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Your search keyword '"Zaugg, Judith B"' showing total 9 results
Start Over Author "Zaugg, Judith B" Publisher elsevier bv
9 results on '"Zaugg, Judith B"'

2. Donor cell memory confers a metastable state of directly converted cells

Author

Kim, Kee-Pyo, primary, Li, Cui, additional, Bunina, Daria, additional, Jeong, Hyun-Woo, additional, Ghelman, Julia, additional, Yoon, Juyong, additional, Shin, Borami, additional, Park, Hongryeol, additional, Han, Dong Wook, additional, Zaugg, Judith B., additional, Kim, Johnny, additional, Kuhlmann, Tanja, additional, Adams, Ralf H., additional, Noh, Kyung-Min, additional, Goldman, Steven A., additional, and Schöler, Hans R., additional

Published
2021
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5. Quantification of Differential Transcription Factor Activity and Multiomics-Based Classification into Activators and Repressors: diffTF

Author

Berest, Ivan, primary, Arnold, Christian, additional, Reyes-Palomares, Armando, additional, Palla, Giovanni, additional, Rasmussen, Kasper Dindler, additional, Giles, Holly, additional, Bruch, Peter-Martin, additional, Huber, Wolfgang, additional, Dietrich, Sascha, additional, Helin, Kristian, additional, and Zaugg, Judith B., additional

Published
2019
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8. Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions

Author

Grubert, Fabian, primary, Zaugg, Judith B., additional, Kasowski, Maya, additional, Ursu, Oana, additional, Spacek, Damek V., additional, Martin, Alicia R., additional, Greenside, Peyton, additional, Srivas, Rohith, additional, Phanstiel, Doug H., additional, Pekowska, Aleksandra, additional, Heidari, Nastaran, additional, Euskirchen, Ghia, additional, Huber, Wolfgang, additional, Pritchard, Jonathan K., additional, Bustamante, Carlos D., additional, Steinmetz, Lars M., additional, Kundaje, Anshul, additional, and Snyder, Michael, additional

Published
2015
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9. Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis

Author

Ranzoni, Anna Maria, Tangherloni, Andrea, Berest, Ivan, Riva, Simone Giovanni, Myers, Brynelle, Strzelecka, Paulina M, Xu, Jiarui, Panada, Elisa, Mohorianu, Irina, Zaugg, Judith B, and Cvejic, Ana

Subjects
fetal hematopoiesis, bone marrow, scRNA-seq, Chromatin Immunoprecipitation Sequencing, Humans, scATAC-seq, Cell Lineage, RNA-Seq, Single-Cell Analysis, Hematopoietic Stem Cells, 3. Good health, fetal liver, Hematopoiesis
Abstract

Regulation of hematopoiesis during human development remains poorly defined. Here we applied single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) to over 8,000 human immunophenotypic blood cells from fetal liver and bone marrow. We inferred their differentiation trajectory and identified three highly proliferative oligopotent progenitor populations downstream of hematopoietic stem cells (HSCs)/multipotent progenitors (MPPs). Along this trajectory, we observed opposing patterns of chromatin accessibility and differentiation that coincided with dynamic changes in the activity of distinct lineage-specific transcription factors. Integrative analysis of chromatin accessibility and gene expression revealed extensive epigenetic but not transcriptional priming of HSCs/MPPs prior to their lineage commitment. Finally, we refined and functionally validated the sorting strategy for the HSCs/MPPs and achieved around 90% enrichment. Our study provides a useful framework for future investigation of human developmental hematopoiesis in the context of blood pathologies and regenerative medicine.

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