1. Thermo-responsive magnetic Fe 3 O 4 @P(MEO 2 MA X -OEGMA 100-X ) NPs and their applications as drug delivery systems
- Author
-
Halima Alem, Abdelaziz Meftah, Raphaël Schneider, Jaafar Ghanbaja, Enaam Jamal Al Dine, Tayssir Hamieh, Joumana Toufaily, Zied Ferjaoui, Thibault Roques-Carmes, Eric Gaffet, Sophie Marchal, Institut Jean Lamour (IJL), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Lebanese University [Beirut] (LU), Unité de nanomatériaux et photonique [Tunis], Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis (FST), Université de Tunis El Manar (UTM)-Université de Tunis El Manar (UTM), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, and Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Drug ,Materials science ,Drug Liberation ,media_common.quotation_subject ,Antineoplastic Agents chemistry ,Pharmaceutical Science ,Nanotechnology ,02 engineering and technology ,Polyethylene Glycols administration & dosage ,010402 general chemistry ,01 natural sciences ,Lower critical solution temperature ,Magnetite Nanoparticles chemistry ,Drug Delivery Systems ,Polyethylene Glycols chemistry ,Polymethacrylic Acids chemistry ,Antineoplastic Agents administration & dosage ,Copolymer ,Humans ,Magnetite Nanoparticles administration & dosage ,Cytotoxicity ,ComputingMilieux_MISCELLANEOUS ,Doxorubicin administration & dosage ,media_common ,Doxorubicin chemistry ,Polymethacrylic Acids administration & dosage ,Temperature ,technology, industry, and agriculture ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Drug delivery ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,Nanomedicine ,Cell Survival drug effects ,0210 nano-technology ,HT29 Cells ,Superparamagnetism - Abstract
The unique physical properties of the superparamagnetic nanoparticles (SPIONs) have made them candidates of choice in nanomedicine especially for diagnostic imaging, therapeutic applications and drug delivery based systems. In this study, superparamagnetic Fe3O4 NPs were synthesized and functionalized with a biocompatible thermoresponsive copolymer to obtain temperature responsive core/shell NPs. The ultimate goal of this work is to build a drug delivery system able to release anticancer drugs in the physiological temperatures range. The core/shell NPs were first synthesized and their chemical, physical, magnetic and thermo-responsive properties where fully characterized in a second step. The lower critical solution temperature (LCST) of the core/shell NPs was tuned in physiological media in order to release the cancer drug at a controlled temperature slightly above the body temperature to avoid any premature release of the drug. The core/shell NPs exhibiting the targeted LCST were then loaded with Doxurubicin (DOX) and the drug release properties were then studied with the temperature. Moreover the cytotoxicity tests have shown that the core/shell NPs had a very limited cytotoxicity up to concentration of 25 mu g/mL. This investigation showed that the significant release occurred at the targeted temperature in the physiological media making those nano-systems very promising for further use in drug delivery platform.
- Published
- 2017
- Full Text
- View/download PDF