactured at a large scale through surface modification of the nanocrystals, liquid-assisted extrusion, and solid-state drawing. An ultimate strength of 353 MPa and a toughness of 107 MJ/m3 can be achieved by these nanocomposites, which are superior compared to the values of many other thermoplastic materials. The mechanism that explains the high toughness of these nanocomposites has been extensively investigated, revealing that sliding of the PLA crystallites present in the materials is the main factor. Moreover, these nanocomposites possess relatively high glass transition temperature and exhibit strain-responsive birefringence behavior, which indicates their great potential in not only structural applications, but also optical strain sensing areas.

Published
2020
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21. Fasting Hyperglycemia and Long-term Outcome in Patients with Acute Ischemic Stroke Treated with Mechanical Thrombectomy

Author

Marcin Wnuk, Roman Pulyk, Paweł Brzegowy, Leszek Drabik, Agnieszka Slowik, Marcin Wiacek, Tadeusz Popiela, Dorota Wloch-Kopec, Halina Bartosik-Psujek, Jeremiasz M. Jagiella, Bartosz Lasocha, and Rafał Kaczorowski

Subjects
Blood Glucose, Male, medicine.medical_specialty, Time Factors, Risk Assessment, Brain Ischemia, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Modified Rankin Scale, Internal medicine, Diabetes mellitus, Diabetes Mellitus, medicine, Humans, In patient, Risk factor, Acute ischemic stroke, Stroke, Aged, Retrospective Studies, Thrombectomy, Aged, 80 and over, business.industry, Rehabilitation, Fasting, Middle Aged, medicine.disease, Mechanical thrombectomy, Treatment Outcome, Hyperglycemia, Ischemic stroke, Cardiology, Female, Surgery, Poland, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Biomarkers, 030217 neurology & neurosurgery
Abstract

Little is known about the prognostic role of fasting glucose after mechanical thrombectomy (MT).We investigated whether fasting glucose on the next day after MT was associated with long-term outcome in acute ischemic stroke patients according to diabetes.We retrospectively analyzed 181 consecutive patients with acute anterior circulation ischemic stroke who underwent MT in 2 comprehensive stroke centers in Poland. Glucose levels were evaluated on admission and on the next day after MT. Fasting hyperglycemia (FHG) was defined as the glucose level above 5.5 mmol/L. Unfavorable outcome was defined as modified Rankin scale (mRS) of 3-6 at day 90 from stroke onset.Patients with FHG had higher mRS at 3-month follow-up compared with those without FHG (3.71 ± 2.56 versus 1.87 ± 2.22, P.001). In the subgroup analyses, FHG was associated with poor neurological outcome in the group without diabetes (3.74 ± 2.52 versus 1.81 ± 3.74, P.001) but not with diabetes (3.64 ± 2.67 versus 2.30 ± 3.74, P= .11). Patients without diabetes who had FHG were older, had higher glucose on admission, higher prevalence of atrial fibrillation, cardioembolic stroke etiology and bleeding brain complications compared with the group with normal fasting glucose. After adjustment for potential confounders, fasting glucose (odds ratio [OR] 1.46; 95% CI 1.19-1.79, P.001), age (OR 1.06; 95% CI 1.02-1.10, P = .001), successful reperfusion (OR 0.09; 95% CI 0.04-0.22, P.001) and baseline NIHSS score (OR 1.18; 95% CI 1.08-1.29, P.001) were predictors of mRS 3-6 at 3-month follow-up in the whole group. In the subgroup without diabetes, fasting glucose (OR 1.57; 95% CI 1.17-2.11, P = .002), age (OR 1.05; 95% CI 1.01-1.08, P = .008), successful reperfusion (OR 0.11; 95% CI 0.04-0.30, P.001) and baseline NIHSS score (OR 1.14; 95% CI 1.04-1.26, P = .011) were independent predictors of unfavorable 3-month outcome.Fasting glucose on the next day after MT in patients with acute ischemic stroke is an independent risk factor for worse 3-month outcome.

