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Start Over Author "Zarrilli, F" Publisher elsevier bv
3 results on '"Zarrilli, F"'

3. DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects

Author

Francesca Lembo, Daniela Punzo, Ermanno Florio, Sonia Mansueto, Francesco Errico, Lorenzo Chiariotti, Giuseppe Castaldo, Tiziana Angrisano, Simona Keller, Federica Zarrilli, Raffaela Pero, Alessandro Usiello, Keller, Simona, Errico, Francesco, Zarrilli, F, Florio, Ermanno, Punzo, Daniela, Mansueto, S, Angrisano, Tiziana, Pero, Raffaela, Lembo, Francesca, Castaldo, Giuseppe, Usiello, A, Chiariotti, Lorenzo, Keller, S, Errico, F, Florio, E, Punzo, D, Angrisano, T, Pero, R, Lembo, F, Castaldo, G, Usiello, Alessandro, and Chiariotti, L.

Subjects
Adult, Male, Statistics as Topic, Gene Expression, Prefrontal Cortex, Striatum, Biology, Young Adult, Schizofrenia, medicine, Humans, RNA, Messenger, Epigenetics, Promoter Regions, Genetic, Prefrontal cortex, Biological Psychiatry, Aged, 80 and over, DNA methylation, BDNF, DNA methylation, Schizophrenia, Brain-Derived Neurotrophic Factor, Methylation, Middle Aged, medicine.disease, Corpus Striatum, Frontal Lobe, Bdnf gene, Psychiatry and Mental health, BDNF, nervous system, CpG site, Schizophrenia, Female, Neuroscience
Abstract

In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated in patients׳group. BDNF mRNA levels in frontal cortex and striatum were variable among individuals but did not associate with disease.

Published
2014
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