Published
2020
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22. Adverse events associated with deep brain stimulation in patients with childhood-onset dystonia

Author

Koy, A., primary, Bockhorn, N., additional, Kühn, A.A., additional, Schneider, G.-H., additional, Krause, P., additional, Lauritsch, K., additional, Witt, K., additional, Paschen, S., additional, Deuschl, G., additional, Krauss, J.K., additional, Saryyeva, A., additional, Runge, J., additional, Borggraefe, I., additional, Mehrkens, J.H., additional, Horn, A., additional, Vesper, J., additional, Schnitzler, A., additional, Siegert, S., additional, Freilinger, M., additional, Eckenweiler, M., additional, Coenen, V.A., additional, Tadic, V., additional, Voges, J., additional, Pauls, K.A.M., additional, Wirths, J., additional, Timmermann, L., additional, Hellmich, M., additional, Abdallat, Mahmoud, additional, Ascencao, Laura Cassini, additional, Grünwald, Svetlana, additional, Wloch, Andreas, additional, Schrader, Christoph, additional, Groiss, Stefan J., additional, and Wojtecki, Lars, additional

Published
2019
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23. Démarche collective et concertée d’évaluation de la santé, des conditions de travail et des mesures de prévention dans les drives de la grande distribution

Author

Karine Wloch, A. Leroyer, and Florian Tone

Subjects
Public Health, Environmental and Occupational Health
Abstract

Introduction Les drives sont un concept en expansion continue depuis les annees 2000 dans le secteur de la grande distribution, marque par une forte sinistralite. Les enjeux de sante au travail y sont nombreux et imposent une prise en compte des risques professionnels et des effets potentiels sur la sante des salaries. Dans ce contexte, nous avons decide de mettre en place en concertation avec la CARSAT une demarche collective d’evaluation de la sante et des conditions de travail des salaries. L’enjeu est de pouvoir ensuite proposer des mesures de prevention des risques professionnels adaptees a ces entreprises. Methode L’etude a ete menee pendant 12 mois aupres de 16 drives (400 salaries interroges) par 13 equipes de sante au travail. Nous avons utilise le questionnaire EVREST et des questions specifiques complementaires. Les resultats ont ete compares avec ceux du referentiel national Evrest des employes libre-service et magasiniers de la grande distribution. Resultats On constate des indicateurs de sante tres perturbes dans cette population jeune (52 % des salaries interroges ont moins de 25 ans) : 47 % des repondants declarent une fatigue (22 % dans le referentiel national Evrest) ; 50 % des salaries interroges decrivent des plaintes du rachis et 28 % des repondants expriment des plaintes du membre superieur (ref. respectivement 24 et 13 %). Concernant les contraintes organisationnelles et physiques, pres de 90 % des salaries declarent etre exposes a des postures contraignantes et au port de charges lourdes et plus de 2/3 d’entre eux decrivent ces expositions comme penibles (ref. respectivement 44 et 48 %) ; les gestes repetitifs penibles sont declares par 1 salarie sur 2 (ref. 32 %) ; une pression temporelle importante est decrite par 57 % des repondants (ref. 41 %) ; 61 % declarent devoir abandonner une tâche pour une autre non prevue (ref. 48 %). 8/16 drives ont beneficie d’une evaluation des risques, suivie d’un plan d’action ; 79 % des accidents de travail ont fait l’objet d’une analyse. Discussion Notre etude confirme que les salaries des drives, une population particulierement jeune, presentent une prevalence inquietante de plaintes de sante, tant mentales qu’osteoarticulaires, et rapportent a une frequence elevee de nombreuses contraintes de travail. Les resultats obtenus renforcent la necessite d’intervention et d’accompagnement en termes de prevention le plus en amont possible et de maniere concertee de tous les acteurs de la sante au travail, afin d’ameliorer cette problematique. Conclusion La prevention organisee et concertee dans le secteur des drives reste le point cle et probablement la piste la plus efficace pour pouvoir observer une amelioration des indicateurs en sante au travail dans ce secteur.

Published
2018
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29. Separation of systems forming solid solutions using counter-current crystallization

Author

Heike Lorenz, Sebastian Wloch, Erik Temmel, Detlef Grawe, Andreas Seidel-Morgenstern, Uwe Müller, and Robert Eilers

Subjects
Materials science, Applied Mathematics, General Chemical Engineering, Counter current, Thermodynamics, General Chemistry, Miscibility, Industrial and Manufacturing Engineering, law.invention, Pilot plant, law, Scientific method, SCALE-UP, Fractional crystallization (chemistry), Crystallization, Solid solution
Abstract

A multi-stage counter-current crystallization is investigated theoretically and experimentally. The process allows separating mixtures, which form complete or partial solid-solutions. An equilibrium stage model is used to describe the progress of the purification with the specific solid–liquid equilibria as main input information. Results presented in this paper concern (a) the demonstration of the process principle for two selected generic systems characterized by complete miscibility in the solid state, namely K2SO4/(NH4)2SO4 and KCl/KBr, (b) the scale up from a laboratory unit to a pilot plant and (c) the evaluation of the potential of the process principle for the purification of systems characterized by partial miscibility in the solid state.

Published
2013
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30. Comparison of Planned Versus Actual Dose Delivered for External Beam Accelerated Partial Breast Irradiation Using Cone-Beam CT and Deformable Registration

Author

Y. Chi, J. Wloch, Jian Liang, Yasmin Hasan, Frank A. Vicini, Alvaro Martinez, Di Yan, and Leo A. Kim

Subjects
Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Population, Planning target volume, Breast Neoplasms, Clinical Protocols, medicine, Humans, Radiology, Nuclear Medicine and imaging, Breast, education, Lung, Cone beam ct, education.field_of_study, Radiation, Cumulative dose, business.industry, Radiotherapy Planning, Computer-Assisted, Partial Breast Irradiation, Heart, Cone-Beam Computed Tomography, Confidence interval, Tumor Burden, Radiation therapy, Clinical Trials, Phase III as Topic, Oncology, Female, Dose Fractionation, Radiation, Radiology, business, Nuclear medicine, Beam (structure)
Abstract

Purpose To assess the adequacy of dose delivery to the clinical target volume (CTV) using external beam (EB) accelerated partial breast irradiation (APBI). Methods and Materials Sixteen patients treated with EB APBI underwent cone beam CT (CBCT) before each fraction and daily helical CT (HCT) scans to determine setup errors and calculate the dose per fraction. For 12 patients, an in-house image-intensity-based deformable registration program was used to register the HCTs to the planning CT and generate the cumulative dose. Treatment was 38.5 Gy in 10 fractions. EB APBI constraints from the National Surgical Adjuvant Breast and Bowel Project B39/Radiation Therapy Oncology Group 0413 Phase III protocol were used. Results The mean setup error per CBCT registration was 9 ± 5 mm. Dose–volume histogram analysis showed only one patient (8%) with a decrease in the CTV V90 (8% underdosage). All other patients demonstrated adequate target coverage. PTV_EVAL V90 was on average 3% (range, 0%–16%) less than planned. For the ipsilateral breast, four patients had an increase in V50 (≤1% increase) and three patients had an increase in V100 (≤9% increase). Only one patient showed an increase >5%. Four patients had an increase in ipsilateral lung V30 (maximum 3%), and one had an increase in heart V5 (1%). Four patients had an increase in MaxDose (maximum 89 cGy). Conclusions The current CTV-to-PTV margin of 10 mm appears sufficient for ∼92% of patients treated with EB APBI. Although expansion of the population PTV margin to 14 mm would provide ∼97% confidence level for CTV coverage, online image guidance should be considered.

Published
2011
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31. Dans un contexte de fusion, quels sont les leviers mobilisables par l’équipe pluridisciplinaire pour engager une entreprise dans l’analyse de son organisation de travail ?

Author

Christophe Leviel, Karine Wloch, Coralie Taisne, Florian Tone, and Karinne Legrand-Cattan

Subjects
Public Health, Environmental and Occupational Health
Abstract

Le secteur de la biologie medicale a ete soumis, par ordonnance en 01/2010, a l’obligation de disposer d’accreditations pour l’ensemble de leurs activites. Un grand nombre de laboratoires s’est engage dans des processus de fusion ou cession visant a disposer de materiels et methodes d’analyses performants. C’est dans ce contexte de fusion, de reorganisation et de son impact sante, que notre equipe pluridisciplinaire s’est mobilisee des 2012, pour engager un laboratoire de 190 salaries a analyser l’organisation de travail et mettre en place une demarche de prevention en lien avec les process qualite. La methodologie s’est appuyee sur un recueil systematise, sur 24 mois, de donnees via le questionnaire EVREST, enrichis d’entretiens semi-directifs infirmiers. Les resultats portant sur 148 salaries, confirment les impressions cliniques. Fatigue et lassitude sont presentes chez plus de 41 % d’entre eux, avec 26 % de troubles du sommeil et 33 % d’anxiete. Une hypertension arterielle traitee concerne 15 % de l’echantillon. Une pression temporelle est evaluee pour 58 % des repondants a plus de 5/10 sur echelle visuelle analogique. Un manque d’autonomie, de reconnaissance, de perte de qualite est mis en avant pour plus d’un salarie sur 2, associe a la peur de perdre son emploi pour 19 % d’entre eux. Trois services sont pointes : prelevement, reception-distribution et les plateaux techniques. Dans un deuxieme temps, orientee par les plaintes rachidiennes (29 % des repondants), une etude est menee par l’ergonome aupres du service prelevement. Les restitutions des constats de l’equipe, en CHSCT, ont permis a terme une prise de conscience de l’etat de sante des salaries et la necessite de modifier l’approche organisationnelle de l’entreprise. A partir de 2015, sous l’impulsion du CHSCT, une demarche participative est mise en place. Elle associera les salaries a l’organisation de la planification des activites des plateaux techniques ; les conclusions de l’ergonome, reprises dans le cadre du dispositif TMS PRO conduiront a des modifications dans l’acheminement des prelevements et dans le choix des outils. La ligne manageriale et les missions seront revues. Des apports formatifs seront proposes aux nouveaux managers. Aujourd’hui, l’entreprise s’inscrit dans une demarche d’amelioration continue. Fin 2016, elle a souhaite disposer de nouveaux indicateurs de sante pour orienter ou conforter ses actions (notamment vis-a-vis du service reception). Une nouvelle phase de recueil est en cours, alors que d’autres fusions sont envisagees pour 2018 amenant l’effectif de l’entreprise a plus de 300 salaries, 17 sites de prelevements et la concentration des analyses sur les 2 plateaux techniques dont le dimensionnement devra etre revu.

Published
2018
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32. Repérage des expositions amiante par l’équipe pluridisciplinaire

Author

Delphine Jacquin, Laetitia Degroote, Karine Wloch, Celine Abraham, Veronique Liebaert, Brigitte Demont, Cornard Nadege, and Christian Morel

Subjects
Public Health, Environmental and Occupational Health
Abstract

Objectif Reperer les expositions actuelles et anciennes a l’amiante afin de mettre en place un suivi de sante adapte. Methodologie Pendant un an, deux equipes pluridisciplinaires ont fait passer un questionnaire de recueil des expositions a l’amiante a une population d’hommes. Le questionnaire, remis par les assistantes d’equipes, etait rempli par le salarie puis revu par le medecin du travail ou l’IDEST a l’occasion des visites d’embauches, periodiques, et entretiens infirmiers. Un questionnaire complementaire, reprenant l’exposition au tabac, l’exposition estimee a l’amiante, les metiers exposants et actuels, la prescription d’examens complementaires et leurs resultats, a fait l’objet d’un traitement statistique. Resultats Quatre cent huit questionnaires ont ete remplis. Cinquante-six pour cent des repondants sont des fumeurs et d’anciens fumeurs. Cent vingt-neuf salaries sont potentiellement concernes par l’amiante. Quatre-vingt-neuf pour cent des expositions sont de type intermediaire. La duree d’exposition moyenne est de 6,7 ans. Quatre-vingt-huit salaries ont eu un examen complementaire. Dix-neuf salaries ont des anomalies detectees, toutes sans rapport avec l’exposition a l’amiante. Conclusion Nous avons rencontre des difficultes : le curriculum laboris exact est difficile a elaborer et ce recueil de donnees est tres chronophage. Les points positifs ont ete l’utilisation des recommandations HAS, l’amelioration du suivi de sante et de l’information des salaries.

Published
2018
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33. EU update

Author

Michael Dizon, Helen Kemmitt, Joanne Pairman, and Nick Wloch

Subjects
Computer Networks and Communications, Law, General Business, Management and Accounting
Published
2009
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34. Image-Guided Radiotherapy via Daily Online Cone-Beam CT Substantially Reduces Margin Requirements for Stereotactic Lung Radiotherapy

Author

K. Chao, Di Yan, A.P. Galerani, Geoffrey D. Hugo, Larry L. Kestin, J. Wloch, and Inga S. Grills

Subjects
Body frame, Cancer Research, Lung Neoplasms, Movement, medicine.medical_treatment, Population, Cbct image, Image guided radiotherapy, Stereotaxic Techniques, Stereotactic radiotherapy, Carcinoma, Non-Small-Cell Lung, medicine, Humans, Radiology, Nuclear Medicine and imaging, education, Cone beam ct, education.field_of_study, Radiation, Lung, business.industry, Cone-Beam Computed Tomography, Radiotherapy, Computer-Assisted, Radiation therapy, medicine.anatomical_structure, Oncology, Calibration, Nuclear medicine, business, Algorithms
Abstract

Purpose To determine treatment accuracy and margins for stereotactic lung radiotherapy with and without cone-beam CT (CBCT) image guidance. Methods and Materials Acquired for the study were 308 CBCT of 24 patients with solitary peripheral lung tumors treated with stereotactic radiotherapy. Patients were immobilized in a stereotactic body frame (SBF) or alpha-cradle and treated with image guidance using daily CBCT. Four (T1) or five (T2/metastatic) 12-Gy fractions were prescribed to the planning target volume (PTV) edge. The PTV margin was ≥5 mm depending on a pretreatment estimate of tumor excursion. Initial daily setup was according to SBF coordinates or tattoos for alpha-cradle cases. A CBCT was performed and registered to the planning CT using soft tissue registration of the target. The initial setup error/precorrection position, was recorded for the superior–inferior, anterior–posterior, and medial–lateral directions. The couch was adjusted to correct the tumor positional error. A second CBCT verified tumor position after correction. Patients were treated in the corrected position after the residual errors were ≤2 mm. A final CBCT after treatment assessed intrafraction tumor displacement. Results The precorrection systematic (Σ) and random errors (σ) for the population ranged from 2–3 mm for SBF and 2–6 mm for alpha-cradle patients; postcorrection errors ranged from 0.4–1.0 mm. Calculated population margins were 9 to 13 mm (SBF) and 10–14 mm (cradle) precorrection, 1–2 mm (SBF), and 2–3 mm (cradle) postcorrection, and 2–4 mm (SBF) and 2–5 mm (cradle) posttreatment. Conclusions Setup for stereotactic lung radiotherapy using a SBF or alpha-cradle alone is suboptimal. CBCT image guidance significantly improves target positioning and substantially reduces required target margins and normal tissue irradiation.

Published
2008
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38. Influence of isomorphous substitution in MFI-type materials on the diffusion of n-hexane: Molecular dynamic studies

Author

J. Wloch

Subjects
Chemistry, Diffusion, General Physics and Astronomy, Isomorphism (crystallography), Surfaces and Interfaces, General Chemistry, Condensed Matter Physics, Molecular sieve, Surfaces, Coatings and Films, Hexane, Molecular dynamics, chemistry.chemical_compound, Adsorption, Isomorphous substitution, Physical chemistry, Zeolite
Abstract

Theoretical studies of the behaviour of an adsorption system MFI/n-hexane were performed with a molecular dynamic method. Investigation of influence of isomorphous substitution on diffusion coefficients was the main objective. It was found that the presence of metals other than silicon in the zeolite framework might cause an increase in the diffusion coefficients. However, it is small, independently of the adsorption level.

Published
2007
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39. Novel microneutralization assay for HCMV using automated data collection and analysis

Author

Larry R. Smith, Mary K. Wloch, and Anna Maria Abai

Subjects
Human cytomegalovirus, Viral protein, viruses, Immunology, Cytomegalovirus, Biology, medicine.disease_cause, Sensitivity and Specificity, Article, Neutralization, 03 medical and health sciences, Neutralization Tests, medicine, Humans, Immunology and Allergy, Microneutralization Assay, Neutralizing antibody, Cells, Cultured, 030304 developmental biology, 0303 health sciences, Miniaturization, 030306 microbiology, ELISPOT, Complement System Proteins, medicine.disease, Virology, Molecular biology, 3. Good health, Staining, Blood, Cytomegalovirus Infections, biology.protein, Antibody
Abstract

In addition to being sensitive and specific, an assay for the assessment of neutralizing antibody activity from clinical trial samples must be amenable to automation for use in high-volume screening. To that effect, we developed a 96-well microplate assay for the measurement of HCMV-neutralizing activity in human sera using the HCMV-permissive human cell line HEL-299 and the laboratory strain of HCMV AD169. The degree to which neutralizing antibodies diminish HCMV infection of cells in the assay is determined by quantifying the nuclei of infected cells based on expression of the 72 kDa IE1 viral protein. Nuclear IE1 is visualized using a highly sensitive immunoperoxidase staining and the stained nuclei are counted using an automated ELISPOT analyzer. The use of Half Area 96-well microplates, with wells in which the surface area of the well bottom is half the area of a standard 96-well microplate plate, improves signal detection compared with standard microplates and economizes on the usage of indicator cells, virus, and reagents. The staining process was also streamlined by using a microplate washer and data analysis was simplified and accelerated by employing a software program that automatically plots neutralization curves and determines NT(50) values using 4-PL curve fitting. The optimized assay is not only fast and convenient, but also specific, sensitive, precise and reproducible and thus has the characteristics necessary for use in measuring HCMV-neutralizing activity in the sera of vaccine trial subjects such as the recipients of Vical's HCMV pDNA vaccine candidates.

Published
2007
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40. Les intérimaires : quel intérêt d’une approche collective ?

Author

Brigitte Leroyer, Karine Wloch, Ariane Leroyer, and Florian Tone

Subjects
03 medical and health sciences, 0302 clinical medicine, Public Health, Environmental and Occupational Health, 030210 environmental & occupational health
Abstract

Objectifs Ameliorer la connaissance des particularites des ouvriers interimaires dans la branche du bâtiment et des travaux publiques (BTP). Comparer leur ressenti au travail avec celui des ouvriers de la meme branche au niveau national. Essayer de determiner des pistes pour ameliorer la prevention des risques professionnels de ces salaries. Methode Etude prospective, descriptive, par questionnaire (questionnaire EVREST avec questions complementaires et score EPICES) rempli en presence du medecin du travail lors des visites medicales pendant une periode de 15 mois. Le referentiel utilise a ete l’echantillon EVREST des ouvriers du BTP au niveau national (1266 salaries). Un recueil des indicateurs de sinistralite aupres des agences d’interim est en attente. Resultats Parmi les 122 questionnaires recueillis : 99 % d’hommes ; 54 % avaient moins de 35 ans et 23 % 45 ans et plus ; 77 % se declaraient en interim « subi ». Pour la population prise comme reference : 99 % d’hommes, 47 % de moins de 35 ans et 29 % de 45 ans et plus. Les plaintes des interimaires concernaient principalement la sphere osteo-articulaire et auditive, a une frequence significativement superieure a celle des ouvriers du BTP (37 % versus 20 % de plaintes rachidiennes et 27 % versus 10 % de plaintes auditives). La frequence de ces plaintes augmentait avec l’âge et l’anciennete dans le BTP. Une difference significative concernait le fait de « devoir faire des choses qu’on desapprouve » (38 % des interimaires versus 25 % des ouvriers du BTP) et « travailler avec la peur de perdre son emploi » (50 % versus 12 %) ; 88 % admettaient avoir les moyens de faire un travail de bonne qualite (94 % pour la reference). Un salarie sur deux declarait avoir peu d’information/sensibilisation sur les risques professionnels. Les autres resultats concernant les contraintes au travail et la sante etaient comparables a ceux des ouvriers du BTP. Concernant le Score Epices, il s’agit d’une population precaire, car seuls 33 % d’entre eux ont un score Conclusion Il s’agit d’une population jeune, precaire, pour la plupart subissant l’interim. Ils ont une exposition importante aux contraintes physiques, avec des plaintes plus frequentes sur la sphere osteo-articulaire que les ouvriers du BTP et peu de formation et sensibilisation sur les risques professionnels et les mesures de prevention individuelles et collectives. D’ou l’importance des actions ciblees, a la fois au niveau des agences d’interim et des entreprises de BTP, mais aussi lors des entretiens individuels dans le suivi medical de cette population.

Published
2016
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47. Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study

Author

Pulit, Sara L, primary, McArdle, Patrick F, additional, Wong, Quenna, additional, Malik, Rainer, additional, Gwinn, Katrina, additional, Achterberg, Sefanja, additional, Algra, Ale, additional, Amouyel, Philippe, additional, Anderson, Christopher D, additional, Arnett, Donna K, additional, Arsava, Ethem Murat, additional, Attia, John, additional, Ay, Hakan, additional, Bartz, Traci M, additional, Battey, Thomas, additional, Benavente, Oscar R, additional, Bevan, Steve, additional, Biffi, Alessandro, additional, Bis, Joshua C, additional, Blanton, Susan H, additional, Boncoraglio, Giorgio B, additional, Brown, Robert D, additional, Burgess, Annette I, additional, Carrera, Caty, additional, Chapman Smith, Sherita N, additional, Chasman, Daniel I, additional, Chauhan, Ganesh, additional, Chen, Wei-Min, additional, Cheng, Yu-Ching, additional, Chong, Michael, additional, Cloonan, Lisa K, additional, Cole, John W, additional, Cotlarciuc, Ioana, additional, Cruchaga, Carlos, additional, Cuadrado-Godia, Elisa, additional, Dave, Tushar, additional, Dawson, Jesse, additional, Debette, Stéphanie, additional, Delavaran, Hossein, additional, Dell, Cameron A, additional, Dichgans, Martin, additional, Doheny, Kimberly F, additional, Dong, Chuanhui, additional, Duggan, David J, additional, Engström, Gunnar, additional, Evans, Michele K, additional, Pallejà, Xavier Estivill, additional, Faul, Jessica D, additional, Fernández-Cadenas, Israel, additional, Fornage, Myriam, additional, Frossard, Philippe M, additional, Furie, Karen, additional, Gamble, Dale M, additional, Gieger, Christian, additional, Giese, Anne-Katrin, additional, Giralt-Steinhauer, Eva, additional, González, Hector M, additional, Goris, An, additional, Gretarsdottir, Solveig, additional, Grewal, Raji P, additional, Grittner, Ulrike, additional, Gustafsson, Stefan, additional, Han, Buhm, additional, Hankey, Graeme J, additional, Heitsch, Laura, additional, Higgins, Peter, additional, Hochberg, Marc C, additional, Holliday, Elizabeth, additional, Hopewell, Jemma C, additional, Horenstein, Richard B, additional, Howard, George, additional, Ikram, M Arfan, additional, Ilinca, Andreea, additional, Ingelsson, Erik, additional, Irvin, Marguerite R, additional, Jackson, Rebecca D, additional, Jern, Christina, additional, Conde, Jordi Jiménez, additional, Johnson, Julie A, additional, Jood, Katarina, additional, Kahn, Muhammad S, additional, Kaplan, Robert, additional, Kappelle, L Jaap, additional, Kardia, Sharon L R, additional, Keene, Keith L, additional, Kissela, Brett M, additional, Kleindorfer, Dawn O, additional, Koblar, Simon, additional, Labovitz, Daniel, additional, Launer, Lenore J, additional, Laurie, Cathy C, additional, Laurie, Cecelia A, additional, Lee, Cue Hyunkyu, additional, Lee, Jin-Moo, additional, Lehm, Manuel, additional, Lemmens, Robin, additional, Levi, Christopher, additional, Leys, Didier, additional, Lindgren, Arne, additional, Longstreth, W T, additional, Maguire, Jane, additional, Manichaikul, Ani, additional, Markus, Hugh S, additional, McClure, Leslie A, additional, McDonough, Caitrin W, additional, Meisinger, Christa, additional, Melander, Olle, additional, Meschia, James F, additional, Mola-Caminal, Marina, additional, Montaner, Joan, additional, Mosley, Thomas H, additional, Müller-Nurasyid, Martina, additional, Nalls, Mike A, additional, O'Connell, Jeffrey R, additional, O'Donnell, Martin, additional, Ois, ángel, additional, Papanicolaou, George J, additional, Paré, Guillaume, additional, Peddareddygari, Leema Reddy, additional, Pedersén, Annie, additional, Pera, Joanna, additional, Peters, Annette, additional, Poole, Deborah, additional, Psaty, Bruce M, additional, Rabionet, Raquel, additional, Raffeld, Miriam R, additional, Rannikmäe, Kristiina, additional, Rasheed, Asif, additional, Redfors, Petra, additional, Reiner, Alex P, additional, Rexrode, Kathryn, additional, Ribasés, Marta, additional, Rich, Stephen S, additional, Robberecht, Wim, additional, Rodriguez-Campello, Ana, additional, Rolfs, Arndt, additional, Roquer, Jaume, additional, Rose, Lynda M, additional, Rosenbaum, Daniel, additional, Rost, Natalia S, additional, Rothwell, Peter M, additional, Rundek, Tatjana, additional, Ryan, Kathleen A, additional, Sacco, Ralph L, additional, Sale, Michèle M, additional, Saleheen, Danish, additional, Salomaa, Veikko, additional, Sánchez-Mora, Cristina, additional, Schmidt, Carsten Oliver, additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Schürks, Markus, additional, Scott, Rodney, additional, Segal, Helen C, additional, Seiler, Stephan, additional, Seshadri, Sudha, additional, Sharma, Pankaj, additional, Shuldiner, Alan R, additional, Silver, Brian, additional, Slowik, Agnieszka, additional, Smith, Jennifer A, additional, Söderholm, Martin, additional, Soriano, Carolina, additional, Sparks, Mary J, additional, Stanne, Tara, additional, Stefansson, Kari, additional, Stine, O Colin, additional, Strauch, Konstantin, additional, Sturm, Jonathan, additional, Sudlow, Cathie LM, additional, Tajuddin, Salman M, additional, Talbert, Robert L, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Thorleifsson, Gudmar, additional, Thorsteindottir, Unnur, additional, Tiedt, Steffen, additional, Traylor, Matthew, additional, Trompet, Stella, additional, Valant, Valerie, additional, Waldenberger, Melanie, additional, Walters, Matthew, additional, Wang, Liyong, additional, Wassertheil-Smoller, Sylvia, additional, Weir, David R, additional, Wiggins, Kerri L, additional, Williams, Stephen R, additional, Wloch-Kopec, Dorota, additional, Woo, Daniel, additional, Woodfield, Rebecca, additional, Wu, Ona, additional, Xu, Huichun, additional, Zonderman, Alan B, additional, Worrall, Bradford B, additional, de Bakker, Paul IW, additional, Kittner, Steven J, additional, Mitchell, Braxton D, additional, Rosand, Jonathan, additional, Pulit, Sara L, additional, Sudlow, Cathie L M, additional, Worrall, Bradford B Worrall, additional, Arnett, Donna K Arnett, additional, Benavente, Oscar, additional, and Wasssertheil-Smoller, Sylvia, additional

Published
2016
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48. Advanced Radiation Therapy (RT) Planning and Delivery Methods Impact Survival in Locally Advanced (LA) NSCLC

Author

Di Yan, G.S. Gustafson, J.L. Wloch, Karna Sura, S.K. Prausa, Inga S. Grills, M.D. Johnson, and Hong Ye

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Radiation, business.industry, medicine.medical_treatment, Locally advanced, Radiation therapy, Delivery methods, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, business, Impact survival
Published
2015
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49. Candidate potency assay for ex vivo modulation of umbilical cord blood with 16,16-dimethyl prostaglandin E2: Adaptation of the ISHAGE gating strategy to evaluate increased CXCR4 on CD34+ cells

Author

David J. Robbins, Pratik S. Multani, Betsy Rezner, Thuy Ai Huyen Le, Mary Wloch, and Daniel Shoemaker

Subjects
Cancer Research, Transplantation, business.industry, Cd34 cells, Immunology, Cell Biology, Gating, Pharmacology, Umbilical cord, CXCR4, medicine.anatomical_structure, Oncology, medicine, Immunology and Allergy, Potency, Prostaglandin E2, business, Genetics (clinical), Ex vivo, medicine.drug
Published
2015
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50. The Influence of Bladder Volume on Small Bowel Toxicity and Posterior Bladder Position in Patients Undergoing Chemoradiation for Treatment of Rectal Cancer

Author

J.L. Wloch, Leonid Zamdborg, K. Balde, Di Yan, A.J. Bergsman, J. Robertson, and K.G. Blas

Subjects
Cancer Research, medicine.medical_specialty, Radiation, Colorectal cancer, business.industry, Urology, medicine.disease, Small bowel toxicity, Position (obstetrics), Neck of urinary bladder, Oncology, medicine, Bladder volume, Radiology, Nuclear Medicine and imaging, In patient, business
Published
2016
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